Alleviation of radiation combined skin injury in rat model by topical application of ascorbate formulation

References

• Allen AR, Eilertson K, Chakraborti A, Sharma S, Baure J, Habdank-Kolaczkowski J, Allen B, Rosi S, Raber J, Fike JR. 2014. Radiation exposure prior to traumatic brain injury induces responses that differ as a function of animal age. Int J Radiat Biol. 90(3):214–223. doi:10.3109/09553002.2014.859761
   PubMed Web of Science ®Google Scholar
• Ashcroft GS. 2004. Sex differences in wound healing. Adv Mol Cell Biol. 34:321–328. doi:10.1016/S1569-2558(03)34022-6
   Google Scholar
• Carter SR, Zahs A, Palmer JL, Wang L, Ramirez L, Gamelli RL, Kovacs EJ. 2013. Intestinal barrier disruption as a cause of mortality in combined radiation and burn injury. Shock. 40(4):281–289. doi:10.1097/SHK.0b013e3182a2c5b5
   PubMed Web of Science ®Google Scholar
• Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. 2018. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 9(6):7204–7218. doi:10.18632/oncotarget.23208
   PubMedGoogle Scholar
• DiCarlo AL, Ramakrishnan N, Hatchett RJ. 2010. Radiation combined injury: Overview of NIAID research. Health Phys. 98(6):863–867. doi:10.1097/HP.0b013e3181a6ee32
   PubMed Web of Science ®Google Scholar
• Du Sert NP, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, et al. 2020. The arrive guidelines 2.0: Updated guidelines for reporting animal research. J Cereb Blood Flow Metab. 40(9):1769–1777. doi:10.1177/0271678X20943823
   PubMed Web of Science ®Google Scholar
• Fukumoto R, Burns TM, Kiang JG. 2014. Ciprofloxacin enhances stress erythropoiesis in the spleen and increases survival after whole-body irradiation combined with skin-wound trauma. PLoS ONE,. 9(2):e90448. doi:10.1371/journal.pone.0090448
   PubMed Web of Science ®Google Scholar
• Kiang JG. 2014. Bone marrow mesenchymal stem cells increase survival after ionizing irradiation combined with wound trauma: Characterization and Therapy. J Cell Sci Ther. 05(06):190. doi:10.4172/2157-7013.1000190
   Google Scholar
• Gęgotek A, Skrzydlewska E. 2022. Antioxidative and anti-inflammatory activity of ascorbic acid. In. Antioxidants (Basel). 11(10):1993. doi:10.3390/antiox11101993
   PubMedGoogle Scholar
• Ghayempour S, Montazer M, Mahmoudi Rad M. 2015. Tragacanth gum as a natural polymeric wall for producing antimicrobial nanocapsules loaded with plant extract. Int J Biol Macromol. 81:514–520. doi:10.1016/j.ijbiomac.2015.08.041
   PubMed Web of Science ®Google Scholar
• Gilliver SC, Ruckshanthi JP, Hardman MJ, Nakayama T, Ashcroft GS. 2008. Sex dimorphism in wound healing: The roles of sex steroids and macrophage migration inhibitory factor. Endocrinology. 149(11):5747–5757. doi:10.1210/en.2008-0355
   PubMed Web of Science ®Google Scholar
• Hao L, Wang J, Zou Z, Yan G, Dong S, Deng J, Ran X, Feng Y, Luo C, Wang Y, et al. 2009. Transplantation of BMSCs expressing hPDGF-A/hBD2 promotes wound healing in rats with combined radiation-wound injury. Gene Ther. 16(1):34–42. doi:10.1038/gt.2008.133
   PubMed Web of Science ®Google Scholar
