Synthesis of N-doped carbon dots for highly selective and sensitive detection of metronidazole in real samples and its cytotoxicity studies

References

• Han C, Chen J, Wu X, et al. Detection of metronidazole and ronidazole from environmental samples by surface enhanced Raman spectroscopy. Talanta. 2014;128:293–298.
   PubMed Web of Science ®Google Scholar
• Zhao J, Pan X, Sun X, et al. Detection of metronidazole in honey and metronidazole tablets using carbon dots-based sensor via the inner filter effect. Luminescence. 2018;33:704–712.
   PubMed Web of Science ®Google Scholar
• http://www.who.int/mediacentre/factsheets/fs355/en/.
   Google Scholar
• http://www.who.int/mediacentre/factsheets/fs297/en/.
   Google Scholar
• Sun T, Zhang YS, Pang B, et al. Engineered nanoparticles for drug delivery in cancer therapy. Angew Chem 2014;53:12320–12364.
   Google Scholar
• Butler JS, Sadler PJ. Targeted delivery of platinum-based anticancer complexes. Curr Opin Chem Biol. 2013;17:175–188.
   PubMed Web of Science ®Google Scholar
• Li K, Jiang Y, Ding D, et al. Folic acid-functionalized two-photon absorbing nanoparticles for targeted MCF-7 cancer cell imaging. Chem Commun. 2011;47:7323–7325.
   PubMed Web of Science ®Google Scholar
• Salata OV. J Nanobiotechnol. 2004;2:1–6.
   PubMedGoogle Scholar
• Sun YP, Zhou B, Lin Y, et al. Quantum-sized carbon dots for bright and colorful photoluminescence. J Am Chem Soc 2006;128:7756–7757.
   PubMed Web of Science ®Google Scholar
• Lin Z, Xue W, Chen H, et al. Classical oxidant induced chemiluminescence of fluorescent carbon dots. Chem Commun 2012;48:1051–1053.
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhou L, Li Y, et al. Highly fluorescent nitrogen-doped carbon dots with excellent thermal and photo stability applied as invisible ink for loading important information and anti-counterfeiting. Nanoscale. 2017;9:491–496.
   PubMed Web of Science ®Google Scholar
• Dong Y, Chen Y, You X, et al. High photoluminescent carbon based dots with tunable emission color from orange to Green. Nanoscale. 2017;9:1028–1032.
   PubMed Web of Science ®Google Scholar
• Yang X, Wang Y, Shen X, et al. One-step synthesis of photoluminescent carbon dots with excitation-independent emission for selective bioimaging and gene delivery. J Colloid Interface Sci 2017;492:1–7.
   PubMed Web of Science ®Google Scholar
• Xu X, Zhang K, Zhao L, et al. Aspirin-based carbon dots, a good biocompatibility of material applied for bioimaging and anti-inflammation. ACS Appl Mater Interfaces. 2016;8:32706–32716.
   PubMed Web of Science ®Google Scholar
• Liu W, Diao H, Chang H, et al. Green synthesis of carbon dots from rose-heart radish and application for Fe3+ detection and cell imaging. Sens Actuators B. 2017;241:190–198.
   Web of Science ®Google Scholar
• Lin Z, Xue W, Chen H, et al. Peroxynitrous-acid-induced chemiluminescence of fluorescent carbon dots for nitrite sensing. Anal Chem 2011;83:8245–8251.
   PubMed Web of Science ®Google Scholar
• Shen G-X, Hu M-X, Qi J-R. Progress of luminescent carbon dots in biomedicine engineering. Nano Biomed Eng. 2016;8:190.
   Google Scholar
• Wang Q, Zhang C-L, Shen G-X, et al. Fluorescent carbon dots as an efficient siRNA nanocarrier for its interference therapy in gastric cancer cells. J Nanobiotechnol. 2014;12:58.
