8
Views
1
CrossRef citations to date
0
Altmetric
Original Article

Enhancement of SR 2508 (Etanidazole) Radiosensitization by Buthionine Sulphoximine at Low-dose-rate Irradiation

, &
Pages 133-143 | Received 02 Jan 1990, Accepted 06 Jun 1990, Published online: 03 Jul 2009

References

  • Adams G.E. Hypoxia-mediated drugs for radiation and chemotherapy. Cancer 1981; 48: 696–709
  • Adams G.E., Stratford I.J. Hypoxia-mediated nitroheterocyclic drugs in the radio- and chemotherapy of cancer. Biochemical Pharmacology 1986; 35: 71–76
  • Albright N. Computer programs for the analysis of cellular survival data. Radiation Research 1987; 112: 331–340
  • Biaglow J.E., Varnes M.E., Clark E.P., Epp E.R. The role of thiols in cellular response to radiation and drugs. Radiation Research 1983; 95: 437–455
  • Biaglow J.E., Varnes M.E., Tuttle S.W., Oleinick N.L., Glazier K., Clark E.P., Epp E.R., Dethlefsen L.A. The effect of L-buthionine sulfoximine on the aerobic radiation response of A549 human lung carcinoma cells. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 1139–1142
  • Brown J.M. Evidence for actuely hypoxic cells in mouse tumour and a possible mechanism of reoxygenation. British Journal of Radiology 1979; 52: 650–656
  • Brown J.M. The mechanisms of cytotoxicity and chemosensitization of misonidazole and other nitroimidazoles. International Journal of Radiation Oncology, Biology, Physics 1982a; 8: 675–682
  • Brown J.M. Clinical perspectives for the use of new hypoxic cell sensitizers. International Journal of Radiation Oncology, Biology, Physics 1982b; 8: 1491–1497
  • Brown J.M., Yu N.Y. Radiosensitization of hypoxic cells in vivo by SR 2508 at low radiation doses: a preliminary report. International Journal of Radiation Oncology, Biology, Physics 1984; 10: 1207–1212
  • Bump E.A., Yu N.Y., Brown J.M. The use of drugs which deplete intracellular glutathione in hypoxic cell radiosensitization. International Journal of Radiation Oncology, Biology, Physics 1982a; 8: 439–442
  • Bump E.A., Yu N.Y., Brown J.M. Radiosensitization of hypoxic tumor cells by depletion of intracellular glutathione. Science 1982b; 127: 544–545
  • Bush R.S., Jenkin R.D.T., Allt W.E.C., Beale F.A., Bean H., Dembo A.J., Pringle J.G. Definitive evidence for hypoxic cells influence in the cure in cancer therapy. British Journal of Cancer 1978; 37(III)302–306
  • Clark E.P., Michaels H.B., Peterson E.C., Epp E.R. Irradiation of mammalian cells in the presence of diamide and low concentrations of oxygen at conventional and at ultrahigh dose rates. Radiation Research 1983; 93: 479–491
  • Clark E.P., Epp E.R., Biaglow J.E., Morse-Gaudio M., Zachgo E. Glutathione depletion, radiosensitization, and misonidazole potentiation in hypoxic Chinese hamster ovary cells by buthionine sulfoximine. Radiation Research 1984; 98: 370–380
  • Dische S. Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy. Radiotherapy and Oncology 1985; 3: 97–115
  • Dische S., Saunders M.I., Dunphy E.P., Bennett M.H., Des Rochers C., Stratford M.R.L., Minchinton A. Concentrations achieved in human tumours after administration of misonidazole, SR 2508 and RO-03-8799. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 1109–1111
  • Epp E., Clark E., Morse-Gaudio M., Biaglow J. Gluthathione depletion and cell radiosensitization in three cell lines irradiated in air. Importance of endogenous thiols. International Journal of Radiation Oncology, Biology, Physics 1984; 10: 1796–1797
  • Fazekas J., Pajak T.F., Wasserman T., Marcial V., Davis L., Kramer S., Rotman M., Stetz J. Failure of misonidazole-sensitized radiotherapy to impact upon outcome among stage III-IV squamous cancers of the head and neck. International Journal of Radiation Oncology, Biology, Physics 1987; 13: 1155–1160
  • Fu K.K., Hurst S., Begg A.C., Brown J.M. The effects of misonidazole during continuous low dose rate irradiation. Cancer Clinical Trials 1980; 3: 257–265
  • Gray L.H., Conger A.D., Ebert M., Hornsey S., Scott O.C.A. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. British Journal of Radiology 1953; 26: 638–648
  • Griffith O.W., Meister A. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine. Journal of Biological Chemistry 1979; 254: 7554–7560
  • Guichard M., Malaise E.P. Radiosensitizing effects of misonidazole and SR2508 on a human melanoma transplanted in nude mice: influence on repair of potentially lethal damage. International Journal of Radiation Oncology, Biology, Physics 1983; 8: 465–468
