9
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Behaviour of Spherical and Irregular (U,Pu)O2 Particles after Inhalation or Intratracheal Instillation in Rat Lung and during in Vitro Culture with Bovine Alveolar Macrophages

, , , , &
Pages 829-842 | Received 09 Jun 1988, Accepted 12 Jan 1989, Published online: 03 Jul 2009

References

  • Adee R.R., Sanders C.L., Berlin J.D. Subcellular localization and identification of alpha emitters by electron microscopic autoradiography. Health Physics 1968; 15: 461–463
  • Adee R.R., Laidler J.J. Subcellular identification of exogenous particles by high-voltage electron microscopy. American Industrial Hygiene Association Journal 1973; 34: 507–511
  • Calamosca M., Tadolini V., Tarroni G., Belvisi M.B., Bassi P. Camera per esposizione acuta di piccoli roditori agli aerosol. Rome 1982, Report of Italian National Committee for Research and Development of Nuclear and Alternative Energy ENEA-RT/BIO (82)7.
  • Drosselmeyer E., Müller H.-L., Pickering S., Seidel A. Indium-doped aluminum oxide as test aerosol for inhalation experiments. Journal of Aerosol Science 1986; 17: 324–327
  • Hillyer R.F., Dagle G.E. Electron diffraction study of plutonium oxide particulates in dog lymph tissue. Microstructural Science. American Elsevier, New York 1974; 2: 197–205
  • James A.C., Stather J.W., Strong J.C., Hostford J.E., Rodwell P., Hodgson A., Kay P. Lung clearance and translocation in rats and hamsters of inhaled dust containing mixed actinide oxides from a fuel fabrication plant. Harwell 1978; 57–64, Report of the National Radiological Protection Board R + D2
  • Metivier H., Rateau G., Masse R., Nolibe D., Discour M. Description d'un dispositif permettant la contamination d'animaux de laboratoire par inhalation d'aerosol radioactifs. Gif-sur-Yvette 1974, Report of French Atomic Energy Commission CEA-N-1722.
  • Mewhinney J.A., Eidson A.F., Stanley J.A., Guilmette R.A. Report of the U.S. Nuclear Regulatory Commission. Washington, DC 1981; 28–41, NUREG/CR-2246, LMF-86
  • Mewhinney J.A., Eidson A.F., Hahn F.F. Dose-response studies in Fischer-344 rats. Washington, DC 1984; 11–20, Report of the U.S. Nuclear Regulatory Commission NUREG/CR-3870
  • Morgan A., Black A., Moores S.R., Pritchard J.N., Walsh M., Lambert B. Alveolar deposition of sized particles of 239PuO2 in the mouse. Radiation Research 1983; 93: 85–92
  • Moores S.R., Talbot R.J., Evans N., Lambert B.E. Macrophage depletion of mouse lung following inhalation of 238PuO2. Radiation Research 1986; 105: 387–404
  • Müller H.-L., Drosselmeyer E., Hotz G., Seidel A., Thiele H., Pickering S., Ray I.L. Report of Kernforschungszentrum Karlsrube and Euratom. Karlsruhe 1987, KfK 4172/EUR 10846 DE.
  • Pickering S. The generation of aerosols by comminution. Aerosols, Formation and Reactivity. Pergamon Press, Oxford 1986; 1061–1064
  • Raabe O.G., Yeh Hsu-Chi, Newton G.J., Phalen R.F., Velasquez D.J. Deposition of inhaled monodisperse aerosols in small rodents. Inhaled Particles, Vol. IV. Pergamon Press, Oxford 1977; 3–21
  • Robinson A.V., Schneider R.P. Phagocytosis, toxicity, and solubility of AmO2 in alveolar macrophages. Pulmonary Toxicology of Respirable Particles. Technical Information Center, U.S. Department of Energy, CONF 791002. 1980; 325–337
  • Sanders C.L. The distribution of inhaled plutonium-239 dioxide particles within pulmonary macrophages. Archives of Environmental Health 1969; 18: 904–912
  • Sanders C.L., Adee R.R. Ultrastructural localization of inhaled 239PuO2 particles in alveolar epithelium and macrophages. Health Physics 1970; 18: 293–295
  • Sanders C.L., Adee R.R., Rhoads K., Madison R.M. Life history of plutonium dioxide in the lung: From macrophage to carcinoma. Pulmonary Macrophage and Epithelial Cells. Technical Information Centre, Energy Research and Development Administration, CONF 760927. 1977; 451–462
  • Seidel A., Volf V. Rapid determination of some transuranium elements in biological material by liquid scintillation counting. International Journal of Applied Radiation and Isotopes 1972; 23: 1–4
  • Stanley J.A., Eidson A.F., Mewhinney J.A. Distribution, retention and dosimetry of plutonium and americium in the rat, dog and monkey after inhalation of an industrial-mixed uranium and plutonium oxide aerosol. Health Physics 1982; 43: 521–530
  • Stather J.W., Brightwell J., Rodwell P., Ellender M. A study of the clearance of plutonium from the lungs of rodents after inhalation of mixed oxide aerosols formed from the oxidation of plutonium in combination with uranium. Harwell 1978; 55–56, Report of the National Radiological Protection Board R + D2,
  • Stather J.W., James A.C., Brightwell J., Rodwell P. The clearance of Pu and Am from the respiratory system of rodents after the inhalation of oxide aerosols of these actinides either alone or in combination with other metals. Biological Implications of Radionuclides Released from Nuclear Industries. International Atomic Energy Agency, Vienna 1979; II: 3–24
  • Strong J.C., James A.C., Hodgson A. A facility for exposing rodents by inhalation to industrial actinide dusts. Harwell 1976; 19–21, Report of the National Radiological Protection Board R + D1
  • Tasat D.R., De Rey B.M. Cytotoxic effect of uranium dioxide on rat alveolar macrophages. Environmental Research 1987; 44: 71–81
  • Walsh M., Pritchard J.N., Black A., Moores S.R., Morgan A. The development of a system for the exposure of mice to aerosols of plutonium oxide. Journal of Aerosol Science 1980; 11: 467–474

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.