Small is beautiful: low activity alpha and gamma sources for small-scale radiation protection research experiments

References

• Agostinelli S, Allison J, Amako K, Apostolakis J, Araujo H, Arce P, Asai M, Axen D, Banerjee S, Barrand G, et al. 2003. Geant4—a simulation toolkit. Nucl Instrum Methods Phys Res Sect A. 506:250–303.
   Web of Science ®Google Scholar
• Bajinskis A, Lindegren H, Johansson L, Harms-Ringdahl M, Forsby A. 2011. Low-dose/dose-rate γ radiation depresses neural differentiation and alters protein expression profiles in neuroblastoma SH-SY5Y cells and C17.2 neural stem cells. Radiat Res. 175:185–192.
   PubMed Web of Science ®Google Scholar
• Bajinskis A, Olsson G, Harms-Ringdahl M. 2012. The indirect effect of radiation reduces the repair fidelity of NHEJ as verified in repair deficient CHO cell lines exposed to different radiation qualities and potassium bromate. Mutat Res. 731:125–132.
   PubMed Web of Science ®Google Scholar
• Belli M, Tabocchini MA, Jourdain JR, Salomaa S, Repussard J. 2015. The European initiative on low-dose risk research: from the HLEG to MELODI. Radiat Prot Dosimetry. 166:178–181.
   PubMed Web of Science ®Google Scholar
• Bilski P, Olko P, Burgkhardt B, Piesch E, Waligórski MPR. 1994. Thermoluminescence Efficiency of LiF:Mg,Cu,P (MCP-N) Detectors to Photons, Beta-Electrons, Alpha Particles and Thermal Neutrons. Radiation Protection Dosimetry. 55:31–38.
   Web of Science ®Google Scholar
• Brehwens K, Bajinskis A, Staaf E, Haghdoost S, Cederwall B, Wojcik A. 2012. A new device to expose cells to changing dose rates of ionising radiation. Radiat Prot Dosimetry. 148:366–371.
   PubMed Web of Science ®Google Scholar
• Brooks AL. 2018. Low dose radiation: the history of the U.S. Depeartment of Energy research program. Washington (DC): Washington State University Press.
   Google Scholar
• Brown A, Suit H. 2004. The centenary of the discovery of the Bragg peak. Radiother Oncol. 73:265–268.
   PubMed Web of Science ®Google Scholar
• Burtt JJ, Thompson PA, Lafrenie RM. 2016. Non-targeted effects and radiation-induced carcinogenesis: a review. J Radiol Prot. 36:R23–R35.
   PubMed Web of Science ®Google Scholar
• Cho K, Imaoka T, Klokov D, Paunesku T, Salomaa S, Birschwilks M, Bouffler S, Brooks AL, Hei TK, Iwasaki T, et al. 2019. Funding for radiation research: past, present and future. Int J Radiati Biol. 95:816–840.
   PubMed Web of Science ®Google Scholar
• Cohen J. 1988. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale (NJ): Lawrence Erlbaum Associates, Publishers.
   Google Scholar
• Czub J, Braziewicz J, Wasilewski A, Wysocka-Rabin A, Wolowiec P, Wojcik A. 2020. Monte Carlo dosimetry using Fluka code and experimental dosimetry with Gafchromic EBT2, XR-RV3 of self-built experimental setup for radiobiological studies with low-energy X-rays. Int J Radiat Biol. 96:718–733.
   PubMed Web of Science ®Google Scholar
• Edwards AA, Purrott RJ, Prosser JS, Lloyd DC. 1980. The induction of chromosome aberrations in human lymphocytes by alpha-radiation. Int J Radiat Biol Relat Stud Phys Chem Med. 38:83–91.
   PubMed Web of Science ®Google Scholar
• Esposito G, Antonelli F, Belli M, Campa A, Simone G, Sorrentino E, Tabocchini MA. 2009. An alpha-particle irradiator for radiobiological research and its implementation for bystander effect studies. Radiat Res. 172:632–642.
   PubMed Web of Science ®Google Scholar
• Goodhead DT, Bance DA, Stretch A, Wilkinson RE. 1991. A versatile plutonium-238 irradiator for radiobiological studies with alpha-particles. Int J Radiat Biol. 59:195–210.
   PubMed Web of Science ®Google Scholar
• HLEG. 2009. European Low Dose Risk Research. High Level and Expert Group Report. European Commission, Directorate-General for Research.
   Google Scholar
• Lind OC, Helen OD, Salbu B. 2019. The NMBU FIGARO low dose irradiation facility. Int J Radiat Biol. 95:76–81.
   PubMed Web of Science ®Google Scholar
• Manesh SS, Deperas-Kaminska M, Fotouhi A, Sangsuwan T, Harms-Ringdahl M, Wojcik A, Haghdoost S. 2014. Mutations and chromosomal aberrations in hMTH1-transfected and non-transfected TK6 cells after exposure to low dose rates of gamma radiation. Radiat Environ Biophys. 53:417–425.
   PubMed Web of Science ®Google Scholar
• Neti PV, de Toledo SM, Perumal V, Azzam EI, Howell RW. 2004. A multi-port low-fluence alpha-particle irradiator: fabrication, testing and benchmark radiobiological studies. Radiat Res. 161:732–738.