  • Hall E.J. Radiation dose rate: a factor of importance in radiobiology and radiotherapy. British Journal of Radiology 1972; 45: 81–97
  • Hall E.J., Roizin-Towle L. Hypoxic sensitizers: radiobiological studies at the cellular level. Radiology 1975; 117: 453–457
  • Hill R.P., Bush R.S. The effect of misonidazole in combination with radiation and dose fractionation. British Journal of Cancer 1978; 37(III)255–258
  • Hodgkiss R.J., Middleton R.W. Enhancement of misonidazole radiosensitization by an inhibitor of glutathione biosynthesis. International Journal of Radiation Biology 1983; 43: 179–183
  • Hodgkiss R.J., Stratford M.R.L. Competitive dose-modification between ascorbate and misonidazole in human and hamster cells: effects of glutathione depletion. International Journal of Radiation Biology 1988; 54: 601–610
  • Howes A.E. An estimation of changes in the proportion and absolute numbers of hypoxic cells after irradiation of transplanted C3H mouse mammary tumors. British Journal of Radiology 1969; 42: 441–447
  • Koch C.J., Stobbe C.C., Bump E.A. The effect on the Km for radiosensitization at 0° of thiol depletion by diethylmaleate pretreatment: qualitative differences found using the radiation sensitizing agents misonidazole or oxygen. Radiation Research 1984; 98: 141–153
  • Ling C.C., Spiro I.J., Mitchell J.B., Stickler R. The variation of OER with dose rate. International Journal of Radiation Oncology, Biology, Physics 1985; 11: 1367–1373
  • Ling C.C., Stickler R., Schell M.C., Spiro I.J. The effect of hypoxic cell sensitizers at different irradiation dose rates. Radiation Research 1987; 109: 396–406
  • Ling C.C., Robinson E., Shrieve D. Repair of radiation induced damage-dependence on oxygen and energy status. International Journal of Radiation Oncology, Biology, Physics 1988; 15: 1179–1186
  • Ling C.C., Wong R.S.L., Basas R. Glutathione depletion and cytotoxicity of buthionine sulphoximine and SR 2508 in rodent and human cells. International Journal of Radiation Oncology, Biology, Physics 1990; 18: 325–330
  • Lowry O.H., Roseborough N.J., Farr A.L. Protein measurement with folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Mitchell J., Phillips T., DeGraff W., Carmichael J., Rajpal R., Russo A. The relationship of SR 2508 sensitizer enhancement ratio to cellular gluthathione levels in human tumor cell lines. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 1143–1146
  • Moriarty M.J., Mulgrew S., Malone J.R., O'Connor M.K. Results and analysis of tumour levels of ascorbic acid. Irish Journal of Medical Science 1977; 146: 74–78
  • Newman H.F.V., Bleehen N.M., Workman P. A phase I study of the combination of two hypoxic cell radiosensitizers, Ro 03-8799 and SR-2508: toxicity and pharmacokinetics. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 1113–1116
  • Packer S., Rotman M. Radiotherapy of choroidal melanoma with iodine-125. Ophthalmology 1980; 87: 582–582
  • Palcic B., Faddegon B., Skarsgard L.D. The effect of misonidazole as a hypoxic radiosensitizer at low dose. Radiation Research 1984; 100: 340–347
  • Phillips T.L., Mitchell J.B., DeGraff W., Russo A., Gladstein E. Variation in sensitizing efficiency for SR 2508 in human cells dependent on glutathione content. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 1627–1635
  • Shrieve D.C., Denekamp J., Minchinton A.I. Effects of glutathione depletion by buthionine sulfoximine on radiosensitization by oxygen and misonidazole in vitro. Radiation Research 1985; 102: 283–294
  • Simpson J.R., Perez C.A., Phillips T.L., Concannon J.P., Carella R.J. Large fraction radiotherapy plus misonidazole for treatment of advanced lung cancer: report of a phase I/II trial. International Journal of Radiation Oncology, Biology, Physics 1982; 8: 303–308
  • Spiro I.J., Kennedy K., Stickler R., Ling C.C. Cellular and molecular repair of X-ray-induced damage: dependence of oxygen tension and nutritional status. Radiation Research 1985; 101: 144–155
  • Stratford I.J., Adams G.E., Hardy C., Hoe S., O'Neill P., Sheldon P.W. Thiol reactive nitroimidazoles: radiosensitization studies in vitro and in vivo. International Journal of Radiation Biology 1984; 46: 731–745
  • Stratford M.R.L., Hodgkiss R.J., Watfa R.R. Studies on the role of antioxidants in radioprotection. Pharmacology and Therapeutics 1988; 39: 389–391
  • Tietze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Analytical Biochemistry 1969; 27: 502–522

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.