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International Journal of Radiation Biology Volume 60, 1991 - Issue 1-2
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Original Article

Antitumour Effects of Indomethacin Alone and in Combination with Radiotherapy: Role of Inhibition of Tumour Angiogenesis

L. Milas Department of Experimental Radiotherapy, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, 77030, USA
,
N. Hunter Department of Experimental Radiotherapy, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, 77030, USA
,
Y. Furuta Department of Experimental Radiotherapy, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, 77030, USA
,
I. Nishiguchi Department of Experimental Radiotherapy, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, 77030, USA
&
S. Runkel Department of Experimental Radiotherapy, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, 77030, USA
Pages 65-70 | Published online: 03 Jul 2009

References

  • Fleck R., Travis E.L. The effects of indomethacin on normal tissue radiation response. 37th Annual Meeting of the Radiation Research Society, Book of Abstracts 1989; 78–78
  • Furuta Y., Hall E.R., Sanduja S., Barkley H.T., Jr, Milas L. Prostaglandin production by murine tumors as a predictor for therapeutic response to indomethacin. Cancer Research 1988a; 48: 3002–3007
  • Furuta Y., Hunter N., Barkley H.T., Jr, Hall E., Milas L. Increase in radioresponse of murine tumors by treatment with indomethacin. Cancer Research 1988b; 48: 3008–3013
  • Hanson W.R., Ainsworth E.J. 16-16 Dimethyl prostaglandin E2 induces radioprotection in murine intestinal and hematopoietic stem cells. Radiation Research 1985; 103: 196–203
  • Milas L., Furuta Y., Hunter N., Nishiguchi I., Runkel S. Dependence of indomethacin-induced potentiation of murine tumor radioresponse on tumor host immunocompetence. Cancer Research 1990; 50: 4473–4477
  • Nishiguchi I., Furuta Y., Hunter N., Murray D., Milas L. Radioprotection of hematopoietic tissues in mice by indomethacin. Radiation Research 1990; 122: 188–192
  • Runkel, S., Hunter, N., Milas, L. An intradermal assay for quantitation and kinetics studies of tumor angiogenesis in mice. Radiation Research, In press, 1991
  • Walden T.L., Jr, Patchen M., Synder S.L. 16,16-Dimethyl prostaglandin E2 increases survival in mice following irradiation. Radiation Research 1987; 109: 440–448
  • Ziche M., Jones S., Gullino P.M. Role of prostaglandin E1 and copper in angiogenesis. Journal of the National Cancer Institute 1982; 69: 475–481

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