Low-dose ionizing radiation attenuates mast cell migration through suppression of monocyte chemoattractant protein-1 (MCP-1) expression by Nr4a2

References

• Aherne CM, McMorrow J, Kane D, FitzGerald O, Mix KS, Murphy EP. 2009. Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol. 46:3345–3357.
   PubMed Web of Science ®Google Scholar
• Bretscher A. 1991. Microfilament structure and function in the cortical cytoskeleton. Annu Rev Cell Biol. 7:337–374.
   PubMedGoogle Scholar
• Brown AM, O'Sullivan AJ, Gomperts BD. 1998. Induction of exocytosis from permeabilized mast cells by the guanosine triphosphatases Rac and Cdc42. Mol Biol Cell. 9:1053–1063.
   PubMed Web of Science ®Google Scholar
• Devreotes PN, Zigmond SH. 1988. Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium. Annu Rev Cell Biol. 4:649–686.
   PubMedGoogle Scholar
• Doi Y, Oki S, Ozawa T, Hohjoh H, Miyake S, Yamamura T. 2008. Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. Proc Nat Acad Sci. 105:8381–8386.
   PubMed Web of Science ®Google Scholar
• Draber P, Sulimenko V, Draberova E. 2012. Cytoskeleton in mast cell signaling. Front Immunol. 3:130.
   PubMed Web of Science ®Google Scholar
• Ellenbroek SI, Collard JG. 2007. Rho GTPases: functions and association with cancer. Clin Exp Metastasis. 24:657–672.
   PubMed Web of Science ®Google Scholar
• Galli SJ, Tsai M. 2012. IgE and mast cells in allergic disease. Nat Med. 18:693–704.
   PubMed Web of Science ®Google Scholar
• Guillemot JC, Montcourrier P, Vivier E, Davoust J, Chavrier P. 1997. Selective control of membrane ruffling and actin plaque assembly by the Rho GTPases Rac1 and CDC42 in FcepsilonRI-activated rat basophilic leukemia (RBL-2H3) cells. J Cell Sci. 110:2215–2225.
   PubMed Web of Science ®Google Scholar
• Han YF, Cao GW. 2012. Role of nuclear receptor NR4A2 in gastrointestinal inflammation and cancers. World J Gastroenterol. 18:6865–6873.
   PubMed Web of Science ®Google Scholar
• Joo HM, Kang SJ, Nam SY, Yang KH, Kim CS, Lee IK, Kim JY. 2015. The inhibitory effects of low-dose ionizing radiation in IgE-mediated allergic responses. Plos One. 10:e0136394
   PubMed Web of Science ®Google Scholar
• Joo HM, Nam SY, Yang KH, Kim CS, Jin YW, Kim JY. 2012. The effects of low-dose ionizing radiation in the activated rat basophilic leukemia (RBL-2H3) mast cells. J Biol Chem. 287:27789–27795.
   PubMed Web of Science ®Google Scholar
• Kim JS, Son Y, Bae MJ, Lee SS, Park SH, Lee HJ, Lee SI, Lee CG, Kim SD, Jo WS, et al. 2015. Continuous exposure to low-dose-rate gamma irradiation reduces airway inflammation in ovalbumin-induced asthma. Plos One. 10:e0143403.
   PubMed Web of Science ®Google Scholar
• Kitaura J, Kinoshita T, Matsumoto M, Chung S, Kawakami Y, Leitges M, Wu D, Lowell CA, Kawakami T. 2005. IgE- and IgE + Ag-mediated mast cell migration in an autocrine/paracrine fashion. Blood. 105:3222–3229.
   PubMed Web of Science ®Google Scholar
• Kuehn HS, Radinger M, Brown JM, Ali K, Vanhaesebroeck B, Beaven MA, Metcalfe DD, Gilfillan AM. 2010. Btk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast cells. J Cell Sci. 123:2576–2585.
   PubMed Web of Science ®Google Scholar
• Luckey TD. 2006. Radiation hormesis: the good, the bad, and the ugly. Dose Response. 4:169–190.
   PubMedGoogle Scholar
• Lundequist A, Calounova G, Wensman H, Ronnberg E, Pejler G. 2011. Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation. Mol Immunol. 48:1753–1761.
