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Original Article

Prostacyclin Production in Cultured Endothelial Cells is Highly Sensitive to Low Doses of Ionizing Radiation

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Pages 631-638 | Received 10 Jun 1992, Accepted 20 Jan 1993, Published online: 03 Jul 2009

References

  • Ager A., Gordon J.N., Moncada S., Pearson J.D., Salmon J.A., Trevethick M.A. Effects of isolation and culture on prostaglandin synthesis by porcine aortic endothelial and smooth muscle cells. Journal of Cellular Physiology 1982; 110: 9–16
  • Allen J.B., Sagerman R.H., Stuart M.J. Irradiation decreases vascular prostacyclin formation with no concomitant effect on platelet thromboxane production. Lancet 1981; 28: 1193–1196
  • Anderson R.E., Lefkovits I. In vitro evaluation of radiation-induced augmentation of the immune response. American Journal of Pathology 1979; 97: 456–472
  • Anderson R.E., Tokuda S., Williams W.L., Spellman C.W. Low dose irradiation permits immunization of A/J mice with subimmunogenic numbers of Sal Cells. British Journal of Cancer 1986; 54: 505–509
  • Anderson R.E., Tokuda S., Williams W.L., Warner N.L. Radiation-induced augmentation of the response of A/J mice to Sal tumor cells. American Journal of Pathology 1982; 108: 24–38
  • Anderson R.E., Warner N.L. Ionizing radiation and the immune response. Advances in Immunology 1976; 24: 215–335
  • Anderson R.E., Williams W.L., Tokuda S. Effect of low-dose irradiation upon T cell subsets involved in the response of primed A/J mice to Sal cells. International Journal of Radiation Biology 1988; 53: 103–118
  • Bergofsky E.H. Humoral control of the pulmonary circulation. Annual Review of Physiology 1980; 42: 221–223
  • Bosi A., Olivieri G. Variability of the adaptive response to ionizing radiations in humans. Mutation Research 1989; 221: 13–17
  • Cai L., Liu S.-Z. Induction of cytogenetic adaptive response of somatic and germ cells in vivo and in vitro by low-dose X-irradiation. International Journal of Radiation Biology 1990; 58: 187–194
  • Chelack W.S., Petkau A. Identifying superoxide-sensitive. International Journal of Radiation Biology 1983; 44: 523–529
  • Clark R.A., Klebanoff S. Chemotactic factor inactivation by the myeloperoxidase-hydrogen peroxide-halide system. Journal of Clinical Investigation 1979; 64: 913–920
  • Cortes F., Dominguez I., Mateos S., Pinera J., Mateosm J.C. Evidence for an adaptive response to radiation damage in plant cells conditioned with X-rays or incorporated tritium. International Journal of Radiation Biology 1990; 57: 537–541
  • Dollery C.T., Fredman L.A., Hensby C.N., Kohner E., Jewis P.J., Porta M., Webster J. Circulating prostacyclin may be reduced in diabetes. Lancet 1979; ii: 1365–1365
  • Egan R.W., Gale P.H., Beverige G.C., Phillips G.B. Radical scavenging as the mechanism for stimulation of prostaglandin cyclooxygenase and depression of inflammation by lipoic acid and sodium iodide. Prostglandins 1978; 16: 861–869
  • Egan R.W., Pazton J., Kuehl F.A., Jr. Mechanism for irreversible self-deactivation of prostaglandinsynthetase. Journal of Biological Chemistry 1976; 251: 7329–7335
  • Eldor A., Vlodavsky I., Hyam E., Atzmon R., Fuks Z. The effect of radiation on prostacyclin (PGI2) production by cultured endothelial cells. Prostaglandins 1983; 25: 263–279
  • Eldor A., Vlodavsky I., Riklis E., Fuks Z. Recovery of prostacyclin capacity of irradiated endothelial cells and the protective effect of vitamin C. Prostaglandins 1987; 34: 241–251
  • Enker W.E., Jacobitz J.L. In vivo splenic irradiation eradicates suppressor T-cells causing the regression and inhibition of established tumor. International Journal of Cancer 1980; 25: 819–825
