Proton Radiobiology, Radiosurgery and Radiotherapy

References

• Archambeau J.O., Slater J.D., Slater J.M., Tangeman R.T. Role for proton beam irradiation in treatment of pediatric CNS malignancies. International Journal of Radiation Oncology, Biology and Physics 1992; 22: 287–294
   PubMed Web of Science ®Google Scholar
• Andersson B., Larsson B., Leksell L., Mair W., Rexed B., Sourander P., Wennerstrand J. Histopathology of late local radiolesions in the goat brain. Acta Radiologica, Therapy Physics Biology 1970; 9: 385–394
   PubMed Web of Science ®Google Scholar
• Ando K., Koike S., Kawachi K., Hiraoka T., Ohara H., Yokota M., Inada S., Hirokawa Y., Sato S., Eguchi K., Urano M. Relative biological effectiveness of the therapeutic proton beams at NIRS and Tsukuba University. Collected papers of PARMS (1980–1989). 1985; 77–81, In
   Google Scholar
• Ashikawa J.K., Sondhaus C.A., Tobias C.A., Greenfield A.G., Paschkes V. Difference in injury mode, dose-rate dependence and RBE of 730-MeV protons, 100-kVp X-rays, and 200-kVp X-rays. Biological Effects of Neutron and Proton Irradiations. International Atomic Energy Agency, Vienna 1964; 1: 249–260, In
   Google Scholar
• Ashikawa J.K., Sondhaus C.A., Tobias C.A., Kayfetz L.L., Stephens S.O., Donovan M. Acute effects of high-energy protons and alpha particles in mice. Radiation Research 1967; 7: 312–324, (Suppl.)
   Google Scholar
• Austin-Seymour M., Munzenrider J.E., Gottein M., Gentry R., Gragoudas E., Koehler A.M., McNulty P., Osbourne E., Ryugo D.K., Seddon J., Urie M., Verhey L., Suit H.D. Progress in low-LET heavy particle therapy: intracranial and paracranial tumors and uveal melanomas. Radiation Research 1985; 8: S219–S226, (Suppl.)
   Google Scholar
• Austin-Seymour M., Munzenrider J.E., Goitein M., Verhey L., Urie M., Gentry R., Birnbaum S., Ruotolo D., McManus P., Skates S., Ojemann R.G., Rosenburg A., Schiller A., Koehler A., Suit H.D. Fractionated proton radiation therapy of chordoma and low-grade chondrosarcoma of the base of the skull. Journal of Neurosurgery 1989; 70: 13–17
   PubMed Web of Science ®Google Scholar
• Barendsen G.W., Walter H.M.D. Effects of different ionizing radiations on human cells in tissue culture. IV. Modification of radiation damage. Radiation Research 1964; 21: 314–329
   PubMed Web of Science ®Google Scholar
• Belli M., Cherubini R., Finotto S., Moschini G., Sapora O., Simone G., Tabocchini M.A. RBE-LET relationship for the survival of V79 cells irradiated with low energy protons. International Journal of Radiation Biology 1989; 55: 93–104
   PubMed Web of Science ®Google Scholar
• Belli M., Goodhead D.T., Ianzini F., Simone G., Tabocchini M.A. Direct comparison of biological effectiveness of protons and alpha-particles of the same LET: II. Mutation induction at the HPRT locus in V79 cells. International Journal of Radiation Biology 1992; 61: 625–629
   PubMed Web of Science ®Google Scholar
• Bennett G.W., Archambeau J.O. Experimental tests of proton beam localization. Medical Physics 1977; 4: 115–117
   PubMedGoogle Scholar
• Bettega D., Birattari C., Bombana M., Fuhrman Conti A.M., Gallini E., Pelucchi T., Tallone Lombardi L. Relative biological effectiveness for protons of energies up to 31 MeV. Radiation Research 1979; 77: 85–97
   PubMed Web of Science ®Google Scholar
• Blomquist E., Russell K.R., Stenerlow B., Montelius A., Grusell E., Carisson J. Relative biological effectiveness of intermediate energy protons. Comparisons with 60Co γ-radiation using two cell lines. Radiotherapy and Oncology 1993, in press
   PubMed Web of Science ®Google Scholar
• Bonet-Maury P., Deysine A., Frilly M., Stephan C. Efficacité biologique relative des protons de 157 MeV. C. R. H. Ebd. Seances Academy of Sciences 1960; 251: 3087–3089
   Google Scholar
• Brovkina A.F., Zarubei G.D. Ciliochoroidal melanomas treated with a narrow medical proton beam. Archives of Ophthalmology 1986; 104: 402–404
   PubMedGoogle Scholar
• Char D.H., Castro J.R., Kroll S.M., Irvine A.R., Quivey J.M., Stone R.D. Five-year follow-up of helium ion therapy for uveal melanoma. Ophthalmology 1990; 108: 209–214
   Web of Science ®Google Scholar
• Char D.H., Quivey J.M., Castro J.R., Kroll S., Phillips T. Helium ions versus Iodine 125 brachytherapy in the management of uveal melanoma: a prospective, randomized, dynamically balanced trial. Ophthalmology 1993; 100: 1547–1554
   PubMed Web of Science ®Google Scholar
• Constable I.J., Goitein M., Koehler A.M., Schmidt R.A. Small field irradiation of monkey eyes with protons and photons. Radiation Research 1976; 65: 304–314
   PubMed Web of Science ®Google Scholar
• Constable I.J., Koehler A.M. Experimental ocular irradiation with accelerated protons. Investigative Ophthalmology 1974; 13: 280–287
   PubMedGoogle Scholar
• Dalrymple G.V., Associates. A series of articles on proton effects. Radiation Research 1966; 28: 406–565
   PubMedGoogle Scholar
• Deering R.A., Rice R. Heavy ion irradiation of HeLa cells. Radiation Research 1962; 17: 774–786
   PubMed Web of Science ®Google Scholar
• Dzhelepov V.P., Goddin L.L. The use of existing charged heavy-particle accelerators and the possibilities of creating new domestic ones for radiation therapy. Proceedings of the Symposium on Problems in the Development of Radiation Therapy Techniques in Oncology. Institute of Experimental and Clinical Oncology, Moscow 1969, In April 1969. Translation JIXR-P9-4560.