   PubMed Web of Science ®Google Scholar
• Nilsson BN. 2015. Exercises with solutions in radiation physics. Berlin (Germany): Walter de Gruyter GmbH & Co KG.
   Google Scholar
• Olofsson D, Cheng L, Fernández RB, Płódowska M, Riego ML, Akuwudike P, Lisowska H, Lundholm L, Wojcik A. 2020. Biological effectiveness of very high gamma dose rate and its implication for radiological protection. Radiat Environ Biophys. 59:451–460.
   PubMed Web of Science ®Google Scholar
• Roos H, Kellerer AM. 1989. Design criteria and performance of an alpha irradiation device for cell studies. Phys Med Biol. 34:1823–1832.
   Web of Science ®Google Scholar
• Salomaa S, Jourdain JR, Kreuzer M, Jung T, Repussard J. 2017. Multidisciplinary European low dose initiative: an update of the MELODI program. Int J Radiat Biol. 93:1035–1039.
   PubMed Web of Science ®Google Scholar
• Schumacher EF. 1974. Small is beautiful, a study of economics as if people mattered. London (UK): Abacus Sphere Books.
   Google Scholar
• Shi X, Seymour C, Mothersill C. 2016. The effects of chronic, low doses of Ra-226 on cultured fish and human cells. Environ Res. 148:303–309.
   PubMed Web of Science ®Google Scholar
• Sollazzo A, Brzozowska B, Cheng L, Lundholm L, Haghdoost S, Scherthan H, Wojcik A. 2017. Alpha particles and X rays interact in inducing DNA damage in U2OS cells. Radiat Res. 188:400–411.
   PubMed Web of Science ®Google Scholar
• Sollazzo A, Brzozowska B, Cheng L, Lundholm L, Scherthan H, Wojcik A. 2018. Live dynamics of 53BP1 foci following simultaneous induction of clustered and dispersed DNA damage in U2OS cells. Int J Mol Sci. 19:519.
   PubMed Web of Science ®Google Scholar
• Staaf E, Brehwens K, Haghdoost S, Pachnerova-Brabcova K, Czub J, Braziewicz J, Nievaart S, Wojcik A. 2012. Characterisation of a setup for mixed beam exposures of cells to 241Am alpha particles and X-rays. Radiat Prot Dosimetry. 151:570–579.
   PubMed Web of Science ®Google Scholar
• Tapio S, Jacob V. 2007. Radioadaptive response revisited. Radiat Environ Biophys. 46:1–12.
   PubMed Web of Science ®Google Scholar
• Thompson JM, Elliott A, D'Abrantes S, Sawakuchi GO, Hill MA. 2019. Tracking down alpha-particles: the design, characterisation and testing of a shallow-angled alpha-particle irradiator. Radiat Prot Dosimetry. 183:264–269.
   PubMed Web of Science ®Google Scholar
• Tisnek N, Kalanxhi E, Serkland CW, Iversen J, Belyakov OV, Dahle J. 2009. A (238)Pu irradiator for exposure of cultured cells with alpha-radiation: construction, calibration and dosimetry. Appl Radiat Isot. 67:1998–2002.
   PubMed Web of Science ®Google Scholar
• UNSCEAR. 2012. Biological mechanisms of radiation actions at low doses. A white paper to guide the Scientific Committee’s future programme of work. Report V 12-57831. New York (NY): United Nations.
   Google Scholar
• Vral A, Thierens H, Ridder de L. 1997. In vitro micronucleus-centromere assay to detect radiation-damage induced by low doses in human lymphocytes. Int J Radiat Biol. 71:61–68.
   PubMed Web of Science ®Google Scholar
• Weiss W, Yonekura Y. 2019. International co-operation in biological research to address low dose radiation risk: Osaka Call-for-Action. Int J Radiat Biol. 95:1351–1353.
   PubMed Web of Science ®Google Scholar
• Wojcik A, Harms-Ringdahl M. 2019. Radiation protection biology then and now. Int J Radiat Biol. 95:841–850.
   PubMed Web of Science ®Google Scholar
• Wojcik A, Shadley JD. 2000. The current status of the adaptive response to ionizing radiation in mammalian cells. Hum Ecol Risk Assess. 6:281–300.
   Web of Science ®Google Scholar
• Wuttke K, Streffer C, Muller WU. 1993. Radiation induced micronuclei in subpopulations of human lymphocytes. Mutat Res. 286:181–188.
   PubMed Web of Science ®Google Scholar
• Yentrapalli R, Azimzadeh O, Barjaktarovic Z, Sarioglu H, Wojcik A, Harms-Ringdahl M, Atkinson MJ, Haghdoost S, Tapio S. 2013. Quantitative proteomic analysis reveals induction of premature senescence in human umbilical vein endothelial cells exposed to chronic low-dose rate gamma radiation. Proteomics. 13:1096–1107.
   PubMed Web of Science ®Google Scholar
• Ziegler JF, Biersack JP, Ziegler MD. 2010. SRIM – the stopping and range of ions in matter. Nucl Instr Meth Phys Res Sec B. 268:1818–1823.
   Web of Science ®Google Scholar