130
Views
1
CrossRef citations to date
0
Altmetric
Review

Research progress on radioprotective effects of bee products

ORCID Icon, , , , &
Pages 444-451 | Received 22 May 2020, Accepted 04 Jan 2021, Published online: 25 Feb 2021

References

  • Ahmad S, Campos M, Fratini F, Altaye S, Li J. 2020. New insights into the biological and pharmaceutical properties of royal jelly. IJMS. 21(2):382.
  • Azab KS, Bashandy M, Salem M, Ahmed O, Tawfik Z, Helal H. 2011. Royal jelly modulates oxidative stress and tissue injury in gamma irradiated male Wister Albino rats. N Am J Med Sci. 3(6):268–276.
  • Badr G, Sayed E, Waly H, Hassan K, Mahmoud M, Selamoglu Z. 2019. The therapeutic mechanisms of propolis against CCl -mediated liver injury by mediating apoptosis of activated hepatic stellate cells and improving the hepatic architecture through PI3K/AKT/mTOR, TGF-β/Smad2, Bcl2/BAX/P53 and iNOS signaling pathways. Cell Physiol Biochem. 53(2):301–322.
  • Benderli Cihan Y, Deniz K. 2011. Effect of propolis against radiation-induced oral mucositis in rats. Kulak Burun Bogaz Ihtisas dergisi. 21(1):32–41.
  • Cai Y, Wang W, Qiu Y, Yu M, Yin J, Yang H, Mei J. 2018. KGF inhibits hypoxia-induced intestinal epithelial cell apoptosis by upregulating AKT/ERK pathway-dependent E-cadherin expression. Biomed Pharmacother. 105:1318–1324.
  • Cao S, Zhu X, Du L. 2017. P38 MAP kinase is involved in oleuropein-induced apoptosis in A549 cells by a mitochondrial apoptotic cascade. Biomed Pharmacother. 95:1425–1435.
  • Charalambous M, Raftopoulos V, Paikousis L, Katodritis N, Lambrinou E, Vomvas D, Georgiou M, Charalambous A. 2018. The effect of the use of thyme honey in minimizing radiation - induced oral mucositis in head and neck cancer patients: a randomized controlled trial. Eur J Oncol Nurs. 34:89–97.
  • Chen F, Liu Y, Wong N, Xiao J, So K. 2017. Oxidative stress in stem cell aging. Cell Transplant. 26(9):1483–1495.
  • Cho S, Shim S, Rhee H, Park H, Jung W, Moon S, Park J, Ko C, Cho K, Park S. 2012. Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson’s disease. Parkinsonism Relat Disord. 18(8):948–952.
  • Cianciosi D, Forbes-Hernández T, Afrin S, Gasparrini M, Reboredo-Rodriguez P, Manna P, Zhang J, Bravo Lamas L, Martínez Flórez S, Agudo Toyos P, et al. 2018. Phenolic compounds in honey and their associated health benefits: a review. Molecules (Basel, Switzerland). 23(9):2322.
  • Co JL, Mejia MB, Que JC, Dizon JM. 2016. Effectiveness of honey on radiation-induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta-analysis and systematic review of literature. Head Neck. 38(7):1119–1128.
  • Cole N, Sou P, Ngo A, Tsang K, Severino J, Arun S, Duke C, Reeve V. 2010. Topical ‘Sydney’ propolis protects against UV-radiation-induced inflammation, lipid peroxidation and immune suppression in mouse skin. Int Arch Allergy Immunol. 152(2):87–97.
  • Darendelioglu E, Aykutoglu G, Tartik M, Baydas G. 2016. Turkish propolis protects human endothelial cells in vitro from homocysteine-induced apoptosis. Acta Histochem. 118(4):369–376.
  • Dong J, Zhang W, Zhang T, Chen X, Zhao J, Zeng Y, Chen Y, Wei X, Lei T, Wang P, et al. 2020. Baseline nutritional status could be a predictor for radiation esophagitis in esophageal cancer patients undergoing radiotherapy. Ann Transl Med. 8(18):1148–1148.
