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Original Articles

Efficient translational rehabilitation randomised controlled trial designs using disease progress modelling and trial simulation

Pages 891-903 | Published online: 29 Oct 2009

FURTHER READING

  • Pinheiro , J. C. and Bates , D. M. 2004 . Mixed-effects models in S and S-Plus , New York : Springer . A detailed “handbook” of NLME modelling using the NLME library in R

REFERENCES

  • Bales , J. W. , Wagner , A. K. , Kline , A. E. and Dixon , C. E. in press . Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis . Neuroscience and Biobehavioral Reviews ,
  • Forsyth , R. , Jayamoni , B. and Paine , T. C. 2003 . Monoaminergic agonists for acute traumatic brain injury (Cochrane Review) . The Cochrane Database of Systematic Reviews , CD000565
  • Forsyth , R. , Vu , T. , Salorio , C. , Christensen , J. and Holford , N. 2009 . Efficient designs for clinical trials using disease progress modelling and trial simulation: A pediatric traumatic brain injury example , Manuscript submitted for publication
  • Giza , C. C. , Griesbach , G. S. and Hovda , D. A. 2005 . Experience-dependent behavioral plasticity is disturbed following traumatic injury to the immature brain . Behavioural Brain Research , 157 ( 1 ) : 11 – 22 .
  • Hamilton , D. A. and Kolb , B. 2005 . Differential effects of nicotine and complex housing on subsequent experience-dependent structural plasticity in the nucleus accumbens . Behavioural Neuroscience , 119 ( 2 ) : 355 – 365 .
  • Holford , N. and Nutt , J. 2008 . Disease progression, drug action and Parkinson's disease: Why time cannot be ignored . European Journal of Clinical Pharmacology , 64 ( 2 ) : 207 – 216 .
  • Holford , N. H. and Peace , K. E. 1992 . Methodologic aspects of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine . Proceedings of the National Academy of Science USA , 89 ( 23 ) : 11466 – 11470 .
  • Jonsson , F. , Marshall , S. , Krams , M. and Jonsson , E. N. 2005 . A longitudinal model for non-monotonic clinical assessment scale data . Journal of Pharmacokinetics and Pharmacodynamics , 32 ( 5–6 ) : 795 – 815 .
  • Lockwood , P. , Ewy , W. , Hermann , D. and Holford , N. 2006 . Application of clinical trial simulation to compare proof-of-concept study designs for drugs with a slow onset of effect: An example in Alzheimer's disease . Pharmacology Research , 23 ( 9 ) : 2050 – 2059 .
  • Medical Research Council . 2000 . A Framework for development and evaluation of RCTs for complex interventions to improve health , London : Medical Research Council .
  • Philipson , P. M. , Ho , W.-K. and Henderson , R. in press . Comparative review of methods for handling drop-out in longitudinal studies . Statistics in Medicine ,
  • Risedal , A. , Mattsson , B. , Dahlqvist , P. , Nordborg , C. , Olsson , T. Johansson , B. B. 2002 . Environmental influences on functional outcome after a cortical infarct in the rat . Brain Research Bulletin , 58 ( 3 ) : 315 – 321 .
  • Schallert , T. , Leasure , J. L. and Kolb , B. 2000 . Experience-associated structural events, subependymal cellular proliferative activity, and functional recovery after injury to the central nervous system . Journal of Cerebral Blood Flow and Metabolism , 20 ( 11 ) : 1513 – 1528 .
  • Sheiner , L. B. 1991 . The intellectual health of clinical drug evaluation . Clinical Pharmacology and Therapeutics , 50 ( 1 ) : 4 – 9 .

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