• Haubner F, Ohmann E, Pohl F, Strutz J, Gassner HG. 2012. Wound healing after radiation therapy: Review of the literature. Radiat Oncol. 7(1):162. doi:10.1186/1748-717X-7-162
   PubMed Web of Science ®Google Scholar
• Jacob A, Shah KG, Wu R, Wang P. 2010. Ghrelin as a novel therapy for radiation combined injury. Mol Med. 16(3-4):137–143. doi:10.2119/molmed.2009.00154
   PubMed Web of Science ®Google Scholar
• Jagetia GC, Rajanikant GK. 2012. Acceleration of wound repair by curcumin in the excision wound of mice exposed to different doses of fractionated γ radiation. Int Wound J. 9(1):76–92. doi:10.1111/j.1742-481X.2011.00848.x
   PubMed Web of Science ®Google Scholar
• Kalonia A, Sharma AK, Shaw P, Kumar A, Bhatt AN, Shukla A, Shukla SK. 2023. Ascorbate formulation improves healing efficacy in excisional wound mice model through interplay between pro and anti-inflammatory cytokines and angiogenic markers. Cytokine. 164:156158. doi:10.1016/j.cyto.2023.156158
   PubMed Web of Science ®Google Scholar
• Kiang JG, Blakely WF. 2023. Combined radiation injury and its impacts on radiation countermeasures and biodosimetry. Int J Radiat Biol. 99(7):1055–1065. doi:10.1080/09553002.2023.2188933
   PubMed Web of Science ®Google Scholar
• Kiang JG, Fukumoto R. 2014. Ciprofloxacin increases survival after ionizing irradiation-combined injury: γ-H2AX formation, cytokine/chemokine, and red blood cells. Health Phys. 106(6):720–726. doi:10.1097/HP.0000000000000108
   PubMed Web of Science ®Google Scholar
• Kiang JG, Garrison BR, Burns TM, Zhai M, Dews IC, Ney PH, Cary LH, Fukumoto R, Elliott TB, Ledney GD. 2012. Wound trauma alters ionizing radiation dose assessment. Cell Biosci. 2(1):20. doi:10.1186/2045-3701-2-20
   PubMedGoogle Scholar
• Kiang JG, Jiao W, Cary LH, Mog SR, Elliott TB, Pellmar TC, Ledney GD. 2010. Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection. Radiat Res. 173(3):319–332. doi:10.1667/RR1892.1
   PubMed Web of Science ®Google Scholar
• Kiang JG, Smith JT, Anderson MN, Elliott TB, Gupta P, Balakathiresan NS, Maheshwari RK, Knollmann-Ritschel B. 2017. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. PLoS One. 12(9):e0184393. doi:10.1371/journal.pone.0184393
   PubMed Web of Science ®Google Scholar
• Kiang JG, Smith JT, Anderson MN, Umali MV, Ho C, Zhai M, Lin B, Jiang S. 2019. A novel therapy, using ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury. Pharm Pharmacol Int J. 7(3):133–145. doi:10.15406/ppij.2019.07.00243
   PubMedGoogle Scholar
• Kiang JG, Zhai M, Liao PJ, Bolduc DL, Elliott TB, Gorbunov NV. 2014. Pegylated G-CSF inhibits blood cell depletion, increases platelets, blocks splenomegaly, and improves survival after whole-body ionizing irradiation but not after irradiation combined with burn. Oxid Med Cell Longev. 2014:481392–481310. doi:10.1155/2014/481392
   PubMed Web of Science ®Google Scholar
• Lausevic Z, Lausevic M, Trbojevic-Stankovic J, Krstic S, Stojimirovic B. 2008. Predicting multiple organ failure in patients with severe trauma. Canadian Journal of Surgery. Journal Canadien de Chirurgie. 51(2):97–102.
