Clodronate-liposomes aggravate irradiation-induced myelosuppression by promoting myeloid differentiation

References

• Alves-Rosa F, Stanganelli C, Cabrera J, van Rooijen N, Palermo MS, Isturiz MA. 2000. Treatment with liposome-encapsulated clodronate as a new strategic approach in the management of immune thrombocytopenic purpura in a mouse model [Research Support, Non-U.S. Gov't]. Blood. 96(8):2834–2840.
   PubMed Web of Science ®Google Scholar
• Bader JE, Enos RT, Velazquez KT, Carson MS, Sougiannis AT, McGuinness OP, Robinson CM, Murphy EA. 2019. Repeated clodronate-liposome treatment results in neutrophilia and is not effective in limiting obesity-linked metabolic impairments. Am J Physiol Endocrinol Metab. 316(3):E358–E372.
   PubMed Web of Science ®Google Scholar
• Barbier V, Winkler IG, Levesque JP. 2012. Mobilization of hematopoietic stem cells by depleting bone marrow macrophages. Methods Mol Biol. 904:117–138.
   PubMedGoogle Scholar
• Bianchi E, Norfo R, Pennucci V, Zini R, Manfredini R. 2016. Genomic landscape of megakaryopoiesis and platelet function defects [Research Support, Non-U.S. Gov't Review]. Blood. 127(10):1249–1259.
   PubMed Web of Science ®Google Scholar
• Broudy VC. 1997. Stem cell factor and hematopoiesis [Research Support, U.S. Gov't, P.H.S. Review]. Blood. 90(4):1345–1364.
   PubMed Web of Science ®Google Scholar
• Carey A, Edwards DKt, Eide CA, Newell L, Traer E, Medeiros BC, Pollyea DA, Deininger MW, Collins RH, Tyner JW, et al. 2017. Identification of interleukin-1 by functional screening as a key mediator of cellular expansion and disease progression in acute myeloid leukemia [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. Cell Rep. 18(13):3204–3218.
   PubMed Web of Science ®Google Scholar
• Chan JY, Lee K, Maxwell EL, Liang C, Laybutt DR. 2019. Macrophage alterations in islets of obese mice linked to beta cell disruption in diabetes [Research Support, Non-U.S. Gov't]. Diabetologia. 62(6):993–999.
   PubMed Web of Science ®Google Scholar
• Czyz A, Labopin M, Giebel S, Socie G, Apperley J, Volin L, Remenyi P, Yakoub-Agha I, Orchard K, Michallet M, et al. 2018. Cyclophosphamide versus etoposide in combination with total body irradiation as conditioning regimen for adult patients with Ph-negative acute lymphoblastic leukemia undergoing allogeneic stem cell transplant: on behalf of the ALWP of the European Society for Blood and Marrow Transplantation [Comparative Study]. Am J Hematol. 93(6):778–785.
   PubMed Web of Science ®Google Scholar
• Friedman DN, Hilden P, Moskowitz CS, Suzuki M, Boulad F, Kernan NA, Wolden SL, Oeffinger KC, Sklar CA. 2017. Cardiovascular risk factors in survivors of childhood hematopoietic cell transplantation treated with total body irradiation: a longitudinal analysis. Biol Blood Marrow Transplant. 23(3):475–482.
   PubMed Web of Science ®Google Scholar
• Fujiwara SI, Kanda J, Tatara R, Ogawa H, Fukuda T, Okumura H, Ohashi K, Iwato K, Ueda Y, Ishiyama K, et al.; HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. 2019. Clinical significance of low-dose total body irradiation in HLA-mismatched reduced-intensity stem cell transplantation. Bone Marrow Transplant. 54(8):1327–1336.
   PubMed Web of Science ®Google Scholar
• Gadotti VM, Martins DF, Pinto HF, Oliveira G, Kaster MP, Quintao NL, Santos AR. 2012. Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice [Research Support, Non-U.S. Gov't]. Pharmacol Biochem Behav. 102(4):549–554.
   PubMed Web of Science ®Google Scholar
• Heideveld E, Masiello F, Marra M, Esteghamat F, Yağcı N, von Lindern M, Migliaccio ARF, van den Akker E. 2015. CD14+ cells from peripheral blood positively regulate hematopoietic stem and progenitor cell survival resulting in increased erythroid yield. Haematologica. 100(11):1396–1406.
   PubMed Web of Science ®Google Scholar
• Heideveld E, van den Akker E. 2017. Digesting the role of bone marrow macrophages on hematopoiesis [Review Research Support, Non-U.S. Gov't]. Immunobiology. 222(6):814–822.
