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Original Article

Electron-affinic Radiosensitizers Possessing NPSH-reactive side Chains: Cytotoxicity and Radiosensitizing Activity Towards Hypoxic EMT6 Cells in Vitro

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Pages 335-346 | Received 06 May 1994, Accepted 13 Oct 1994, Published online: 03 Jul 2009

References

  • Adams G.E. Radiation chemical mechanisms in radiation biology. Advances in Radiation Chemistry 1972; 3: 125–208
  • Adams G.E. Failla memorial lecture: redox, radiation, and reductive bioactivation. Radiation Research 1992; 132: 129–139
  • Adams G.E., Flockhart I.R., Smithen C.E., Stratford I.J., Wardman P., Watts M.E. Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers. Radiation Research 1976; 67: 9–20
  • Adams G.E., Stratford I.J., Wallance R.G., Wavolman P., Watts M.E. Toxicity of nitro compounds toward hypoxic mammalian cells: dependence upon reduction potential. Journal of the National Cancer Institute 1980; 64: 555–560
  • Astor M., Hall E.J., Biaglow J.E., Parham C.J. Newly synthesized hypoxia-mediated drugs as radiosensitizers and cytotoxic agents. International Journal of Radiation, Oncology, Biology and Physics 1982a; 8: 75–83
  • Astor M., Hall E.J., Martin J., Flynn M., Biaglow J., Parham J.C. Radiosensitizing and cytotoxic properties of ortho-substituted 4- and 5-nitroimidazoles: role of NPSH reactivity. International Journal of Radiation, Oncology, Biology and Physics 1982b; 8: 409–413
  • Baker M.A., Taylor Y.C., Brown J.M. Radiosensitization, thiol oxidation and inhibition of DNA repair by SR 4077. Radiation Research 1988; 113: 346–355
  • Biaglow J.E., Varnes M.E., Astor M., Hall E.J. Non-protein thiols and cellular response to drugs and radiation. International Journal of Radiation, Oncology, Biology and Physics 1982; 8: 719–724
  • Biaglow J.E., Varnes M.E., Clarck E.P., Epp E.R. Symposium: Thiols. The role of thiols in cellular response to radiation drugs. Radiation Research 1983; 95: 437–455
  • Biaglow J.E., Varnes M.E., Tuttle S.W., Oleinick N.L., Glazer K., Clark E.P., Epp E.R., Dethlefsen L.A. The effect of l-buthionine sulfoximine of the aerobic radiation response of A549 human lung carcinoma cells. International Journal of Radiation, Oncology, Biology and Physics 1986; 12: 1139–1142
  • Brown J.M. Electron-affinic agents: development of the optimum radiosensitizer and chemosensitizer for clinical application. Modification of Radiosensitivity in Cancer Treatment, S. Sugahara. Academic, Tokyo 1984; 139–174, In
  • Bump E.A., Taylor Y.C., Brown J.M. Role of glutathione in the hypoxic cell cytotoxicity of misonidazole. Cancer Research 1983; 43: 997–1002
  • Edgren M., Nishidai Scotto C.A., Revesz L. Combined effect of misonidazole and glutathione depletion by buthionine sulfoximine on cellular radiation response. International Journal of Radiation Biology 1985; 47: 463–474, Fleming, I., 1976, Frontier Orbitals and Organic Chemical Reactions (Wiley, London).
  • Franko A.J. Misonidazole and other hypoxia markets: metabolism and applications. International Journal of Radiation, Oncology, Biology and Physics 1986; 12: 1195–1202
  • Fujita T., Iwasa J., Hansh C. A new substitutent constant, π, derived from partition coefficients. Journal of the American Chemical Society 1964; 86: 5175–5180
  • Han A., Sinclair W.K., Kimler B.F. The effect of N-ethylmaleimide on the response to X rays of synchronized hela cells. Radiation Research 1976; 65: 337–350
  • Harris J.W., Power J.A. Diamide: a new radiosensitizer for anoxic cells. Radiation Research 1973; 56: 97–109
  • Held K.D. Models for thiol protection of DNA in cells. Pharmacology and Therapeutics 1988; 39: 123–131
  • Held K.D., Epp E.R., Clark E.P. Effect of dimethyl fumarate on the radiation sensitivity of mammalian cells in vitro. Radiation Research 1988; 115: 495–502
  • Kagiya T., Nishimoto S., Shibamoto Y., Zhou L., Wang J., He Y.L., Sasai K., Takahashi M., Abe M. Importance of tumor affinity of nitroazoles in hypoxic radiosensitization. International Journal of Radiation, Oncology, Biology and Physics 1989; 16: 1033–1037
  • Kosower N.S., Kosower E.M. The glutathion-glutathione disulfide system. Free Radical in Biology, W.A. Pryor. Academic, New York 1976; 55–84, In
  • Ling C.C., Wong R.S.L., Basas R.D. Glutathione depletion and cytotoxicity of buthionine sulfoxmine and SR2508 in rodent and human cells. International Journal of Radiation, Oncology, Biology and Physics 1990; 18: 325–330
  • Mitchell J.B., Phillips T.L., Degraff W., Carmichael J., Rajpal R.K., Russo A. The relationship of SR-2508 sensitizer enhancement ratio to cellular glutathione level in human tumor cell lines. International Journal of Radiation, Oncology, Biology and Physics 1986; 12: 1143–1146
  • Nishimoto S., Zhou L. Cellular non-protein thiol depletion and radiosensitization of hypoxic cells by a novel 2-nitroimidazole derivative possessing an NPSH-reactive side chain. Bioorganic and Medicinal Chemistry Letters 1994; 4: 439–442
  • Shibamoto Y., Nishimoto S., Mi F., Sasai K., Kagiya T., Abe M. Evaluation of various types of new hypoxic cell sensitizers using the EMT6 single cell-spheroid-solid tumor system. International Journal of Radiation Biology 1987; 52: 347–357
  • Stratford I.J. Mechanisms of hypoxic cell radiosensitization and development of new compounds. International Journal of Radiation, Oncology, Biology and Physics 1982; 8: 391–398
  • Stratford I.J. Keynote address: concepts and developments in radiosensitization of mammalian cells. International Journal of Radiation, Oncology, Biology and Physics 1992; 22: 529–523
  • Stratford I.J., Adams G.E., Hardy C., Hoe S., O'Neill P., Sheldon P.W. Thiol reactive nitroazoles; radiosensitization studies in vitro and in vivo. International Journal of Radiation Biology 1984; 42: 31–43
  • Stratford I.J., Hoe S., Adams G.E., Hardy C., Williamson C. Abnormal radiosensitizing and cytotoxic properties of ortho-substituted nitroimidazoles. 1983
  • Tietze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: application to mammalian blood and other tissues. Analytical Biochemistry 1969; 27: 502–522
  • Varghese A.J. Glutathione conjugates of misonidazole. Biochemical and Biophysical Research Communications 1983; 112: 1013–1020
  • Wardman P. The kinetics of the reaction of ‘anomalous’ 4-nitroimidazole radiosensitizer with thiols. International Journal of Radiation Biology 1982; 41: 231–235
  • Wong T.W., Whitomore G.F., Gulyas S. Studies on the toxicity and radiosensitizing ability of misonidazole under condition of prolong incubation. Radiation Research 1978; 75: 541–555

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