13
Views
42
CrossRef citations to date
0
Altmetric
Original Article

Radiosensitive Xrs-5 and Parental CHO Cells Show Identical DNA Neutral Filter Elution Dose—response: Implications for a Relationship between Cell Radiosensitivity and Induction of DNA Double-strand Breaks

, &
Pages 55-62 | Received 27 Nov 1987, Accepted 01 Mar 1988, Published online: 03 Jul 2009

References

  • Beetham K.L., Tolmach L.J. The action of caffeine on x-irradiated HeLa cells: VI. Damping of the structured age-survival function. Radiation Research 1984; 100: 104–116
  • Beetham K.L., Tolmach L.J. The action of caffeine on x-irradiated HeLa cells: VIII. Recovery from potentially lethal damage. Radiation Research 1986; 107: 272–285
  • Bradley M.D., Kohn K.W. X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution. Nucleic Acids Research 1979; 7: 793–804
  • Curtis S.B. Lethal and potentially lethal lesions induced by radiation—a unified repair model. Radiation Research 1986; 106: 252–270
  • Giaccia A., Weinstein R., Hu. J., Stamato T.D. Cell cycle dependent repair of double strand DNA breaks in a gamma ray sensitive chinese hamster cell line. Somatic Cell and Molecular Genetics 1985; 11: 485–491
  • Goodhead D.T. Saturable repair models of radiation action in mammalian cells. Radiation Research 1985; 104(8)58–67
  • Iliakis G. Effects of beta-arabinofuranosyladenine on the growth and repair of potentially lethal damage in Ehrlich ascites tumor cells. Radiation Research 1980; 83: 535–552
  • Iliakis G. Characterization and properties of repair of potentially lethal damage as measured with the help of beta-arabinofuranosyladenine in plateau-phase EAT-cells. Radiation Research 1981; 86: 77–90
  • Iliakis G. Evidence for the induction of two types of potentially lethal damage after exposure of plateau-phase Chinese hamster V79-cells to gamma-rays. Radiation and Environmental Biophysics 1985; 24: 185–202
  • Iliakis G., Nuesse M. Evidence that repair and expression of potentially lethal damage cause the variations in cell survival after x-irradiation observed through the cell cycle in Ehrlich ascites tumor cells. Radiation Research 1983; 95: 87–107
  • Iliakis G., Okayasu R. The level of induced DNA double strand breaks does not correlate with cell killing in x-irradiated mitotic and G1-phase CHO-cells. International Journal of Radiation Biology 1988; 53: 395–404
  • Iliakis G., Bryant P.E., Ngo F.Q.H. Independent forms of potentially lethal damage fixed in plateau-phase Chinese hamster cells by post-irradiation treatment in hypertonic salt solution or araA. Radiation Research 1985; 104: 329–345
  • Iliakis G., Pantelias G., Okayasu R., Seaner R. 125IdUrd induced chromosome fragments, assayed by premature chromosome condensation, and DNA double strand breaks have similar repair kinetics in G1-phase CHO-cells. International Journal of Radiation Biology 1987; 52: 705–722
  • Iliakis, G., Pantelias, G.E., Seaner, R. Effect of arabinofuranosyladenine on radiation induced chromosome damage in plateau phase CHO cells measured by premature chromosome condensation: Implications for repair and fixation of alpha PLD. Radiation Research, in press, 1988
  • Jeggo P.A., Kemp L.M. X-ray-sensitive mutants of Chinese hamster ovary cell lines: Isolation and cross-sensitivity to other DNA-damaging agents. Mutation Research 1983; 112: 313–327
  • Kemp L.M., Sedgwick S.G., Jeggo P.A. X-ray sensitive mutants of CHO cells defective in double strand break rejoining. Mutation Research 1984; 132: 189–196
  • Okayasu R., Bloecher D., Iliakis G. Variation through the cell cycle of DNA neutral filter elution dose response in x-irradiated synchronous CHO-cells. International Journal of Radiation Biology 1988; 53: 729–748
  • Pohlit W., Heyder I.R. The shape of dose-survival curves for mammalian cells and repair of potentially lethal damage analyzed by hypertonic treatment. Radiation Research 1981; 87: 613–634
  • Radford I.R. The level of induced DNA double strand breakage correlates with cell killing after x-irradiation. International Journal of Radiation Biology 1985; 48: 45–54
  • Radford I.R. Effect of radiomodifying agents on the ratios of x-ray-induced lesions in cellular DNA: Use in lethal lesion determination. International Journal of Radiation Biology 1986A; 49: 622–637
  • Radford I.R. Evidence for a general relationship between the induced level of DNA double-strand breakage and cell killing after x-irradiation of mammalian cells. International Journal of Radiation Biology 1986b; 49: 611–620
  • Radford I.R., Broadhurst S. Enhanced induction by x-irradiation of DNA double-strand breakage in mitotic as compared with S-phase V79-cells. International Journal of Radiation Biology 1986; 49: 909–914
  • Radford I.R., Hodgson G.S. 125I-induced DNA double strand breaks: Use in calibration of the neutral filter elution technique and comparison with x-ray induced breaks. International Journal of Radiation Biology 1985; 48: 555–566
  • Tobias C.A., Blakely E.A., Ngo F.Q.H., Yang T.C.H. The repair misrepair model of cell survival. Radiation Biology and Cancer Research, R.E. Meyn, H.R. Withers. Raven Press, New York 1980; 195–230
  • Wlodek D., Hittelman W.N. Repair of double-strand DNA breaks correlates with radiosensitivity of L5178Y and L5178Y-R cells. Radiation Research 1987; 112: 1–10

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.