A potential new role of ATM inhibitor in radiotherapy: suppressing ionizing Radiation-Activated EGFR

References

• Bensimon A, Aebersold R, Shiloh Y. 2011. Beyond ATM: The protein kinase landscape of the DNA damage response. FEBS Lett. 585(11):1625–1639.
   PubMed Web of Science ®Google Scholar
• Blasco M. T, Navas C, Martín-Serrano G, Graña-Castro O, Lechuga C. G, Martín-Díaz L, Djurec M, Li J, Morales-Cacho L, Esteban-Burgos L, et al. 2019. Complete regression of advanced pancreatic ductal adenocarcinomas upon combined inhibition of EGFR and C-RAF. Cancer Cell. 35(4):573–587.e576.
   PubMed Web of Science ®Google Scholar
• Carruthers R, Ahmed S U, Strathdee K, Gomez-Roman N, Amoah-Buahin E, Watts C, Chalmers A J. 2015. Abrogation of radioresistance in glioblastoma stem‐like cells by inhibition of ATM kinase. Mol Oncol. 9(1):192–203.
   PubMed Web of Science ®Google Scholar
• Chalmers AJ, Ruff EM, Martindale C, Lovegrove N, Short SC. 2009. Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent. Int J Radiat Oncol Biol Phys. 75(5): 01.
   PubMed Web of Science ®Google Scholar
• Chen D. J, Nirodi C. S. 2007. The epidermal growth factor receptor: a role in repair of Radiation-Induced DNA damage. Clin Cancer Res. 13(22):6555–6560.
   PubMed Web of Science ®Google Scholar
• Dittmann K, Mayer C, Rodemann H. P. 2005. Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiother Oncol. 76(2):157–161.
   Web of Science ®Google Scholar
• Durant ST, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, Yang Z, Riches L, Trinidad AG, Fok JHL, et al. 2018. The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models. Sci Adv. 4(6):06.
   Web of Science ®Google Scholar
• Erdem-Eraslan L, Gao Y, Kloosterhof N. K, Atlasi Y, Demmers J, Sacchetti A, Kros J. M, Sillevis Smitt P, Aerts J, et al. 2015. Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation. Eur J Cancer. 51(7):893–903.
   PubMed Web of Science ®Google Scholar
• Fan Q.-W, Cheng C. K, Gustafson W. C, Charron E, Zipper P, Wong R. A, Chen J, Lau J, Knobbe-Thomsen C, Weller M, et al. 2013. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 24(4):438–449.
   PubMed Web of Science ®Google Scholar
• Friedmann B. J, Caplin M, Savic B, Shah T, Lord C. J, Ashworth A, Hartley J. A, Hochhauser D. 2006. Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment. Mol Cancer Ther. 5(2):209–218.
   PubMed Web of Science ®Google Scholar
• Golding S. E, Rosenberg E, Khalil A, McEwen A, Holmes M, Neill S, Povirk L. F, Valerie K. 2004. Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells. J Biol Chem. 279(15):15402–15410.
   PubMed Web of Science ®Google Scholar
• Graham R. P, Treece A. L, Lindeman N. I, Vasalos P, Shan M, Jennings L. J, Rimm D. L. 2018. Worldwide frequency of commonly detected EGFR mutations. Arch Pathol Lab Med. 142(2):163–167.
   PubMed Web of Science ®Google Scholar
• Gunn A, Bennardo N, Cheng A, Stark J. M. 2011. Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNAdependent protein kinase DNA-PKcs, and transcription context. J Biol Chem. 286(49):42470–42482.
   PubMed Web of Science ®Google Scholar
• Herbst R. S. 2004. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys. 59(2 Suppl):21–26.
   PubMed Web of Science ®Google Scholar
• Hu B, Wang X, Hu S, Ying X, Wang P, Zhang X, Wang J, Wang H, Wang Y. 2017. miR-21-mediated Radioresistance Occurs via Promoting Repair of DNA Double Strand Breaks. J Biol Chem. 292(8):3531–3540.
   PubMed Web of Science ®Google Scholar
• Kang K. B, Zhu C, Wong Y. L, Gao Q, Ty A, Wong M. C. 2012. Gefitinib radiosensitizes stem-like glioma cells: inhibition of epidermal growth factor receptor-Akt-DNAPK signaling, accompanied by inhibition of DNA double-strand break repair. Int J Radiat Oncol Biol Phys. 83(1):e43–52.
   PubMed Web of Science ®Google Scholar
• Lee H. J, Lan L, Peng G, Chang W. C, Hsu M. C, Wang Y. N, Cheng C. C, Wei L, Nakajima S, Chang S. S, et al. 2015. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res. 25(2):225–236.
   PubMed Web of Science ®Google Scholar
• Liccardi G, Hartley J. A, Hochhauser D. 2014. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin Cancer Res. 20(13):3496–3506.
   PubMed Web of Science ®Google Scholar
• Lucero H, Gae D, Taccioli G. E. 2003. Novel localization of the DNA-PK complex in lipid rafts: a putative role in the signal transduction pathway of the ionizing radiation response. J Biol Chem. 278(24):22136–22143.
   PubMed Web of Science ®Google Scholar
• Moore M. J, Goldstein D, Hamm J, Figer A, Hecht J. R, Gallinger S, Au H. J, Murawa P, Walde D, Wolff R. A, et al. 2007. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 25(15):1960–1966.
   PubMed Web of Science ®Google Scholar
• Shen M, Xu Z, Xu W, Jiang K, Zhang F, Ding Q, Xu Z, Chen Y. 2019. Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway. J Exp Clin Cancer Res. 38(1):8.
   PubMedGoogle Scholar
• Singh D, Attri B. K, Gill R. K, Bariwal J. 2016. Review on EGFR inhibitors: critical updates. Mini Rev Med Chem. 16(14):1134–1166.
   PubMed Web of Science ®Google Scholar
• Stockert J. C, Horobin R. W, Colombo L. L, Blazquez-Castro A. 2018. Tetrazolium salts and formazan products in Cell Biology: Viability assessment, fluorescence imaging, and labeling perspectives. Acta Histochem. 120(3):159–167.
   PubMed Web of Science ®Google Scholar
• Tang S, Liu L, Liu M, Li Z, Liu J, Wang H, Wang J, Oh Y.-T, Shen L, Wang Y. 2019. Ionizing radiation-induced growth in soft agar is associated with miR-21 upregulation in wild-type and DNA double strand break repair deficient cells. DNA Repair. 78:37–44.
   PubMed Web of Science ®Google Scholar
• Verma P, Greenberg R. A. 2016. Noncanonical views of homology-directed DNA repair. Genes Dev. 30(10):1138–1154.
   PubMed Web of Science ®Google Scholar
• Wee P, Wang Z. 2017. Epidermal growth factor receptor cell proliferation signaling pathways. Cancers. 9(5):52.
   PubMed Web of Science ®Google Scholar
• Yin Y, Xu L, Chang Y, Zeng T, Chen X, Wang A, Groth J, Foo WC, Liang C, Hu H, et al. 2019. N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway. Mol Cancer. 18(1):11.
   Web of Science ®Google Scholar