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International Journal of Radiation Biology Volume 60, 1991 - Issue 1-2
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Original Article

Interleukin-1α-induced Tumour Pathophysiologies Can Be Exploited with Bioreductive Alkylating Agents

P.G. Braunschweiger Department of Radiation Oncology (D-31) and The Sylvester Cancer Center, University of Miami, PO Box 016960, Miami, FL, 33101, USA
,
S.A. Jones Department of Cell Biology, University of Colorado Health Sciences Center, Denver, CO, 80202, USA
,
C.S. Johnson Department of Otolaryngology (CSJ), University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA
&
P. Furmanski Department of Biology (PF), New York University, New York, NY, 10003, USA
Pages 369-372 | Published online: 03 Jul 2009

References

  • Braunschweiger P.G., Johnson C.S., Kumar N., Ord V., Furmanski P. Antitumor effects of recombinant human interleukin-1c in RIF-1 and Panc02 solid tumors. Cancer Research 1988; 48: 6011–6016
  • Braunschweiger P.G., Johnson C.S., Kumar N., Ord V., Furmanski P. The effect of adrenalectomy and dexamethasone on interleukin-1 induced responses in RIF-1 tumors. British Journal of Cancer 1990; 61: 9–13
  • Brown J.M., Twentyman P.R., Zamvil S.S. Response of the RIF-1 tumor in vitro and in C3H/Km mice to X-radiation (cell survival, regrowth delay and tumor control), chemotherapeutic agents and activated macrophages. Journal of the National Cancer Institute 1980; 64: 605–611
  • Constantinidis I., Braunschweiger P.G., Wehrle J.P., Kumar N., Johnson C.S., Furmanski P., Glickson J.D. 31P-NMR studies of the effect of recombinant human interleukin-1α on the bioenergetics of RIF-1 tumors. Cancer Research 1989; 49: 6379–6382
  • Fracasso P.M., Sartorelli A.C. Cytotoxicity and DNA lesions produced by Mitomycin C and Porfiromycin in hypoxic and aerobic EMT-6 and Chinese hamster ovary cells. Cancer Research 1986; 46: 3939–3944
  • Sun J.-R., Brown J.M. Enhancement of the antitumor effect of Falavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma. Cancer Research 1989; 49: 5667–5670
  • Whitmore G.F., Gulyas S. Studies on the toxicity of RSU 1069. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 1219–1222
  • Zeman E.M., Brown J.M., Lemmons M.J., Hirst V.K., Lee W.W. SR 4233: A new Bioreductive agent with high selectivite toxicity for hypoxic mammalian cells. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 1239–1242.6

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