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Review Article

The effects of cognitive-focused interventions on cognition and psychological well-being in persons with multiple sclerosis: A meta-analysis

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Pages 767-786 | Received 06 Jul 2017, Accepted 17 Jun 2018, Published online: 05 Jul 2018

References

  • Akbar, N., Honarmand, K., & Feinstein, A. (2011). Self-assessment of cognition in multiple sclerosis: The role of personality and anxiety. Cognitive and Behavioral Neurology, 24, 115–121. doi: 10.1097/WNN.0b013e31822a20ae
  • *Amato, M. P., Goretti, B., Viterbo, R. G., Portaccio, E., Niccolai, C., Hakiki, B., … Trojano, M. (2014). Computer-assisted rehabilitation of attention in patients with multiple sclerosis: Results of a randomized, double-blind trial. Multiple Sclerosis Journal, 20, 91–98. doi: 10.1177/1352458513501571
  • Amato, M. P., Langdon, D., Montalban, X., Benedict, R. H. B., DeLuca, J., Krupp, L. B., … Comi, G. (2013). Treatment of cognitive impairment in multiple sclerosis: Position paper. Journal of Neurology, 260, 1452–1468. doi: 10.1007/s00415-012-6678-0
  • Arnett, P. A., & Strober, L. B. (2011). Cognitive and neurobehavioral features in multiple sclerosis. Expert Review of Neurotherapeutics, 11, 411–424. doi: 10.1586/ern.11.12
  • Bailey, A., Channon, S., & Beaumont, J. G. (2007). The relationship between subjective fatigue and cognitive fatigue in advanced multiple sclerosis. Multiple Sclerosis Journal, 13, 73–80. doi: 10.1177/1352458506071162
  • Baughman, B. C., Basso, M. R., Sinclair, R. R., Combs, D. R., & Roper, B. L. (2015). Staying on the job: The relationship between work performance and cognition in individuals diagnosed with multiple sclerosis. Journal of Clinical and Experimental Neuropsychology, 37, 630–640. doi: 10.1080/13803395.2015.1039963
  • Benedict, R. H. B., Cookfair, D., Gavett, R., Gunther, M., Munschauer, F., Garg, N., & Weinstock-Guttman, B. (2006). Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS). Journal of the International Neuropsychological Society, 12, 549–558. doi: 10.1017/S1355617706060723
  • Benedict, R. H. B., Munschauer, F., Linn, R., Miller, C., Murphy, E., Foley, F. W., & Jacobs, L. (2003). Screening for multiple sclerosis cognitive impairment using a self-administered 15-item questionnaire. Multiple Sclerosis Journal, 9, 95–101. doi: 10.1191/1352458503ms861oa
  • Benedict, R. H. B., Wahlig, E., Bakshi, R., Fishman, I., Munschauer, F., Zivadinov, R., & Weinstock-Guttman, B. (2005). Predicting quality of life in multiple sclerosis: Accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change. Journal of the Neurological Sciences, 231, 29–34. doi: 10.1016/j.jns.2004.12.009
  • Benito-Leon, J., Morales, J. M., & Rivera-Navarro, J. (2002). Health-related quality of life and its relationship to cognitive and emotional functioning in multiple sclerosis patients. European Journal of Neurology, 9, 497–502. doi: 10.1046/j.1468-1331.2002.00450.x
  • Borenstein, M., Hedges, L., Higgins, L., & Rothstein, H. (2005). Comprehensive meta-analysis version 2. Engelwood, NJ: Biostat.
  • Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009). Introduction to meta-analysis. West Sussex: John Wiley & Sons.
  • *Brissart, H., Leroy, M., Morele, E., Baumann, C., Spitz, E., & Debouverie, M. (2013). Cognitive rehabilitation in multiple sclerosis. Neurocase, 19, 553–565. doi: 10.1080/13554794.2012.701644
  • *Campbell, J., Langdon, D., Cercignani, M., & Rashid, W. (2016). A randomised controlled trial of efficacy of cognitive rehabilitation in multiple sclerosis: A cognitive, behavioural, and MRI study. Neural Plasticity 2016, 4292585. doi:10.1155/2016/4292585.