  • Fajardo L.F. The unique physiology of endothelial cells and its implication in radiobiology. Radiation Tolerance of Normal Tissues, J.M. Vaeth, J.L. Meyer. Karger, Basel 1989; 96–112, In
  • Feinendegen L.E., Mühlensiepen H., Lindberg C., Marx J., Porshen W., Booz J. Acute and temporary inhibition of thymidine kinase in mouse bone marrow cells after low-dose exposure. International Journal of Radiation Biology 1984; 45: 205–215
  • Friedman M., Saunders D.S., Madden M.C., Chaney E.L., Kwoch L. The effects of ionizing radiation on the pulmonary endothelial cell uptake of α-aminoisobutyric acid and synthesis of prostacyclin. Radiation Research 1986; 106: 171–181
  • Fucci I., Oliver C.N., Coon M.J., Stadman E.R. Inactivation of key metabolic enzymes by mixed-function oxidation reactions: possible implication in protein turnover and ageing. Proceedings of the National Academy of Sciences, USA 1983; 74: 3922–3926
  • Gal D., Strickland D.M., Lifshitz S., Buchsbaum H.J., Mitchell M.D. Effect of radiation on prostaglandin production by human bowel in vitro. International Journal of Radiation Oncology, Biology and Physics 1984; 10: 653–657
  • Gimbrone M.A., Jr. Culture of vascular endothelium. Progress in Hemostasis and Thrombosis 1976; 3: 1–28
  • Hahn G.L., Menconi M.J., Cahill M., Polgar P. The influence of gamma radiation on arachidonic acid release and prostacyclin synthesis. Prostaglandins 1983; 25: 783–791
  • Ham E.A., Egan R.W., Soderman D.D., Gale P.H., Kuehl F.A., Jr. Peroxidase-dependent deactivation of prostacyclin synthetase. Journal of Biological Chemistry 1979; 254: 1292–1294
  • Harlan J.M., Callahan K.S. Role of hydrogen peroxide in the neutrophil-mediated release of prostacyclin from cultured endothelial cells. Journal of Clinical Investigation 1984; 74: 442–448
  • Hellström K.E., Hellström I. Evidence that tumor antigens enhance tumor growth in vivo by interacting with a radiosensitive (suppressor?) cell population. Proceedings of the National Academy of Sciences, USA 1978; 75: 436–440
  • Hellström I., Hellström K.E. Antitumor effect of whole-body X-irradiation: possible role of an X-ray-sensitive T suppressor cell population. Transplantation Proceedings 1979; 11: 1073–1076
  • Hellström T., Hellström K.E., Bernstein I.D. Tumor-enhancing suppressor activator T cells in spleens and thymuses of tumor immune mice. Proceedings of the National Academy of Sciences, USA 1979; 76: 5294–5298
  • Hellström K.E., Hellström I., Kant J.A., Tamerius J.D. Regression and inhibition of sarcoma growth by interference with a radiosensitive T-cell population. Journal of Experimental Medicine 1978; 24: 799–804
  • Hemler M.E., Cook H.W., Lands W.E.M. Prostaglandin biosynthesis can be triggered by lipid peroxides. Archives of Biochemistry and Biophysics 1979; 193: 340–345
  • Hemler M.E., Lands W.E.M. Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis. Journal of Biological Chemistry 1980; 255: 6253–6261
  • Hosoi, Y., Sakamoto, K. Suppressive effect of low dose total body irradiation on lung metastasis: dose dependency and effective period. Radiotherapy and Oncology, in press, 1993
  • Ikushima T. Chromosomal responses to ionizing radiation reminiscent of an adaptive response in cultured Chinese hamster cells. Mutation Research 1987; 180: 215–221
  • Ikushima T. Radio-adaptive response: characterization of a cytogenetic repair induced by low-level ionizing radiation in cultured chinese hamster cells. Mutation Research 1989; 227: 241–246
  • Ishii K., Muto N., Yamamoto I. Augmentation in mitogen-induced proliferation of rat splenocytes by low dose whole body X-irradiation. Nippon Acta Radiologica 1990; 50: 1262–1267
  • James S.J., Makinodan T. T cell potentiation in normal and autoimmune-prone mice after extended exposure to low doses of ionizing radiation and/or caloric restriction. International Journal of Radiation Biology 1988; 53: 137–152
