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Articles

Quantitative evaluation of the consciousness level of patients in a vegetative state using virtual reality and an eye-tracking system: A single-case experimental design study

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Pages 2628-2645 | Received 14 Mar 2021, Accepted 25 Aug 2021, Published online: 06 Sep 2021

References

  • Andrews, K., Murphy, L., Munday, R., & Littlewood, C. (1996). Misdiagnosis of the vegetative state: Retrospective study in a rehabilitation unit. BMJ, 313(7048), 13–16. https://doi.org/10.1136/bmj.313.7048.13
  • Bagnato, S., Boccagni, C., Sant’Angelo, A., Fingelkurts, A. A., Fingelkurts, A. A., & Galardi, G. (2017). Longitudinal assessment of clinical signs of recovery in patients with unresponsive wakefulness syndrome after traumatic or nontraumatic brain injury. Journal of Neurotrauma, 34(2), 535–539. https://doi.org/10.1089/neu.2016.4418
  • Blascheck, T., Kurzhals, K., Raschke, M., Burch, M., Weiskopf, D., & Ertl, T. (2017). Visualization of eye tracking data: A taxonomy and survey. Computer Graphics Forum, 36(8), 260–284. https://doi.org/10.1111/cgf.13079
  • Burke, M., & Barnes, G. (2006). Quantitative differences in smooth pursuit and saccadic eye movements. Experimental Brain Research, 175(4), 596–608. https://doi.org/10.1007/s00221-006-0576-6
  • Candelieri, A., Cortese, M. D., Dolce, G., Riganello, F., & Sannita, W. G. (2011). Visual pursuit: Within-day variability in the severe disorder of consciousness. Journal of Neurotrauma, 28(10), 2013–2017. https://doi.org/10.1089/neu.2011.1885
  • Childs, N. L., Mercer, W. N., & Childs, H. W. (1993). Accuracy of diagnosis of persistent vegetative state. Neurology, 43(8), 1465–1467. https://doi.org/10.1212/WNL.43.8.1465
  • Chittaro, L., Sioni, R., Crescentini, C., & Fabbro, F. (2017). Mortality salience in virtual reality experiences and its effects on users’ attitudes towards risk. International Journal of Human-Computer Studies, 101, 10–22. https://doi.org/10.1016/j.ijhcs.2017.01.002
  • Cortese, M. D., Riganello, F., Arcuri, F., Pugliese, M. E., Lucca, L. F., Dolce, G., Sannita WG. (2015). Coma recovery scale-r: Variability in the disorder of consciousness. BMC Neurology, 15(1), 1–7. https://doi.org/10.1186/s12883-015-0455-5
  • Elor, A., Kurniawan, S., & Teodorescu, M. (2018). Towards an immersive virtual reality game for smarter post-stroke rehabilitation. Proc Int Conf Smart Comput SMARTCOMP, 219–225. https://doi.org/10.1109/SMARTCOMP.2018.00094
  • Giacino, J. T., Ashwal, S., Childs, N., Cranford, R., Jennett, B., Katz, D. I., Kelly J.P., Rosenberg J.H., Whyte J., Zafonte R.D., Zasler N.D. (2002). The minimally conscious state: Definition and diagnostic criteria. Neurology, 58(3), 349–353. https://doi.org/10.1212/WNL.58.3.349
  • Giacino, J. T., Fins, J. J., Laureys, S., & Schiff, N. D. (2014). Disorders of consciousness after acquired brain injury: The state of the science. Nature Reviews Neurology, 10(2), 99–114. https://doi.org/10.1038/nrneurol.2013.279
  • Giacino, J. T., Schnakers, C., Rodriguez-Moreno, D., Kalmar, K., Schiff, N., & Hirsch, J. (2009). Behavioral assessment in patients with disorders of consciousness: Gold standard or fool’s gold? Progress in Brain Research, 177, 33–48. https://doi.org/10.1016/S0079-6123(09)17704-X
  • Gruart, A., Blázquez, P., & Delgado-García, J. (1995). Kinematics of unconditioned and conditioned eyelid movements in the alert cat. Journal of Neurophysiology, 74(1), 226–248. https://doi.org/10.1152/jn.1995.74.1.226
  • Kondziella, D., Friberg, C. K., Frokjaer, V. G., Fabricius, M., & Møller, K. (2016). Preserved consciousness in vegetative and minimal conscious states: Systematic review and meta-analysis. Journal of Neurology Neurosurgery & Psychiatry, 87(5), 485–492. https://doi.org/10.1136/jnnp-2015-310958
  • Krassanakis, V., Filippakopoulou, V., & Nakos, B. (2014). EyeMMV toolbox: An eye movement post-analysis tool based on a two-step spatial dispersion threshold for fixation identification. J Eye Mov. Res, 7(1), doi:https://doi.org/10.16910/jemr.7.1.1.
  • Løvstad, M., Frøslie, K. F., Giacino, J. T., Skandsen, T., Anke, A., & Schanke, A. K. (2010). Reliability and diagnostic characteristics of the JFK Coma Recovery scale–revised. Journal of Head Trauma Rehabilitation, 25(5), 349–356. https://doi.org/10.1097/HTR.0b013e3181cec841
  • Majerus, S., Gill-Thwaites, H., Andrews, K., & Laureys, S. (2005). Behavioral evaluation of consciousness in severe brain damage. Progress in Brain Research, 150, 397–413. https://doi.org/10.1016/S0079-6123(05)50028-1
  • Medical aspects of the persistent vegetative state. (1994). The multi-society task force on PVS. New England Journal of Medicine, 330(21), 1499–1508. https://doi.org/10.1056/NEJM199405263302107