   PubMed Web of Science ®Google Scholar
• Ledney GD, Elliott TB. 2010. Combined injury: Factors with potential to impact radiation dose assessments. Health Phys. 98(2):145–152. doi:10.1097/01.HP.0000348466.09978.77
   PubMed Web of Science ®Google Scholar
• Levenson SM, Gruber CA, Rettura G, Gruber DK, Demetriou AA, Seifter E. 1984. Supplemental vitamin A prevents the acute radiation-induced defect in wound healing. Ann Surg. 200(4):494–512. doi:10.1097/00000658-198410000-00011
   PubMed Web of Science ®Google Scholar
• Lisman T. 2018. Platelet–neutrophil interactions as drivers of inflammatory and thrombotic disease. Cell Tissue Res. 371(3):567–576. doi:10.1007/s00441-017-2727-4
   PubMed Web of Science ®Google Scholar
• Liu C, Hao Y, Huang J, Li H, Yang Z, Zeng Y, Liu J, Li R. 2017. Ghrelin accelerates wound healing in combined radiation and wound injury in mice. Exp Dermatol. 26(2):186–193. doi:10.1111/exd.13224
   PubMed Web of Science ®Google Scholar
• Mathew D, Nair CKK, Jacob JA, Biswas N, Mukherjee T, Kapoor S, Kagiya TV. 2007. Ascorbic acid monoglucoside as antioxidant and radioprotector. J Radiat Res. 48(5):369–376. doi:10.1269/jrr.07007
   PubMed Web of Science ®Google Scholar
• Mavragani IV, Laskaratou DA, Frey B, Candéias SM, Gaipl US, Lumniczky K, Georgakilas AG. 2015. Key mechanisms involved in ionizing radiation-induced systemic effects. A current review. Toxicol Res (Camb). 5(1):12–33. doi:10.1039/c5tx00222b
   PubMed Web of Science ®Google Scholar
• Medhora M, Gasperetti T, Schamerhorn A, Gao F, Narayanan J, Lazarova Z, Jacobs ER, Tarima S, Fish BL. 2020. Wound trauma exacerbates acute, but not delayed, effects of radiation in rats: Mitigation by lisinopril. Int J Mol Sci. 21(11):3908. doi:10.3390/ijms21113908
   PubMed Web of Science ®Google Scholar
• Myung H, Jang H, Myung JK, Lee C, Lee J, Kang JH, Jang WS, Lee SJ, Kim H, Kim HY, et al. 2020. Platelet-rich plasma improves the therapeutic efficacy of mesenchymal stem cells by enhancing their secretion of angiogenic factors in a combined radiation and wound injury model. Exp Dermatol. 29(2):158–167. doi:10.1111/exd.14042
   PubMed Web of Science ®Google Scholar
• Narendran N, Luzhna L, Kovalchuk O. 2019. Sex difference of radiation response in occupational and accidental exposure. Front Genet. 10:260. doi:10.3389/fgene.2019.00260
   PubMed Web of Science ®Google Scholar
• Oryan A, Tabatabaei Naeini A, Moshiri A, Mohammadalipour A, Tabandeh MR. 2012. Modulation of cutaneous wound healing by silymarin in rats. J Wound Care. 21(9):457–464. doi:10.12968/jowc.2012.21.9.457
   PubMed Web of Science ®Google Scholar
• Pellmar TC, Ledney GD. 2005. Combined injury: Radiation in combination with trauma, infectious disease, or chemical exposures. Nato Rtg. 99:1–9.
   Google Scholar
• Peres AR, De Melo Júnior J, Casas VF, Macente BI, Menegasso Mansano CF. 2015. Use of castor oil in tissue repair of extensive wound in senile horse. Acta Scientiae Veterinariae. 43(1):101.
   Google Scholar
• Phillips CL, Combs SB, Pinnell SR. 1994. Effects of ascorbic acid on proliferation and collagen synthesis in relation to the donor age of human dermal fibroblasts. J Invest Dermatol. 103(2):228–232. doi:10.1111/1523-1747.ep12393187
   PubMed Web of Science ®Google Scholar
• Qian LW, Fourcaudot AB, Yamane K, You T, Chan RK, Leung KP. 2016. Exacerbated and prolonged inflammation impairs wound healing and increases scarring. Wound Repair Regen. 24(1):26–34. doi:10.1111/wrr.12381
   PubMed Web of Science ®Google Scholar
• Ran XZ, Shi CM, Zheng HE, Su YP, Cheng TM. 2011. Experimental research on the management of combined radiation-burn injury in China. Radiat Res. 175(3):382–389. doi:10.1667/RR2198.1
   PubMed Web of Science ®Google Scholar
• Sami DG, Abdellatif A. 2021. Histological and clinical evaluation of wound healing in pressure ulcers: A novel animal model. J Wound Care. 30(Sup6):S12–S21. doi:10.12968/jowc.2021.30.sup6.s12
   PubMedGoogle Scholar
