HIF-1α affects sensitivity of murine squamous cell carcinoma to boron neutron capture therapy with BPA

References

• Barthelemy C, André B. 2019. Ubiquitylation and endocytosis of the human LAT1/SLC7A5 amino acid transporter. Sci Rep. 9(1):16760.
   PubMedGoogle Scholar
• Chu VT, Weber T, Graf R, Sommermann T, Petsch K, Sack U, Volchkov P, Rajewsky K, Kühn R. 2016. Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes. BMC Biotechnol. 16:4.
   PubMed Web of Science ®Google Scholar
• Coderre JA, Button TM, Micca PL, Fisher CD, Nawrocky MM, Liu HB. 1994. Neutron capture therapy of the 9L rat gliosarcoma using the p-boronophenylalanine-fructose complex. Int J Radiat Oncol Biol Phys. 30(3):643–652.
   PubMed Web of Science ®Google Scholar
• Elorza A, Soro-Arnáiz I, Meléndez-Rodríguez F, Rodríguez-Vaello V, Marsboom G, de Cárcer G, Acosta-Iborra B, Albacete-Albacete L, Ordóñez A, Serrano-Oviedo L, et al. 2012. HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5. Mol Cell. 48(5):681–691.
   PubMed Web of Science ®Google Scholar
• Fisher R, Pusztai L, Swanton C. 2013. Cancer heterogeneity: implications for targeted therapeutics. Br J Cancer. 108(3):479–485.
   PubMed Web of Science ®Google Scholar
• Gordan JD, Bertout JA, Hu C, Diehl JA, Simon MC. 2007. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity . Cancer Cell. 11(4):335–347.
   PubMed Web of Science ®Google Scholar
• Harada T, Hirose K, Wada Y, Sato M, Ichise K, Aoki M, Kato T, Takeda K, Takai Y. 2020. YC-1 sensitizes the antitumor effects of boron neutron capture therapy in hypoxic tumor cells. J Radiat Res. 61(4):524–534.
   PubMed Web of Science ®Google Scholar
• Harris AL. 2002. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer. 2(1):38–47.
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Kanda K. 1983. Microanalysis system of ppm-order 10B concentrations in tissue for neutron capture therapy by prompt gamma-ray spectrometry. Nucl Instrum Methods Phys Res. 204(2-3):525–531.
   Web of Science ®Google Scholar
• Luo Z, Bai M, Xiao X, Zhang W, Liu X, Yang X, Li S, Huan Y, Wu Z, Zhang X, et al. 2015. Silencing of HIF-1α enhances the radiation sensitivity of human glioma growth in vitro and in vivo. Neuropharmacology. 89:168–174.
   PubMed Web of Science ®Google Scholar
• Masunaga S, Sakurai Y, Tanaka H, Tano K, Suzuki M, Kondo N, Narabayashi M, Nakagawa Y, Watanabe T, Maruhashi A, et al. 2014. The dependency of compound biological effectiveness factors on the type and the concentration of administered neutron capture agents in boron neutron capture therapy. Springerplus. 3:128.
   PubMed Web of Science ®Google Scholar
• Masunaga S, Sanada Y, Tano K, Sakurai Y, Tanaka H, Takata T, Suzuki M, Ono K. 2020. An attempt to improve the therapeutic effect of boron neutron capture therapy using commonly employed 10B-carriers based on analytical studies on the correlation among quiescent tumor cell characteristics, tumor heterogeneity and cancer stemness. J Radiat Res. 61(6):876–885.
   PubMed Web of Science ®Google Scholar
• Masunaga S, Tatebe H, Nishimura Y, Tano K, Sanada Y, Moriwaki T, Sakurai Y, Tanaka H, Suzuki M, Kondo N, et al. 2016. Effect of oxygen pressure during incubation with a (10)B-carrier on (10)B uptake capacity of cultured p53 wild-type and mutated tumor cells: dependency on p53 status of tumor cells and types of (10)B-carriers. Int J Radiat Biol. 92(4):187–194.
   PubMed Web of Science ®Google Scholar
• Mayer A, Schmidt M, Seeger A, Serras AF, Vaupel P, Schmidberger H. 2014. GLUT-1 expression is largely unrelated to both hypoxia and the Warburg phenotype in squamous cell carcinomas of the vulva. BMC Cancer. 14:760.
