Modulation of radiation-induced apoptosis by thiolamines

References

• AGUILERA, J. A., NEWTON, G. L., FAHEY, R. C. and WARD, J. F., 1992, Thiol uptake by Chinese hamster V79 cells and aerobic radioprotection as a function of net charge on the thiol. Radiation Research, 130, 194–204.
   PubMed Web of Science ®Google Scholar
• BACQ, Z. M., HERVE, A., LECOMTE, J., FISHER, J., BLAVIER, J., DECHAMPS, G., LE GIHAN, H. and RAYET, P., 1951, Protection contre le rayonnement X par la fi-mercapt-ethylamine. Archives Internationales de P hy siologie, 59, 442–447.
   PubMed Web of Science ®Google Scholar
• BARRON, E. S. G., DICKMAN, S., MUNTZ, J. A. and SINGER, T. P., 1949, Studies on the mechanism of action of ionizing radiations. I. Inhibition of enzymes by X-rays. Journal of General Physiology, 32, 537–552.
   Google Scholar
• BENOVA, D., 1987, Antimutagenic properties of WR-2721 and a radioprotective mixture, ATP-AET-Serotonin, with regard to X-ray-induced reciprocal translocations in mouse spermatogonia. International Journal of Radiation Oncology, Biology, Physics, 13, 117–119.
   PubMedGoogle Scholar
• CHERBONNEL-LASSERRE, C., GAUNY, S. and KRONENBERG, A., 1996, Suppression of apoptosis by Bc1-2 and Bc1-XL promotes susceptibility to mutagenesis. 0 nco gene, 13, 1489–1497.
   Google Scholar
• CORN, B. J., LIBER, H. L. and LITTLE, J. B., 1987, Differential effects of radical scavengers on X-ray-induced mutations and cytotoxicity in human cells. Radiation Research, 109, 100–108.
   PubMed Web of Science ®Google Scholar
• GRDINA, D. J., GUILFORD, W. H., SIGDESTAD, C. P. and GIOMETTI, 5.7 1988, Effects of radioprotectors on DNA damage and repair, proteins and cell cycle progression. Pharmacology and Therapeutics, 39, 133–137.
   Google Scholar
• GRDINA, D. J., KATAOKA, Y., BASIC, I. and PERRIN, J.7 19927 WR2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transfe rase locus in mouse splenocytes when administered prior to or following irradiation. C arcinogenesis, 13, 811–814.
   Google Scholar
• GRDINA, D. J., NAGY, B., HILL, C. K., WELLS, R. L. and PERAINO, C., 1985, The radioprotector WR-1065 reduces radiation-induced mutation at the hypoxanthine-guanine phosphorib osyl transferaselocusinV79cells.arcino genesis, 6, 929–931.
   PubMed Web of Science ®Google Scholar
• GRDINA, D. J., SHIGEMATSU, N., DALE, P., NEWTON, G. L., AGUILERA, J. A. and Emmy, R. C., 1995, Thiol and disulfide metabolites of the radiation protector and poten-tial chemopreventive agent WR2721 are linked to both its anticytotoxic and anti-mutagenic mechanisms of action. C arcinogenesis, 16, 767–774.
   PubMedGoogle Scholar
• GRDINA, D. J., SIGDESTAD, C. P. and CARNES, B. A" 1989, Protection by WR-1065 and WR-151326 against fission-neutron-induced mutations at the HGPRT locus in V79 Cells. Radiation Research, 117, 500–510.
   Google Scholar
• HAIMOVITZ-FRIEDMAN, A., KAN, C.-C., EHLEITER, D., PERSAUD, R. S., McLouoHLIN, M., Fuxs, Z. and KoLEsmcK, R. N., 1994, Ionizing radiation acts on cellular membranes to generate ceramide and induce apoptosis. Journal of Experimental Medicine, 180, 525–535.
   Google Scholar
• HALL, E. J., 1994, Radioprotectors. In R adio biology for the Radiologist, 4th edn (J. B. Lippincott, New York), pp. 183–190.
   Google Scholar
• HELD, K. D., SYLVESTER, F. C., HOPCIA, K. L. and BIAGLOW, J. E., 1996, Role of Fenton chemistry in thiol-induced toxicity and apoptosis. Radiation Research, 145, 542–553.
