11
Views
34
CrossRef citations to date
0
Altmetric
Original Article

Lifespan Studies in Rats Exposed to 239PuO2 Aerosol. III. Survival and Lung Tumours

, &
Pages 417-430 | Received 30 Mar 1993, Accepted 23 Jun 1993, Published online: 03 Jul 2009

References

  • Adamson I.Y.R., Bowden D.H. The type 2 cell as progenitor of alveolar epithelial regeneration: a cytodynamic study in mice after exposure to oxygen. Laboratory Investigation 1974; 30: 35–42
  • BEIR V. Health effects of exposure to low levels of ionizing radiation. National Research Council Committee on the Biological Effects of Ionizing Radiations, Board of Radiation Effects Research, Commission on Life Sciences, National Academy of Sciences. National Academy Press, Washington, D.C. 1990
  • Brooks A.L., Guilmette R.A., Hahn F.F., Haley P.J., Muggenburg B.A., Mewhinney J.A., McClellan R.O. Distribution and biological effects of inhaled 239Pu(NO3)4 in Cynomolgus monkeys. Radiation Research 1992; 130: 79–87
  • Buldakov L.A., Lyubchansky E.R., Moskalev Yu.I., Nifatov A.F. Problemy Toksikologii Plutoniya. Atom Publications, Moscow 1968, (Translated as Problems of Plutonium Toxicology, LF-tr-41 (Albuquerque, NM: Lovelace Foundation, 1970).
  • Dagle G.E., Park J.F., Gilbert E.S., Weller R.E. Risk estimates for lung tumours from inhaled 239PuO2, 238PuO2 and 239Pu(NO3)4 in beagle dogs. Radiation Protection Dosimetry 1989; 26: 173–176
  • Gilbert E.S., Fry S.A., Wiggs L.D., Voelz G.L., Cragle D.L., Petersen G.R. Analyses of combined mortality data on workers at the Hanford site, Oak Ridge National Laboratory and Rocky Flats Nuclear Weapons Plant. Radiation Research 1989; 120: 19–35
  • Gilbert E.S., Cross F.T., Sanders C.L., Dagle G.E. Models for comparing lung cancer risks in radonand plutonium-exposed experimental animals. 29th Hanford Symposium, Indoor Radon and Lung Cancer: Reality or Myth?, F.T. Cross. Battelle Press, Richland, WA 1992; 783–802, In Part 2
  • ICRP. Task group of the ICRP on lung dynamics, deposition and retention models for internal dosimetry of the human respiratory tract. Health Physics 1966; 12: 173–173
  • ICRP. Biological effects of inhaled radionuclides. Annals of ICRP 1980; 4: 22–108
  • Johnson N.F., Hubbs A.F., Thomassen D.G. Epithelial progenitor cells in the rat respiratory tract. Biology, Toxicology and Carcinogenesis of Respiratory Epithelium, D.G. Thomassen, P. Nettesheim. Hemisphere, Washington, DC 1990; 88–98, In
  • Keough R.F., Powers G.J. Determination of plutonium in biological materials by extraction and liquid scintillation counting. Analytical Chemistry 1970; 42: 419–421
  • Lafuma J.D., Chmelevsky J., Chameaud J., Morin M., Masse R., Kellerer A.H. Lung carcinomas in Sprague-Dawley rats after exposure to low doses of radon daughters, fission neutrons and γ-rays. Radiation Research 1989; 118: 230–245
  • Lambert B.E., Phipps M.L., Lindop P.J., Black A., Moores S.R. Induction of lung tumours in mice following the inhalation of 239PuO2. Radiological Protection—Advances in Theory and Practice. Society for Radiological Protection, London 1982; 370–375, In
  • Lisco H. Autoradiographic and histopathologic studies in radiation carcinogenesis of the lung. Laboratory Investigation 1959; 8: 162–170