  • *Carr, S. E., das Nair, R., Schwartz, A. F., & Lincoln, N. B. (2014). Group memory rehabilitation for people with multiple sclerosis: A feasibility randomized controlled trial. Clinical Rehabilitation, 28, 552–561. doi: 10.1177/0269215513512336
  • *Cerasa, A., Gioia, M. C., Valentino, P., Nisticò, R., Chiriaco, C., Pirritano, D., … Quattrone, A. (2013). Computer-assisted cognitive rehabilitation of attention deficits for multiple sclerosis: A randomized trial with fMRI correlates. Neurorehabilitation and Neural Repair, 27, 284–295. doi: 10.1177/1545968312465194
  • *Charvet, L. E., Yang, J., Shaw, M. T., Sherman, K., Haider, L., Xu, J., … Friede, T. (2017). Cognitive function in multiple sclerosis improves with telerehabilitation: Results from a randomized controlled trial. PLoS ONE, 12, e0177177. doi: 10.1371/journal.pone.0177177
  • Chiaravalloti, N. D., & DeLuca, J. (2008). Cognitive impairment in multiple sclerosis. The Lancet Neurology, 7, 1139–1151. doi: 10.1016/S1474-4422(08)70259-X
  • *Chiaravalloti, N. D., DeLuca, J., Moore, N. B., & Ricker, J. H. (2005). Treating learning impairments improves memory performance in multiple sclerosis: A randomized clinical trial. Multiple Sclerosis Journal, 11, 58–68. doi: 10.1191/1352458505ms1118oa
  • *Chiaravalloti, N. D., Moore, N. B., Nikelshpur, O. M., & DeLuca, J. (2013). An RCT to treat learning impairment in multiple sclerosis: The MEMREHAB trial. Neurology, 81, 2066–2072. doi: 10.1212/01.wnl.0000437295.97946.a8
  • Cicerone, K. D., Langenbahn, D. M., Braden, C., Malec, J. F., Kalmar, K., Fraas, M., … Ashman, T. (2011). Evidence-based cognitive rehabilitation: Updated review of the literature from 2003 through 2008. Archives of Physical Medicine and Rehabilitation, 92, 519–530. doi: 10.1016/j.apmr.2010.11.015
  • Cohen, J. (1988). Statistical power analysis for the behavioral sciences. Hillsdale: Lawrence Erlbaum Associates.
  • dasNair, R., Martin, K. J., & Lincoln, N. B. (2016). Memory rehabilitation for people with multiple sclerosis (review). Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD008754.pub2
  • *De Giglio, L., Tona, F., De Luca, F., Petsas, N., Prosperini, L., Bianchi, V., … Pantano, P. (2016). Multiple sclerosis: Changes in thalamic resting-state functional connectivity induced by a home-based cognitive rehabilitation program. Radiology, 280, 202–211. doi: 10.1148/radiol.2016150710
  • DeLuca, J., Barbieri-Berger, S., & Johnson, S. K. (1994). The nature of memory impairments in multiple sclerosis: Acquisition versus retrieval. Journal of Clinical and Experimental Neuropsychology, 16, 183–189. doi: 10.1080/01688639408402629
  • DeLuca, J., Gaudino, E. A., Diamond, B. J., Christodoulou, C., & Engel, R. A. (1998). Acquisition and storage deficits in multiple sclerosis. Journal of Clinical and Experimental Neuropsychology, 20, 376–390. doi: 10.1076/jcen.20.3.376.819
  • DeLuca, J., Leavitt, V. M., Chiaravalloti, N. D., & Wylie, G. (2013). Memory impairment in multiple sclerosis is due to a core deficit in initial learning. Journal of Neurology, 260, 2491–2496. doi: 10.1007/s00415-013-6990-3
  • Duquette, P., Pleines, J., Girard, M., Charest, L., Senecal-Quevillon, M., & Masse, C. (1992). The increased susceptibility of women to multiple sclerosis. Canadian Journal of Neurological Sciences, 19, 466–471. doi: 10.1017/S0317167100041664
  • *Filippi, M., Riccitelli, G., Mattioli, F., Capra, R., Stampatori, C., Pagani, E., … Rocca, M. A. (2012). Multiple sclerosis: Effects of cognitive rehabilitation on structural and functional MR imaging measures--an explorative study. Radiology, 262, 932–940. doi: 10.1148/radiol.11111299
  • *Fink, F., Rischkau, E., Butt, M., Klein, J., Eling, P., & Hildebrandt, H. (2010). Efficacy of an executive function intervention programme in MS: A placebo-controlled and pseudo-randomized trial. Multiple Sclerosis Journal, 16, 1148–1151 doi: 10.1177/1352458510375440
  • *Gich, J., Freixanet, J., García, R., Vilanova, J. C., Genís, D., Silva, Y., … Ramió-Torrentà, L. (2015). A randomized, controlled, single-blind, 6-month pilot study to evaluate the efficacy of MS-Line!: A cognitive rehabilitation programme for patients with multiple sclerosis. Multiple Sclerosis Journal, 21, 1332–1343. doi: 10.1177/1352458515572405
  • Glass, G. (1977). Integrating findings: The meta-analysis of research. Review of Research in Education, 5, 351–379.