   PubMed Web of Science ®Google Scholar
• Huang MY, Lian SL, Wu HL, Chai CY, Chang SJ, Huang CJ, Tang JY. 2007. Effects of zinc compound on body weight and recovery of bone marrow in mice treated with total body irradiation [Research Support, Non-U.S. Gov't]. Kaohsiung J Med Sci. 23(9):453–462.
   PubMed Web of Science ®Google Scholar
• Huang P, Li X, Meng Y, Yuan B, Liu T, Jiao M, Wang X, Liu Y, Yin H. 2019. Interleukin-33 regulates hematopoietic stem cell regeneration after radiation injury. Stem Cell Res Ther. 10(1):123.
   PubMedGoogle Scholar
• Jacobsen RN, Nowlan B, Brunck ME, Barbier V, Winkler IG, Levesque JP. 2016. Fms-like tyrosine kinase 3 (Flt3) ligand depletes erythroid island macrophages and blocks medullar erythropoiesis in the mouse [Research Support, Non-U.S. Gov't]. Exp Hematol. 44(3):207–212. e204.
   PubMed Web of Science ®Google Scholar
• Jordan MB, van Rooijen N, Izui S, Kappler J, Marrack P. 2003. Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. Blood. 101(2):594–601.
   PubMed Web of Science ®Google Scholar
• Ju W, Smith AO, Sun T, Zhao P, Jiang Y, Liu L, Zhang T, Qi K, Qiao J, Xu K, et al. 2018. Validation of housekeeping genes as reference for reverse-transcription-qPCR analysis in Busulfan-injured microvascular endothelial cells [Validation Studies]. Biomed Res Int. 2018:4953806.
   PubMed Web of Science ®Google Scholar
• Kaur S, Raggatt LJ, Batoon L, Hume DA, Levesque JP, Pettit AR. 2017. Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches [Review Research Support, Non-U.S. Gov't]. Semin Cell Dev Biol. 61:12–21.
   PubMed Web of Science ®Google Scholar
• Kaur S, Raggatt LJ, Millard SM, Wu AC, Batoon L, Jacobsen RN, Winkler IG, MacDonald KP, Perkins AC, Hume DA, et al. 2018. Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment [Research Support, Non-U.S. Gov't]. Blood. 132(7):735–749.
   PubMed Web of Science ®Google Scholar
• Kawanishi N, Mizokami T, Niihara H, Yada K, Suzuki K. 2016. Macrophage depletion by clodronate liposome attenuates muscle injury and inflammation following exhaustive exercise. Biochem Biophys Rep. 5:146–151.
   PubMedGoogle Scholar
• Kebriaei P, Anasetti C, Zhang MJ, Wang HL, Aldoss I, de Lima M, Khoury HJ, Sandmaier BM, Horowitz MM, Artz A, et al. 2018. Intravenous Busulfan compared with total body irradiation pretransplant conditioning for adults with acute lymphoblastic leukemia [Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.]. Biol Blood Marrow Transplant: J Am Soc Blood Marrow Transplant. 24(4):726–733.
   PubMed Web of Science ®Google Scholar
• Kiang JG, Zhai M, Liao PJ, Ho C, Gorbunov NV, Elliott TB. 2017. Thrombopoietin receptor agonist mitigates hematopoietic radiation syndrome and improves survival after whole-body ionizing irradiation followed by wound trauma. Mediators Inflamm. 2017:7582079.
   PubMed Web of Science ®Google Scholar
• Li Z, Xu X, Feng X, Murphy PM. 2016. The macrophage-depleting agent clodronate promotes durable hematopoietic chimerism and donor-specific skin allograft tolerance in mice [Research Support, N.I.H., Intramural]. Sci Rep. 6:22143.
   PubMed Web of Science ®Google Scholar
• Luo Y, Shao L, Chang J, Feng W, Liu YL, Cottler-Fox MH, Emanuel PD, Hauer-Jensen M, Bernstein ID, Liu L, et al. 2018. M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion. Blood Adv. 2(8):859–870.
   PubMed Web of Science ®Google Scholar
• Mathes M, Jordan M, Dow S. 2006. Evaluation of liposomal clodronate in experimental spontaneous autoimmune hemolytic anemia in dogs [Comparative Study Research Support, Non-U.S. Gov't]. Exp Hematol. 34(10):1393–1402.
   PubMed Web of Science ®Google Scholar
• McCabe A, Smith JNP, Costello A, Maloney J, Katikaneni D, MacNamara KC. 2018. Hematopoietic stem cell loss and hematopoietic failure in severe aplastic anemia is driven by macrophages and aberrant podoplanin expression. Haematologica. 103(9):1451–1461.
   PubMed Web of Science ®Google Scholar
• Moreno SG. 2018. Depleting macrophages in vivo with clodronate-liposomes. Methods Mol Biol. 1784:259–262.
