52
Views
58
CrossRef citations to date
0
Altmetric
Original Article

Lethality of Heavy Ion-induced DNA Double-strand Breaks in Mammalian Cells

&
Pages 169-178 | Received 14 Dec 1992, Accepted 22 Apr 1993, Published online: 03 Jul 2009

References

  • Akpa T.C., Weber K.J., Schneider E., Kiefer J., Frankenberg-Schwager M., Harbich R., Frankenberg D. Heavy ion-induced DNA doublestrand breaks in yeast. International Journal of Radiation Biology 1992; 62: 279–287
  • Aufderheide E., Rink H., Hieber L., Kraft G. Heavy ion effects on cellular DNA: strand break induction and repair in cultured diploid lens epithelial cells. International Journal of Radiation Biology 1987; 51: 779–790
  • Barendsen G.W. Response of cultured cells, tumours and normal tissues to radiation of different linear energy transfer. Current Topics in Radiation Research 1968; 4: 293–356
  • Blakely E.A., Ngo F.Q.H., Curtis S.B., Tobias C.A. Heavy-ion radiobiology: cellular studies. Advances in Radiation Biology 1984; 11: 295–389
  • Blöcher D. DNA double-strand break repair determines the RBE of α-particles. International Journal of Radiation Biology 1988; 54: 761–771
  • Blöcher D. In CHEF-electrophoresis a linear induction of dsb corresponds to a nonlinear fraction of extracted DNA with dose. International Journal of Radiation Biology 1990a; 57: 7–12
  • Blöcher D. Dose response in neutral filter elution. Radiation Research 1990b; 123: 176–181
  • Blöcher D., Kuhni M. DNA double-strand break analysis by CHEF electrophoresis. International Journal of Radiation Biology 1990; 58: 23–34
  • Bradley M.O., Kohn K.W. X-ray induced DNA double-strand break production and repair as measured by neutral filter elution. Nucleic Acids Research 1979; 7: 793–804
  • Brenner D.J. Track structure, lesion development and cell survival. Radiation Research 1990; 124: S29–S37
  • Brenner D.J., Ward J.F. Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks. International Journal of Radiation Biology 1992; 61: 737–748
  • Charlton D.E., Nikjoo H., Humm J.L. Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alphaparticles. International Journal of Radiation Biology 1989; 56: 1–19
  • Chatterjee A., Holley W.R. Biochemical mechanisms and clusters of damage for high-LET radiation. Advances in Space Research 1992; 12(2)33–43
  • Christensen R.C., Tobias C.A., Taylor W.D. Heavy-ion induced single and double strand breaks in ΦX-174 replicative form DNA. International Journal of Radiation Biology 1972; 22: 457–477
  • Chu G., Vollrath D., Davies R.W. Separation of large DNA molecules by contour-clamped homogeneous electric fields. Science 1986; 234: 1582–1585
  • Coquerelle T.M., Weibezahn K.F., Lücke-Huhle C. Rejoining of double strand breaks in normal human and ataxia-telangiectasia fibroblasts after exposure to 60Co-rays, 241Am α-particles or bleomycin. International Journal of Radiation Biology 1987; 51: 209–218
  • Fox J.C., McNally N.J. Cell survival and DNA double-strand break repair following X-ray or neutron irradiation of V79 cells. International Journal of Radiation Biology 1988; 54: 1021–1030
  • Frankenberg D., Frankenberg-Schwager M., Blöcher D., Harbich R. Evidence for DNA double-strand breaks as the critical lesion in yeast cells irradiated with sparsely or densely ionizing radiation under oxic or anoxic conditions. Radiation Research 1981; 88: 524–532
  • Frankenberg-Schwager M. Induction, repair and biological relevance of radiation-induced DNA lesions in eucaryotic cells. Radiation and Environmental Biophysics 1990; 29: 272–292
  • Frankenberg-Schwager M., Frankenberg D., Harbich R. Repair of DNA double-strand breaks as a determinant of RBE of α-particles. British Journal of Cancer 1984; 49(Suppl. VI)169–173
  • Goodhead D.T. Models to link DNA damage to RBEs for final cellular effects. The Early Effects of Radiation on DNA, E.M. Fielden, P. O'Neill. Springer-Verlag, Berlin 1991; 271–286, In
  • Goodhead D.T., Munson R.J., Thacker J., Cox R. Mutation and inactivation of cultured mammalian cells exposed to beams of accelerated heavy ions. IV. Biophysical interpretation. International Journal of Radiation Biology 1980; 37: 135–167
  • Heilmann J. Zelluläre and molekulare Wirkungen beschleunigter schwerer Ionen auf kultivierte Säugerzellen. GSI Report 1991; 91: 17–17, GSI Darmstadt
  • Höver K.H., Kronholz H.L. Three dimensional clinical dosimetry in inhomogeneous phantoms. 4th Symposium on Neutron Dosimetry, G. Burger, H.G. Ebert. Commission of the European Communities, Brussels 1981; 843–851, In