  • Goretti, B., Viterbo, R. G., Portaccio, E., Niccolai, C., Hakiki, B., Piscolla, E., … Amato, M. P. (2014). Anxiety state affects information processing speed in patients with multiple sclerosis. Neurological Sciences, 35, 559–563. doi: 10.1007/s10072-013-1544-0
  • *Goverover, Y., Chiaravalloti, N. D., Genova, H., & DeLuca, J. (2018). A randomized controlled trial to treat impaired learning and memory in multiple sclerosis: The self-GEN trial. Multiple Sclerosis Journal, 24(8), 1096–1104. doi: 10.1177/1352458517709955
  • Grech, L. B., Kiropoulos, L. A., Kirby, K. M., Butler, E., Paine, M., & Hester, R. (2015). The effect of executive function on stress, depression, anxiety, and quality of life in multiple sclerosis. Journal of Clinical and Experimental Neuropsychology, 37, 549–562. doi: 10.1080/13803395.2015.1037723
  • *Hancock, L. M., Bruce, J. M., Bruce, A. S., & Lynch, S. G. (2015). Processing speed and working memory training in multiple sclerosis: A double-blind randomized controlled pilot study. Journal of Clinical and Experimental Neuropsychology, 37, 113–127. doi: 10.1080/13803395.2014.989818
  • *Hanssen, K. T., Beiske, A. G., Landro, N. I., Hofoss, D., & Hessen, E. (2016). Cognitive rehabilitation in multiple sclerosis: A randomized controlled trial. Acta Neurologica Scandinavica, 133, 30–40. doi: 10.1111/ane.12420
  • Harel, Y., Appleboim, N., Lavie, M., & Achiron, A. (2009). Single dose of methylphenidate improves cognitive performance in multiple sclerosis patients with impaired attention process. Journal of the Neurological Sciences, 276, 38–40. doi: 10.1016/j.jns.2008.08.025
  • Hedges, L., & Olkin, I. (1985). Statistical methods for meta-analysis. New York, NY: Academic Press.
  • Hedges, L. V. (1981). Distribution theory for Glass’s estimator of effect size and related estimators. Journal of Educational Statistics, 6, 107–128. doi: 10.3102/10769986006002107
  • *Hildebrandt, H., Lanz, M., Hahn, H. K., Hoffmann, E., Schwarze, B., Schwendemann, G., & Kraus, J. A. (2007). Cognitive training in MS: Effects and relation to brain atrophy. Restorative Neurology and Neuroscience, 25, 33–43.
