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International Journal of Radiation Biology Volume 60, 1991 - Issue 1-2
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Original Article

Monitoring Metabolic Responses after Induction of Hypoxia in the KHT Tumour Using 31P NMR Spectroscopy

J.C.M. Bremner MRC Radiobiology Unit, Chilton, Didcot, OX11 0RD, UK
,
C.J.R. Counsell Wellcome Research Laboratories, Beckenham, Kent, UK
,
H.S. Edwards MRC Radiobiology Unit, Chilton, Didcot, OX11 0RD, UK
,
I.J. Stratford Wellcome Research Laboratories, Beckenham, Kent, UK
,
G.E. Adams MRC Radiobiology Unit, Chilton, Didcot, OX11 0RD, UK
,
A.B.W. Nethersell Wellcome Research Laboratories, Beckenham, Kent, UK
&
P. Bedford MRC Radiobiology Unit, Chilton, Didcot, OX11 0RD, UK
 show all
Pages 363-367 | Published online: 03 Jul 2009

References

  • Adams G.E., Stratford I.J., Nethersell A.B.W., White R.D. Induction of severe tumour hypoxia by the modifiers of oxygen affinity of hemoglobin. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1179–1182
  • Bedford P., Nethersell A.B.W., Stratford I.J., Cole S., Bremner J.C.M., Adams G.E. Potentiation of bioreductive drugs by BW12C. Journal of Cancer Research and Clinical Oncology 1990; 16(Suppl. 1)621–621
  • Bremner J.C.M., Stratford I.J., Bowler J., Adams G.E. Bioreductive drugs and the selective induction of tumour hypoxia. British Journal of Cancer 1990; 61: 717–721
  • Chaplin D.J. Post-irradiation modification of tumour blood flow: a method to increase the effectiveness of chemical radiosensitizers. Radiation Research 1988; 115: 292–302
  • Dunn J.F., Frostick S., Adams G.E., Stratford I.J., Howells N., Hogan G., Radda G.K. Induction of tumour hypoxia by a vasoactive agent. A combined NMR and radiobiological study. FEBS Letters 1989; 249: 343–347
  • Edwards H., Bremner J.C.M., Stratford I.J. Induction of hypoxia in the KHT sarcoma by tumour necrosis factor and flavone acetic acid. International Journal of Radiation Biology 1991a; 59: 419–432
  • Edwards H., Bremner J.C.M., Stratford I.J. Induction of tumour hypoxia by FAA and TNF: Interaction with bioreductive drugs. International Journal of Radiation Biology 1991b; 60: 371–375
  • Honess D., White R.D., Nethersell A.B.W., Bleehen N.M. Effects of the manipulation of oxyhemoglobin status by BW12C on tumour thermosensitivity and on blood flow in tumour and normal tissues in mice. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1187–1191
  • Okunieff P., Kallinowski F., Vaupel P., Neuringer L.J. Effects of hydralazine-induced vasodilation on the energy metabolism of murine tumours studied by in vivo31P nuclear magnetic resonance spectroscopy. Journal of the National Cancer Institute 1988; 80: 745–750
  • Stratford I.J., Adams G.E., Godden J., Howells N. Induction of tumour hypoxia post-irradiation: a method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo. International Journal of Radiation Biology 1989; 55: 411–422

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