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Original Articles

Modeling of dose and linear energy transfer homogeneity in cell nuclei exposed to alpha particles under various setup conditions

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 1248-1256 | Received 06 Apr 2022, Accepted 08 Dec 2022, Published online: 02 Feb 2023

References

  • Agostinelli S, Allison J, Amako K, Apostolakis J, Araujo H, Arce P, Asai M, Axen D, Banerjee S, Barrand G, et al. 2003. Geant4 - a simulation toolkit. Nucl Instrum Methods Phys Res A. 506(3):250–303.
  • Allison J, Amako K, Apostolakis J, Arce P, Asai M, Aso T, Bagli E, Bagulya A, Banerjee S, Barrand G, et al. 2016. Recent developments in Geant4. Nucl Instrum Methods Phys Res A. 835:186–225.
  • Barendsen GW. 1994. The relationships between RBE and LET for different types of lethal damage in mammalian cells: biophysical and molecular mechanisms. Radiat Res. 139(3):257–270.
  • Czub J, Banaś D, Błaszczyk A, Braziewicz J, Buraczewska I, Choiński J, Górak U, Jaskóła M, Korman A, Lankoff A, et al. 2008. Biological effectiveness of (12)C and (20)Ne ions with very high LET. Int J Radiat Biol. 84(10):821–829.
  • Dingfelder M. 2002. Cross section calculations in condensed media: charged particles in liquid water. Radiat Prot Dosimetry. 99(1-4):23–28.
  • Edwards AA, Purrott RJ, Prosser JS, Lloyd DC. 1980. The induction of chromosome aberrations in human lymphocytes by alpha-radiation. Int J Radiat Biol Relat Stud Phys Chem Med. 38(1):83–91.
  • Esposito G, Antonelli F, Belli M, Campa A, Simone G, Sorrentino E, Tabocchini MA. 2009. An alpha-particle irradiator for radiobiological research and its implementation for bystander effect studies. Radiat Res. 172(5):632–642.
  • Friedland W, Dingfelder M, Kundrat P, Jacob P. 2011. Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC. Mutat Res. 711(1-2):28–40.
  • Friedland W, Kundrát P. 2014. Modeling of radiation effects in cells and tissues. In: Brahme A, editor. Comprehensive biomedical physics. Netherlands: Elsevier; p. 105–142.
  • Goodhead DT. 1990. Mechanisms for the biological effectiveness of high-LET radiations. J Radiat Res. 40(Suppl):1–13.
  • Goodhead DT. 2006. Energy deposition stochastics and track structure: what about the target? Radiat Prot Dosimetry. 122(1-4):3–15.
  • Goodhead DT, Bance DA, Stretch A, Wilkinson RE. 1991. A versatile plutonium-238 irradiator for radiobiological studies with alpha-particles. Int J Radiat Biol. 59(1):195–210.
  • Griffiths SD, Marsden SJ, Wright EG, Greaves MF, Goodhead DT. 1994. Lethality and mutagenesis of B lymphocyte progenitor cells following exposure to alpha-particles and X-rays. Int J Radiat Biol. 66(2):197–205.
  • Hakanen A, Siiskonen T, Pöllänen R, Kosunen A, Turunen A, Belyakov O. 2006. Design, spectrum measurements and simulations for a 238Pu alpha-particle irradiator for bystander effect and genomic instability experiments. Appl Radiat Isot. 64(8):864–867.
  • ICRP. 2003. Relative biological effectiveness (RBE), quality factor (Q), and radiation weighting factor (wR) (International Commission on Radiological Protection Publication 92). Ann ICRP. 33(4):97–107.
  • Incerti S, Gault N, Habchi C, Lefaix JL, Moretto P, Poncy JL, Pouthier T, Seznec H. 2006. A comparison of cellular irradiation techniques with alpha particles using the Geant4 Monte Carlo simulation toolkit. Radiat Prot Dosimetry. 122(1-4):327–329.
  • Kantemiris I, Karaiskos P, Papagiannis P, Angelopoulos A. 2011. Dose and dose averaged LET comparison of (1)H, (4)He, (6)Li, (8)Be, (1)(0)B, (1)(2)C, (1)(4)N, and (1)(6)O ion beams forming a spread-out Bragg peak. Med Phys. 38(12):6585–6591.
  • Karthik K, Rajan V, Pandey BN, Sivasubramanian K, Paul SFD, Venkatachalam P. 2019. Direct and bystander effects in human blood lymphocytes exposed to 241Am alpha particles and the relative biological effectiveness using chromosomal aberration and micronucleus assay. Int J Radiat Biol. 95(6):725–736.
  • Krewski D, Lubin JH, Zielinski JM, Alavanja M, Catalan VS, Field RW, Klotz JB, Létourneau EG, Lynch CF, Lyon JI, et al. 2005. Residential radon and risk of lung cancer: a combined analysis of 7 North American case-control studies. Epidemiology. 16(2):137–145.
