Advanced search
Publication Cover
International Journal of Radiation Biology Volume 75, 1999 - Issue 2
Submit an article Journal homepage
8
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Regional cholesterol synthesis in the intestinal mucosa of the genetically hypercholesterolaemic RICO rat: kinetic study following whole-body gamma-irradiation

C. LUTTON Institut de Protection et de Surete Nucleaire, Departement de Protection de la Sante de lHomme et de Dosimetrie, Section Autonome de Radiobiologie Appliquee a la Medecine, IPSN,BP 6, F92265 Fontenay aux Roses Cedex, France.
Pages 175-181 | Published online: 03 Jul 2009

  • BARBER, J. and JAMES, R. D., 1995, Radiation effects on the human gastrointestinal tract. In Radiation and Gut, edited by C. S. Potten and J. H. Hendry (Amsterdam: Elsevier Science), pp. 231-252.
  • BECCIOLINI, A., 1987, Relative radiosensitivities of the small and large intestine. In Advances in Radiation Biology, Vol. 12, edited by J. T. Lett and K. I. Altmann (Orlando and London: Academic Press), pp. 83-127.
  • BECCIOLINI, A., BALZI, M. and POTTEN, C. S., 1995, Radiation effects on proliferation and differentiation in the rat small intestine. In Radiation and Gut, edited by C. S. Potten and J. H. Hendry (Amsterdam: Elsevier Science), pp. 85-143.
  • CARDONA-SANCLEMENTE, L. E., VERNEAU, C., MATHE, D. and LUTTON, C., 1987, Cholesterol metabolism in the genetically hypercholesterolemic rat (RICO). I. Measurement of turnorver processes. Biochimica Biophysiea Acta, 919, 205-212.
  • CHEVALLIER, F. and LUTTON, C., 1973, The intestine is the major site of cholesterol synthesis in the rat. Nature New Biology, 242, 61-62.
  • CHWALINSKI, S., POTTEN, C. S. and EVANS, G., 1988, Double labelling with bromodeoxyuridine and 3H-thymidine of proliferative cells in small intestinal epithelium in steady state and after irradiation. Cell Tissue Kinetics, 21,317-329.
  • CROFT, D. N. and LUBRAN, M., 1975, The estimation of desoxyribonucleic acid in the presence of sialic acid. Application to analysis in human gastric washings. Journal of Biochemistry, 95, 612-620.
  • GORNALL, A. J., BARDAWILL, C. J. and DAVID, M. M., 1949, Determination of serum proteins by means of the biuret reaction. Journal of Biological Chemistry, 177, 751-755.
  • COULD, R. G., BELL, V. L. and LILLY, E. H., 1959, Stimulation of cholesterol biosynthesis from acetate in rat liver and adrenals by whole body X-irradiation. American Journal of Physiology, 196, 1231-1237.
  • GUNTER-SMITH, P. J., 1987, Effect of ionizing radiation on gastrointestinal physiology, edited by J. J. Conklin and R. I. Walker (New York: Academic Press), pp. 135-151.
  • LUTTON, C., 1976, The role of the digestive tract in cholesterol metabolism. Digestion, 14, 342-356.
  • LUTTON, C., 1996, Anatomical heterogeneity of the intestinal mucosa and cholesterol homeostasis. Digestion, 57, 1-10.
  • LUTTON, C., FEREZOU, J., SEROUGNE, C., VERNEAU, C., CHAMPARNAUD, G., MAGOT, T., MATHE, D. and SULPICE, J. C., 1990, Critical analysis of the use of 14C acetate for measuring rat cholesterol synthesis. Reproduction, Nutrition, Development, 30, 71-84.
  • OUGUERRAM, K., MAGOT, T. and LUTTON, C., 1990, Alterations in cholesterol metabolism in the genetically hypercholesterolemic RICO rat: an overview. In Dyslipoproteinemia and Atherosclerosis, edited by C. L. Malmendier, P. Alaupovic and H. B. Brewer (New York and London: Plenum Press), pp. 257-274.
  • PERRODIN, M. and LUTTON, C., 1985, In vivo cholesterol synthesis by the digestive tract in the rat. I. Topological study. Reproduction, Nutrition, Development, 25, 647- 657.
  • POTTEN, C. S., 1990. A comprehensive study of the radiobiological response of the murine (BDF 1) small intestine. International Journal of Radiation Biology,58, 925- 973.
  • POTTEN, C. S., MERRITT, A., HICKMAN, J., H AU, P. and FARANDA, A., 1994, Characterization of radiation-induced apoplosis in the small intestine and ils biological implications. International Journal of Radiation Biology, 65, 71- 78.
  • QUASTLER. H., 1956, The nature of intestinal radiation death. Radiation, Research. 4, 303 - 320.
  • SPADY, D. K. and DIETSCHY, J. M., 1983. Sterol synthesis hi vivo in 18 tissues of the squirrel monkey, guinea pig. rabbit, hamster and rat. Journal of Lipid Research, 24, 303-315.
  • WEISER, M. M., 1973. Intestinal epithelial cell surface membrane glycoprotein synthesis. An indication of cellular differentiation. Journal of Biological Chemistry, 248, 2536- 2541.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.