  • Hutchinson F. On the measurement of DNA double-strand breaks by neutral elution. Radiation Research 1989; 120: 182–186
  • Jenner T.J., Belli M., Goodhead D.T., Ianzini F., Simone G., Tabocchini M.A. Direct comparison of biological effectiveness of protons and alpha-particles of the same LET. III. Initial yield of DNA double-strand breaks in V79 cells. International Journal of Radiation Biology 1992; 61: 631–637
  • Kampf G., Eichhorn K. DNA strand breakage by different radiation qualities and relations to cell killing: further results after the influence of α-particles and carbon ions. Studia Biophysica 1983; 93: 17–26
  • Katz R. Radiobiological modelling based on track structure. Quantitative Mathematical Models in Radiation Biology, J. Kiefer. Springer-Verlag, Berlin 1988; 57–83, In
  • Kiefer J. On the interpretation of heavy ion survival data. Radiation Protection (8th Symposium on Microdosimetry), J. Booz, H.G. Ebert. Commission of the European Communities, Brussels 1983; 729–742, In
  • Kiefer J. Cellular and subcellular effects of very heavy ions. International Journal of Radiation Biology 1985; 48: 873–892
  • Kraft G. Radiobiological effects of very heavy ions: inactivation, induction of chromosome aberrations and strand breaks. Nuclear Science Applications 1987; 3: 1–28
  • Kraft G., Daues H.W., Fischer B., Kopf U., Liebold H.P., Quis D., Stelzer H., Kiefer J., Schöpfer F., Schneider E., Weber K.J., Wulf H., Dertinger H. Irradiation chamber and sample changer for biological samples. Nuclear Instruments and Methods 1980; 168: 175–179
  • Lett J.T. Damage to cellular DNA from particulate radiations, the efficacy of its processing and the radio-sensitivity of mammalian cells. Emphasis on DNA double-strand breaks and chromatin breaks. Radiation and Environmental Biophysics 1992; 31: 257–277
  • Michalik V. Model of DNA damage induced by radiations of various qualities. International Journal of Radiation Biology 1992; 62: 9–20
  • Okayasu R., Iliakis G. Linear DNA elution dose response curves obtained in CHO cells with non-unwinding filter elution after appropriate selection of lysis conditions. International Journal of Radiation Biology 1989; 61: 569–581
  • Peak M.J., Wang L., Hill C.K., Peak J.G. Comparison of repair of DNA double-strand breaks caused by neutrons or gamma radiation in cultured human cells. International Journal of Radiation Biology 1991; 60: 891–898
  • Prise K.M., Folkard M., Davies S., Michael B.D. The irradiation of V79 mammalian cells by protons with energies below 2 MeV. Part II. Measurement of oxygen enhancement ratios and DNA damage. International Journal of Radiation Biology 1990; 58: 261–277
  • Radford I.R., Hodgson G.S. 1251-induced DNA double-strand breaks: use in calibration of the neutral filter elution technique and comparison with X-ray induced breaks. International Journal of Radiation Biology 1985; 48: 555–566
  • Ritter M.A., Cleaver J.E., Tobias C.A. High-LET radiations induce a large proportion of non-rejoining DNA breaks. Nature 1977; 266: 653–655
  • Roots R., Holley W., Chatterjee A., Irizarry M., Kraft G. The formation of strand breaks in DNA after high-LET irradiation: a comparison of data from in vitro and cellular studies. International Journal of Radiation Biology 1990; 58: 55–69
  • Roots R., Yang T.C., Craise L., Blakely E.A., Tobias C.A. Impaired repair capacity of DNA breaks induced in mammalian cellular DNA by accelerated heavy ions. Radiation Research 1979; 78: 38–49
  • Rydberg B. DNA strand breaks induced by low energetic heavy ions. International Journal of Radiation Biology 1985; 47: 57–61
  • Taucher-Scholz G., Stanton J.A., Schneider M., Kraft G. Induction of DNA breaks in SV40 by heavy ions. Advances in Space Research 1992; 12(2)73–80
  • Todd P.W., Tobias C.A. Cellular radiation biology. Space Radiation Biology and Related Topics, C.A. Tobias, P.W. Todd. Academic, New York 1974; 142–187, In
  • van der Schans G.P., Paterson M.C., Cross W.G. DNA strand break and rejoining in cultured human fibroblasts exposed to fast neutrons or gamma-rays. International Journal of Radiation Biology 1983; 44: 75–85
  • Ward J.F. DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and repairability. Progress in Nucleic Acids Research and Molecular Biology 1988; 35: 95–125
  • Weber K.J., Schneider E., Kiefer J., Kraft G. Heavy ion effects on yeast: Inhibition of ribosomal RNA synthesis. Radiation Research 1990; 123: 61–67

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.