   PubMed Web of Science ®Google Scholar
• Sun C, Zhang Y, Kalytchuk S, et al. Down-conversion monochromatic light-emitting diodes with the color determined by the active layer thickness and concentration of carbon dots. J Mater Chem C. 2015;3:6613–6615.
   Web of Science ®Google Scholar
• Wang Y, Hu A. Carbon quantum dots: synthesis, properties and applications. J Mater Chem C. 2014;2:6921.
   Web of Science ®Google Scholar
• Fu H, Ji Z, Chen X, et al. A versatile ratiometric nanosensing approach for sensitive and accurate detection of Hg2+ and biological thiols based on new fluorescent carbon quantum dots. Anal Bioanal Chem 2017;409:2373–2382.
   PubMed Web of Science ®Google Scholar
• Zhong Y, Chen Q, Li J, et al. One-step synthesis of nitrogen and chlorine co-doped carbon quantum dots for detection of Fe3+. Nano. 2017;12:1750135.
   Web of Science ®Google Scholar
• Liu Y, Duan W, Song W, et al. Red emission B, N, S-co-doped carbon dots for colorimetric and fluorescent dual mode detection of Fe3+ions in complex biological fluids and living cells. ACS Appl Mater Interfaces. 2017;9:12663–12672.
   PubMed Web of Science ®Google Scholar
• Niu W-J, Shan D, Zhu R-H, et al. Dumbbell-shaped carbon quantum dots/AuNCs nanohybrid as an efficient ratiometric fluorescent probe for sensing cadmium (II) ions and l-ascorbic acid. Carbon N Y. 2016;96:1034–1042.
   Web of Science ®Google Scholar
• Ding H, Yu SB, Wei JS, et al. Full-color light-emitting carbon dots with a surface-state-controlled luminescence mechanism. ACS Nano. 2016;10:484–491.
   PubMed Web of Science ®Google Scholar
• Chen J, Wei JS, Zhang P, et al. Red-emissive carbon dots for fingerprints detection by spray method: coffee ring effect and unquenched fluorescence in drying process. ACS Appl Mater Interfaces. 2017;9:18429–18433.
   PubMed Web of Science ®Google Scholar
• Gong XJ, Lu WJ, Paau MC, et al. Facile synthesis of nitrogen-doped carbon dots for Fe3+ sensing and cellular imaging. Anal Chim Acta. 2015;861:74–84.
   PubMed Web of Science ®Google Scholar
• Zhou ZX, Shen YF, Li Y, et al. Chemical cleavage of layered carbon nitride with enhanced photoluminescent performances and photoconduction. ACS Nano. 2015;9:12480–12487.
   PubMed Web of Science ®Google Scholar
• Wang Q, Zhang S, Zhong Y, et al. Preparation of yellow-Green-Emissive carbon dots and their application in constructing a fluorescent turn-On nanoprobe for imaging of selenol in Living cells. Anal Chem 2017;89:1734–1741.
   PubMed Web of Science ®Google Scholar
• Barman S, Sadhukhan M. Facile bulk production of highly blue fluorescent graphitic carbon nitride quantum dots and their application as highly selective and sensitive sensors for the detection of mercuric and iodide ions in aqueous media. J Mater Chem. 2012;22:21832–21837.
   Web of Science ®Google Scholar
• Atchudan R, Edison TNJI, Perumal S, et al. Hydrophilic nitrogen-doped carbon dots from biowaste using dwarf banana peel for environmental and biological applications. Fuel. 2020;275:117821.
   Web of Science ®Google Scholar
• Das P, Ganguly S, Bose M, et al. Zinc and nitrogen ornamented bluish white luminescent carbon dots for engrossing bacteriostatic activity and Fenton based bio-sensor. Mat Sci Eng C. 2018;88:115–129.
   PubMed Web of Science ®Google Scholar
• Liu ML, Chen BB, Yang T, et al. One-pot carbonization synthesis of europium-doped carbon quantum dots for highly selective detection of tetracycline. Fluoresc. 2017;5:015003.
