Advanced search
Publication Cover
International Journal of Radiation Biology Volume 59, 1991 - Issue 1
Submit an article Journal homepage
9
Views
11
CrossRef citations to date
0
Altmetric
Original Article

Evaluation of a New 2-nitroimidazole Nucleoside Analogue, RK-28 as a Radiosensitizer for Clinical Use

Y. Shibamoto Department of Radiology, Faculty of Medicine, Kyoto University, Kyoto, 606, Japan
,
K. Sasai Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, 4300, Essen 1, FRG
,
M. Sakaguchi Pola Corporation, Yokohama, 244, Japan
,
P. Tamulevicius Department of Radiology, Faculty of Medicine, Kyoto University, Kyoto, 606, Japan
,
Y. Kitakabu Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, 4300, Essen 1, FRG
,
C. Streffer Pola Corporation, Yokohama, 244, Japan
&
M. Abe Department of Radiology, Faculty of Medicine, Kyoto University, Kyoto, 606, Japan
 show all
Pages 105-115 | Received 21 Mar 1990, Accepted 19 Jun 1990, Published online: 03 Jul 2009

References

  • Agrawal K.C., Rupp W.D., Rockwell S. Radiosensitization, pharmacokinetics, and toxicity of a 2-nitroimidazole nucleoside (RA-263). Radiation Research 1986; 105: 227–239
  • Antoku S., Ayabe Y. Screening of radiosensitizers using cultured cells. Annual Reports of Cancer Research Program of the Ministry of Education, Science and Culture (59010066). 1985; 52–57, (in Japanese).
  • Conroy P.J., Von Burg R., Passalacqua W., Penny D.P., Sutherland R.M. Misonidazole neurotoxicity in the mouse: evaluation of functional, pharmacokinetic, electro-physiologic and morphologic parameters. International Journal of Radiation Oncology, Biology and Physics 1979; 5: 983–991
  • Dennis M.F., Stratford M.R.L., Wardman P., Watts M.E. Cellular uptake of misonidazole and analogues with acidic or basic functions. International Journal of Radiation Biology 1985; 47: 629–643
  • Hall E.J., Astor M., Biaglow J., Parham J.C. The enhanced sensitivity of mammalian cells to killing by X-rays after prolonged exposure to several nitroimidazoles. International Journal of Radiation Oncology, Biology and Physics 1982; 8: 447–451
  • Matsumoto Y., Sakamoto K. The effect of a new hypoxic cell sensitizer RK-28 on mouse squamous cell carcinoma. Nippon Acta Radiologica 1984; 44: 234–234, (in Japanese).
  • Miyamoto Y. Radiosensitizing effect of new hypoxic cell radiosensitizer, RK-28 on experimental animal normal tissue and Ehrlich tumor. Nippon Acta Radiologica 1985; 45: 1142–1151, (in Japanese)
  • Murayama C., Tanaka N., Miyamoto Y., Sakaguchi M., Mori T. In vitro and in vivo radiosensitizing effects of 2-nitroimidazole derivatives with sugar component. Strahlentherapie und Onkologie 1987; 163: 385–390
  • Murayama C., Suzuki A., Suzuki T., Miyata Y., Sakaguchi M., Tanabe Y., Tanaka N., Mori T. Radiosensitization by a new nucleoside analogue: 1-[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl-2-nitroimidazole (RP-170). International Journal of Radiation Oncology, Biology and Physics 1989; 17: 575–581
  • Sakaguchi M., Larroquette C.A., Agrawal K.C. Potential radiosensitizing agents. 6. 2-nitroimidazole nucleosides: arabinofuranosyl and hexapyranosyl analogues. Journal of Medicinal Chemistry 1983; 26: 20–24
  • Sasai K., Ono K., Nishidai T., Tsutsui K., Shibamoto Y., Takahashi M., Abe M. Variation in tumor response to fluoxol-DA (20%). International Journal of Radiation Oncology, Biology, and Physics 1989; 16: 1149–1152
  • Sasai K., Shibamoto Y., Takahashi M., Ito T., Nishimoto S., Abe M. Pharmacokinetics of 2-nitroimidazole derivative hypoxic cell radiosensitizers in rodent peripheral nervous tissue. International Journal of Radiation Biology 1990; 57: 971–980
  • Shibamoto Y., Sakano K., Kimura R., Nishidai T., Nishimoto S., Ono K., Kagiya T., Abe M. Radiosensitization in vitro and in vivo by 3-nitrotriazoles. International Journal of Radiation Oncology, Biology and Physics 1986a; 12: 1063–1066
  • Shibamoto Y., Ono K., Takahashi M., Kano E., Hori H., Shibata T., Inayama S., Abe M. An in vitro and in vivo screening system for new hypoxic cell radiosensitizers using EMT6 cells. Japanese Journal of Cancer Research (Gann) 1986b; 77: 1027–1033
  • Shibamoto Y., Ono K., Takahashi M., Abe M., Hori H., Shibata T., Inayama S. Radioprotective phenomena in murine tumors induced by radiosensitizers at high dose levels. Nippon Acta Radiologica 1986c; 46: 725–727, (in Japanese).
  • Shibamoto Y., Nishimoto S., Mi F., Sasai K., Kagiya T., Abe M. Evaluation of various types of new hypoxic cell sensitizers using the EMT6 single cell-spheroid-solid tumour system. International Journal of Radiation Biology 1987; 52: 347–357
  • Shibamoto Y., Nishimoto S., Shimokawa K., Hisanaga Y., Zhou L., Wang J., Sasai K., Takahashi M., Abe M., Kagiya T. Characteristics of fluorinated nitroazoles as hypoxic cell radiosensitizers. International Journal of Radiation Oncology, Biology, and Physics 1989; 16: 1045–1048
  • Tanaka M., Fukuda H., Nakajima T., Sugimoto K., Onoyama Y., Hori H., Inayama S. Radiosensitizing effect of the nitroimidazole derivatives RK-28 and DNIE on murine tumors. Nippon Acta Radiologica 1988; 48: 1249–1260, (in Japanese).
  • Tamulevicius P., Luscher G., Steffer C. Effects on intermediary metabolism in mouse tissues by Ro-03-8799. British Journal of Cancer 1987; 56: 315–320

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.