• Sharma AK, Shukla SK, Kalonia A, Shaw P, Yashavarddhan MH, Manda K. 2020. Evaluation of wound healing potential of ascorbic acid, castor oil, and gum tragacanth formulation in murine excisional wound model. Pharmacogn Mag. 16(69):359–368. doi:10.4103/pm.pm_440_19
   Web of Science ®Google Scholar
• Sharma AK, Prasad A, Kalonia A, Shaw P, Kumar R, Shukla SK. 2022. Combined radiation burn injuries: A note. J Radiol Prot. 42(4):043502. doi:10.1088/1361-6498/ac9e61
   Web of Science ®Google Scholar
• Shaw, Priyanka, Sharma, Ajay Kumar, Kalonia, Aman, Shukla, Amit, Kumar, Rishav, Shukla, Sandeep Kumar, Kirti, (2023). Early cutaneous inflammatory response at different degree of burn and its significance for clinical diagnosis and management.J Tissue Viability, 32(4), 550–563. doi:10.1016/j.jtv.2023.06.011
   PubMed Web of Science ®Google Scholar
• Shukla SK, Sharma AK, Shaw P, Kalonia A, Yashavarddhan MH, Singh S. 2020. Creation of rapid and reproducible burn in animal model with a newly developed burn device. Burns. 46(5):1142–1149. doi:10.1016/j.burns.2019.12.005
   PubMed Web of Science ®Google Scholar
• Sim SL, Kumari S, Kaur S, Khosrotehrani K. 2022. Macrophages in skin wounds: functions and therapeutic potential. Biomolecules. 12(11):1659. doi:10.3390/biom12111659
   PubMed Web of Science ®Google Scholar
• Sinclair WK, Mossman KL, Mills WA. 1993. The biological basis of radiation protection practice. Radiat Res. 134(3):400. doi:10.2307/3578206
   Google Scholar
• Singh VK, Seed TM. 2019. The efficacy and safety of amifostine for the acute radiation syndrome. Expert Opin Drug Saf. 18(11):1077–1090. doi:10.1080/14740338.2019.1666104
   PubMed Web of Science ®Google Scholar
• Somosy Z, Horváth G, Telbisz A, Réz G, Pálfia Z. 2002. Morphological aspects of ionizing radiation response of small intestine. Micron. 33(2):167–178. doi:10.1016/S0968-4328(01)00013-0
   PubMed Web of Science ®Google Scholar
• Song S, Cheng T. 1997. The effect of systemic and local irradiation on wound macrophages and the repair promoting action of phenytoin sodium. Zhonghua Yi Xue Za Zhi. 77(1):54–57.
   PubMedGoogle Scholar
• Stromberg LR, Mclaughlin MM, Donati RM. 1968. Combined surgical and radiation injury. III. The effect of pre-irradiation radioprotective drug treatment. Proc Soc Exp Biol Med. 129(1):140–143. doi:10.3181/00379727-129-33270
   PubMed Web of Science ®Google Scholar
• Taghavizadeh Yazdi ME, Nazarnezhad S, Mousavi SH, Sadegh Amiri M, Darroudi M, Baino F, Kargozar S. 2021. Gum tragacanth (Gt): A versatile biocompatible material beyond borders. Molecules. 26(6):1510. doi:10.3390/molecules26061510
   PubMed Web of Science ®Google Scholar
• Utariani A, Rahardjo E, Perdanakusuma DS. 2020. Effects of albumin infusion on serum levels of albumin, proinflammatory cytokines (TNF-α, IL-1, and IL-6), CRP, and MMP-8; tissue expression of EGRF, ERK1, ERK2, TGF-β, collagen, and MMP-8; and wound healing in sprague dawley rats. Int J Inflam. 2020:3254017–3254013. doi:10.1155/2020/3254017
   PubMed Web of Science ®Google Scholar
• Wang L, Lin B, Zhai M, Cui W, Hull L, Zizzo A, Li X, Kiang JG, Xiao M. 2022. Deteriorative effects of radiation injury combined with skin wounding in a mouse model. Toxics. 10(12):785. doi:10.3390/toxics10120785
   PubMed Web of Science ®Google Scholar
• Wang L, Zhai M, Lin B, Cui W, Hull L, Li X, Anderson MN, Smith JT, Umali MV, Jiang S, et al. 2021. PEG-G-CSF and L-citrulline combination therapy for mitigating skin wound combined radiation injury in a mouse model. Radiat Res. 196(1):113–127. doi:10.1667/RADE-20-00151.1
   PubMed Web of Science ®Google Scholar
• Wang Y, Boerma M, Zhou D. 2016. Ionizing radiation-induced endothelial cell senescence and cardiovascular diseases. Radiat Res. 186(2):153–161. doi:10.1667/RR14445.1
   PubMed Web of Science ®Google Scholar
• Zhang F, Zhang T, Teng ZH, Zhang R, Wang JB, Mei QB. 2009. Sensitization to γ-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells. Cancer Biol Ther. 8(9):823–831. doi:10.4161/cbt.8.9.8143
   PubMed Web of Science ®Google Scholar