  • Kent R.S., Diedrich S.L., Whorton A.R. Regulation of vascular prostaglandin synthesis by metabolites of arachidonic acid in perfused rabbit aorta. Journal of Clinical Investigation 1983; 72: 455–465
  • Kent R.S., Kitchell B.B., Shand D.G., Whorton A.R. The ability of vascular tissue to produce prostacyclin decrease with age. Prostaglandins 1981; 21: 483–490
  • Liu S.Z., Liu W.H., Sun J.B. Radiation hormesis: its expression in immune system. Health Physics 1987; 52: 579–583
  • Livesey J.C., Reed D.J. Chemical protection against ionizing radiation. Advances in Radiation Biology 13, J.T. Lett, V.K. Ehmann, A.B. Cox. Academic Press, San Diego 1987; 285–353, In
  • Marnett L.J., Wilcox C.L. Stimulation of prostaglandin biosynthesis by lipoic acid. Biochimica et Biophysica Acta 1977; 487: 222–230
  • Menconi M., Taylor L., Polgar P. Studies on effect of gamma radiation on prostacyclin and platelet-activating factor synthesis and on cell growth using smooth muscle, fibroblast, and endothelial cells in cultures. Prostaglandin and Lipid Metabolism in Radiation Injury, T.L. Walden, H.N. Hughes. Plenum Press, New York 1987; 135–147, In
  • Menconi M., Polgar P. Radiation, lipid peroxidation and the role of oxygen radicals in eicosanoid metabolism. Eicosanoids and Radiation, P. Polgar. Kluwer Academic Publishers, Boston 1988; 119–127, In
  • Miyamoto M., Sakamoto K. Anti-tumor effect of total body irradiation of low dose on WHT/Ht mice. Japanese Journal of Cancer Clinics 1987; 33: 1211–1220
  • Moncada S., Gryglewski R., Bumting S., Vane J.R. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 1976; 263: 663–665
  • Moncada S., Vane J.R. Arachidonic acid metabolites and the interaction between platelets and blood-vessel walls. New England Journal of Medicine 1979; 300: 1142–1147
  • Murota S., Morita I., Kanayasu T. A kallikrein induced new peptide stimulating prostacyclin production by vascular endothelial cells. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 1989; 19: 244–247
  • Nakano M., Sugioka K., Nakamura T., Oki T. Interaction between an organic hydroperoxide and an unsaturated phospholipid and α-tocopherol in model membranes. Biochimica et Biophysica Acta 1980; 619: 274–286
  • Olivieri G., Bodycote J., Wolff S. Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science 1984; 233: 594–597
  • Petkau A. Radiation carcinogenesis from a membrane perspective. Acta Physiologica Scandinavica 1980; 492: 81–90
  • Petkau A., Chelack W.S. Radioprotection by superoxide dismutase of macrophage progenitor cells from mouse bone marrow. Biochemical and Biophysical Research Communications 1984; 119: 1089–1095
  • Polgar P., Taylor L. Stimulation of prostaglandin synthesis by ascorbic acid via hydrogen peroxide formation. Prostaglandins 1980; 19: 693–700
  • Rossi V., Breviario F., Ghezzi P., Dejana E., Mantovani A. Prostacyclin synthesis induced in vascular cells by interleukin-a. Science 1985; 229: 174–176
  • Rubin D.B., Drba E.A., Ts'ao C.-H., Gardner D., Ward W.F. Prostacyclin synthesis in-irradiated endothelial cells cultured from bovine aorta. Journal of Applied Physiology 1985; 58: 592–597
  • Ryan U.S., Mortara M., Whitaker C. Methods for microcarrier culture of bovine pulmonary artery endothelial cells avoiding the use of enzyme. Tissue and Cell 1980; 12: 619–635
  • Sakamoto K., Miyamoto M., Watabe N. The effect of low-dose total body irradiation on tumor control. Japanese Journal of Cancer and Chemotherapy 1987; 14: 1545–1549
  • Sanderson B.J.S., Morley A.A. Exposure of human lymphocytes to ionizing radiation reduces mutagenesis by subsequent ionizing radiation. Mutation Research 1986; 14: 347–351
  • Sankaranarayanan K., Duyn A.V., Loos M.J., Natarajan A.T. Adaptive response of human lymphocytes to low-level radiation from radioisotopes or X-rays. Mutation Research 1989; 211: 7–12