   PubMed Web of Science ®Google Scholar
• HENDRY, J. H. and POTTEN, C. 5.,1982, Intestinal cell radiosens-itivity: a comparison of cell death assayed by apoptosis or by a loss of clonogenicity. International J ournal of R adiation Biology, 42, 621–628.
   Google Scholar
• KASTAN, M. B., ONYEKWERE, 0., SIDRANSKY, D., VOGELSTEIN, B. and CRAIG, R. W., 1991, Participation of p53 in the cellular response to DNA damage. Cancer Research, 51, 6304–6311.
   Google Scholar
• KELLEY, L. L., GREEN, W. F., HICKS, G. G., BONDURANT, M. C., KOURY, M. J. and RULEY, H. E., 1994, Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53. Molecular and C ellular B iology, 14, 4183–4192.
   Google Scholar
• LIBER, J. L., BENFORADO, K. and LITTLE, J. B., 1989, The molecular nature of mutants induced by X rays is altered by the presence of the radioprotector cysteamine. Radiation Research, 118, 324–329.
   PubMedGoogle Scholar
• LOHMAN, P., Vos, 0., VAN SLUIS, C. and COHEN, J. A" 1970, Chemical protection against breaks induced in DNA of human and bacterial cells by X-irradiation. B iochimica et B iophy sica A cta, 224, 339–352.
   Google Scholar
• MURRAY, D., VAN ANKEREN, S. C., MILAS, L. and MEYN, R. E., 1988a, Radioprotective action of WR-1065 on radiation induced DNA strand breaks in cultured Chinese hamster ovary Cells. Radiation Research, 113, 155–170.
   PubMed Web of Science ®Google Scholar
• MURRAY, D., MILAS, L. and MEYN, R. E., 1988b, Radioprotection of mouse jejunum by WR-2721 and WR-1065: effects on DNA strand-break induction and rejoining. Radiation Research, 114, 268–280.
   PubMedGoogle Scholar
• NEWTON, G. L., WARD, J. W. and FAHEY, R. C., 1996, Polyamine-induced compaction and aggregation of DNA—a major factor in radioprotection of chromatin under physiological conditions. Radiation Research, 145, 776–780.
   PubMed Web of Science ®Google Scholar
• PATT, M. M., TYREE, E. B., STAUBE, R. L. and SMITH, D. E., 1949, Cysteine protection against X-irradiation. Science, 110, 213–214.
   PubMed Web of Science ®Google Scholar
• POTTEN, C. 5.7 1992, The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. Cancer Metastasis Reviews, 11, 179–195.
   Google Scholar
• RADFORD, I. R., 1991, Mouse lymphoma cells that undergo interphase death show markedly increased sensitivity to radiation-induced DNA double strand breakage as com-pared with cells that undergo mitotic death. International Journal of Radiation Biology, 59, 1353–1369.
   PubMed Web of Science ®Google Scholar
• ROBERTS, J. C., KOCH, K. E., DETRICK, S. R., WARTERS, R. L. and LUBEC, G., 1995, Thiazolidine prodrugs of cysteam-ine and cysteine as radioprotective agents. Radiation Research, 143, 203–213.
   PubMedGoogle Scholar
• ROOTS, R. and OKADA, 5.7 1972, Protection of DNA molecules of cultured mammalian cells from radiation-induced single-strand scissions by various alcohols and SH com-pounds. International Journal of Radiation Biology, 21, 329–342.
   Google Scholar
• SAWADA, S. and OKADA, S., 1970, Cysteamine, cysteine and single-strand breaks of DNA in cultured mammalian cells. Radiation Research, 44, 116–132.
   PubMed Web of Science ®Google Scholar
• SCHWARTZ, J. L., GIOVANAZZI, S. M., KARRISON, T., JONES, C. andGRDINA,D.J.,1988,2- [(Aminopropy1)-amino]ethanethiol-mediated reductions in mCo 7-ray and fission-spectrum neutron-induced chromosome damage in V79 Cells. Radiation Research, 113, 145–154.