   PubMedGoogle Scholar
• Opperman KS, Vandyke K, Clark KC, Coulter EA, Hewett DR, Mrozik KM, Schwarz N, Evdokiou A, Croucher PI, Psaltis PJ, et al. 2019. Clodronate-liposome mediated macrophage depletion abrogates multiple myeloma tumor establishment in vivo. Neoplasia. 21(8):777–787.
   PubMed Web of Science ®Google Scholar
• Paix A, Antoni D, Waissi W, Ledoux MP, Bilger K, Fornecker L, Noel G. 2018. Total body irradiation in allogeneic bone marrow transplantation conditioning regimens: a review [Review]. Crit Rev Oncol Hematol. 123:138–148.
   PubMed Web of Science ®Google Scholar
• Pietras EM, Mirantes-Barbeito C, Fong S, Loeffler D, Kovtonyuk LV, Zhang S, Lakshminarasimhan R, Chin CP, Techner JM, Will B, et al. 2016. Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. Nat Cell Biol. 18(6):607–618.
   PubMed Web of Science ®Google Scholar
• Qiao J, Liu L, Xia Y, Ju W, Zhao P, Jiang Y, Li M, Li W, Ding L, Wu Y, et al. 2018. Macrophages ameliorate bone marrow inflammatory injury and promote hematopoiesis in mice following hematopoietic stem cell transplantation. Exp Ther Med. 16(2):567–572.
   PubMed Web of Science ®Google Scholar
• Refaie MMM, El-Hussieny M. 2017. The role of interleukin-1b and its antagonist (diacerein) in estradiol benzoate-induced endometrial hyperplasia and atypia in female rats. Fundam Clin Pharmacol. 31(4):438–446.
   PubMed Web of Science ®Google Scholar
• Sim X, Poncz M, Gadue P, French DL. 2016. Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets [Review]. Blood. 127(10):1227–1233.
   PubMed Web of Science ®Google Scholar
• Taoka K, Arai S, Kataoka K, Hosoi M, Miyauchi M, Yamazaki S, Honda A, Aixinjueluo W, Kobayashi T, Kumano K, et al. 2018. Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate. Sci Rep. 8(1):15855.
   PubMedGoogle Scholar
• Travnickova J, Tran Chau V, Julien E, Mateos-Langerak J, Gonzalez C, Lelievre E, Lutfalla G, Tavian M, Kissa K. 2015. Primitive macrophages control HSPC mobilization and definitive haematopoiesis. Nat Commun. 6:6227.
   PubMed Web of Science ®Google Scholar
• Tseng YD, Stevenson PA, Cassaday RD, Cowan A, Till BG, Shadman M, Graf SA, Ermoian R, Smith SD, Holmberg LA, et al. 2018. Total body irradiation is safe and similarly effective as chemotherapy-only conditioning in autologous stem cell transplantation for mantle cell lymphoma [Research Support, N.I.H., Extramural]. Biol Blood Marrow Transplant. 24(2):282–287.
   PubMed Web of Science ®Google Scholar
• van Rooijen N, Hendrikx E. 2010. Liposomes for specific depletion of macrophages from organs and tissues. Methods Mol Biol. 605:189–203.
   PubMedGoogle Scholar
• Winkler IG, Sims NA, Pettit AR, Barbier V, Nowlan B, Helwani F, Poulton IJ, van Rooijen N, Alexander KA, Raggatt LJ, et al. 2010. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs [Research Support, Non-U.S. Gov't]. Blood. 116(23):4815–4828.
   PubMed Web of Science ®Google Scholar
• Zhang J, Xiang D, Zhu S, Mao W, Lu H, Wu M, Wang Q, Yu Y, Herbst KD, Han W. 2009. Interleukin 1 receptor antagonist inhibits normal hematopoiesis and reduces lethality and bone marrow toxicity of 5-fluouracil in mouse [Research Support, Non-U.S. Gov't]. Biomed Pharmacother. 63(7):501–508.
   PubMed Web of Science ®Google Scholar
• Zhao HY, Lyu ZS, Duan CW, Song Y, Han TT, Mo XD, Wang Y, Xu LP, Zhang XH, Huang XJ, et al. 2018. An unbalanced monocyte macrophage polarization in the bone marrow microenvironment of patients with poor graft function after allogeneic haematopoietic stem cell transplantation. Br J Haematol. 182(5):679–692.
   PubMed Web of Science ®Google Scholar
• Zhou BO, Yu H, Yue R, Zhao Z, Rios JJ, Naveiras O, Morrison SJ. 2017. Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF [Comparative Study]. Nat Cell Biol. 19(8):891–903.
   PubMed Web of Science ®Google Scholar