DNA Damage and Repair in Rodent and Human Cells after Exposure to JANUS Fission Spectrum Neutrons: A Minor Fraction of Single-strand Breaks as Revealed by Alkaline Elution is Refractory to Repair

References

• Bloecher D.B., Pohlit W. DNA strand breaks in Ehrlich ascites tumor cells at low doses of X-rays. 2. Can cell death be attributed to double strand breaks?. International Journal of Radiation Biology 1982; 47: 329–338
   Google Scholar
• Borak T.B., Stinchcomb T.G. Calculations of charged-particle recoils, slowing down spectra, LET and event-size distributions for fast neutrons and comparison with measurements. Physics in Medicine and Biology 1979; 24: 18–36
   PubMed Web of Science ®Google Scholar
• Broerse J.J., Barendsen G.W. Recovery of cultured cells after fast neutron irradiation. International Journal of Radiation Biology 1969; 15: 335–339
   Google Scholar
• Chadwick K.H., Leenhouts H.P. The Molecular Theory of Radiation Biology. Springer-Verlag, Berlin 1981
   Google Scholar
• Cunningham M.L., Peak J.G., Peak M.J. Single-strand DNA breaks in rodent and human cells produced by superoxide anion or its reduction products. Mutation Research 1987; 184: 217–222
   PubMed Web of Science ®Google Scholar
• Dugle D.L., Gillespie C.J., Chapman J.D. DNA strand breaks, repair, and survival in x-irradiated mammalian cells. Proceedings of the National Academy of Sciences, U.S.A. 1976; 73: 809–812
   PubMed Web of Science ®Google Scholar
• Elkind M.M., Redpath J.L. Molecular and cellular biology of radiation lethality. Cancer: A Comprehensive Treatise, F. Beckes. Plenum Press, New York 1977; 6
   Google Scholar
• Field S.B. An historical survey of radiobiology and radiotherapy with fast neutrons. Current Topics in Radiation Research Quarterly 1976; 11: 1–86
   PubMedGoogle Scholar
• Furuno I., Yada T., Matsudaira H., Maruyama T. Induction and repair of DNA strand breaks in cultured mammalian cells following fast neutron inactivation. International Journal of Radiation Biology 1979; 36: 639–648
   Web of Science ®Google Scholar
• Han A., Elkind M.M. Transformation of mouse C3H/10T½ cells by single and fractionated doses of X-rays and fission-spectrum neutrons. Cancer Research 1979; 39: 123–130
   PubMed Web of Science ®Google Scholar
• Hesslewood I.P. DNA strand breaks in resistant and sensitive murine lymphoma cells detected by the hydroxyapatie chromatographic technique. International Journal of Radiation Biology 1978; 34: 461–469
   Web of Science ®Google Scholar
• Hill C.K., Buonaguro F.M., Myears C.P., Han A., Elkind M.M. Fission-spectrum neutrons at reduced dose rates enhanced neoplastic transformation. Nature 1982; 298: 67–69
   PubMed Web of Science ®Google Scholar
• Hill C.K., Han A., Elkind M.M. Fission-spectrum neutrons at a low dose rate enhance neoplastic transformation in the linear, low-dose region (0–10 cGy). International Journal of Radiation Biology 1984; 46: 11–15
   Web of Science ®Google Scholar
• Hill C.K., Carnes B.A., Han A., Elkind M.M. Neoplastic transformation is enhanced by multiple low doses of fission-spectrum neutrons. Radiation Research 1985; 102: 404–410
   PubMed Web of Science ®Google Scholar
• Hill C.K., Holland J., Chang-Liu C.M., Buess E.M., Peak J.G., Peak M.J. Human epithelial tetratiocarcinoma cells (P3): Radiobiological characterization, DNA damage, and comparison with other rodent and human cell lines. Radiation Research 1988; 113: 278–288
   PubMed Web of Science ®Google Scholar
• Kohn K.W., Ewig R.A.G., Erickson L.G., Zwelling L.A. Measurement of strand breaks and crosslinks by alkaline elution. DNA Repair 1. A Laboratory Manual of Research Procedures, E.C. Friedberg, P.C. Hanawalt. Marcel Dekker, New York 1981; 379–401