  • Lundgren D.L., Hahn F.F., Diel J.H. Repeated inhalation exposure of rats to aerosols of 144CeO2. II. Effects on survival and lung, liver, and skeletal neoplasms. Radiation Research 1992; 132: 325–333
  • Lundgren D.L., Mauderly J.L., Rebar A.H., Gillett N.A., Hahn F.F. Modifying effects of preexisting pulmonary fibrosis on biological responses of rats to inhaled 239PuO2. Health Physics 1991; 60: 353–363
  • McShane J.F., Dagle G.E., Park J.F. Pulmonary distribution of inhaled 239PuO2 in dogs. Pulmonary Toxicology of Respirable Particles, C.L. Sanders, F.T. Cross, G.E. Dagle, J.A. Mahatfey. NTIS, Springfield, VA 1980; 248–255, In CONF-791002
  • Maletskos C.J., Groer P.G., Algutifan F., Shanahan M.M., Evans R.D. Hazard-function analysis of a subset of the subjects in the US radium toxicity study. Health Physics 1992; S18–S18, (Abstracts of the 37th Annual Meeting of the Health Physics Society)
  • Masse R. Histogenesis of lung tumors induced in rats by inhalation of alpha emitters; an overview. Pulmonary Toxicology of Respiratory Particles, C.L. Sanders, F.T. Cross, G.E. Dagle, J.A. Mahatfey. NTIS, Springfield, VA 1980; 498–521, In CONF-791002
  • Morlier J.-P., Morin M., Chameaud J., Masse R., Bottard S., LaFuma L. Importance du role du debit de dose sur l'apparition des cancers chez le rat apres inhalation de radon. Compte rendu Academie des Sciences 1992; 463–466, t. 315, Serie III
  • Nettesheim P., Szakal A.K. Morphogenesis of alveolar bronchiolarization. Laboratory Investigation 1972; 26: 210–219
  • Nicholls L.G., Moores S.R., Talbot R.J., de Saint-Georges L. Fibrotic and pneumonitic changes in the mouse lung following inhalation of 239PuO2. AERE R 11795, United Kingdom Atomic Energy Authority. Harwell, OxfordshireUK 1986, In
  • Ootsuyama A., Tanooka H. One hundred percent tumor induction in mouse skin after repeated β-irradiation in a limited dose range. Radiation Research 1988; 115: 488–494
  • Ootsuyama A., Tanooka H. Threshold-like dose of repetitive beta irradiation for induction of skin tumors in mice. Radiation Research. A Twentieth-Century Perspective, Vol. 1: Congress Abstracts. Academic, San Diego, CA 1991; 254–254, In
  • Raabe O.G., Book S.A., Parks N.J. Lifetime bone cancer dose-response relationships in beagles and people from skeletal burdens of 226Ra and 90Sr. Health Physics 1983; 44(Suppl. 1)33–48
  • Raabe O.G., Culbertson M.R., Spangler W.L., White R.G., Cain G.R., Samuels S.J., Rosenblatt L.S. Cancer risks in lifetime studies of 90Sr-fed beagles. 1992; S17–S17, (Abstracts of the 37th Annual Meeting of the Health Physics Society).
  • Ratcliff H.L. Spontaneous tumors in two colonies of rats in the Wistar Institute of Anatomy and Biology. American Journal of Pathology 1940; 16: 237–254
  • Rhoads K., Mahaffey J.A., Sanders C.L. Distribution of inhaled 239PuO2 in rat and hamster lung. Health Physics 1982; 42: 645–656
  • Rhoads K., Maheffey J.A., Sanders C.L. A morphometric study of rat and hamster lung following inhalation of 239PuO2. Radiation Research 1981; 88: 266–279
  • Ross M.H., Bras G. Influence of protein under- and overnutrition on spontaneous tumor prevalence in the rat. Journal of Nutrition 1973; 103: 944–963
  • Sanders C.L. Inhalation toxicology of 238PuO2 and 239PuO2 in Syrian golden hamsters. Radiation Research 1977; 70: 334–344
  • Sanders C.L. Pleural mesothelioma in the rat following exposure to 239PuO2. Health Physics 1992; 63: 695–697
