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Original Article

Heterogeneous Radiation and Heat Sensitivity in Vitro of Human Melanoma Xenograft Lines Established from Different Lesions in the Same Patient

Comparisons with the Radiation and Heat Sensitivity of Cells Isolated from the Donor Patient's Surgical Specimens

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Pages 1113-1122 | Received 13 Nov 1989, Accepted 06 Feb 1990, Published online: 03 Jul 2009

References

  • Courtenay V.D., Mills J. An in vitro colony assay for human tumours grown in immune-suppressed mice and treated in vivo with cytotoxic agents. British Journal of Cancer 1978; 37: 261–268
  • Harris J.F., Chambers A.F., Hill R.P., Ling V. Metastatic variants are generated spontaneously at a high rate in mouse KHT tumor. Proceedings of the National Academy of Sciences, USA 1982; 79: 5547–5551
  • Heppner G.H. Tumour heterogeneity. Cancer Research 1984; 44: 2259–2265
  • Heppner G.H., Miller B.E. Therapeutic implications of tumor heterogeneity. Seminars in Oncology 1989; 16: 91–105
  • Heppner G.H., Dexter D.L., DeNucci T., Miller F.R., Calabresi P. Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor. Cancer Research 1978; 38: 3758–3763
  • Leith J.T., Dexter D.L. Mammalian Tumor Cell Heterogeneity. CRC Press, Roca Raton 1986; 97–120
  • Leith J.T., Dexter D.L., DeWyngaert J.K., Zeman E.Z., Chu M.Y., Calabresi P., Glicksman A.S. Differential responses to X-irradiation of subpopulations of two heterogeneous human carcinomas in vitro. Cancer Research 1982; 42: 2556–2561
  • Nicolson G.L. Tumor progression, oncogenes and the evolution of metastatic phenotypic diversity. Clinical and Experimental Metastasis 1984; 2: 85–105
  • Poste G., Doll J., Fidler I.J. Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells. Proceedings of the National Academy of Sciences, USA 1981; 78: 6226–6230
  • Rofstad E.K. Radiation response of the cells of a human malignant melanoma xenograft. Effect of hypoxic cell radiosensitizers. Radiation Research 1981; 87: 670–683
  • Rofstad E.K. Radiation biology of human tumour xenografts. International Journal of Radiation Biology 1989; 56: 573–581
  • Rofstad E.K., Brustad T. Differential responses to radiation and hyperthermia of cloned cell lines derived from a single human melanoma xenograft. International Journal of Radiation Oncology, Biology, Physics 1984; 10: 857–864
  • Rofstad E.K., Wahl A., Brustad T. Radiation sensitivity in vitro of cells isolated from human tumor surgical specimens. Cancer Research 1987; 47: 106–110
  • Rofstad E.K., Wahl A., Tveit K.M., Monge O.R., Brustad T. Survival curves after X-ray and heat treatments for melanoma cells derived directly from surgical specimens of tumours in man. Radiotherapy and Oncology 1985; 4: 33–44
  • Schlag P., Schreml W. Heterogeneity in growth pattern and drug sensitivity of primary tumor and metastases in the human tumor colony forming assay. Cancer Research 1982; 42: 4086–4089
  • Schwartz J.L., Vaughan A.T.M. Association among DNA/chromosome break rejoining rates, chromatin structure alterations, and radiation sensitivity in human tumour cell lines. Cancer Research 1989; 49: 5054–5057
  • Schwartz J.L., Rotmensch J., Giovanazzi S., Cohen M.B., Weichselbaum R.R. Faster repair of DNA double-strand breaks in radioresistant human tumor cells. International Journal of Radiation Oncology, Biology, Physics 1988; 15: 907–912
  • Slack N.H., Bross I.D.J. The influence of site of metastasis on tumour growth and response to chemotherapy. British Journal of Cancer 1975; 32: 78–86
  • Tanigawa N., Mizuno Y., Hashimura T., Honda K., Satomura K., Hikasa Y., Niwa O., Sugahara T., Yoshida O., Kern D.H. Comparisons of drug sensitivity among tumor cells within a tumor, between primary tumor and metastases, and between different metastases in the human colony-forming assay. Cancer Research 1984; 44: 2309–2312
  • Von Hoff D.D., Clark G.M., Forseth B.J., Cowan J.D. Simultaneous in vitro drug sensitivity testing on tumors from different sites in the same patient. Cancer 1986; 58: 1007–1033
  • Welch D.R., Tomasovic S.P. Implications of tumor progression on clinical oncology. Clinical and Experimental Metastasis 1985; 3: 151–188
  • Welch D.R., Milas L., Tomasovic S.P., Nicolson G.L. Heterogeneous response and clonal drift of sensitivities of metastatic 13762NF mammary adenocarcinoma clones to γ-radiation in vitro. Cancer Research 1983; 43: 6–10

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