   Google Scholar
• Maki H., Saito M., Kobayashi T., Kawai K., Akaboshi M. Cell inactivation and DNA single- and double-strand breaks in cultured mammalian cells irradiated by a thermal neutron beam. International Journal of Radiation Biology 1986; 50: 795–810
   Web of Science ®Google Scholar
• Marshall I.R., Williamson F.S. Microdosimetric spectra measurements of JANUS-neutrons. Radiation and Proton Dosimetry 1985; 13: 111–115
   Web of Science ®Google Scholar
• McWilliams R.S., Gross W.G., Kaplan J.G., Birnboin H.C. Rapid rejoining of DNA strand breaks in resting human lymphocytes after irradiation by low doses of 60Co γ rays or 14.6 MV neutrons. Radiation Research 1983; 94: 499–507
   PubMed Web of Science ®Google Scholar
• Ngo F.Q.H., Han A., Elkind M.M. On the repair of sublethal damage in V79 Chinese hamster cells resulting from irradiation with fast neutrons or fast neutrons combined with X-rays. International Journal of Radiation Biology 1977; 32: 507–511
   Web of Science ®Google Scholar
• Painter R.B. The role of DNA damage and repair in cell killing induced by ionizing radiation. Radiation Biology in Cancer Research, R.E. Meyn, H.R. Withers. Raven Press, New York 1980; 59–68
   Google Scholar
• Painter R.B., Young B.R., Burkhi H.J. Non-repairable strand breaks induced by 125I incorporated into mammalian DNA. Proceedings of the National Academy of Sciences, U.S.A. 1974; 71: 4836–4838
   PubMed Web of Science ®Google Scholar
• Radford I.R. The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation. International Journal of Radiation Biology 1985; 48: 45–54
   Web of Science ®Google Scholar
• Radford I.R. Evidence for a general relationship between the induced level of DNA double-strand breakage and cell killing after X-irradiation of mammalian cells. International Journal of Radiation Biology 1986; 49: 611–620
   Web of Science ®Google Scholar
• Ritter M.A., Cleaver J.E., Tobias C.A. High LET radiations induce a large proportion of non-rejoining DNA breaks. Nature 1977; 266: 653–655
   PubMed Web of Science ®Google Scholar
• Sakai K., Suzuki S., Nakamura N., Okada S. Induction and subsequent repair of DNA damage by fast neutrons in cultured mammalian cells. Radiation Research 1987; 110: 311–320
   PubMed Web of Science ®Google Scholar
• Sinclair W.K., Fry R.J.M. Mechanisms of radiation interaction with DNA: Potential implications for radiation protection. Radiation Research 1987; 112: 407–417
   PubMedGoogle Scholar
• Thomson J.F., Williamson F.S., Grahn D., Ainsworth E.J. Life shortening in mice exposed to fission neutrons and gamma-rays. I. Single and short term fractionated exposures. Radiation Research 1981; 86: 559–579
   PubMed Web of Science ®Google Scholar
• Ullrich R.L. Tumor induction in Balb/c mice after fractionated or protracted exposure to fission-spectrum neutrons. Radiation Research 1984; 97: 587–597
   PubMed Web of Science ®Google Scholar
• Van der Schans G.P., Paterson M.C., Gross W.G. DNA strand break and rejoining in cultured human fibroblasts exposed to fast neutrons or gamma-rays. International Journal of Radiation Biology 1983; 44: 75–85
   Web of Science ®Google Scholar
• Ward J.F., Blakely W.F., Joner E.I. Mammalian cells are not killed by DNA single-strand breaks caused by hydroxyl radicals from hydrogen peroxide. Radiation Research 1985; 103: 383–392
   PubMed Web of Science ®Google Scholar
• Wlodek D., Hittelman W.N. The repair of double-strand DNA breaks correlates with radiosensitivity of L5178Y-S and L51178Y-R Cells. Radiation Research 1987; 112: 146–155
   PubMed Web of Science ®Google Scholar