   Google Scholar
• Fabrikant J.I., Levy R.P., Steinberg G.K., Phillips M.H., Frankel K.A., Lyman J.T., Marks M.P., Silverberg G.D. Charged-particle radiosurgery for intracranial vascular malformations. Neurosurgery Clinics of North America 1992; 3: 99–139
   PubMedGoogle Scholar
• Falkmer S., Fors B., Larsson B., Lindell A., Naeslund J., Sténson S. Pilot study on proton irradiation of human carcinoma. Acta Radiologica, Therapy Physics Biology 1962; 58: 33–51
   Google Scholar
• Falkmer S., Larsson B., Sténson S. Effects of single dose proton irradiation of normal skin and Vx2 carcinoma in rabbit ears. Acta Radiologica 1959; 52: 217–234
   PubMed Web of Science ®Google Scholar
• Folkard M., Prise K.M., Vojnovic D.S., Roper M.J., Michael B.D. The irradiation of V79 cells by protons with energies below 2 MeV. Part 1. Experimental arrangement and measurement of cell survival. International Journal of Radiation Biology 1989; 56: 221–237
   PubMed Web of Science ®Google Scholar
• Fors B., Larsson B., Lindell A., Naeslund J., Sténson S. Effect of high energy protons on human genital carcinoma. Acta Radiologica, Therapy Physics Biology 1964; 2: 384–398
   PubMed Web of Science ®Google Scholar
• Gademann G., Wannenmacher M. Charged particle therapy to pediatric tumors of the retroperitoneal region: a possible indication. International Journal of Radiation, Oncology, Biology and Physics 1992; 22: 375–381
   PubMed Web of Science ®Google Scholar
• Gayle C.C., Larsson B. Radiation induced hypophysectomy and hypothalamic lesions in lactating goats. Acta Physiologica Scandinavia 1963; 59: 299–318
   PubMedGoogle Scholar
• Goitein M., Abrams M. Multi-dimensional treatment planning: 1. Delineation of anatomy. International Journal of Radiation, Oncology, Biology and Physics 1983; 9: 777–787
   PubMed Web of Science ®Google Scholar
• Goitein M., Abrams M., Rowell D., Pollari H., Wiles J. Multi-dimensional treatment planning: II Beam's eye-view, back projection through CT sections. International Journal of Radiation, Oncology, Biology and Physics 1983; 9: 789–797
   PubMed Web of Science ®Google Scholar
• Goodhead D.T., Belli M., Mill A.J., Bance D.A., Allen L.A., Hall S.C., Ianzini F., Simone G., Stevens D.L., Stretch A., Tabocchini M.A., Wilkinson R.E. Direct comparison between protons and alpha-particles of the same LET: I. Irradiation methods and inactivation of asynchronous V79, HeLa and C3H 10TI/2 cells. International Journal of Radiation Biology 1992; 61: 611–624
   PubMed Web of Science ®Google Scholar
• Graffman S. On the evaluation of new radiation modalities in tumor therapy: an experimental and clinical study with special reference to high energy protons. UMEA University Medical Dissertations. Department of Physical Biology, Gustave Werner Institute and Department of Radiation Therapy, UppsalaSweden 1975; 1: 1–45, In
   Google Scholar
• Graffman S., Hugosson R., Jung B., Nohrman B.A. High-energy protons in the post-operative treatment of glioblastoma mulliforme. Proceedings of XI International Congress of Radiology. Excerpta Medica. 1965; 105: 1050–1055, In
   Google Scholar
• Graffman S., Jung B. Clinical trials in radiotherapy and the merits of high-energy protons. Acta Radiologica, Therapy Physics Biology 1970; 9: 1–23
   PubMedGoogle Scholar
• Graffman S., Larsson B. (1975) High-energy protons for radiotherapy—a review of activities at the 185-MeV synchrocyclotron in Uppsala. Proceedings of an International Workshop on Particle Radiation Therapy, Key Biscayne, Florida, October, 1–31975. American College of Radiology, 505–527, In
   Google Scholar
• Graffman S., Larsson B. High-energy protons for radiotherapy—a review of the activities at the 185-MeV synchroton at Uppsala. Atom Kernenergie 1976; 27: 148–154
   Google Scholar
• Gragoudas E.S., Goitein M., Koehler A., Constable I.J., Wagner M.S., Verhey L., Tepper J., Sutt H.D., Brockhurst R.J., Schneider R.J., Johnson K.N. Proton irradiation of choroidal melanomas. Preliminary results. Archives of Ophthalmology 1978; 96: 1583–1591
   PubMedGoogle Scholar