  • Johnson, S. K., Lange, G., DeLuca, J., Korn, L. R., & Natelson, B. (1997). The effects of fatigue on neuropsychological performance in patients with chronic fatigue syndrome, multiple sclerosis, and depression. Applied Neuropsychology, 4, 145–153. doi: 10.1207/s15324826an0403_1
  • *Jonsson, A., Korfitzen, E. M., Heltberg, A., Ravnborg, M. H., & Byskov-Ottosen, E. (1993). Effects of neuropsychological treatment in patients with multiple sclerosis. Acta Neurologica Scandinavica, 88, 394–400. doi: 10.1111/j.1600-0404.1993.tb05366.x
  • Kalmar, J. H., Gaudino, E. A., Moore, N. B., Halper, J., & DeLuca, J. (2008). The relationship between cognitive deficits and everyday functional activities in multiple sclerosis. Neuropsychology, 22, 442–449. doi: 10.1037/0894-4105.22.4.442
  • Klein, O. A., Drummond, A., Mhizha-Murira, J. R., Mansford, L., & dasNair, R. (2017). Effectiveness of cognitive rehabilitation for people with multiple sclerosis: A meta-synthesis of patient perspectives. Neuropsychological Rehabilitation, 1–22. doi: 10.1080/09602011.2017.1309323
  • Krupp, L. B., Christodoulou, C., Melville, P., Scherl, W. F., MacAllister, W. S., & Elkins, L. E. (2004). Donepezil improved memory in multiple sclerosis in a randomized clinical trial. Neurology, 63, 1579–1585. doi: 10.1212/01.WNL.0000142989.09633.5A
  • Krupp, L. B., Serafin, D. J., & Christodoulou, C. (2010). Multiple sclerosis-associated fatigue. Expert Review of Neurotherapeutics, 10, 1437–1447. doi: 10.1586/ern.10.99
  • LaRocca, N. (2011). Cognitive impairment and mood disturbances. In B. Giesser (Ed.), Primer on multiple sclerosis (pp. 241–262). New York: Oxford University Press.
  • Lester, K., Stepleman, L., & Hughes, M. (2007). The association of illness severity, self-reported cognitive impairment, and perceived illness management with depression and anxiety in a multiple sclerosis clinic population. Journal of Behavioral Medicine, 30, 177–186. doi: 10.1007/s10865-007-9095-6
  • *Lincoln, N. B., Dent, A., Harding, J., Weyman, N., Nicholl, C., Blumhardt, L. D., & Playford, E. D. (2002). Evaluation of cognitive assessment and cognitive intervention for people with multiple sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry, 72, 93–98. doi: 10.1136/jnnp.72.1.93
  • Lublin, F. D., & Reingold, S. C. (1996). Defining the clinical course of multiple sclerosis results of an international survey. Neurology, 46, 907–911. doi: 10.1212/WNL.46.4.907
  • Lublin, F. D., Reingold, S. C., Cohen, J. A., Cutter, G. R., Sørensen, P. S., Thompson, A. J., … Polman, C. H. (2014). Defining the clinical course of multiple sclerosis the 2013 revisions. Neurology, 83, 278–286. doi: 10.1212/WNL.0000000000000560
  • *Mantynen, A., Rosti-Otajarvi, E., Koivisto, K., Lilja, A., Huhtala, H., & Hamalainen, P. (2014). Neuropsychological rehabilitation does not improve cognitive performance but reduces perceived cognitive deficits in patients with multiple sclerosis: A randomised, controlled, multi-centre trial. Multiple Sclerosis Journal, 20, 99–107. doi: 10.1177/1352458513494487
  • *Mattioli, F., Stampatori, C., Zanotti, D., Parrinello, G., & Capra, R. (2010). Efficacy and specificity of intensive cognitive rehabilitation of attention and executive functions in multiple sclerosis. Journal of the Neurological Sciences, 288, 101–105. doi: 10.1016/j.jns.2009.09.024
  • *Mattioli, F., Stampatori, C., Bellomi, F., Danni, M., Compagnucci, L., Uccelli, A., … Capra, R. (2015). A RCT comparing specific intensive cognitive training to aspecific psychological intervention in RRMS: The SMICT study. Frontiers in Neurology, 5, 1139. doi: 10.3389/fneur.2014.00278
  • *Mendoza, R. J., Pittenger, D. W., & Weinstein, C. S. (2001). Unit management of depression of patients with multiple sclerosis using cognitive remediation strategies: A preliminary study. Neurorehabilitation and Neural Repair, 15, 9–14. doi: 10.1177/154596830101500102
  • *Mendozzi, L., Pugnetti, L., Motta, A., Barbieri, E., Gambini, A., & Cazzullo, C. L. (1998). Computer-assisted memory retraining of patients with multiple sclerosis. The Italian Journal of Neurological Sciences, 19, S431–S438. doi: 10.1007/BF00539601
  • Middleton, L. S., Denney, D. R., Lynch, S. G., & Parmenter, B. (2006). The relationship between perceived and objective cognitive functioning in multiple sclerosis. Archives of Clinical Neuropsychology, 21, 487–494. doi: 10.1016/j.acn.2006.06.008
