Characterizing the DNA damage response in fibrosarcoma stem cells by in-situ cell tracking

References

• Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. 2003. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA. 100:3983–3988.
   PubMed Web of Science ®Google Scholar
• Antonelli F, Campa A, Esposito G, Giardullo P, Belli M, Dini V, Meschini S, Simone G, Sorrentino E, Gerardi S, et al. 2015. Induction and repair of DNA DSB as revealed by H2AX phosphorylation foci in human fibroblasts exposed to low- and high-LET radiation: relationship with early and delayed reproductive cell death. Radiat Res. 183:417–431.
   PubMed Web of Science ®Google Scholar
• Asaithamby A, Chen DJ. 2009. Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation. Nucleic Acids Res. 37:3912–3923.
   PubMed Web of Science ®Google Scholar
• Banáth JP, Klokov D, MacPhail SH, Banuelos CA, Olive PL. 2010. Residual gammaH2AX foci as an indication of lethal DNA lesions. BMC Cancer. 1:12. doi:10.1186/1471-2407-10-4.
   Google Scholar
• Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. 2006. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 444:756–760.
   PubMed Web of Science ®Google Scholar
• Belyaev IY. 2010. Radiation-induced DNA repair foci: spatio-temporal aspects of formation, application for assessment of radiosensitivity and biological dosimetry. Mutat Res. 704:132–141.
   PubMed Web of Science ®Google Scholar
• Caron P, Choudjaye J, Clouaire T, Bugler B, Daburon V, Aguirrebengoa M, Mangeat T, Iacovoni JS, Álvarez-Quilón A, Cortés-Ledesma F, et al. 2015. Non-redundant functions of ATM and DNA-PKcs in response to DNA double-strand breaks. Cell Rep. 13:1598–1609.
   PubMed Web of Science ®Google Scholar
• Coffman VC, Wu JQ. 2012. Counting protein molecules using quantitative fluorescence microscopy. Trends Biochem Sci. 37:499.
   PubMed Web of Science ®Google Scholar
• Deckbar D, Jeggo PA, Lobrich M. 2011. Understanding the limitations of radiation-induced cell cycle checkpoints. Crit Rev Biochem Mol Biol. 46:271–283.
   PubMed Web of Science ®Google Scholar
• Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, et al. 2009. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 458:780–783.
   PubMed Web of Science ®Google Scholar
• Falk M, Lukasova E, Gabrielova B, Ondrej V, Kozubek S. 2007. Chromatin dynamics during DSB repair. Biochim Biophys Acta. 1773:1534–1545.
   PubMed Web of Science ®Google Scholar
• Frame FM, Pellacani D, Collins AT, Simms MS, Mann VM, Jones GDD, Meuth M, Bristow RG, Maitland NJ. 2013. HDAC inhibitor confers radiosensitivity to prostate stem-like cells. Br J Cancer. 109:3023–3033.
   PubMed Web of Science ®Google Scholar
• Fu Q, Quan Y, Wang W, Mei T, Wu J, Li J, Yang G, Ren X, Xue J, Wang Y. 2012. Response of cancer stem-like cells and non-stem cancer cells to proton and γ-ray irradiation. Nucl Instr Meth Phys Res B. 286:346–350.
   Web of Science ®Google Scholar
• Gemenetzidis E, Gammon L, Biddle A, Emich H, Mackenzie IC. 2015. Invasive oral cancer stem cells display resistance to ionising radiation. Oncotarget. 6:43964–43977.
   PubMedGoogle Scholar
• Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, et al. 2007. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell. 1:555–567.
   PubMed Web of Science ®Google Scholar
• Goodarzi AA, Jeggo P, Lobrich M. 2010. The influence of heterochromatin on DNA double strand break repair: getting the strong, silent type to relax. DNA Repair (Amst). 9:1273–1282.
   PubMed Web of Science ®Google Scholar
• Honoki K, Fujii H, Kubo A, Kido A, Mori T, Tanaka Y, Tsujiuchi T. 2010. Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. Oncol Rep. 24:501–505.
   PubMed Web of Science ®Google Scholar
• Huang EH, Hynes MJ, Zhang T, Ginestier C, Dontu G, Appelman H, Fields JZ, Wicha MS, Boman BM. 2009. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res. 69:3382–3389.
   PubMed Web of Science ®Google Scholar
• Iliakis G, Murmann T, Soni A. 2015. Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: implications for the formation of chromosome translocations. Mutat Res Genet Toxicol Environ Mutagen. 793:166–175.
   PubMed Web of Science ®Google Scholar
• Jamal M, Rath BH, Tsang PS, Camphausen K, Tofilon PJ. 2012. The brain microenvironment preferentially enhances the radioresistance of CD133(+) glioblastoma stem-like cells. Neoplasia. 14:150–158.
   PubMed Web of Science ®Google Scholar
• Jeggo PA, Löbrich M. 2006. Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability. DNA Repair (Amst). 5:1192–1198.
   PubMed Web of Science ®Google Scholar
• Kruhlak MJ, Celeste A, Nussenzweig A. 2006. Spatio-temporal dynamics of chromatin containing DNA breaks. Cell Cycle. 5:1910–1912.
   PubMed Web of Science ®Google Scholar
• Liu Y, Kobayashi A, Maeda T, Fu Q, Oikawa M, Yang G, Konishi T, Uchihori Y, Hei TK, Wang Y. 2015. Target irradiation induced bystander effects between stem-like and non-stem-like cancer cells. Mutat Res. 773:43–47.
   PubMed Web of Science ®Google Scholar
• Manuel Iglesias J, Beloqui I, Garcia-Garcia F, Leis O, Vazquez-Martin A, Eguiara A, Cufi S, Pavon A, Menendez JA, Dopazo J, et al. 2013. Mammosphere formation in breast carcinoma cell lines depends upon expression of E-cadherin. PLoS One. 8:e77281.
   PubMed Web of Science ®Google Scholar
• Marková E, Schultz N, Belyaev IY. 2007. Kinetics and dose-response of residual 53BP1/gamma-H2AX foci: co-localization, relationship with DSB repair and clonogenic survival. Int J Radiat Biol. 83:319–329.
   PubMed Web of Science ®Google Scholar
• Phillips TM, McBride WH, Pajonk F. 2006. The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst. 98:1777–1785.
   PubMed Web of Science ®Google Scholar
• Pollard SM, Yoshikawa K, Clarke ID, Danovi D, Stricker S, Russell R, Bayani J, Head R, Lee M, Bernstein M, et al. 2009. Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell. 4:568–580.
   PubMed Web of Science ®Google Scholar
• Rappold I, Iwabuchi K, Date T, Chen J. 2001. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol. 153:613–620.
   PubMed Web of Science ®Google Scholar
• Schultz LB, Chehab NH, Malikzay A, Halazonetis TD. 2000. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol. 151:1381–1390.
   PubMed Web of Science ®Google Scholar
• Sollazzo A, Brzozowska B, Cheng L, Lundholm L, Scherthan H, Wojcik A. 2018. Live dynamics of 53BP1 foci following simultaneous induction of clustered and dispersed DNA damage in U2OS cells. Int J Mol Sci. 19(2): pii: E519.
   Google Scholar
• Vadhavkar N, Pham C, Georgescu W, Deschamps T, Heuskin AC, Tang J, Costes SV. 2014. Combinatorial DNA damage pairing model based on X-ray-induced foci predicts the dose and LET dependence of cell death in human breast cells. Radiat Res. 182:273–281.
   PubMed Web of Science ®Google Scholar