• Gragoudas E.S., Goitein M., Koehler A.M., Verhey L., Tepper J., Suit H., Brockhurst R., Constable I.J. Proton irradiation of small choroidal malignant melanomas. American Journal of Ophthalmology 1977; 83: 665–673
   PubMed Web of Science ®Google Scholar
• Gragoudas E.S., Seddon J.M., Egan K., Glynn R., Munzenrider J.E., Austin-Seymour M., Goitein M., Verhey L.J., Urie M., Koehler A. Long-term results of proton beam irradiated uveal melanomas. Ophthalmology 1987; 94: 349–353
   PubMed Web of Science ®Google Scholar
• Haley T.J., Snider R.S. Response of the Nervous System to Ionizing Radiation. Academic, New York 1962
   Google Scholar
• Haley T.J., Snider R.S. Response of the Nervous System to Ionizing Radiation. Little Brown, Boston 1964
   Google Scholar
• Hall E.J., Kellerer A.M., Rossi H.H., Lam Y.-M. The relative biological effectiveness of 160 MeV protons. II. Biological data and their interpretation in terms of microdosimetry. International Journal of Radiation, Oncology, Biology and Physics 1978; 4: 1009–1013
   PubMed Web of Science ®Google Scholar
• Inada T., Kawachi K., Kanai T., Nojiri I. Inactivation of cultured human tumor cells irradiated by cyclotron neutrons and protons. Journal of Radiation Research 1981; 22: 143–153
   PubMed Web of Science ®Google Scholar
• Jenner T.J., Belli M., Goodhead D.T., Ianzini F., Simone G., Tabocchini M.A. Direct comparison of biological effectiveness of protons and alpha-particles of the same LET. III. Initial yield of DNA double-strand breaks in V79 cells. International Journal of Radiation Biology 1992; 61: 631–637
   PubMed Web of Science ®Google Scholar
• Jung H., Zimmer K.G. Some chemical and biological effects of elastic nuclear collisions. Current Topics in Radiation Research, M. Ebert, A. Howard. North-Holland, Amsterdam 1966; 2: 69–127, In
   Google Scholar
• Kanai T., Kawachi K., Matsuzawa H., Inada S. Three dimensional beam scanning for proton therapy. Nuclear Instruments and Methods 1983; 214: 491–496
   Google Scholar
• Kjellberg R.N. Proton beam therapy for arteriovenous malformations of the brain. Operative Neurosurgical Techniques, H. Schmidek, W. Sweet. Grune and Stratton. 1988; 911–915, Chapter 81
   Google Scholar
• Kjellberg R.N., Abe M. Stereotactic Bragg-peak proton beam therapy. Modern Stereotactic Neurosurgery, L.D. Lunsford, 1988; 463–470, In
   Google Scholar
• Kjellberg R.N., Hanamura T., Davis K.R., Lyons S.L., Adams R.D. Bragg-peak proton beam therapy for arteriovenous malformations of the brain. New England Journal of Medicine 1983; 309: 269–274
   PubMed Web of Science ®Google Scholar
• Kjellberg R.N., Kliman B. Life time effectiveness—a system of therapy for pituitary adenomas, emphasizing Bragg-peak proton hypophysectomy. Recent Advances in the Diagnosis and Treatment of Pituitary Tumors, J.A. Linfoot. Raven, New York 1979; 269–288, In
   Google Scholar
• Kjellberg R.N., Kliman B., Swisher B., Butler W. Proton beam therapy of Cushing's disease and Nelson's syndrome. Progress in Endocrine Research and Therapy, P.McL. Black. Raven, New York 1984; 1: 295–307, In
   Google Scholar
• Kjellberg R.N., Koehler A.M., Preston W.M., Sweet W.H. Intracranial lesions made by the Bragg peak of a proton beam in Response of nervous system to ionizing radiation. Proceedings of Second International Symposium, T.J. Haley, R.S. Snider, 1964; 36–53, In
   Google Scholar
• Kjellberg R.N., McMeel J.W., McManus W.L., Koehler A.M. Pituitary suppression in diabetic retinopathy by proton beam in surgically unfit patients. Proceedings of the Symposium on the Treatment of Diabetic Retinopathy, M.F. Goldberg, S.L. Find. US Public Health Service, Washington 1969; 249–276, No. 1890, chapter 23
   Google Scholar
• Kjellberg R.N., Shintani A., Franitz A.G., Kliman B. Proton-beam therapy in acromegaly. New England Journal of Medicine 1968; 278: 689–695
   PubMed Web of Science ®Google Scholar
• Kjellberg R.N., Sweet W.H., Preston W.M., Koehler A.M. The Bragg-peak of a proton beam in intracranial therapy of tumors. American Neurological Association Transactions 1962; 87: 216–218
   PubMedGoogle Scholar
• Kliauga P.J., Colvett R.D., Lam Y.-M., Rossi H.H. The relative biological effectiveness of 160 MeV protons. I. Microdosimetry. International Journal of Radiation, Oncology, Biology and Physics 1978; 4: 1001–1008