  • Mitolo, M., Venneri, A., Wilkinson, I. D., & Sharrach, B. (2015). Cognitive rehabilitation in multiple sclerosis: A systematic review. Journal of the Neurological Sciences, 354, 1–9. doi: 10.1016/j.jns.2015.05.004
  • Morrow, S. A., Drake, A., Zivadinov, R., Munschauer, F., Weinstock-Guttman, B., & Benedict, R. H. B. (2010). Predicting loss of employment over three years in multiple sclerosis: Clinically meaningful cognitive decline. The Clinical Neuropsychologist, 24, 1131–1145. doi: 10.1080/13854046.2010.511272
  • *Mousavi, S., Zare, H., Etemadifar, M., & Neshatdoost, H. T. (2018). Memory rehabilitation for the working memory of patients with multiple sclerosis (MS). Journal of Clinical and Experimental Neuropsychology, 40, 405–410. doi: 10.1080/13803395.2017.1356269
  • National Multiple Sclerosis Society. (n.d). MS prevalence. Retrieved from http://www.nationalmssociety.org/About-the-Society/MS-Prevalence
  • O’Brien, A., Gaudino-Goering, E., Shawaryn, M., Komaroff, E., Moore, N. B., & DeLuca, J. (2007). Relationship of the multiple sclerosis neuropsychological questionnaire (MSNQ) to functional, emotional, and neuropsychological outcomes. Archives of Clinical Neuropsychology, 22, 933–948. doi: 10.1016/j.acn.2007.07.002
  • O’Brien, A. R., Chiaravalloti, N., Goverover, Y., & DeLuca, J. (2008). Evidenced-based cognitive rehabilitation for persons with multiple sclerosis: A review of the literature. Archives of Physical Medicine and Rehabilitation, 89, 761–769. doi: 10.1016/j.apmr.2007.10.019
  • Orwin, R. G. (1983). A fail-safe N for effect size in meta-analysis. Journal of Educational Statistics, 8, 157–159.
  • Parmenter, B. A., Denney, D. R., & Lynch, S. G. (2003). The cognitive performance of patients with multiple sclerosis during periods of high and low fatigue. Multiple Sclerosis Journal, 9, 111–118. doi: 10.1191/1352458503ms859oa
  • Paul, R. H., Beatty, W. W., Schneider, R., Blanco, C. R., & Hames, K. A. (1998). Cognitive and physical fatigue in multiple sclerosis: Relations between self-report and objective performance. Applied Neuropsychology, 5, 143–148. doi: 10.1207/s15324826an0503_5
  • *Pedullà, L., Brichetto, G., Tacchino, A., Vassallo, C., Zaratin, P., Battaglia, M. A., … Bove, M. (2016). Adaptive vs. non-adaptive cognitive training by means of a personalized app: A randomized trial in people with multiple sclerosis. Journal of NeuroEngineering and Rehabilitation, 13, 1221. doi: 10.1186/s12984-016-0193-y
  • *Pérez-Martín, M. Y., González-Platas, M., Eguía-del Rio, P., Croissier-Elías, C., & Sosa, A. J. (2017). Efficacy of a short cognitive training program in patients with multiple sclerosis. Neuropsychiatric Disease and Treatment, 13, 245–252. doi: 10.2147/NDT.S124448
  • Planche, V., Gibelin, M., Cregut, D., Pereira, B., & Clavelou, P. (2016). Cognitive impairment in a population-based study of patients with multiple sclerosis: Differences between late relapsing-remitting, secondary progressive and primary progressive multiple sclerosis. European Journal of Neurology, 23, 282–289. doi: 10.1111/ene.12715
  • *Pusswald, G., Mildner, C., Zebenholzer, K., Auff, E., & Lehrner, J. (2014). A neuropsychological rehabilitation program for patients with multiple sclerosis based on the model of the ICF. NeuroRehabilitation, 35, 519–527. doi: 10.3233/NRE-141145
  • Rao, S. M., Grafman, J., DiGuilio, D., & Mittenberg, W. (1993). Memory dysfunction in multiple sclerosis: Its relation to working memory, semantic encoding and implicit learning. Neuropsychology, 7, 364–374. doi: 10.1037/0894-4105.7.3.364
  • *Rilo, O., Peña, J., Ojeda, N., Rodríguez-Antigüedad, A., Mendibe-Bilbao, M., Gómez-Gastiasoro, A., … Ibarretxe-Bilbao, N. (2018). Integrative group-based cognitive rehabilitation efficacy in multiple sclerosis: A randomized clinical trial. Disability and Rehabilitation, 40, 208–216. doi: 10.1080/09638288.2016.1250168
  • Rogers, J. M., & Panegyres, P. K. (2007). Cognitive impairment in multiple sclerosis: Evidence-based analysis and recommendations. Journal of Clinical Neuroscience, 14, 919–927. doi: 10.1016/j.jocn.2007.02.006
  • Rosenthal, R. (1986). Meta-analytic procedures for social research. London: Sage.