   Google Scholar
• SCHWARTZ, J. L., JORDAN, R., SEDITA, B. A., SWENNINGSEN, M. J., BANATH, J. P. and OLIVE, P. L., 1995, Different sensitivity to cell killing and chromosome mutation induc-tion by gamma rays in two human lymphoblastoid cell lines derived from a single donor: possible role of apoptosis. M utagenesis, 10, 227–233.
   PubMed Web of Science ®Google Scholar
• SELLINS, K. S. and COHEN, J. J., 1991, Hyperthermia induces apoptosis in thymocytes. Radiation Research, 126, 88–95.
   PubMed Web of Science ®Google Scholar
• SHIGEMATSU, N., SCHWARTZ, J. L. and GRDINA, D. J.7 1994, Protection against mutagenesis at the hprt locus in CHO cells by spermine and N,W-(dithiodi-2,1-ethanedyl)bis-1,3-propanediamine (WR-33278). M uta-genesis, 9, 355–360.
   Google Scholar
• SMOLUK, G. D., FAHEY, R. C., CALABRO-JONES, P., AGUILERA, J. and WARD, J., 1988, Radioprotection of cells in culture by WR-2721 and derivatives: form of the drug responsible for protection. Cancer Research, 48, 3641–3647.
   Google Scholar
• SMOLUK, G. D., FAHEY, R. C. and WARD, J. F., 1986, Equilibrium dialysis studies on the binding of radioprotector com-pounds to DNA. Radiation Research, 107, 194–204.
   PubMed Web of Science ®Google Scholar
• STEPHENS, L. C., KING, S. K., PETERS, L. J., ANG, K. K., SCHULTHEISS, T. E. and JARDINE, J. F1.7 1986, Acute and late radiation injury in rhesus monkey parotid glands. American Journal of Pathology, 124, 469–478.
   Google Scholar
• SWEENEY, T. R., 1979, A Survey of Compounds from the Antiradiat ion Drug Development Program of the U .S . Army Medical Research and Development Command (Walter Reed Army Institute of Medical Research, Washington).
   Google Scholar
• VAUGHAN, A. T. M., GRDINA, D. J., MEECHAN, P. J., MILNER, A. E. and GORDON, D. J., 1989, Conformational changes in chromatin structure induced by the radioprotective aminothiol, WR1065. British Journal of Cancer, 60, 893–896.
   Google Scholar
• VERHELI, M., BOSE, R., LIN, X. H., YAO, B., JARVIS, W. D., GRANT, S., BIRRER, M. J., SZABO, E., ZON, L. I., KYRIAKIS, J. M., HAIMOVITZ-FRIEDMAN, A., FUKS, Z. and KOLESNICK, R. N., 1996, Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature, 380, 75–79.
   Google Scholar
• VIRSIK, R. P. and HARDER, D 1982, Effect of L-cysteine on the dose-effect relationship for chromosome aberrations in irradiated human lymphocytes. International Journal of Radiation Biology, 42, 211–214.
   Google Scholar
• VON SONNTAG, C., 1987, The Chemical Basis of Radiation Biology, (New York: Taylor & Francis).
   Google Scholar
• WARTERS, R. L., 1992, Radiation-induced apoptosis in a murine T-cell hybridoma. Cancer Research, 52, 883–890.
   PubMed Web of Science ®Google Scholar
• WARTERS, R. L. and LYONS, B. W., 19927 Variation in radiation-induced formation of DNA double-strand breaks as a function of chromatin structure. Radiation Research, 130, 309–318.
   Google Scholar
• WOLF, D. and ROTTER, V., 1985, Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 Cells. Proceedings of the N ational Academy of Sciences, USA, 82, 790–794.
   PubMed Web of Science ®Google Scholar
• WYLLIE, A. H., 1980, The significance of apoptosis. International Review of Cytology, 68, 251–306.
   PubMedGoogle Scholar
• XIA, F., WANG, X., WANG, Y.-H., TSANG, N.-M., YANDELL, D. W., KELSEY, K. T. and LIBER, H. L., 1995, Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines. Cancer Research, 55, 12–15.
   Google Scholar
• ZHENG, S., NEWTON, G. L., GONICK, G., FAHEY, R. C. and WARD, J. F., 1988, Radioprotection of DNA by thiols: relationship between the net charge on a thiol and its ability to protect DNA. Radiation Research, 114, 11–27.
   PubMed Web of Science ®Google Scholar