   PubMed Web of Science ®Google Scholar
• Kliman B., Kjellberg R.N., Swisher B., Butler W. Proton-beam therapy of acromegaly: a 20-year experience. Progress in Endocrine Research and Therapy, Peter McL. Black. Raven, New York 1984; 1: 191–211, In
   Google Scholar
• Koehler A.M., Preston W.M. Protons in radiation therapy. Radiology 1972; 104: 191–195
   PubMed Web of Science ®Google Scholar
• Koehler A.M., Schneider R.J., Sisterson J.M. Flattening of proton dose distributions for large field radiotherapy. Medical Physics 1977; 4: 297–301
   PubMedGoogle Scholar
• Konnov B.A. (1987) Proton therapy at Leningrad Synchrocyclotron. Proceedings of Proton Therapy Cooperative Group and 2nd International Charged Particle Therapy Workshop, Loma Linda University Medical Center, Loma LindaCalifornia, October, 12–14, 1–25, In
   Google Scholar
• Konnov B., Melnikov L., Zargaroa O. Narrow proton beam therapy for intracranial lesions. International Workshop on Proton and Narrow Photon Beam Therapy. University of Oulu Printing Center, OuluFinland 1989; 48–55, In
   Google Scholar
• Larsson B. Pretherapeutic physical experiments with high energy protons. British Journal of Radiology 1961; 34: 143–151
   PubMed Web of Science ®Google Scholar
• Larsson B. On the application of a 185 MeV proton beam to experimental cancer therapy and neurosurgery. Abstracts of Uppsala Dissertations in Science. No. 9. 1962
   Google Scholar
• Larsson B. Radiological properties of beams of high-energy protons. Radiation Research 1967; 7: 304–311, (Suppl.)
   Google Scholar
• Larsson B. (1989) Proton therapy: review of the clinical results. Presented at the EULIMA workshop held in Nice. November, 3–51988
   Google Scholar
• Larsson B., Kihlman B.A. Chromosome aberrations following irradiation with high-energy protons and secondary radiation: a study of dose distribution and biological efficiency using root-tips of Vicia faba and Allium cepa. International Journal of Radiation Biology 1960; 2: 8–19
   Web of Science ®Google Scholar
• Larsson B., Leksell L., Rexed B. The use of high energy protons for cerebral surgery in man. Acta Chir Scandinavia 1963; 125: 1–7
   Google Scholar
• Larsson B., Leksell L., Rexed B., Sourander P. Effect of high energy protons on the spinal cord. Acta Radiologica 1959; 51: 52–64
   PubMed Web of Science ®Google Scholar
• Larsson B., Leksell L., Rexed B., Sourander P., Mair W., Andersson B. The high-energy proton beam as a neurosurgical tool. Nature (London) 1958; 182: 1222–1223
   PubMed Web of Science ®Google Scholar
• Larsson B., Svedberg T., Tyrén H. Radiotherapy at the depth with protons from the Uppsala synchrocyclotron. The Swedish Cancer Society Year Book. 1957; 41–41, In (in Swedish)
   Google Scholar
• Larsson B., Lidén K., Sarby B. Irradiation of small structures through the intact skull. Acta Radiologica, Therapy Physics Biology 1974; 13: 512–534
   PubMed Web of Science ®Google Scholar
• Lawrence J.H. Proton irradiation of the pituitary. Cancer 1957; 10: 795–798
   PubMed Web of Science ®Google Scholar
• Lawrence J.H., Tobias C.A., Born J.L. Acromegaly. Transactions of the American Clinical and Climatological Association. 1961; 73: 176–185, In
   Google Scholar
• Leksell L. The stereotactic method and radiosurgery of the brain. Acta Chir Scandinavia 1951; 102: 316–319
   PubMedGoogle Scholar
• Leksell L., Larsson B., Andersson B., Rexed B., Sourander P., Mair W. Lesions in the depth of the brain produced by a beam of high energy protons. Acta Radiologica 1960; 54: 251–264
   PubMed Web of Science ®Google Scholar
• Levy R.P., Fabrikant J.I. Medical applications of stereotactic radiosurgery. Physical Aspects of Stereotactic Radiosurgery, M.H. Phillips. Plenum, New York 1993; 239–278, In
   Google Scholar
• Levy R.P., Fabrikant J.I., Frankel K.A., Phillips M.H., Lyman J.T. Charged-particle radiosurgery of the brain. Neurosurgery Clinics of North America 1990; 1: 955–990
   PubMedGoogle Scholar
• Levy R.P., Lo E.H., Fabrikant J.I. Biologic basis for stereotactic radiosurgery. Physical Aspects of Stereotactic Radiosurgery, M.H. Phillips. Plenum, New York 1993; 189–238, In