  • Rosti-Otajarvi, E. M., & Hamalainen, P. (2014). Neuropsychological rehabilitation for multiple sclerosis. Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD009131.pub3
  • Savettieri, G., Messina, D., Andreoli, V., Bonavita, S., Caltagirone, C., Cittadella, R., … Quattrone, A. (2004). Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis. Journal of Neurology, 251, 1208–1214. doi: 10.1007/s00415-004-0508-y
  • *Shatil, E., Metzer, A., Horvitz, O., & Miller, A. (2010). Home-based personalized cognitive training in MS patients: A study of adherence and cognitive performance. NeuroRehabilitation, 26, 143–153. doi: 10.3233/NRE-2010-0546
  • Smith, M. M., & Arnett, P. A. (2005). Factors related to employment status changes in individuals with multiple sclerosis. Multiple Sclerosis Journal, 11, 602–609. doi: 10.1191/1352458505ms1204oa
  • *Solari, A., Motta, A., Mendozzi, L., Pucci, E., Forni, M., Mancardi, G., & Pozzilli, C. (2004). Computer-aided retraining of memory and attention in people with multiple sclerosis: A randomized, double-blind controlled trial. Journal of the Neurological Sciences, 222, 99–104. doi: 10.1016/j.jns.2004.04.027
  • Strober, L. B., Rao, S. M., Lee, J.-C., Fischer, E., & Rudick, R. (2014). Cognitive impairment in multiple sclerosis: An 18 year follow-up study. Multiple Sclerosis and Related Disorders, 3, 473–481. doi: 10.1016/j.msard.2014.03.004
  • *Stuifbergen, A. K., Becker, H., Perez, F., Morison, J., Kullberg, V., & Todd, A. (2012). A randomized controlled trial of a cognitive rehabilitation intervention for persons with multiple sclerosis. Clinical Rehabilitation, 26, 882–893. doi: 10.1177/0269215511434997
  • Tarrier, N., & Wykes, T. (2004). Is there evidence that CBT is an effective treatment for schizophrenia: A cautious or cautionary tale? Behaviour Research and Therapy, 42, 1377–1401. doi: 10.1016/j.brat.2004.06.020
  • *Tesar, N., Bandion, K., & Baumhackl, U. (2005). Efficacy of a neuropsychological training programme for patients with multiple sclerosis – a randomised controlled trial. Wiener Klinische Wochenschrift, 117, 747–754. doi: 10.1007/s00508-005-0470-4
  • Thornton, A. E., Raz, N., & Tucke, K. A. (2002). Memory in multiple sclerosis: Contextual encoding deficits. Journal of the International Neuropsychological Society, 8, 395–409. doi: 10.1017/S1355617702813200
  • *Vogt, A., Kappos, L., Calabrese, P., Stocklin, M., Gschwind, L., Opwis, K., & Penner, I. K. (2009). Working memory training in patients with multiple sclerosis--comparison of two different training schedules. Restorative Neurology and Neuroscience, 27, 225–235. doi: 10.3233/RNN-2009-0473
  • Wykes, T., Huddy, V., Cellard, C., McGurk, S. R., & Czobor, P. (2011). A meta-analysis of cognitive remediation for schizophrenia: Methodology and effect sizes. American Journal of Psychiatry, 168, 472–485. doi: 10.1176/appi.ajp.2010.10060855
  • * Denotes inclusion of the study in the meta-analysis.

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