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International Journal of Radiation Biology Volume 69, 1996 - Issue 2
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Research Article

Withaferin A: a new radiosensitizer from the Indian medicinal plant Withania somnifera

P. UMA DEVI Department of Radiology, Kansai Medical University, Osaka, 570, Japan.
Pages 193-197 | Published online: 03 Jul 2009

References

  • ASTHANA, R. and RAINA, M. K., 1989, Pharmacology of Withania somnifera (Linn) Dunal— a review. Indian Drugs, 26, 199–205.
  • FUSKA, J., FUSKOVA, A., RosAzzA, J. P. and NICHOLAS, A. W., 1984, Novel cytotoxic and antitumour agents. IV. Withaferin A: relation of its structure to the in vivo cytotoxic effects on P-388 cells. Neoplasma, 31, 31–36.
  • HALL, E. J., 1994, Radiobiology for the Radiologist (J. B. Lippin-cott, Philadelphia), p. 295.
  • KUPCHAN, S. M., DOSKOTCH, R. W., BOLLINGER, p. MCPHAIL, A., Sim, G. A. and RENAULD, J. A. S., 1965, The isolation and structural elucidation of a novel steroidal tumor inhi-bitor from Ancitus arborescens. Journal of the American Chemical Society, 87, 5805–5806.
  • KURUP, P. A., 1956, Antibiotic principle of the leaves of With-ania somnifera. Current Science (India), 25, 57–58.
  • KURUP, P. A., 1958, The antibacterial principle of Withania somnifera. I. Isolation and antibacterial activity. Antibio-tics and Chemotherapy, 8, 511–515.
  • LAVIE, D., GLOTTER, E. and Snvo, Y, 1965, Constituents of Withania somnifera. Journal of Organic Chemistry, 30, 1774–1778.
  • SHARADA, A. C., SOLOMON, F. E., UMA DEVI, P., UDUPA, N. and SRINIVASAN K. K., 1995, Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcin-oma in vivo. Acta Oncologica (in press).
  • SHOHAT, B., GITTER, S., ABRAHAM, A. and LAVIE, D., 1967, Anti-tumor activity of withaferin A. Cancer Chemotherapy Report, 51, 271–276.
  • SHOHAT, B., GITTER, S. and LAVIE, D., 1970, Effect of withaferin A on Ehrlich ascites tumor cells—cytological observations. International Journal of Cancer, 5, 244–252.
  • SUBRAMANIAN, S. S. and SETHI, P. D., 1969, Withaferin A from Withania coagulans roots. Current Science (India), 38, 267–268.
  • UMA DEVI, P., SHARADA, A. C., SOLOMON, F. E. and KAMATH, M. S., 1992, In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. Indian Journal of Experimental Biology, 30, 169–172.
  • UMA DEVI, P., SHARADA, A. C. and SOLOMON, F. E., 1993, Anti-tumor and radiosensitizing effect of the medicinal plant Withania somnifera (Ashwagandha) on a trans-plantable mouse tumor Sarcoma-180. Indian Journal of Experimental Biology, 31, 607–611.

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