   Google Scholar
• Levin C.V. Potential for gain in the use of proton beam boost to the para-aortic lymph nodes in carcinoma of the cervix. International Journal of Radiation, Oncology, Biology and Physics 1992; 22: 355–359
   PubMed Web of Science ®Google Scholar
• Linfoot J.A. Heavy ion therapy: alpha particle therapy of pituitary tumours. Recent Advances in the Diagnosis and Treatment of Pituitary Tumors, J.A. Linfoot. Raven, New York 1979; 245–268, In
   Google Scholar
• Linfoot J.A., Born J.L., Garcia J.F., Manougian E., Kling R., Chong C.Y., Tobias C.A., Carlson R.A., Lawrence J.H. Metabolic and ophthalmological observations following heavy particle pituitary suppressive therapy. Proceedings of the Symposium on Diabetic Retinopathy, M.F. Goldberg, S.L. Find. US Public Health Service, Washington 1969; 277–289, No. 1890
   Google Scholar
• Lutz W., Winston K.R., Maleki N. A system for stereotactic radiosurgery with a linear accelerator. International Journal of Radiation, Oncology, Biology and Physics 1988; 14: 373–381
   PubMed Web of Science ®Google Scholar
• Marcus R., Million R. The incidence of myelitis after irradiation of the cervical spinal cord. International Journal of Radiation, Oncology, Biology and Physics 1990; 19: 3–8
   PubMed Web of Science ®Google Scholar
• Minakova Y.I., Krymsky V.A., Luchin Y.I. Proton beam therapy in neurosurgical clinical practice. Medical Radiology (Moskow) 1987; 32: 36–42, (in Russian)
   PubMedGoogle Scholar
• Minakova Y.I., Luchin Y.I., Krymsky V.A., Kirbatozskaya L.E., Shishkina L.V. Narrow proton beam radioneurosurgery and large fraction radiotherapy at ITEP: clinical results (submitted). 1992
   Google Scholar
• Miralbell R., Crowell C., Suit H.D. Potential improvement of three dimension treatment planning and proton therapy in the outcome of maxillary sinus cancer. International Journal of Radiation, Oncology, Biology and Physics 1992; 22, 30 310
   PubMed Web of Science ®Google Scholar
• Montelius A., Blomquist E., Naeser P., Brahme A., Carlsson J., Carlsson A.-C., Graffman S., Grusell E., Hillén S., Jakobsson P., Jung B., Larsson B. The narrow proton beam therapy unit at the Svedberg Laboratory in Uppsala. Acta Oncologica 1991; 30: 739–745
   PubMed Web of Science ®Google Scholar
• Munzenrider J.E., Austin-Seymour M., Gragoudas E.S., Seddon J.M., Verhey L.J., Goitein M., Gentry R., Urie M., Ruotolo D., Birnbaum S., Johnson K., Sisterson J.M., McNulty P., Sutt H.D., Koehler A.M. (1987) Clinical results of proton beam radiotherapy in Boston. Proceedings of the 8th International Congress of Radiation Research, Edinburgh, July, 19–241987, E.M. Fielden, J.F. Fowler, J.H. Hendry, D. Scott. Taylor & Francis, London, 916–921, In
   Google Scholar
• Munzenrider J.E., Gragoudas E.S., Seddon J.M., Sisterson J., McNulty P., Birnbaums S., Johnson K., Austin-Seymour M., Slater J., Goitein M., Verhey L.J., Ruotolo D., Egan K., Osuna F. Conservative treatment of uveal melanoma: probability of eye retention after proton treatment. International Journal of Radiation, Oncology, Biology and Physics 1988; 15: 553–558
   PubMed Web of Science ®Google Scholar
• Munzenrider J.E., Shipley W.U., Verhey L.J. Future prospects of radiation therapy with protons. Seminars in Oncology 1981; 8: 110–124
   PubMed Web of Science ®Google Scholar
• Munzenrider J.E., Verhey L.J., Gragoudas E.S., Seddon J.M., Urie M., Gentry R., Birnbaum S., Ruotolo D.M., Crowell C., McManus P., Finn S., Sisterson J., Johnson K., Egan K., Lento D., Bassin P. Conservative treatment of uveal melanoma: Local recurrence after proton beam therapy. International Journal of Radiation, Oncology, Biology and Physics 1989; 17: 493–498
   PubMed Web of Science ®Google Scholar
• Nowakowski V.A., Castro J.R., Petti P.L., Collier J.M., Daftari I., Ahn D., Gauger G., Gutin P., Linstadt D.E., Phillips T.L. Charged particle radiotherapy of paraspinal tumors. International Journal of Radiation, Oncology, Biology and Physics 1992; 22: 295–303
   PubMed Web of Science ®Google Scholar
• Raju M.R. Heavy-particle studies with silicon detectors. Radiation Research 1967; 7: 43–52, (Suppl.)
