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Editorial

Flying by the seat of our pants: is low dose radiation therapy for COVID-19 an option?

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Pages 1219-1223 | Received 23 Apr 2020, Accepted 05 May 2020, Published online: 26 May 2020

References

  • Álvarez B, Montero Á, Aramburu F, Calvo E, Ángel de la Casa M, Valero J, Hernando O, López M, Ciérvide R, García-Aranda M, et al. 2020. Radiotherapy for ostheoarticular degenerative disorders: when nothing else works. Osteoarthr Cartil Open. 1(3–4):100016.
  • Arnaldez FI, O'Day SJ, Drake CG, Fox BA, Fu B, Urba WJ, Montesarchio V, Weber JS, Wei H, Wigginton JM, et al. 2020. The society for immunotherapy of cancer perspective on regulation of interleukin 6 signaling in COVID-19 – related systemic inflammatory response. J Immunother Cancer. 8(1):e000930.
  • Baldridge CW, Gerard RW. 1932. The extra respiration of phagocytes. Am J Physiol Legacy Cont. 103(1):235–236.
  • Bao L, Ma J, Chen G, Hou J, Hei TK, Yu KN, Han W. 2016. Role of heme oxygenase-1 in low dose radioadaptive response. Redox Biol. 8(8333):333–340.
  • Calabrese EJ, Dhawan G. 2013. How radiotherapy was historically used to treat pneumonia: could it be useful today? Yale J Biol Med. 86(4):555–570.
  • Demaria S, Bhardwaj N, McBride WH, Formenti SC. 2005. Combining radiotherapy and immunotherapy: a revived partnership. Int J Radiat Oncol Biol Phys. 63(3):655–666.
  • Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, et al. 2014. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity. 41(5):843–852.
  • DesJardins AU. 1935. Roentgen therapy. In: Mock HE, Pemberton R, Coulter JS, editors. Principles and practice of physical therapy. Hagerstown (MD): W. F. Prior Co. Inc.
  • Edling L. 1925. The Roentgen treatment of surgical tuberculosis. Acta Radiol. 4(5):397–456.
  • FDA Reagan-Udall Foundation. 2020. Clinical trials and expanded access. COVID-19 Investigational Treatment Hub. [accessed 2020 Apr 28]. https://reaganudall.org/covid-19-treatment-hub/covid-listings.
  • Fischer U, Kamprad F, Koch F, Ludewig E, Melzer R, Hildebrandt G. 1998. [The effects of low-dose Co-60 irradiation on the course of aseptic arthritis in a rabbit knee joint]. Strahlenther Onkol. 174(12):633–639.
  • Forrester SJ, Kikuchi DS, Hernandes MS, Xu Q, Griendling KK. 2018. Reactive oxygen species in metabolic and inflammatory signaling. Circ Res. 122(6):877–902.
  • Gattinoni L, Coppola S, Cressoni M, Busana M, Rossi S, Chiumello D. 2020. Covid-19 does not lead to a “typical” acute respiratory distress syndrome. Am J Respir Crit Care Med. 201:1299–1300
  • Hartlova A, Erttmann SF, Raffi FA, Schmalz AM, Resch U, Anugula S, Lienenklaus S, Nilsson LM, Kroger A, Nilsson JA, et al. 2015. DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity. Immunity. 42(2):332–343.
  • Harvey WG. 1908. On the pathological effects of Röntgen rays on animal tissues. J. Pathol. 12(3):549–556.
  • Heinecke H. 1903. Über die Einwirkung der Röntgenstrahlen auf Tiere. Münch Med Wochenschr. 50:2090–2092.
  • Hildebrandt G, Seed MP, Freemantle CN, Alam CA, Colville-Nash PR, Trott KR. 1998a. Effects of low dose ionizing radiation on murine chronic granulomatous tissue. Strahlenther Onkol. 174(11):580–588.
  • Hildebrandt G, Seed MP, Freemantle CN, Alam CA, Colville-Nash PR, Trott KR. 1998b. Mechanisms of the anti-inflammatory activity of low-dose radiation therapy. Int J Radiat Biol. 74(3):367–378.
  • Kern PM, Keilholz L, Forster C, Hallmann R, Herrmann M, Seegenschmiedt MH. 2000. Low-dose radiotherapy selectively reduces adhesion of peripheral blood mononuclear cells to endothelium in vitro. Radiother Oncol. 54(3):273–282.
  • Kirkby C, Mackenzie M. 2020. Is low dose radiation therapy a potential treatment for COVID-19 pneumonia? Radiother Oncol. DOI:10.1016/j.radonc.2020.04.004.
  • Koc BB, Schotanus MGM, Borghans R, Jong B, Maassen ME, Buijsen J, Jansen E. 2019. Short-term pain reduction after low-dose radiotherapy in patients with severe osteoarthritis of the hip or knee joint: a cohort study and literature review. Eur J Orthop Surg Traumatol. 29(4):843–847.
  • Kriz J, Seegenschmiedt HM, Bartels A, Micke O, Muecke R, Schaefer U, Haverkamp U, Eich HT. 2018. Updated strategies in the treatment of benign diseases—a patterns of care study of the German cooperative group on benign diseases. Adv Radiat Oncol. 3(3):240–244.
  • Large M, Hehlgans S, Reichert S, Gaipl US, Fournier C, Rodel C, Weiss C, Rodel F. 2015. Study of the anti-inflammatory effects of low-dose radiation: the contribution of biphasic regulation of the antioxidative system in endothelial cells. Strahlenther Onkol. 191(9):742–749.
