Spatial Characterization of Glutathione Depletion in the KHT Sarcoma Using Flow Cytometry

References

• Bridges B.A. Sensitization of Escherichia coli to gamma-radiation by N-ethylmaleimide. Nature 1960; 188: 415–415
   Web of Science ®Google Scholar
• Bridges B.A. Sensitization of organisms to radiation by sulphydryl binding agents. Advances in Radiation Biology 1969; 3: 123–176
   Google Scholar
• Brown J.M. Evidence for acute hypoxic cells in mouse tumours and a possible mechanism of reoxygenation. British Journal of Radiology 1979; 52: 650–656
   PubMed Web of Science ®Google Scholar
• Bump E.A., Yu N.Y., Brown J.M. Radiosensitization of hypoxic tumour cells by depletion of intracellular glutathione. Science 1982a; 217: 544–545
   PubMed Web of Science ®Google Scholar
• Bump E.A., Yu N.Y., Brown J.M. The use of drugs which deplete intracellular glutathione in hypoxic cell radiosensitization. International Journal of Radiation Oncology, Biology, Physics 1982b; 8: 439–447
   PubMed Web of Science ®Google Scholar
• Bush R.S., Jenkin R.D.T., Allt W.E.C., Beale F.A., Bean H., Dembo A.J., Pringle J.F. Definitive evidence for hypoxic cells influencing cure in cancer therapy. British Journal of Cancer 1978; 37(Suppl. 37)302–306
   Google Scholar
• Chaplin D.J., Durand R.E., Olive P.L. Cell selection from a murine tumour using the fluorescent probe Hoechst 33342. British Journal of Cancer 1985; 51: 569–572
   PubMedGoogle Scholar
• Chaplin D.J., Durand R.E., Olive P.L. Acute hypoxia in tumours: implications for modifiers of radiation effects. International Journal of Radiation Oncology, Biology, Physics 1987; 12: 1279–1282
   Google Scholar
• Chaplin D.J., Olive P.L., Durand R.E. Intermittent blood flow in murine tumours: radiobiological effects. Cancer Research 1987; 47: 597–601
   PubMed Web of Science ®Google Scholar
• Courtney V.D. A soft agar colony assay for Lewis lung tumour and B16 melanoma taken directly from the mouse. British Journal of Cancer 1979; 34: 39–45
   Google Scholar
• Dethmers J.K., Meister A. Glutathione export by human lymphoid cells: Depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation. Proceedings of the National Academy of Sciences, USA 1981; 78: 7492–7496
   PubMed Web of Science ®Google Scholar
• Dische S., Anderson P.J., Sealy R., Watson E.R. Carcinoma of the cervix—anaemia, radiotherapy and hyperbaric oxygen. British Journal of Radiology 1983; 56: 251–255
   PubMed Web of Science ®Google Scholar
• Edgren M., Révész L. Compartmentalized depletion of glutathione in cells treated with buthionine sulphoximine. British Journal of Radiology 1987; 60: 723–724
   PubMed Web of Science ®Google Scholar
• Griffith O.W., Meister A. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). Journal of Biological Chemistry 1979; 254: 7558–7560
   PubMed Web of Science ®Google Scholar
• Guichard M., Lespinasse F., Malaise E.P. Influence of buthionine sulphoximine and misonidazole on glutathione level and radiosensitivity of human tumour xenografts. Radiation Research 1986; 105: 115–125
   PubMed Web of Science ®Google Scholar
• Harris J.W., Wara W.M., Kane L.J. Sensitization of anoxic mouse tumours to X-rays with diamide and nifuroxime. International Journal of Radiation Biology 1974; 26: 227–235
   Web of Science ®Google Scholar
• Henk J.M. Late results of a trial of hyperbaric oxygen and radiotherapy in head and neck cancer: a rationale for hypoxic cell sensitizers?. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 1339–1341
   PubMed Web of Science ®Google Scholar
• Hodgkiss R.J., Middleton R.W. Enhancement of misonidazole radiosensitization by an inhibitor of glutathione biosynthesis. International Journal of Radiation Biology 1983; 43: 179–183
   Web of Science ®Google Scholar
• Kallman R.F., Silini J., van Putten L.J. Factors influencing the quantitation of the in vivo survival of cells from solid tumours. Journal of the National Cancer Institute 1967; 39: 539–549
   PubMed Web of Science ®Google Scholar