   Google Scholar
• Raju M.R. Heavy Particle Radiotherapy. Protons, Chapter 4. Academic, New York 1980; 188–251, In
   Google Scholar
• Raju M.R., Amols H.I., Bain E., Carpenter S.G., Cox R.A., Robertson J.B. A heavy particle comparative study, Part III. OER and RBE. British Journal of Radiobiology 1978b; 51: 712–719
   PubMed Web of Science ®Google Scholar
• Raju M.R., Bain E., Carpenter S.G., Cox R.A., Robertson J.B. A comparative study of heavy particles in radiation therapy (n, π, p. He, C, Ne, Ar). II. Cell survival as a function of depth of penetration. British Journal of Radiology 1978a; 51: 704–711
   PubMedGoogle Scholar
• Raju M.R., Carpenter S.G. A heavy particle comparative study. Part IV. Acute and late reactions. British Journal of Radiology 1978; 51: 720–727
   PubMed Web of Science ®Google Scholar
• Rexed B., Mair W., Sourander P., Larsson B., Leksell L. Effect of high energy protons on the brain of the rabbit. Acta Radiologica 1960; 53: 289–299
   Web of Science ®Google Scholar
• Robertson J.B., Eaddy J.M., Archambeau J.O., Coutrakon G.B., Miller D.W., Moyers M.F., Siebers J.V., Slater J.M., DiCello J.F. (1993) Variation of measured proton relative biological effectiveness (RBE) as a function of initial proton energy. Wall poster during International Symposium on Hadron Therapy, Como, October, 18–21, (in press)
   Google Scholar
• Robertson J.B., Williams J.R., Schmidt R.A., Little J.B., Flynn D.F., Suit H.D. Radiobiological studies of a high-energy modulated proton beam utilizing cultured mammalian cells. Cancer 1975; 35: 1664–1677
   PubMed Web of Science ®Google Scholar
• Rodriguez A., Levy R.P., Fabrikani J.I. Experimental central nervous system injury after charged-particle irradiation. Radiation Injury to the Nervous System, P.H. Gutin, S.A. Leibel, G.E. Sheline. Raven, New York 1991; 149–182, In
   Google Scholar
• Seddon J.M., Gragoudas E.S., Egan K.M. Uveal melanomas near the optic disc or fovea: visual results after proton beam irradiation. Ophthalmology 1987; 94: 354–361
   PubMed Web of Science ®Google Scholar
• Shultheiss T. Spinal cord radiation tolerance: doctrine versus data. International Journal of Radiation, Oncology, Biology and Physics 1990; 19: 219–221
   PubMed Web of Science ®Google Scholar
• Simpson M.E., Van Wagenen G., Van Dyke D.C., Koneff A.A., Tobias C.A. Deuteron irradiation of the monkey pituitary. Endocrinology 1959; 65: 831–857
   PubMed Web of Science ®Google Scholar
• Sisterson J. ‘Particles’, News letter. Harvard Cyclotron Laboratory, Harvard University, Cambridge, MA 1994, No. 3 January
   Google Scholar
• Skarsgard L.D., Kihlman B.A., Parker L., Pujara C.M., Richardson S. Survival, chromosome abnormalities, and recovery in heavyion and X-irradiated mammalian cells. Radiation Research 1967; 7: 208–221, (Suppl.)
   Google Scholar
• Skarsgard L.D., Wouters B.G., Lam G.K.Y., Durand R.E., Sy A. (1994) RBE determinations for the MeV proton beam at TRIUMF using cultured V79-WNRE cells. Presented at PTCOG meeting held in Chester, UK, May, 16–18, (in press)
   Google Scholar
• Slater J.D., Slater J.M., Wahlen S. The potential for proton beam therapy in locally advanced carcinoma of the cervix. International Journal of Radiation Oncology, Biology and Physics 1992; 22: 343–347
   PubMed Web of Science ®Google Scholar
• Slater J.M., Archambeau J.O., Miller D.W., Notarus M.I., Preston W., Slater J.M., Slater J.D., Archambeau J.O. Carcinoma of the tonsillar region: Potential for use of proton beam therapy. International Journal of Radiation Oncology, Biology and Physics 1992; 22: 311–319
   PubMed Web of Science ®Google Scholar
• Slater J.D. The proton treatment center: rationale for and description of its development. International Journal of Radiation Oncology, Biology and Physics 1992; 22: 383–389
   PubMed Web of Science ®Google Scholar
• Smtt B.M. Prospects for proton therapy in carcinoma of the cervix. International Journal of Radiation, Oncology, Biology and Physics 1992; 22: 349–353
   PubMed Web of Science ®Google Scholar
• Stallard H.B. Malignant melanoblastoma of the choroid. Modern Problem Ophthalmology 1968; 75: 16–38
   Google Scholar
• Steinberg G.K., Fabrikant J.I., Marks M.P. Stereotactic heavy-charged particle Bragg-peak radiation for intracranial arteriovenous malformations. New England Journal of Medicine 1990; 323: 96–101
   PubMed Web of Science ®Google Scholar
• Steiner L. Radiosurgery in cerebral arteriovenous malformations. Cerebral Vascular Surgery, J.M. Fein, E.S. Flamm. Springler. 1985; 1161–1215, In
   Google Scholar
• Steiner L., Leksell L., Forster D.M.C., Greitz T., Backlund E.-O. Stereotactic radiosurgery in intracranial arteriovenous malformations. Acta Neurochir (Wien) 1974; 195–209, (Suppl.)