  • Sanders C.L. Lifespan studies in rats exposed to 239PuO2 aerosol. II. Non-pulmonary tumor formation in control and exposed groups. Journal of Environmental Pathology, Toxicology and Oncology 1993; 11: 265–277
  • Sanders C.L., Adee R.R., Jackson T.A. Fine structure of alveolar areas in the lung following inhalation of 239PuO2 particles. Archives of Environmental Health 1971; 22: 525–533
  • Sanders C.L., Dagle G.E., Cannon W.C., Craig D.K., Powers G.J., Meier D.M. Inhalation carcinogenesis of high-fired 239PuO2 in rats. Radiation Research 1976; 68: 349–360
  • Sanders C.L., Dagle G.E., Mahaffey J.E. Incidence of brain tumors in rats exposed to an aerosol of 239PuO2. International Journal Radiation Biology 1992; 62: 97–102
  • Sanders C.L., Lauhala K.E., McDonald K.E. Scanning electron microscopy of lung following alpha-irradiation. Scanning Microscopy 1989a; 3: 907–918
  • Sanders C.L., Lauhala K.E., McDonald K.E., Sanders G.A. Lifespan studies in rats exposed to 239PuO2 aerosol. Health Physics 1993; 64: 509–521
  • Sanders C.L., Mahaffey J.A. Inhalation carcinogenesis of high-fired 244CmO2 in rats. Radiation Research 1978; 76: 384–401
  • Sanders C.L., Mahaffey J.A. Inhalation carcinogenesis of repeated exposures to high-fired 239PuO2. Health Physics 1981; 41: 629–644
  • Sanders C.L., McDonald K.E., Killand B.W., Mahaffey J.A., Cannon W.C. Low-level lifespan studies with inhaled 239PuO2 in rats. Life-Span Radiation Effects Studies in Animals: What Can They Tell Us?. NTIS, Springfield, VA 1986; 429–449, CONF-830951
  • Sanders C.L., McDonald K.E., Lauhala K.E. Promotion of pulmonary carcinogenesis by plutonium particle aggregation following inhalation of 239PuO2. Radiation Research 1988a; 116: 393–405
  • Sanders C.L., McDonald K.E., Lauhala K.E. SEM autoradiography: aggregation of inhaled 239PuO2. International Journal Radiation Biology 1988c; 54: 115–121
  • Sanders C.L., McDonald K.E., Lauhala K.E. Quantitative scanning electron microscopic autoradiography of inhaled 239PuO2. Health Physics 1989b; 56: 321–325
  • Sanders C.L., McDonald K.E., Mahaffey J.A. Lung tumor response to inhaled Pu and its implications for radiation protection. Health Physics 1988b; 55: 455–462
  • Spencer H. Pathology of the Lung. Pergamon, Oxford 1985; 1: 76–76
  • Thomas R.G. Dose-effect parameters from the Argonne radium dial painter study. Abstracts of the 37th Annual Meeting of the Health Physics Society. 1992; S18–S18
  • Tubiana M., Lafuma J., Masse R., Latarjet R. The assessment of the carcinogenic effects of low dose radiation. BIR Report 22. The Future of Human Radiation Research. Session 6: Cancer from Combined Exposures with Other Carcinogens. British Institute of Radiology, London 1991; 109–118, In
  • Ullrich R.L., Jernigan M.C., Adams L.M. Induction of lung tumors in RFM mice after localized exposures to X-rays and neutrons. Radiation Research 1979; 80: 464–473
  • Upton A.C. The question of threshold for radiation and chemical carcinogenesis. Cancer Investigation 1989; 7: 267–276
  • Voelz G.L., Lawrence J.N.P. A 42-y medical follow-up of Manhattan project plutonium workers. Health Physics 1991; 61: 181–190
  • Yuile C.L., Berke H.L., Hull T. Lung cancer following Polonium-210 inhalation in rats. Radiation Research 1967; 31: 760–774

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.