• Kramer R.A., Schuller H.M., Smith A.C., Boyd M.R. Effects of buthionine sulphoximine on the nephrotoxicity of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosurea (meCCNU). Journal of Pharmacology and Experimental Therapeutics 1985; 234: 498–506
   PubMed Web of Science ®Google Scholar
• Krough A. The number and distribution of capillaries in muscle with the calculation of the oxygen pressure head necessary for supplying the tissue. Journal of Physiology 1919; 52: 409–415
   Google Scholar
• Meister A. Roles and function of glutathione: an overview. Biochemical Society Transactions 1982; 10: 78–79
   Google Scholar
• Meredith M.J., Reed D.J. Status of the mitochondrial pool of glutathione in the isolated hepatocyte. Journal of Biological Chemistry 1982; 257: 3747–3753
   PubMed Web of Science ®Google Scholar
• Minchinton A.I. Measurements of glutathione and other thiols in cells and tissues: a simplified procedure based on the HPLC separation of monobromobimine derivatives of thiols. International Journal of Radiation Oncology, Biology, Physics 1984; 10: 1503–1506
   PubMed Web of Science ®Google Scholar
• Minchinton A.I., Rojas A., Smith K.A., Soranson J.A., Shrieve D.C., Jones N.R., Bremner J.C. Glutathione depletion in tissues after administration of buthionine sulphoximine. International Journal of Radiation Oncology, Biology, Physics 1984; 10: 1261–1264
   PubMed Web of Science ®Google Scholar
• Minchinton A.I., Durand R.E., Chaplin D.J. Intermittent blood flow in the KHT sarcoma-flow cytometry studies using Hoechst 33342. British Journal of Cancer 1990; 62: 195–200
   PubMed Web of Science ®Google Scholar
• Olive P.L., Chaplin D.J., Durand R.E. Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine tumours. British Journal of Cancer 1985; 52: 739–746
   PubMedGoogle Scholar
• Ono K., Komuro C., Nishidai T., Shibamoto Y., Tsutsui K., Takahashi M., Abe M. Radiosensitizing effect of misonidazole in combination with an inhibitor of glutathione synthesis in murine tumors. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 1661–1666
   Google Scholar
• Orrenius S., Moldéus P. The multiple roles of glutathione in drug metabolism. Trends in Pharmacological Sciences 1984; 5: 432–435
   Web of Science ®Google Scholar
• Rice G.C., Bump E.A., Shrieve D.C., Lee W., Kovacs M. Quantitative analysis of cellular glutathione by flow cytometry utilizing monochlorobimane: some applications to radiation and drug resistance in vitro and in vivo. Cancer Research 1986; 46: 6105–6110
   PubMed Web of Science ®Google Scholar
• Rojas A., Smith K.A., Soranson J.A., Minchinton A.I., Midleton R.W., Denekamp J. Enhancement of misonidazole radiosensitization by buthionine sulphoximine. Radiotherapeutic Oncology 1984; 2: 325–332
   PubMed Web of Science ®Google Scholar
• Shrieve D.C., Denekamp J., Minchinton A.I. Effects of glutathione depletion by buthionine sulphoxomine on radiosensitization by oxygen and misonidazole in vitro. Radiation Research 1985; 102: 283–294
   PubMed Web of Science ®Google Scholar
• Shrieve D.C., Bump E.A., Rice G.C. Heterogeneity of cellular glutathone among cells derived from a murine fibrosarcoma or a human renal cell carcinoma detected by flow cytometric analysis. Journal of Biological Chemistry 1988; 263: 14107–14114
   PubMed Web of Science ®Google Scholar
• Sutherland R.M. Cell and environment interactions in tumor microregions. The multicell spheroid mode. Science 1988; 240: 177–184
   PubMed Web of Science ®Google Scholar
• Thomlinson R.H., Gray L.H. The histological structure of some human lung cancers and the possible implications for radiotherapy. British Journal of Cancer 1955; 9: 539–549
   PubMed Web of Science ®Google Scholar
• Watson E.R., Halnan K.E., Dische S., Saunders M.I., Cade I.S., McEwarn J.B., Wierneik G., Perrins D.J.D., Sutherland I. Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the cervix. British Journal of Radiology 1978; 51: 879–887
   PubMed Web of Science ®Google Scholar
• Wolf C.R., Lewis A.D., Carmichael J., Adams D.J., Allan S.G., Ansell D.J. The role of glutathione in determining the response of normal and tumour cells to anticancer drugs. Biochemical Society Transactions 1987; 15: 728–730
   Google Scholar