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Original Article

Reversibility of Inhibition of DNA Double Strand Break Repair by 2-Deoxy-d-Glucose in Ehrlich Ascites Tumour Cells

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Pages 459-467 | Received 03 Aug 1992, Accepted 04 Dec 1992, Published online: 03 Jul 2009

References

  • Ahn S.Y., Nevaldine B., Hahn P.J. Direct measurement by pulsed-field gel electrophoresis of induction and rejoining of X-ray-induced double-strand breaks in cultured mouse cells. International Journal of Radiation Biology 1991; 59: 661–675
  • Blöcher D., Einspenner M., Zajackowski J. CHEF electrophoresis, a sensitive technique for the determination of DNA double-strand breaks as potentially lethal lesions. International Journal of Radiation Biology 1989; 56: 437–448
  • Blöcher D., Pohlit W. Double strand breaks in Ehrlich ascites tumour cells at low doses of X-rays. II. Can cell death be attributed to double strand breaks?. International Journal of Radiation Biology 1982; 42: 329–338
  • Bryant P.E. Enzymatic restriction of mammalian cell DNA: evidence for the double strand breaks as potentially lethal lesions. International Journal of Radiation Biology 1985; 48: 55–60
  • Demetrakopoulis G.E., Linn B., Amos H. Starvation, deoxy-sugars, ouabain, and ATP metabolism in normal and malignant cells. Biochimica Biophysica Acta 1982; 6: 65–74
  • Durante M., Grossi G.F., Napolitano, Gialanella G. Repair of potentially lethal damage by introduction of T4 DNA ligase in eucaryotic cells. International Journal of Radiation Biology 1991; 59: 963–971
  • Dwarkanath B.S., Jain V.K. Modification of the radiation induced damage by 2-deoxy-d-glucose in organ culture of human cerebral gliomas. International Journal of Radiation Oncology, Biology, Physics 1987; 13: 741–746
  • Dwarkanath B.S., Jain V.K. Energy linked modifications of the radiation response in human cerebral glioma cell line. International Journal of Radiation Oncology, Biology, Physics 1989; 17: 1033–1040
  • Dwarkanath B.S., Jain V.K. Effects of gammarays and glucose analogs on the energy metabolism of a cell line derived from human cerebral glioma. Indian Journal of Experimental Biology 1991; 28: 203–209
  • Frankenberg-Schwager M. Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radiation. Radiotherapy and Oncology 1989; 14: 307–320
  • Frankenberg-Schwager M., Harbich R., Frankenberg D., Jain V. 2-deoxy-d-glucose inhibits rejoining of radiation-induced double-strand breaks in yeast. International Journal of Radiation Biology 1992; 61: 185–190
  • Horton R.W., Meldrum B.S., Bachelard H.S. Enzymic and cerebral metabolic effects of 2-deoxy-d-glucose. Journal of Neurochemistry 1973; 21: 507–520
  • Iliakis G., Blöcher D., Metzger L., Pantelias G. Comparison of DNA double-strand break rejoining as measured by pulsed field gel electrophoresis, neutral sucrose gradient centrifugation and nonunwinding filter elution in irradiated plateau-phase CHO cells. International Journal of Radiation Biology 1991b; 59: 927–939
  • Iliakis G., Metzger L., Denko N., Stamato T.D. Detection of DNA double-strand breaks in synchronous cultures of CHO cells by means of asymmetric field inversion gel electrphoresis. International Journal of Radiation Biology 1991a; 59: 321–341
  • Iliakis G., Nüsse M., Bryant P. Effects of aphidicolin on cell proliferation, repair of potentially lethal damage and repair of DNA strand breaks in Ehrlich ascites tumour cells exposed to X-rays. International Journal of Radiation Biology 1982; 42: 417–434
  • Iliakis G., Pohlit W. Quantitative aspects of repair of potentially lethal damage in mammalian cells. International Journal of Radiation Biology 1979; 36: 649–658
  • Jain V.K., Gupta I., Lata K. Energetics of cellular repair processes in a respiratory-deficient mutant of yeast. Radiation Research 1982; 92: 463–473
  • Jain V.K., Kalia V.K., Gopinath P.M., Naqvi S., Kucheria K. Optimization of cancer therapy. Part III. Effects of combining 2-deoxy-d-glucose treatment with gamma radiation on normal mice. Indian Journal of Experimental Biology 1979; 17: 1320–1325
  • Jain V.K., Kalia V.K., Sharma R., Maharajan V., Menon M. Effects of 2-deoxy-d-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells. International Journal of Radiation Oncoology, Biology, Physics 1985; 11: 943–950
  • Jain V.K., Purohit S.C., Pohlit W. Optimization of cancer therapy. Part I: Inhibition of repair of X-ray induced potentially lethal damage by deoxy-d-glucose in Ehrlich ascites tumour cells. Indian Journal of Experimental Biology 1977; 15: 711–713
  • Jha B., Pohlit W. Effect of 2-deoxy-d-glucose on DNA double strand break repair, cell survival and energy metabolism in euoxic Ehrlich ascites tumour cells. International Journal of Radiation Biology 1992; 62: 409–415
  • Kalia V.K., Jain V.K., Otto F.J. Optimization of cancer therapy. Part IV. effect of 2-deoxy-d-glucose on radiation induced chromosomal damage in PHA stimulated peripheral human leukozytes. Indian Journal of Experimental Biology 1982; 20: 884–888
  • Kaplan O., Navon G., Lyon R.C., Faustino P.J., Straka E.J., Cohen J.S. Effects of 2-deoxy-d-glucose on drug resistant human breast cancer cells: toxicity and magnetic resonance spectroscopy studies of metabolism. Cancer Research 1990; 50: 544–551
  • Matsudaira H., Furuno I., Otsuka H. Possible requirement of adenosine triphosphate for the rejoining of X-ray-induced breaks in the DNA of Ehrlich ascites tumour cells. International Journal of Radiation Biology 1970; 17: 339–347
  • Metzger L., Iliakis G. Kinetics of DNA double-strand break repair throughout the cell cycle as assayed by pulsed field gel electrophoresis in CHO cells. International Journal of Radiation Biology 1991; 59: 1325–1339
  • Naqvi S., Joshi K.N., Basu A.K., Jain V.K. Optimizing cancer therapy—studies on the combination of 131-I with 2-deoxy-d-glucose in the treatment of thyroid cancer. Abstract VI. Annual Conference, Society of Nuclear Medicine, Bombay, India 1974; 3–3
  • Singh S.P., Singh S., Jain V.K. Effects of 5-bromo-2-deoxyuridine and 2-deoxy-d-glucose on radiation induced micronuclei in mouse bone marrow. International Jorunal of Radiation Biology 1990; 58: 791–797
  • Ward J.F. the yield of DNA double strand breaks produced intracellularly by ionizing radiation: a review. International Joruanl of Radiation Biology 1990; 57: 1141–1150

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