  • Shadley J.D., Afzal V., Wolff S. Characterization of the adaptive response to ionizing radiation induced by low doses of X rays to human lymphocytes. Radiation Research 1987; 111: 511–517
  • Shadley J.D., Wiencke J.K. Induction of the adaptive response by X-rays is dependent on radiation intensity. International Journal of Radiation Biology 1989; 56: 107–118
  • Silberbauer K., Shernthaner G., Sinzinger H., Piza-Katzer H., Winter M. Decreased vascular prostacyclin in juvenile-onset diabetes. New England Journal of Medicine 1979; 300: 366–367
  • Sinzinger H., Cromwell M., Firbas W. Long-lasting depression of rabbit aortic prostacyclin formation by single-dose irradiation. Radiation Research 1984; 97: 533–536
  • Sinzinger H., Feigl W., Silberbauer K. Prostacyclin generation in atherosclerotic arteries. Lancet 1979; ii: 469–469
  • Sinzinger H., Firbas W., Cromwell M. Radiation induced alterations in rabbit aortic prostacyclin formation. Prostaglandins 1982; 24: 323–329
  • Sochanowicz B., Dancewicz A.M. Irradiation of rats abolishes susceptibility of PGI2 synthesis of blood vessels to peroxidative agents. Prostaglandins 1990; 39: 287–298
  • Spellman C., Anderson R.E. Low dose radiosensitivity of alloimmune cytotoxic T cells. Journal of Experimental Medicine 1982; 155: 1858–1863
  • Sporn L.A., Rubin P., Marder V.J., Wagner D.D. Irradiation induces release of von Willebrand protein from endothelial cells in culture. Blood 1984; 64: 567–570
  • Umeda F., Inoguchi T., Nawata H.M. Reduced stimulatory activity on prostacyclin production by cultured endothelial cells in serum from aged and diabetic patients. Atherosclerosis 1989; 75: 61–66
  • Vicker M.G., Bultmann H., Glade U., Häfker T. Ionizing radiation at low doses induces inflammatory reaction in human blood. Radiation Research 1991; 128: 251–257
  • Weksler B.B., Marcus A.J., Jaffe E.A. Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells. Proceedings of the National Academy of Sciences, USA 1977; 74: 3922–3926
  • Whorton A.R., Montgomery M.E., Kent R.S. Effect of hydrogen peroxide on prostaglandin production and cellular integrity in cultured porcine aortic endothelial cells. Journal of Clinical Investigation 1985; 76: 295–302
  • Wiencke J.K., Afzal V., Olivieri G., Wolff S. Evidence that the [3H] thymidine-induced adaptive response of human lymphocytes to subsequent dose of X-rays involves the induction of a chromosomal repair mechanism. Mutagenesis 1986; 1: 375–380
  • Wojcik A., Tuschl H. Indication of an adaptive response in C57BL mice pre-exposed in vivo to low doses of ionizing radiation. Mutation Research 1990; 243: 67–73
  • Wolff S., Afzal V., Wiencke J.K., Olivieri G., Michaell A. Human lymphocytes exposed to low doses of ionizing radiations become refractor to high doses of radiation as well as to chemical mutagens that induced double-strand breaks in DNA. International Journal of Radiation Biology 1988; 53: 39–48
  • Woloschak G.E., Chang-Liu C.M. Differential modulation of specific gene expression following high- and low-LET radiations. Radiation Research 1990; 124: 183–189
  • Woloschak G.E., Chang-Liu C.-M., Jones P.S., Jones C.A. Modulation of gene expression in Syrian hamster embryo cells following ionizing radiation. Cancer Research 1990; 50: 339–344
  • Yamaoka K., Edamatsu R., Mori A. Increased SOD activities and decreased lipid peroxide levels induced by low dose X irradiation in rat organs. Free Radical Biology and Medicine 1991; 11: 299–306
  • Youngblom J.H., Wiencke J.K., Wolff S. Inhibition of the adaptive response of human lymphocytes to very low doses of ionizing radiation by the protein synthesis inhibitor cycloheximide. Mutation Research 1989; 227: 257–261

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