  • Dörr H, Meineke V. 2011. Acute radiation syndrome caused by accidental radiation exposure – therapeutic principles. BMC Med. 9:126.
  • Dutta A, Gupta M, Kalita B. 2015. The combination of the active principles of Podophyllum hexandrum supports early recovery of the gastrointestinal system via activation of Nrf2-HO-1 signaling and the hematopoietic system, leading to effective whole-body survival in lethally irradiated mice. Free Radic Res. 49(3):317–330.
  • Elsass FT. 2017. A sweet solution: the use of medical-grade honey on oral mucositis in the pediatric oncology patient. Wounds. 29(12):E115–E117.
  • Erdem O, Güngörmüş Z. 2014. The effect of royal jelly on oral mucositis in patients undergoing radiotherapy and chemotherapy. Holist Nurs Pract. 28(4):242–246.
  • Fang J, Yin H, Liao L, Qin H, Ueda F, Uemura K, Eguchi K, Bharate G, Maeda H. 2016. Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases. J Control Release. 223:188–196.
  • Feng W, Chu J, Yu L, Zhang F, Li L, Wang Z. 2011. Experimental study of Brazilian propolis against acute radiation-induced liver injury in rats. Modern Oncol. 019(008):1504–1507.
  • Gajski G, Garaj-Vrhovac V. 2009. Radioprotective effects of honeybee venom (Apis mellifera) against 915-MHz microwave radiation-induced DNA damage in wistar rat lymphocytes: in vitro study. Int J Toxicol. 28(2):88–98.
  • Gapeyev A, Aripovsky A, Kulagina T. 2015. Modifying effects of low-intensity extremely high-frequency electromagnetic radiation on content and composition of fatty acids in thymus of mice exposed to X-rays. Int J Radiat Biol. 91(3):277–285.
  • Geyikoglu F, Koc K, Colak S, Erol H, Cerig S, Yardimci B, Cakmak O, Dortbudak M, Eser G, Aysin F, et al. 2019. Propolis and its combination with boric acid protect against ischemia/reperfusion-induced acute kidney injury by inhibiting oxidative stress, inflammation, DNA damage, and apoptosis in rats. Biol Trace Elem Res. 192(2):214–221.
  • Goc Z, Szaroma W, Kapusta E, Dziubek K. 2017. Protective effects of melatonin on the activity of SOD, CAT, GSH-Px and GSH content in organs of mice after administration of SNP. Chin J Physiol. 60(1):1–10.
  • Guo Y, Zhao H, Wu Q, Tian Y. 2004. Prophylactic and therapeutic effect of propolis on bone marrow radiation injury in rats. Radiat Protect. 024(001):56–58.
  • Hekim N, Cetin Z, Nikitaki Z, Cort A, Saygili E. 2015. Radiation triggering immune response and inflammation. Cancer Lett. 368(2):156–163.
  • Ippolito E, Floreno B, Rinaldi CG, Trodella L, Meroni FL, Iurato A, D’Angelillo RM, Ramella S, Fiore M. 2018. Efficacy of a propolis-based syrup (FARINGEL) in preventing radiation-induced esophagitis in locally advanced lung cancer. Chemotherapy. 63(2):76–82.
  • Javadzadeh BA, Tonkaboni A, Aledavood SA, Fathi Najafi M, Delavarian Z, Shakeri MT, Mohtashami A. 2015. Preventing and therapeutic effect of propolis in radiotherapy induced mucositis of head and neck cancers: a triple-blind, randomized, placebo-controlled trial. Iran J Cancer Prev. 8(5):e4019.
  • Kalman N, Zhao S, Anscher M, Urdaneta A. 2017. Current status of targeted radioprotection and radiation injury mitigation and treatment agents: a critical review of the literature. Int J Radiat Oncol Biol Phys. 98(3):662–682.
  • Kanno I, Ito Y, Okuyama S. 1970. [Radioprotection by bee venom]. Nihon Igaku Hoshasen Gakkai Zasshi. 29(12):1494–1500.