   PubMed Web of Science ®Google Scholar
• Maijenburg MW, Gilissen C, Melief SM, Kleijer M, Weijer K, Ten Brinke A, Roelofs H, Van Tiel CM, Veltman JA, de Vries CJ, et al. 2012. Nuclear receptors Nur77 and Nurr1 modulate mesenchymal stromal cell migration. Stem Cells Dev. 21:228–238.
   PubMed Web of Science ®Google Scholar
• Maxwell MA, Muscat GE. 2006. The NR4A subgroup: immediate early response genes with pleiotropic physiological roles. Nucl Recept Signal. 4:e002
   PubMedGoogle Scholar
• Metcalfe DD, Baram D, Mekori YA. 1997. Mast cells. Physiol Rev. 77:1033–1079.
   PubMed Web of Science ®Google Scholar
• Mix KS, McMahon K, McMorrow JP, Walkenhorst DE, Smyth AM, Petrella BL, Gogarty M, Fearon U, Veale D, Attur MG, et al. 2012. Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription. Arthritis Rheum. 64:2126–2136.
   PubMed Web of Science ®Google Scholar
• Murphy EP, McEvoy A, Conneely OM, Bresnihan B, FitzGerald O. 2001. Involvement of the nuclear orphan receptor NURR1 in the regulation of corticotropin-releasing hormone expression and actions in human inflammatory arthritis. Arthritis Rheum. 44:782–793.
   PubMed Web of Science ®Google Scholar
• Nakatsukasa H, Tsukimoto M, Ohshima Y, Tago F, Masada A, Kojima S. 2008. Suppressing effect of low-dose gamma-ray irradiation on collagen-induced arthritis. J Radiat Res. 49:381–389.
   PubMed Web of Science ®Google Scholar
• Nobes CD, Hall A. 1995. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 81:53–62.
   PubMed Web of Science ®Google Scholar
• Norman JC, Price LS, Ridley AJ, Koffer A. 1996. The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways. Mol Biol Cell. 7:1429–1442.
   PubMed Web of Science ®Google Scholar
• Okayama Y, Kawakami T. 2006. Development, migration, and survival of mast cells. Immunol Res. 34:97–115.
   PubMed Web of Science ®Google Scholar
• Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. 2005. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem. 280:29256–29262.
   PubMed Web of Science ®Google Scholar
• Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P. 2006. NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat Med. 12:1048–1055.
   PubMed Web of Science ®Google Scholar
• Price LS, Norman JC, Ridley AJ, Koffer A. 1995. The small GTPases Rac and Rho as regulators of secretion in mast cells. Curr Biol. 5:68–73.
   PubMed Web of Science ®Google Scholar
• Ridley AJ, Hall A. 1992. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 70:389–399.
   PubMed Web of Science ®Google Scholar
• Steffen A, Ladwein M, Dimchev GA, Hein A, Schwenkmezger L, Arens S, Ladwein KI, Holleboom JM, Schur F, Small JV, et al. 2013. Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation. J Cell Sci. 126:4572–4588.
   PubMed Web of Science ®Google Scholar
• Wang X, Hayashi S, Umezaki M, Yamamoto T, Kageyama-Yahara N, Kondo T, Kadowaki M. 2014. Shikonin, a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells. Chem Biol Interact. 224:117–127.
   PubMed Web of Science ®Google Scholar
• Zetterstrom RH, Solomin L, Jansson L, Hoffer BJ, Olson L, Perlmann T. 1997. Dopamine neuron agenesis in Nurr1-deficient mice. Science. 276:248–250.
   PubMed Web of Science ®Google Scholar
• Zhang L, Paine C, Dip R. 2010. Selective regulation of nuclear orphan receptors 4A by adenosine receptor subtypes in human mast cells. J Cell Commun Signal. 4:173–183.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Bruemmer D. 2010. NR4A orphan nuclear receptors: transcriptional regulators of gene expression in metabolism and vascular biology. Arterioscler Thromb Vasc Biol. 30:1535–1541.
   PubMed Web of Science ®Google Scholar
• Zhao ZZ, Sugerman PB, Walsh LJ, Savage NW. 2002. Expression of RANTES and CCR1 in oral lichen planus and association with mast cell migration. J Oral Pathol Med. 31:158–162.
   PubMed Web of Science ®Google Scholar