   Google Scholar
• Luo Z, Lu Y, Somers LA, et al. High yield preparation of macroscopic graphene oxide membranes. J Am Chem Soc 2009;131:898–899.
   PubMed Web of Science ®Google Scholar
• Zhu S, Song Y, Zhao X, et al. The photoluminescence mechanism in carbon dots (graphene quantum dots, carbon nanodots, and polymer dots): current state and future perspective. Nano Res. 2015;8:355–381.
   Web of Science ®Google Scholar
• Atchudan R, Edisona TNJI, Perumal S, et al. Eco-friendly synthesis of tunable fluorescent carbon nanodots from Malus floribunda for sensors and multicolor bioimaging. Photobiol A. 2020;390:112336.
   Web of Science ®Google Scholar
• Atchudan R, Edison TNJI, Aseer KR, et al. Highly fluorescent nitrogen-doped carbon dots derived from phyllanthus acidus utilized as a fluorescent probe for label-free selective detection of Fe3+ ions, live cell imaging and fluorescent ink. Biosens Bioelectron 2018;99:303–311.
   PubMed Web of Science ®Google Scholar
• Atchudan R, Edison TNJI, Aseer KR, et al. Hydrothermal conversion of Magnolia liliiflora into nitrogen-doped carbon dots as an effective turn-off fluorescence sensing, multi-colour cell imaging and fluorescent ink. Colloid Surfaces B. 2018;169:321–328.
   PubMed Web of Science ®Google Scholar
• Edison TNJI, Atchudan R, Sethuraman MG, et al. Microwave assisted Green synthesis of fluorescent N-doped carbon dots: cytotoxicity and bio-imaging applications. J Photochem Photobiol B. 2016;161:154–161.
   PubMed Web of Science ®Google Scholar
• Edison TNJI, Atchudan R, Karthik N, et al. Facile hydrothermal synthesis of nitrogen rich blue fluorescent carbon dots for cell bio-imaging of Candida albicans. Process Biochem 2020;88:113–119.
   Web of Science ®Google Scholar
• Edison TNJI, Atchudan R, Shim J, et al. Turn-off fluorescence sensor for the detection of ferric ion in water using Green synthesized N-doped carbon dots and its bio-imaging. J Photochem Photobiol B. 2016;158:235–242.
   PubMed Web of Science ®Google Scholar
• Ma Y, Cen Y, Sohail M, et al. A ratiometric fluorescence universal platform based on N, Cu codoped carbon dots to detect metabolites participating in H2O2-generation reactions. ACS Appl Mater Interfaces. 2017;9:33011–33019.
   PubMed Web of Science ®Google Scholar
• Arul V, Sethuraman MG. Facile green synthesis of fluorescent N-doped carbon dots from Actinidia deliciosa and their catalytic activity and cytotoxicity applications. Opt Mater 2018;78:181–190.
   Web of Science ®Google Scholar
• Sevilla M, Fuertes AB. The production of carbon materials by hydrothermal carbonization of cellulose. Carbon N Y. 2009;47:2281–2289.
   Web of Science ®Google Scholar
• Lin FE, Gui C, Wen W, et al. Dopamine assay based on an aggregation-induced reversed inner filter effect of gold nanoparticles on the fluorescence of graphene quantum dots. Talanta. 2016;158:292–298.
   PubMed Web of Science ®Google Scholar
• Liu JJ, Chen YL, Wang WF, et al. “Switch-on” fluorescent sensing of ascorbic acid in food samples based on carbon quantum dots–MnO2Probe. J Agric Food Chem. 64 (2016) 371–380.
   PubMed Web of Science ®Google Scholar
• Zheng M, Xie ZG, Qu D, et al. On–off–on fluorescent carbon dot nanosensor for recognition of chromium(VI) and ascorbic acid based on the inner filter effect. ACS Appl Mater Interfaces. 2013;5:13242–13247.