  • Khayyal MT, Abdel-Naby DH, El-Ghazaly MA. 2019. Propolis extract protects against radiation-induced intestinal mucositis through anti-apoptotic mechanisms. Environ Sci Pollut Res Int. 26(24):24672–24682.
  • Khayyal MT, El-Hazek RM, El-Ghazaly MA. 2015. Propolis aqueous extract preserves functional integrity of murine intestinal mucosa after exposure to ionizing radiation. Environ Toxicol Pharmacol. 40(3):901–906.
  • Kim HB, Yoo BS. 2016. Propolis inhibits UVA-induced apoptosis of human keratinocyte HaCaT cells by scavenging ROS. Toxicol Res. 32(4):345–351.
  • Kocot J, Kiełczykowska M, Luchowska-Kocot D, Kurzepa J, Musik I. 2018. Antioxidant potential of propolis, bee pollen, and royal jelly: possible medical application. Oxid Med Cell Longev. 2018:7074209.
  • Kohen R, Nyska A. 2002. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol. 30(6):620–650.
  • Li H, Wu F, Tan J, Wang K, Zhang C, Zheng H, Hu F. 2016. Caffeic acid phenethyl ester exhibiting distinctive binding interaction with human serum albumin implies the pharmacokinetic basis of propolis bioactive components. J Pharm Biomed Anal. 122:21–28.
  • Liang L. 2012. Study on the effect of royal jelly against radiation damage. Heilongjiang Med. 036(10):724–726.
  • Malyarenko O, Usoltseva R, Zvyagintseva T, Ermakova S. 2019. Laminaran from brown alga Dictyota dichotoma and its sulfated derivative as radioprotectors and radiosensitizers in melanoma therapy. Carbohydr Polym. 206:539–547.
  • Mărgăoan R, Stranț M, Varadi A, Topal E, Yücel B, Cornea-Cipcigan M, Campos MG, Vodnar DC. 2019. Bee collected pollen and bee bread: bioactive constituents and health benefits. Antioxidants (Basel, Switzerland). 8(12):568.
  • Mirzayans R, Andrais B, Scott A, Wang YW, Murray D. 2013. Ionizing radiation-induced responses in human cells with differing TP53 status. Int J Mol Sci. 14(11):22409–22435.
  • Mishra KN, Moftah BA, Alsbeih GA. 2018. Appraisal of mechanisms of radioprotection and therapeutic approaches of radiation countermeasures. Biomed Pharmacother. 106:610–617.
  • Montoro A, Barquinero JF, Almonacid M, Montoro A, Sebastià N, Verdú G, Sahuquillo V, Serrano J, Saiz M, Villaescusa JI, et al. 2011. Concentration-dependent protection by ethanol extract of propolis against γ-ray-induced chromosome damage in human blood lymphocytes. Evid Based Complement Alternat Med. 2011:174853.
  • Oryan A, Alemzadeh E, Moshiri A. 2016. Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis. J Tissue Viability. 25(2):98–118.
  • Prasanna PG, Narayanan D, Hallett K, Bernhard EJ, Ahmed MM, Evans G, Vikram B, Weingarten M, Coleman CN. 2015. Radioprotectors and radiomitigators for improving radiation therapy: the small business innovation research (SBIR) gateway for accelerating clinical translation. Radiat Res. 184(3):235–248.
  • Rafat N, Monfared AS, Shahidi M, Pourfallah TA. 2016. The modulating effect of royal jelly consumption against radiation-induced apoptosis in human peripheral blood leukocytes. J Med Phys. 41(1):52–57.
  • Reisz JA, Bansal N, Qian J, Zhao W, Furdui CM. 2014. Effects of ionizing radiation on biological molecules-mechanisms of damage and emerging methods of detection. Antioxid Redox Signal. 21(2):260–292.
  • Robson V, Cooper R. 2009. Using leptospermum honey to manage wounds impaired by radiotherapy: a case series. Ostomy/Wound Manage. 55(1):38–47.
