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International Journal of Radiation Biology Volume 72, 1997 - Issue 3
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Research Article

Reduction of subacute lethal radiotoxicity of polonium-210 in rats by chelating agents

J. RENCOVA, V. SVOBODA, R. HOLUSA, V. VOLF, M. M. JONES and P. K. SINGH Vanderbilt University, Departm ent of Chemistry, PO Box 1583, Nashville, Tennesse e 37235, USA.
Pages 341-348 | Published online: 03 Jul 2009

References

  • APOSHIAN, H. V., DART, R. C., APOSHIAN, M. M. and DAWSON, B. V., 1987, Tissue decorporation of polonium-210 in rats by DMPA. Research Communications in Chemical Pathology and Pharmacology, 58, 157–171.
  • CASARETT, G. W., 1964a, Pathology of single intravenous doses of polonium. Radiation Research, supplement, 5, 246–321.
  • CASARETT, G. W., 1964b, Hematology of single intravenous doses of polonium. Radiation Research, supplement, 5, 322–346.
  • DELLA ROSA, R. J. and STANNARD, J. N., 1964, Acute toxicity as a function of route of administration. Radiation Research supplement, 5, 205–215.
  • FINK, R. M. (ed), 1950, Biological studies with polonium, radium and plutonium (New York: McGraw Hill).
  • GOYER, R. A., 1995, Chelation of toxic metals: current interests. Environmental Health Perspectives, 103, 988–989.
  • LILLIE, L. E., TEMPLE, N. J. and FLORENCE, L. Z., 1996, Reference values for young normal Sprague-Dawley rats: weight gain, hematology and clinical chemistry. Human and Experimental Toxicology, 15, 612–616.
  • RENCOV.A, J., VOLE, V., JONES, M. M. and SINGH, P. 1(.7 1994, Decorporation of polonium from rats by new chelating agents. Radiation Protection D osimetry, 53, 311–313.
  • RENCOV.A, J., VOLE, V., JONES, M. M., SINGH, P. K. and FILGAS, R., 1995, Bis-dithiocarbamates: effective chelating agents for mobilization of polonium-210 from rat. International journal of Radiation Biology, 67, 229–234.
  • SINGH, P. K., JONES, M. M., JONES, S. G., GALE, G. R., ATKINS, L. M., SMITH, A. Band BuLLmAN, R. A., 1989, Effect of chelating agent structure on the mobilization of cadmium from intracellular deposits. Journal of Toxicology and Environmental Health, 28, 501–518.
  • STANNARD, J. N, 1964, Distribution and excretion of polonium-210. I. Comparison of oral and intravenous routes in the rat. Radiation Research, supplement, 5, 49–59.
  • VOLE, V., RENCOV.A, J., JONES, M. M. and SINGH, P. 1(.7 1995, Combined chelation treatment for polonium after simu-lated wound contamination in rat. International journal of Radiation Biology, 68, 395–404.

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