Lack of Effect of Inhibitors of DNA Synthesis/Repair on the Ionizing Radiation-induced Chromosomal Damage in G₂ Stage of Ataxia Telangiectasia Cells

References

• Antoccia A., Palitti F., Raggi T., Catena C., Tanzarella C. The yield of fission neutron-induced chromatid aberrations in G2-stage of human lymphocytes: effect of caffeine, hydroxyurea and cytosine arabinoside post-irradiation. International Journal of Radiation Biology 1992; 62: 563–570
   PubMed Web of Science ®Google Scholar
• Bender M.A., Moore R. DNA polymerase α does not mediate G0–G1 increase in yield of X-ray-induced exchange aberrations in human peripheral blood lymphocytes. Mutation Research 1990; 244: 111–114
   PubMedGoogle Scholar
• Bender M.A., Moore R.C., Pyatt B.E. Role of DNA polymerase α and δ in radiation clastogenesis. Mutation Research 1991; 262: 31–36
   PubMedGoogle Scholar
• Bender M.A., Preston R.J. Role of base damage in aberration formation: interaction of aphidicolin and X-rays. Progress in Mutation Research, A.T. Natarajan, G. Obe, H. Altmann. Elsevier, Amsterdam 1982; 4: 37–46, In
   Google Scholar
• Bertazzoni U., Scovassi A.I., Stefanini M., Giulotto E., Spadari S., Pedrini A.M. DNA polymerases α, β and γ in inherited diseases affecting DNA repair. Nucleic Acids Research 1978; 5: 2189–2196
   PubMed Web of Science ®Google Scholar
• Collins A. Cellular responses to ionizing radiation: effect of interrupting DNA repair with chemical agents. International Journal of Radiation Biology 1987; 51: 971–983
   Web of Science ®Google Scholar
• Cornforth M.N., Bedford J.S. On the nature of a defect in cells from individuals with ataxia telangiectasia. Science 1985; 227: 1589–1591
   PubMed Web of Science ®Google Scholar
• Cox R., Debhenam P.G., Masson W.K., Webb W.B.T. Ataxia telangiectasia: a human mutation giving high-frequency misrepair of DNA double-stranded scisions. Molecular Biology in Medicine 1986; 3: 229–244
   PubMedGoogle Scholar
• Dresler S.L., Kimbro K.S. 2′, 3′-Dideoxythymidine 5′-triphosphate inhibition of DNA replication and ultraviolet-induced DNA repair synthesis in human cells: evidence for involvement of DNA polymerase δ. Biochemistry 1987; 26: 2664–2668
   PubMed Web of Science ®Google Scholar
• Francis A.A., Synder R.D., Dunn W.C., Regan J.D. Classification of chemical agents as to their ability to induce long- or short-patch DNA repair in human cells. Mutation Research 1981; 83: 159–169
   PubMed Web of Science ®Google Scholar
• Ganesh A., North P., Thacker J. Repair and misrepair of site-specific DNA double strand breaks by human cell extracts. Mutation Research 1993; 299: 251–259
   PubMed Web of Science ®Google Scholar
• Gedik C.M., Collins A.R. The mode of action of 1-β-D-arabinofuranosylcitosyne in inhibiting DNA repair: new evidence using a sensitive assay for repair DNA synthesis and ligation in permeable cells. Mutation Research 1991; 254: 231–237
   PubMed Web of Science ®Google Scholar
• Hittelman W.N., Sen P. Heterogeneity in chromosome damage and repair rates after bleomycin in ataxia telangiectasia cells. Cancer Research 1988; 48: 276–279
   PubMed Web of Science ®Google Scholar
• Hansson K., Palitti F., Kihlman B.A., Karlsson M.B. Potentiation of X-ray and streptonigrin-induced chromosomal aberrations in human lymphocytes by post-treatments with hydroxyurea and caffeine. Hereditas 1982; 97: 51–58
   PubMed Web of Science ®Google Scholar
• IAEA. Biological Dosimetry: Chromosomal Aberration Analysis for Dose Assessment. Technical Reports Series No. 260, Vienna 1986
   Google Scholar
• Holley W.R., Chatterjee A. The application of chemical models to cellular DNA damage. The Early Effects of Radiation on DNA, E.M. Fielden, P. O'Neill. Springer, Berlin 1991; 54: 195–209, In
   Google Scholar
• Kastan M.B., Zhan Q., El-Deiry W.S., Carrier F., Jacks T., Walsh W.V., Plunkett B.S., Vogelstein B., Fornace A.J. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 1992; 71: 587–597
   PubMed Web of Science ®Google Scholar
• Kees U.R., Ford J., Dowson V.M., Piall E., Aherne G. Development of resistance to 1-β-D-arabinofuranosylcitosyne after high-dose treatment in childhood lymphoblastic leukemia: analysis of resistance mechanism in established cell lines. Cancer Research 1989; 49: 3015–3019
   PubMed Web of Science ®Google Scholar
• Liu P.K., Chang C., Trosko J.E., Dube D.K., Martin G.M., Loeb L.A. Mammalin mutator mutant with an aphidicolin-resistant DNA polymerase α. Proceedings of the National Academy of Sciences, USA 1983; 80: 797–801
   PubMed Web of Science ®Google Scholar
• McKinnon P.J. Ataxia-telangiectasia: an inherited disorder of ionizing radiation sensitivity in man. Human Genetics 1987; 75: 197–208