  • Santos G, Tsutsumi S, Vieira D, Bartolini P, Okazaki K. 2014. Effect of Brazilian propolis (AF-08) on genotoxicity, cytotoxicity and clonogenic death of Chinese hamster ovary (CHO-K1) cells irradiated with (60)Co gamma-radiation. Mutat Res Genet Toxicol Environ Mutagen. 762:17–23.
  • Shapla U, Solayman M, Alam N, Khalil M, Gan S. 2018. 5-Hydroxymethylfurfural (HMF) levels in honey and other food products: effects on bees and human health. Chem Cent J. 12(1):35.
  • Sharma D, Singh A, Pathak M, Kaur L, Kumar V, Roy B, Ojha H. 2020. DNA binding and antiradical potential of ethyl pyruvate: key to the DNA radioprotection. Chem Biol Interact. 332:109313.
  • Shin D, Lee G, Sohn SH, Park S, Jung KH, Lee JM, Yang J, Cho J, Bae H. 2016. Regulatory T cells contribute to the inhibition of radiation-induced acute lung inflammation via bee venom phospholipase A2 in mice. Toxins. 8(5):131.
  • Singh VK, Ducey EJ, Brown DS, Whitnall MH. 2012. A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute. Int J Radiat Biol. 88(4):296–310.
  • Socarras K, Theophilus P, Torres J, Gupta K, Sapi E. 2017. Antimicrobial activity of bee venom and melittin against Borrelia burgdorferi. Antibiotics (Basel, Switzerland). 6(4):31.
  • Takagi Y, Choi IS, Yamashita T, Nakamura T, Suzuki I, Hasegawa T, Oshima M, Gu YH. 2005. Immune activation and radioprotection by propolis. Am J Chin Med. 33(2):231–240.
  • Taniguchi CM, Miao YR, Diep AN, Wu C, Rankin EB, Atwood TF, Xing L, Giaccia AJ. 2014. PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2. Sci Transl Med. 6(236):236ra64–236ra64.
  • Varanda EA, Monti R, Tavares DC. 1999. Inhibitory effect of propolis and bee venom on the mutagenicity of some direct-and indirect-acting mutagens. Teratog Carcinog Mutagen. 19(6):403–413.
  • Wei S, Shan X, Wang X, Luo H, Liu R. 2010. Clinical observation of honey topical blended golden powder applied externally in the treatment of acute radiation skin injury. New J Tradit Chin Med. 042(12):74–75.
  • Xu S, Zhang F, Wang L, Hao M, Yang X, Li N, Ji H, Xu P. 2018. Flavonoids of Rosa roxburghii Tratt offers protection against radiation induced apoptosis and inflammation in mouse thymus. Apoptosis. 23(9–10):470–483.
  • Xu T. 2010. Discussion on traditional Chinese medicine diagnosis and treatment of andrological diseases. Shandong J Tradit Chin Med. 29(6):365–366.
  • Xu X, Pu R, Li Y, Wu Z, Li C, Miao X, Yang W. 2019. Penicillium notatum chemical compositions of propolis from China and the United States and their antimicrobial activities against. Molecules (Basel, Switzerland). 24(19):3576.
  • Xue X, Han X, Li Y, Chu X, Miao W, Zhang J, Fan S. 2017. Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis. Stem Cell Res Ther. 8(1):7.
  • Yalcin CO, Aliyazicioglu Y, Demir S, Turan I, Bahat Z, Misir S, Deger O. 2016. Evaluation of the radioprotective effect of Turkish propolis on foreskin fibroblast cells. J Can Res Ther. 12(2):990–994.
  • Yi Y. 1999. Observation of the therapeutic effect of honey licorice on allergic esophagitis. Chinese J Radiol Med Protect. 19(5):346.
  • Yu H, Haskins J, Su C, Allum A, Haskins A, Salinas V, Sunada S, Inoue T, Aizawa Y, Uesaka M, et al. 2016. In vitro screening of radioprotective properties in the novel glucosylated flavonoids. Int J Mol Med. 38(5):1525–1530.
  • Zhang P, Tang Y, Li N, Zhu Y, Duan J. 2014. Bioactivity and chemical synthesis of caffeic acid phenethyl ester and its derivatives. Molecules. 19(10):16458–16476.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.