  • Nagel, M., Sprenger, A., Hohagen, F., Binkofski, F., & Lencer, R. (2008). Cortical mechanisms of retinal and extraretinal smooth pursuit eye movements to different target velocities. Neuroimage, 41(2), 483–492. https://doi.org/10.1016/j.neuroimage.2008.02.058
  • Parsons, T. D., Silva, T. M., Pair, J., & Rizzo, A. A. (2008). Virtual environment for assessment of neurocognitive functioning: Virtual reality cognitive performance assessment test. Studies in Health Technology and Informatics, 132, 351–356.
  • Piumsomboon, T., Lee, G., Lindeman, R. W., & Billinghurst, M. (2017). Exploring natural eye-gaze-based interaction for immersive virtual reality. Proc IEEE Symp. 3D User Interfaces, 36–39. https://doi.org/10.1109/3DUI.2017.7893315.
  • Royal College of Physicians. (2020). Prolonged disorders of consciousness following sudden onset brain injury: National clinical guidelines. RCP.
  • Sattin, D., Giovannetti, A. M., Ciaraffa, F., Covelli, V., Bersano, A., Nigri, A., Ferraro S., Minati L., Rossi D., Duran D., Parati E., Leonardi M., (2014). Assessment of patients with disorder of consciousness: Do different Coma Recovery Scale scoring correlate with different settings? Journal of Neurology, 261(12), 2378–2386. https://doi.org/10.1007/s00415-014-7478-5
  • Sattin, D., Sebastiano, D. R., D’Incerti, L., Guido, D., Marotta, G., Benti, R., Tirelli S., Magnani F.G., Bersano A., Duran D., Ferraro S., Minati L., Nigri A., Rosazza C., Bianchi Marzoli S., Leonardi M. (2020). Visual behaviors in disorders of consciousness: Disentangling conscious visual processing by a multimodal approach. European Journal of Neuroscience, 52(10), 4345–4355. https://doi.org/10.1111/ejn.14875
  • Sattin, D., Sebastiano, D. R., Magnani, F. G., D'Incerti L., Marotta G., Benti R., Tirelli S., Bersano A., Duran D., Visani E., Ferraro S., Minati L., Nigri A., Rosazza C., Bianchi Marzoli S., Ciasca P., Carcagni A., Bruzzone M.G., Franceschetti S., Leonardi M., Guido D., (2021). Visual fixation in disorders of consciousness: Development of predictive models to support differential diagnosis. Physiology & Behavior, 230, 113310. https://doi.org/10.1016/j.physbeh.2021.113310
  • Schnakers, C., Vanhaudenhuyse, A., Giacino, J., Ventura, M., Boly, M., Majerus, S., Moonen G., Laureys S. (2009). Diagnostic accuracy of the vegetative and minimally conscious state: Clinical consensus versus standardized neurobehavioral assessment. BMC Neurology, 9(35), https://doi.org/10.1186/1471-2377-9-35
  • Seel, R. T., Sherer, M., Whyte, J., Katz, D. I., Giacino, J. T., Rosenbaum, A. M., Hammond F. M., Kalmar K., Pape T. L-B., Zafonte R., Biester R. C., Kaelin D., Kean J., Zasler N., (2010). Assessment scales for disorders of consciousness: Evidence-based recommendations for clinical practice and research. Archives of Physical Medicine and Rehabilitation, 91(12), 1795–1813. https://doi.org/10.1016/j.apmr.2010.07.218
  • Tavy, D. L., van Woerkom, T. C., Bots, G. T., & Endtz, L. J. (1984). Persistence of the blink reflex to sudden illumination in a comatose patient: A clinical and pathologic study. Archives of Neurology, 41(3), 323–324. https://doi.org/10.1001/archneur.1984.04050150105025
  • Thonnard, M., Wannez, S., Keen, S., Brédart, S., Bruno, M.-A., Gosseries, O., Demertzi A., Thibaut A., Chatelle C., Charland-Verville V., Heine L., Habbal D., Laureys S., Vanhaudenhuyse A. (2014). Detection of visual pursuit in patients in minimally conscious state: A matter of stimuli and visual plane? Brain Injury, 28(9), 1164–1170. https://doi.org/10.3109/02699052.2014.920521
  • Trojano, L., Moretta, P., Loreto, V., Cozzolino, A., Santoro, L., & Estraneo, A. (2012). Quantitative assessment of visual behavior in disorders of consciousness. Journal of Neurology, 259(9), 1888–1895. https://doi.org/10.1007/s00415-012-6435-4
  • Vanhaudenhuyse, A., Giacino, J., Schnakers, C., Kalmar, C., Smart, M., Bruno, A., Gosseries O., Moonen G., Laureys S. (2008). Blink to visual threat does not herald consciousness in the vegetative state. Neurology, 71(17), 1374–1375. https://doi.org/10.1212/01.wnl.0000320110.70134.60
  • Wannez, S., Hoyoux, T., Langohr, T., Bodart, O., Martial, C., Wertz, J., Chatelle C., Verly J. G., Laureys S., (2017). Objective assessment of visual pursuit in patients with disorders of consciousness: An exploratory study. Journal of Neurology, 264(5), 928–937. https://doi.org/10.1007/s00415-017-8469-0
  • Zhou, F., Li, H., Wang, K., He, Y., Chen, Y., Ni, X., Guo Y., Lv W., Zhang J., Xie Q., Yu R., (2018). Finger or light: Stimulation sensitivity of visual startle in the Coma Recovery Scale-Revised for disorders of consciousness. Neuroscience Bulletin, 34(4), 709–712. https://doi.org/10.1007/s12264-018-0261-3

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