  • Linstrom PJ, Mallard WG. 2022. NIST chemistry WebBook, NIST standard reference data-base. Gaithersburg, MD: National Institute of Standards and Technology; p. 20899.
  • Metting NF, Koehler AM, Nagasawa H, Nelson JM, Little JB. 1995. Design of a benchtop alpha particle irradiator. Health Phys. 68(5):710–715.
  • Neti PV, de Toledo SM, Perumal V, Azzam EI, Howell RW. 2004. A multi-port low-fluence alpha-particle irradiator: fabrication, testing and benchmark radiobiological studies. Radiat Res. 161(6):732–738.
  • Nikjoo H, Girard P. 2012. A model of the cell nucleus for DNA damage calculations. Int J Radiat Biol. 88(1-2):87–97.
  • Nikjoo H, O'Neill P, Wilson WE, Goodhead DT. 2001. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat Res. 156(5 Pt 2):577–583.
  • O’Sullivan JM. 2019. Where do we see alpha emitters in clinical practice? A radiation oncology perspective. J Med Imaging Radiat Sci. 50(4S1):S31–S33.
  • Pietrzak M, Mietelska M, Bancer A, Rucinski A, Brzozowska B. 2021. Geant4-DNA modeling of nanodosimetric quantities in the Jet Counter for alpha particle. Phys Med Biol. 66(22):225008.
  • Płódowska M, Lopez-Riego M, Akuwudike P, Sobota D, Filipek M, Kłosowski M, Kaźmierczak U, Brzozowska B, Baliga A, Lisowska H, et al. 2021. Small is beautiful: low activity alpha and gamma sources for small-scale radiation protection research experiments. Int J Radiat Biol. 97(4):541–552.
  • Pszona S, Kula J, Marjanska S. 2000. New method for measuring ion clusters produced by charged particles in nanometre track sections of DNA size. Nucl Instrum Methods Phys Res Sect A Accel Spectrom Detect Assoc Equip. 447(3):601–607.
  • Raju MR, Jett JH. 1974. RBE and OER variations of mixtures of plutonium alpha particles and X-rays for damage to human kidney cells (T-1). Radiat Res. 60(3):473–481.
  • Roos H, Kellerer AM. 1989. Design criteria and performance of an alpha irradiation device for cell studies. Phys Med Biol. 34(12):1823–1832.
  • Rucinski A, Biernacka A, Schulte R. 2021. Applications of nanodosimetry in particle therapy planning and beyond. Phys Med Biol. 66(24):24TR01.
  • Sharma S, Cabana R, Shariatmadar S, Krishan A. 2008. Cellular volume and marker expression in human peripheral blood apheresis stem cells. Cytometry A. 73(2):160–167.
  • Shuryak I, Fornace AJ Jr, Datta K, Suman S, Kumar S, Sachs RK, Brenner DJ. 2017. Scaling human cancer risks from low LET to high LET when dose-effect relationships are complex. Radiat Res. 187(4):476–482.
  • Staaf E, Brehwens K, Haghdoost S, Pachnerová-Brabcová K, Czub J, Braziewicz J, Nievaart S, Wojcik A. 2012. Characterization of a setup for mixed beams exposure of cells to 241Am alpha particles and X-rays. Radiat Prot Dosimetry. 151(3):570–579.
  • Szefliński Z, Filipek M, Gotlib J, Kaźmierczak U. 2019. Radiobiological research and dosimetry using a flat alpha source. RAP Conf Proc. 4:7–9.
  • Thomas P, Tracy B, Ping T, Baweja A, Wickstrom M, Sidhu N, Hiebert L. 2007. Relative biological effectiveness (RBE) of alpha radiation in cultured porcine aortic endothelial cells. Int J Radiat Biol. 83(3):171–179.
  • Thompson JM, Elliott A, D'Abrantes S, Sawakuchi GO, Hill MA. 2019. Tracking down alpha-particles: the design, characterisation and testing of a shallow-angled alpha-particle irradiator. Radiat Prot Dosimetry. 183(1-2):264–269.
  • Tracy BL, Stevens DL, Goodhead DT, Hill MA. 2015. Variation in RBE for survival of V79-4 cells as a function of alpha-particle (helium ion) energy. Radiat Res. 184(1):33–45.
  • Wakeford R. 2009. Radiation in the workplace-a review of studies of the risks of occupational exposure to ionising radiation. J Radiol Prot. 29(2A):A61–A79.
  • Wambersie A, Gahbauer RA, Menzel HG. 2004. RBE and weighting of absorbed dose in ion-beam therapy. Radiother Oncol. 73:S176–S182.
  • Wang R, Coderre JA. 2005. A bystander effect in alpha-particle irradiations of human prostate tumor cells. Radiat Res. 164(6):711–722.

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