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Letter to the Editor

Response to “Hydroxyl radical is predominantly involved in oxidatively generated base damage to cellular DNA exposed to ionizing radiation” by Cadet et al.

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Page 581 | Received 11 Apr 2022, Accepted 09 Jun 2022, Published online: 18 Jul 2022

References

  • Cadet J, Angelov D, Wagner JR. 2022. Hydroxyl radical is predominantly involved in oxidatively generated base damage to cellular DNA exposed to ionizing radiation. Int J Radiat Biol. (in Press).
  • Cotton FA, Wilkinson G. 1972. Advanced inorganic chemistry. Third ed. New York: John Wiley & Sons, Inc.
  • Fleming AM, Burrows CJ. 2020. Iron Fenton oxidation of 2'-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical. Chem Commun 56(68):9779–9782.
  • Fleming AM, Burrows CJ. 2022. Chemistry of ROS-mediated oxidation to the guanine base in DNA and its biological consequences. Int J Radiat Biol. 98(3):452–460.
  • Halliwell B, Adhikary A, Dingfelder M, Dizdaroglu M. 2021. Hydroxyl radical is a significant player in oxidative DNA damage in vivo. Chem Soc Rev. 50(15):8355–8360.
  • Illes E, Mizrahi A, Marks V, Meyerstein D. 2019. Carbonate-radical-anions, and not hydroxyl radicals, are the products of the Fenton reaction in neutral solutions containing bicarbonate. Free Radic Biol Med. 131:1–6.

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