   PubMed Web of Science ®Google Scholar
• Sténson S. Weight change and mortality of rats after abdominal proton and Roentgen irradiation: a comparative investigation. Acta Radiologica Therapy 1969a; 8: 423–432
   PubMed Web of Science ®Google Scholar
• Sténson S. Effects of proton and roentgen radiation on the rectum of the rat. Acta Radiologica Therapy 1969b; 8: 263–278
   PubMed Web of Science ®Google Scholar
• Sténson S. Effects of high-energy protons on healthy organs and malignant tumors. Abstracts of Uppsala Dissertations in Medicine 1969c; 73: 1–21
   Google Scholar
• Suit H. (1992) Potential for proton beams in clinical radiation oncology. Proceedings of 9th ICRR, Toronto, July, 7–121991. Academic Press Inc., New York, 2: 3–13, In
   Google Scholar
• Sutt H.D., Goitein M. Dose-limiting tissues in relation to types and location of tumors: Implications for efforts to improve radiation dose distribution. European Journal of Cancer 1974; 10: 217–224
   PubMed Web of Science ®Google Scholar
• Suit H.D., Goitein M., Tepper J., Koehler A.M., Schmidt R.A., Schneider R. Exploratory study of proton radiation therapy using large field techniques and fractionated dose schedules. Cancer 1975; 35: 1646–1657
   PubMed Web of Science ®Google Scholar
• Suit H.D., Urano M., Goitein M., Verhey L. (1979) Biological properties of protons. Proceedings of the International Congress of Radiation Research, Tokyo, May, 1979, 771–779, In
   Google Scholar
• Suit H.D., Urie M. Review: proton beams in radiation therapy. Journal of the National Cancer Institute 1992; 84: 155–164
   PubMed Web of Science ®Google Scholar
• Sweet W.H., Kjellberg R.N., Field R.A., Koehler A.M., Preston W.M. Time-intensity data in solar cosmicray events: biological data relevant to their effects in man. Radiation Research 1967; 7: 369–383, (Suppl.)
   Google Scholar
• Tepper J., Verhey L., Goitein M., Suit H.D., Koehler A.M. In vivo determinations of RBE in a high energy modulated proton beam using normal tissue reactions and fractionated dose schedules. International Journal of Radiation Oncology, Biology and Physics 1977; 2: 1115–1122
   PubMed Web of Science ®Google Scholar
• Tobias C.A. Pituitary irradiation. Radiation Physics and Biology in Recent Advances in the Diagnosis and Treatment of Pituitary Tumors, J.A. Linfoot, 1979; 221–242, In
   Google Scholar
• Tobias C.A., Anger H.O., Lawrence J.H. Radiological use of high energy deuterons and alpha particles. American Journal of Roentgenology Radiation Therapy and Nuclear Medicine 1952; 67: 1–27
   PubMedGoogle Scholar
• Tobias C.A., Grigoryev Yu.G. Ionizing radiation. 1975, Chapter 12, Vol II, Book 2 Ecological and Physiological bases of Space Biology and Medicine in Foundations of Space Biology and Medicine. Joint USA/USSR publication in three volumes. Edited by: Melvin Calvin (USA) and Oleg G. Gazenko (USSR) Scientific and Technical Information Office, National Aeronautics and Space Administration.