   PubMed Web of Science ®Google Scholar
• Jose AR, Sivasankaran U, Menon S, et al. A silicon nanoparticle based turn off fluorescent sensor for Sudan I. Anal Methods. 2016;8:5701–5706.
   Web of Science ®Google Scholar
• Fang AJ, Long Q, Wu QQ, et al. Upconversion nanosensor for sensitive fluorescence detection of Sudan I–IV based on inner filter effect. Talanta. 2016;148:129–134.
   PubMed Web of Science ®Google Scholar
• Liu X, Yang C, Zheng B, et al. Green anhydrous synthesis of hydrophilic carbon dots on large-scale and their application for broad fluorescent pH sensing. Actuators B-Chem. 2018;255:572–579.
   Web of Science ®Google Scholar
• Morcoss MM, Abdelwahab NS, Ali NW, et al. Different chromatographic methods for simultaneous determination of diloxanide furoate, metronidazole and its toxic impurity. J Iran Chem Soc. 2016;13:1643.
   Web of Science ®Google Scholar
• Lin W, Stayton I, Huang Y-W, et al. Cytotoxicity and cell membrane depolarization induced by aluminum oxide nanoparticles in human lung epithelial cells A549. Toxicol Environ Chem 2008;90:983–996.
   Google Scholar
• Fahmy B, Cormier SA. Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells. Toxicol in Vitro. 2009;23:1365–1371.
   PubMed Web of Science ®Google Scholar
• Jain R, Jain N, Jain DK, et al. Novel UV spectrophotometer methods for quantitative estimation of metronidazole and furazolidone using mixed hydrotropy solubilization. Arabian J Chem. 2017;10:151–156.
   Web of Science ®Google Scholar
• Manke A, Wang L, Rojanasakul T. Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed Res Int 2013;2013:1–15.
   Web of Science ®Google Scholar
• Lakowicz JR. Principles of fluorescence spectroscopy. 3rd ed. New York (NY): Springer; 2006.
   Google Scholar
• Sarkar A, Ghosh M, Sil PC, et al. Nanotoxicity: oxidative stress mediated toxicity of metal and metal oxide nanoparticles. Nanotechnol. 2014;14:730–743.
   Web of Science ®Google Scholar
• Knaapen AM, Borm PJ, Albrecht C, et al. Inhaled particles and lung cancer. part A: mechanisms. Int J Cancer. 2004;109:799–809.
   PubMed Web of Science ®Google Scholar
• Risom L, Møller P, Loft S. Oxidative stress-induced DNA damage by particulate air pollution. Mutat Res 2005;592:119–137.
   PubMed Web of Science ®Google Scholar
• Khanna P, Ong C, Bay BH, et al. Nanotoxicity: An interplay of Oxidative stress, Inflammation and cell death. Nanomaterials. 2015;5:1163–1180.
   Web of Science ®Google Scholar
• Wang J, Sun P, Bao Y, et al. Cytotoxicity of single-walled carbon nanotubes on PC12 cells. Toxicol in Vitro. 2011;25:242–250.
   PubMed Web of Science ®Google Scholar
• Zhornik EV, Baranova LA, Strukova AM, et al. ROS induction and structural modification in human lymphocyte membrane under the influence of carbon nanotubes. Biophysics. 2012;57:325–331.
   Google Scholar
• Misawa M, Takahashi J. Generation of reactive oxygen species induced by gold nanoparticles under x-ray and UV irradiations. Nanomedicine. 2011;7:604–614.
   PubMed Web of Science ®Google Scholar
• Tammina SK, Mandal BK, Ranjan S, et al. Cytotoxicity study of Piper nigrum seed mediated synthesized SnO2 nanoparticles towards colorectal (HCT116) and lung cancer (A549) cell lines. Photobio B. 2017;166:158–168.
   PubMed Web of Science ®Google Scholar