   PubMed Web of Science ®Google Scholar
• McWhir J., Selfridge J., Harrison D.J., Squires S., Melton D. Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning. Nature Genetics 1993; 5: 217–224
   PubMed Web of Science ®Google Scholar
• Meuth M. The relevance of DNA precursor pool to repair. DNA Repair and its Inhibition, A. Collins, C.S. Downes, R.T. Johnson. IRL, Oxford 1982; 217–229, In
   Google Scholar
• Mozdarani H., Bryant P. Cytogenetic response of normal human and ataxia telangiectasia G2 cells exposed to X-rays and ara-C. Mutation Research 1989; 226: 223–238
   PubMedGoogle Scholar
• Natarajan A.T., Obe G. Molecular mechanisms involved in the production of chromosomal aberrations. I. Utilization of Neurospora endonuclease for the study of aberration production in G2 stage of cell cycle. Mutation Research 1978; 52: 137–149
   PubMed Web of Science ®Google Scholar
• Natarajan A.T., Obe G. Molecular mechanisms involved in the production of chromosomal aberrations. III. Restriction endonucleases. Chromosoma 1984; 90: 120–127
   PubMed Web of Science ®Google Scholar
• Nishida C., Reinhard P., Linn S. DNA repair synthesis in man fibroblasts requires DNA polymerase δ. Journal of Biological Chemistry 1988; 263: 510–517
   Web of Science ®Google Scholar
• Obe G., Johannes C., Schulte-Frohlinde D. DNA double-strand breaks induced by sparsely ionizing radiation and endonucleases as critical lesions for cell death, chromosomal aberrations, mutations and oncogenic transformation. Mutagenesis 1992; 7: 3–12
   PubMed Web of Science ®Google Scholar
• Ohno Y., Spriggs D., Matsukage A., Ohno T., Kufe D. Effects of 1-β-D-arabinofuranosylcytosine incorporation elongation of specific DNA sequences by DNA polymerase. Cancer Research 1988; 48: 1494–1498
   PubMed Web of Science ®Google Scholar
• Painter R.B., Young B.R. Radiosensitivity of ataxia-telangiectasia: a new explantation. Proceedings of the National Academy of Sciences, USA 1980; 77: 7315–7317
   PubMed Web of Science ®Google Scholar
• Pandita T.K., Hittelman M.W. Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells. Radiation Research 1992; 130: 94–103
   PubMed Web of Science ®Google Scholar
• Powell S., Whitaker S., Peacock J., McMillan T. Ataxia telangiectasia: an investigation of the repair defect in the cell line AT5BIVA by plasmid recostitution. Mutation Research 1993; 294: 9–20
   PubMed Web of Science ®Google Scholar
• Preston R.J. The effect of cytosine arabinoside on the frequency of X-ray induced chromosome aberrations in normal human leukocytes. Mutation Research 1980; 69: 71–79
   PubMed Web of Science ®Google Scholar
• Preston G.A., Payne H.S., Preston R.J. Isolation and characterization of a 1-β-d-arabinofuranosylcytosine-resistant Chinese hamster ovary cell mutant that is also X-ray sensitive and is noncomplementary with ataxia telangiectasia cells. Cancer Research 1992; 52: 319–327
   PubMed Web of Science ®Google Scholar
• Runger T.M., Poot M., Kraemer K.H. Abnormal processing of transfected plasmid DNA in cells from patients with ataxia telangiectasia. Mutation Research 1992; 293: 47–54
   PubMed Web of Science ®Google Scholar
• Spector B.D., Filipovich A.H., Perry G.S., Kersey J.H. Epedimiology of cancer in ataxia telangiectasia. Ataxia Telangiectasia. A Cellular and Molecular Link Between Cancer, Neuropathology and Immune Deficiency, B.A. Bridges, D.G. Harnden. Wiley, New York 1982; 103–138, In
   Google Scholar
• Sugino A., Nakayama K. DNA polymerase α mutants from Drosophila melanogaster cell line. Proceedings of the National Academy of Sciences, USA 1980; 77: 7049–7053
   PubMed Web of Science ®Google Scholar
• Thacker J. The use of integrating DNA vectors to analyse the molecular defects in ionising radiationsensitive mutants of mammalian cells including ataxiatelangiectasia. Mutation Research 1989; 220: 187–204
   PubMed Web of Science ®Google Scholar
• Thelander L., Reichard P. Reduction of ribonucleotides. Annual Review of Biochemistry 1979; 48: 133–158
   PubMed Web of Science ®Google Scholar
• Wang T.S.F. Eukariotic DNA polymerases. Annual Review of Biochemistry 1991; 60: 513–552
   PubMed Web of Science ®Google Scholar
• Wang Z., Wu X., Friedberg E. DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase ϵ and is influenced by DNA polymerase α and δ in Saccharomyces cerevisiae. Molecular and Cellular Biology 1993; 13: 1051–1058
   PubMed Web of Science ®Google Scholar
• Wright G.E., Dudycz L.W. Synthesis and characterization of N-(p-n-butylphenyl-)-2-deoxiguanosine and its 5′-triphosphate and their inhibition of HeLa DNA polymerase α. Journal of Medical Chemistry 1984; 27: 175–181
   PubMed Web of Science ®Google Scholar