   Google Scholar
• Tobias C.A., Lawrence J.H., Born J.L., McCombs R.K., Roberts J.E., Anger H.O., Low-Beer B.V.A., Huggins C.B. Pituitary irradiation with high-energy proton beams: a preliminary report. Cancer Research 1958; 18: 121–134
   PubMed Web of Science ®Google Scholar
• Tobias C.A., Lawrence J.H., Lyman J., Born J.L., Gottschalk A., Linfoot J., McDonald J. Progress report on pituitary irradiation in response of nervous system to ionizing radiation. Proceedings of Second International Symposium, T.J. Haley, R.S. Snider, 1964; 19–35, In
   Google Scholar
• Tobias C.A., Roberts J.E., Lawrence J.H., Low-Beer B.V.A., Anger H.O., Born J.L., McCombs R., Huggins C. Irradiation of hypophysectomy and related studies using 340-MeV protons and 190-MeV deuterons. Peaceful Uses of Atomic Energy 1956; 10: 95–106
   Google Scholar
• Tobias C.A., Van Dyke D.C., Simpson M.E., Anger H.O., Huff R.L., Koneff A.A. Irradiation of the pituitary of the rat with high energy deuterons. American Journal of Roentgenology and Radiation Therapy in Nuclear Medicine 1954; 72: 1–21
   PubMed Web of Science ®Google Scholar
• Todd P.W. Heavy ion irradiation of cultured human cells. Radiation Research 1967; 7: 196–207, (Suppl.)
   Google Scholar
• Tsujii H., Tsujii H., Inada T., Murahashi A., Hayakawa Y., Takaday Y., Tada J., Fukomoto S., Tatuzaki H., Ohara K., Kitagawa T. Clinical results of fractionated proton therapy. International Journal of Radiation Oncology, Biology and Physics 1992; 25: 49–60
   Web of Science ®Google Scholar
• Tsunemoto H., Ishikawa T., Morita S. Indications of particle radiation therapy in the treatment of carcinoma of the esophagus. International Journal of Radiation Oncology, Biology and Physics 1992; 22: 321–324
   PubMed Web of Science ®Google Scholar
• Tsunemoto H., Morita S., Ishikawa T., Furukawa S., Kawachi K., Kanai T., Ohara H., Kitagawa T., Inada S. Proton therapy in Japan. Radiation Research 1985; 7(104)S235–S243, (Suppl.)
   Google Scholar
• Tverskoi G.B. Influence of cervical sympathectomy and pituitary stalk section upon milk secretion in goats. Nature (London) 1960; 186: 782–784
   PubMed Web of Science ®Google Scholar
• Ueno Y., Grigoryev Y.G. The RBE of protons with energy greater than 126 MeV. British Journal of Radiology 1969; 42: 425–425
   Web of Science ®Google Scholar
• Urano M., Verhey L.J., Goitein M., Tepper J., Suit H.D., Mendiondo O., Gragoudas E., Koehler A. Relative biological effectiveness of modulated proton beams in various murine tissues. International Journal of Radiation Oncology, Biology and Physics 1984; 10: 509–514
   PubMed Web of Science ®Google Scholar
• Urie M.M., Fullerton B., Tatsuzaki H., Birnbaum S., Suit H.D., Convery K., Skates S., Goitein M. A dose response analysis of injury to cranial nerves and/or nuclei following proton beam radiation therapy. International Journal of Radiation Oncology, Biology and Physics 1992; 23: 27–39
   PubMed Web of Science ®Google Scholar
• VanDyke D.C., Simpson M.E., Koneff A.A., Tobias C.A. Long term effects of deuteron irradiation on the rat pituitary. Endocrinology 1959; 64: 240–257
   PubMed Web of Science ®Google Scholar
• Verhey L.J., Munzenrider J.E. Proton beam therapy. Annual Review of Biophysics and Bioengineering 1982; 11: 331–357
   PubMedGoogle Scholar
• Wainson A.A., Lomanov M.F., Shmakova N.L., Blokhin S.I., Jarmonenko S.P. The RBE of accelerated protons in different parts of the Bragg curve. British Journal of Radiology 1972; 45: 525–529
   PubMed Web of Science ®Google Scholar
• Wambersie A., Gregvoire V., Brucher J.M. Potential clinical gain of proton (and heavy ion) beams for brain tumors in children. International Journal of Radiation Oncology, Biology and Physics 1992; 22: 275–286
   PubMed Web of Science ®Google Scholar
• Williams J.R., Gould R.G., Flynn D., Robertson J.B., Little J.B. Relative survival of hybrid X-ray-resistant and normally sensitive mammalian cells exposed to X-rays and protons under aerobic and hypoxic conditions. Radiation Research 1978; 73: 585–590
   PubMed Web of Science ®Google Scholar
• Wilson R.R. Radiological use of fast protons. Radiology 1946; 47: 487–491
   PubMed Web of Science ®Google Scholar
• Withers H.R., Elkind M.M. Radiosensitivity and fractionation response of crypt cells of mouse jejunum. Radiation Research 1969; 38: 598–613
   PubMed Web of Science ®Google Scholar
• Withers H.R., Elkind M.M. Microcology survival assay for cells of mouse intestinal mucosa exposed to radiation. International Journal of Radiation Biology 1970; 17: 261–267
   Web of Science ®Google Scholar
• Wollensak G., Zografos L., Perret C., Egger E., Fritz-Niggli H. Experimental study on the fractionation schedule for proton-irradiation of uveal melanoma. Graefe's Archive for Clinical and Experimental Ophthalmologys 1990; 228: 562–568
   PubMed Web of Science ®Google Scholar