  • Micke O, Seegenschmiedt MH, Adamietz IA, Kundt G, Fakhrian K, Schaefer U, Muecke R. 2017. Low-dose radiation therapy for benign painful skeletal disorders: the typical treatment for the elderly patient? Int J Radiat Oncol Biol Phys. 98(4):958–963.
  • Nakatsukasa H, Tsukimoto M, Ohshima Y, Tago F, Masada A, Kojima S. 2008. Suppressing effect of low-dose gamma-ray irradiation on collagen-induced arthritis. J Radiat Res. 49(4):381–389.
  • NIH News Releases. 2020. NIH to launch public-private partnership to speed COVID-19 vaccine and treatment options. [accessed 2020 Apr 17]. https://www.nih.gov/news-events/news-releases/nih-launch-public-private-partnership-speed-covid-19-vaccine-treatment-options.
  • Piacenza L, Trujillo M, Radi R. 2019. Reactive species and pathogen antioxidant networks during phagocytosis. J Exp Med. 216(3):501–516.
  • Powell EV. 1938. Roentgen therapy of lobar pneumonia. JAMA. 110(1):19–22.
  • Rodrigues-Moreira S, Moreno SG, Ghinatti G, Lewandowski D, Hoffschir F, Ferri F, Gallouet AS, Gay D, Motohashi H, Yamamoto M, et al. 2017. Low-dose irradiation promotes persistent oxidative stress and decreases self-renewal in hematopoietic stem cells. Cell Rep. 20(13):3199–3211.
  • Rodriguez B. 2020. COVID19 insights #9; PSA #10 Is the ICU and ventilator management of Covid-19 appropriate? [accessed 2020 Apr 11]. https://covid19-insights.squarespace.com.
  • Roedel F, Frey B, Gaipl U, Keilholz L, Fournier C, Manda K, Schöllnberger H, Hildebrandt G, Rödel C. 2012a. Modulation of inflammatory immune reactions by low-dose ionizing radiation: molecular mechanisms and clinical application. Curr Med Chem. 19(12):1741–1750.
  • Roedel F, Frey B, Manda K, Hildebrandt G, Hehlgans S, Keilholz L, Seegenschmiedt MH, Gaipl US, Roedel C. 2012b. Immunomodulatory properties and molecular effects in inflammatory diseases of low-dose x-irradiation. Front Oncol. 2:120.
  • Roedel F, Voll R, Haentschel M, Herrmann M, Beuscher HU, Sauer R. 2001. Dose-dependent biphasic expression of nuclear factor KappaB (NF-kB) in endothelial cells by low-dose ionizing radiation. Int J Radiat Oncol Biol Phys. 51(3):230–231.
  • Schaue D, Marples B, Trott KR. 2002. The effects of low-dose X-irradiation on the oxidative burst in stimulated macrophages. Int J Radiat Biol. 78(7):567–576.
  • Schillinger R. 1932. The apparent therapeutic effect of the Roentgen ray upon the clinical course of acute mastoiditis (preliminary report). Radiology. 18(4):763–776.
  • Scott WR. 1939. X-ray therapy in the treatment of acute pneumonia. Radiology. 33(3):331–349.
  • Seegenschmiedt MH, Katalinic A, Makoski H, Haase W, Gademann G, Hassenstein E. 2000. Radiation therapy for benign diseases: patterns of care study in Germany. Int J Radiat Oncol Biol Phys. 47(1):195–202.
  • Seegenschmiedt MH, Micke O, Willich N. 2004. Radiation therapy for nonmalignant diseases in Germany. Current concepts and future perspectives. Strahlenther Onkol. 180(11):718–730.
  • Shi Y, Wang Y, Shao C, Huang J, Gan J, Huang X, Bucci E, Piacentini M, Ippolito G, Melino G. 2020. COVID-19 infection: the perspectives on immune responses. Cell Death Differ. 27(5):1451–1454.
  • Shohan J. 1916. Some theoretical considerations on the present status of Roentgen therapy. Boston Med Surg J. 175(10):321–327.
  • Staurengo-Ferrari L, Badaro-Garcia S, Hohmann MSN, Manchope MF, Zaninelli TH, Casagrande R, Verri WA. 2018. Contribution of Nrf2 modulation to the mechanism of action of analgesic and anti-inflammatory drugs in pre-clinical and clinical stages. Front Pharmacol. 9(1536):1536.
  • Steffen C, Muller C, Stellamor K, Zeitlhofer J. 1982. Influence of x-ray treatment on antigen-induced experimental arthritis. Ann Rheum Dis. 41(5):532–537.
  • Trott K, Kamprad F, Hildebrandt G. 2008. Radiobiological Principles. In: Seegenschmiedt M, Makoski H, Trott K, Brady L. Radiotherapy for non-malignant disorders. Berlin, Heidelberg: Springer; p. 3–27.
  • Trott KR. 1994. Therapeutic effects of low radiation doses. Strahlenther Onkol. 170(1):1–12.
  • Trott KR, Kamprad F. 1999. Radiobiological mechanisms of anti-inflammatory radiotherapy. Radiother Oncol. 51(3):197–203.
  • Wiig H. 2011. Pathophysiology of tissue fluid accumulation in inflammation. J Physiol (Lond.). 589(Pt 12):2945–2953.
  • Wu Z, McGoogan JM. 2020. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA. 323(13):1239–1242.
  • Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, Zhu L, et al. 2020. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 8(4):420–422.

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