   Google Scholar
• Onishi Y, Hiraiwa M, Kamada H, Iezaki T, Yamada T, Kaneda K, Hinoi E. 2019. Hypoxia affects Slc7a5 expression through HIF-2α in differentiated neuronal cells. FEBS Open Bio. 9(2):241–247.
   PubMed Web of Science ®Google Scholar
• Pereira ER, Frudd K, Awad W, Hendershot LM. 2014. Endoplasmic reticulum (ER) stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 (HIF-1) transcriptional activity on targets like vascular endothelial growth factor (VEGF). J Biol Chem. 289(6):3352–3364.
   PubMed Web of Science ®Google Scholar
• Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F. 2013. Genome engineering using the CRISPR-Cas9 system. Nat Protoc. 8(11):2281–2308.
   PubMed Web of Science ®Google Scholar
• Rossini AE, Dagrosa MA, Portu A, Martin GS, Thorp S, Casal M, Navarro A, Juvenal GJ, Pisarev MA. 2015. Assessment of biological effectiveness of boron neutron capture therapy in primary and metastatic melanoma cell lines. Int J Radiat Biol. 91(1):81–89.
   PubMed Web of Science ®Google Scholar
• Sanada Y, Sasanuma H, Takeda S, Tano K, Masunaga S. 2018. Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma. Int J Radiat Biol. 94(1):88–96.
   PubMed Web of Science ®Google Scholar
• Scanlon SE, Glazer PM. 2015. Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment. DNA Repair (Amst)). 32:180–189.
   PubMed Web of Science ®Google Scholar
• Seki K, Kinashi Y, Takahashi S. 2015. Influence of p53 status on the effects of boron neutron capture therapy in glioblastoma. Anticancer Res. 35(1):169–174.
   PubMed Web of Science ®Google Scholar
• Takagaki M, Ono K, Masunaga S, Kinashi Y, Sakurai Y, Kobayashi T, Miyatake S, Hashimoto N. 2001. 10B quantitative determination in ppb range by particle tracks reading for boron neutron capture therapy. J Radioanal Nucl Chem. 247(2):389–392.
   Web of Science ®Google Scholar
• Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Takamiya K, Maruhashi A, Ono K. 2014. Development of a simple and rapid method of precisely identifying the position of 10B atoms in tissue: an improvement in standard alpha autoradiography. J Radiat Res. 55(2):373–380.
   PubMed Web of Science ®Google Scholar
• Wada Y, Hirose K, Harada T, Sato M, Watanabe T, Anbai A, Hashimoto M, Takai Y. 2018. Impact of oxygen status on 10B-BPA uptake into human glioblastoma cells, referring to significance in boron neutron capture therapy. J Radiat Res. 59(2):122–128.
   PubMed Web of Science ®Google Scholar
• Watanabe T, Tanaka H, Fukutani S, Suzuki M, Hiraoka M, Ono K. 2016. L-Phenylalanine preloading reduces the (10)B(n, α)(7)Li dose to the normal brain by inhibiting the uptake of boronophenylalanine in boron neutron capture therapy for brain tumours. Cancer Lett. 370(1):27–32.
   PubMed Web of Science ®Google Scholar
• Wirthner R, Wrann S, Balamurugan K, Wenger RH, Stiehl DP. 2008. Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts. Carcinogenesis. 29(12):2306–2316.
   PubMed Web of Science ®Google Scholar
• Wongthai P, Hagiwara K, Miyoshi Y, Wiriyasermkul P, Wei L, Ohgaki R, Kato I, Hamase K, Nagamori S, Kanai Y. 2015. Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2. Cancer Sci. 106(3):279–286.
   PubMed Web of Science ®Google Scholar
• Yan R, Zhao X, Lei J, Zhou Q. 2019. Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex. Nature. 568(7750):127–130.
   PubMed Web of Science ®Google Scholar
• Zgheib O, Pataky K, Brugger J, Halazonetis TD. 2009. An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks. Mol Cell Biol. 29(4):1050–1058.
   PubMed Web of Science ®Google Scholar