In vitro antibiofilm, antibacterial, antioxidant, and antitumor activities of the brown alga Padina pavonica biomass extract

References

• Agregán R, Munekata PES, Franco D, Carballo J, Barba FJ, Lorenzo JM. 2018. Antioxidant potential of extracts obtained from macro- (ascophyllum nodosum, fucus vesiculosus, and bifurcaria bifurcata) and micro-algae (chlorella vulgaris and spirulina platensis) assisted by ultrasound. Medicines. 5(2):10–33. doi:10.3390/medicines5020033.
   Google Scholar
• Aisha K, Shameel M 2010. Occurrence of the Genus Padina (Dictyophyceae, Phaeophycota) in the Coastal Waters of Karachi. Pakistan Journal of Botany. 42:319–340.
   Web of Science ®Google Scholar
• Al-Araby SQ, Rahman MA, Chowdhury MAH, Das RR, Chowdhury TA, Hasan CMM, Afroze M, Hashem MA, Hajjar D, Alelwani W, et al. 2020. Padina tenuis (marine alga) attenuates oxidative stress and streptozotocin-induced type 2 diabetic indices in Wistar albino rats. S Afr J Bot. 128:87–100. doi:10.1016/j.sajb.2019.09.007.
   Web of Science ®Google Scholar
• Aleem AA. 1993. The marine algae of alexandria, Egypt (1-55). Alexandria: Privately Published.
   Google Scholar
• Al-Hazzani AA, Shehata AI, Moubayed NMS, Al Houri HJ. 2014. Antimicrobial and biochemical properties of selected edible brown and red marine macroalgae. J Pure Appl Microbiol. 8:1275–1282.
   Google Scholar
• Arsic B, Zhu Y, Heinrichs DE, McGavin MJ. 2012. Induction of the staphylococcal proteolytic cascade by antimicrobial fatty acids in community acquired methicillin resistant Staphylococcus aureus. PLoS ONE. 7(9):45952. doi:10.1371/journal.pone.0045952.
   PubMed Web of Science ®Google Scholar
• Assessing national capacity for the prevention and control of noncommunicable diseases: report of the 2019 global survey. Geneva: World Health Organization; 2020.
   Google Scholar
• Awad NE, Motawe HM, Selim MA, Matloub AA. 2009. Volatile constituents of the brown algae Padina pavonia (L.) gaill. and hydroclathrus clathratus (C. Agardh) howe and their antimicrobial activity. Med Aromat Plant Sci Biotechnol. 3(1):12–15.
   Google Scholar
• Ba-Akdah MA. 2018. Antibiofilm activities of macroalgae sargassum and padina from the red sea, Saudi Arabia. Int J Sci Humanities. 4(1):1–13.
   Google Scholar
• Barba F, Mariutti L, Bragagnolo N, Mercadante A, Barbosa-C G, Orlien V. 2017. Bioaccessibility of bioactive compounds from fruits and vegetables after thermal and nonthermal processing. Trends Food Sci Technol. 28(6):1713–1721. doi:10.1016/j.tifs.2017.07.006.
   Google Scholar
• Benita M, Dubinsky Z, Iluz D. 2018. Padina pavonica: morphology and calcification functions and mechanism. Am J Plant Sci. 9(06):1156–1168. doi:10.4236/ajps.2018.96087.
   Google Scholar
• Blois MS. 1958. Antioxidant determinations by the use of a stable free radical. Nature. 181(4617):1199–1200. doi:10.1038/1811199a0.
   Web of Science ®Google Scholar
• Blunt J, Copp B, Keyzers R, Munro M, Prinsep M. 2015. Marine natural products. Nat Prod Rep. 32(2):116–211. doi:10.1039/C4NP00144C.
   PubMed Web of Science ®Google Scholar
• Blunt JW, Copp BR, Keyzers RA, Munro MH, Prinsep MR. 2016. Marine natural products. Nat Prod Rep. 33:382–431. doi:10.1039/C5NP00156K.
   PubMed Web of Science ®Google Scholar
• Brenner D, Mak TW. 2009. Mitochondrial cell death effectors. Curr Opin Cell Biol. 21:871–877. doi:10.1016/j.ceb.2009.09.004.
   PubMed Web of Science ®Google Scholar
• Carneiro RF, Duarte PL, Chaves RP, da Silva SR, Feitosa RR, de Sousa BL, da Silva Alves AW, de Vasconcelos MA, da Rocha BAM, Teixeira EH, et al. 2020. New lectins from Codium isthmocladum Vickers show unique amino acid sequence and antibiofilm effect on pathogenic bacteria. J Appl Phycol. 32:4263–4276. doi:10.1007/s10811-020-02198-x.
   Web of Science ®Google Scholar
• Curran PJ, Hussong AM. 2003. The use of latent trajectory models in psychopathology research. J Abnorm Psychol. 112(4):526–544. doi:10.1037/0021-843X.112.4.526.
   PubMed Web of Science ®Google Scholar
• Dalia MSAS, Mona MI, Hermine RZT. 2020. Evaluation of the antibiofilm activity of three seaweed species and their biosynthesized iron oxide nanoparticles (Fe3o4-NPs. Egypt J Aquat Res. 46(4):333–339. doi:10.1016/j.ejar.2020.09.001.
   Web of Science ®Google Scholar
• Demir P, Onde S, Severcan F. 2015. Phylogeny of cultivated and wild wheat species using ATR-FTIR spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc. 135:757–763. doi:10.1016/j.saa.2014.07.025.
   PubMed Web of Science ®Google Scholar
• Deyab MA, Habbak LZ, Ward FM. 2012. Antitumor activity of water extract and some fatty acids of Turbinaria ornata. (Turner) J Agardh Egypt J Exp Biol. 8(2):199–204.
   Google Scholar
• Duh PD, Yeh DB, Yen GC. 1992. Extraction and identification of an antioxidative component from peanut hulls. J Am Oil Chem Soc. 69:814–818. doi:10.1007/BF02635922.
   Web of Science ®Google Scholar
• El-Kassas HY, Attia AA. 2014. Bactericidal application and cytotoxic activity of biosynthesized silver nanoparticles with an extract of the red seaweed Pterocladiella capillacea on the HepG2 cell line. Asian Pac J Cancer Prev. 15(3):1299–1306. doi:10.7314/APJCP.2014.15.3.1299.
   PubMedGoogle Scholar
• El-Kassas HY, El-Sheekh MM. 2014. Cytotoxic activity of biosynthesized gold nanoparticles with an extract of the red seaweed corralina officinalis on human breast cancer (MCF-7) cell line. Asian Pac J Cancer Prev. 15(9):4311–4317. doi:10.7314/APJCP.2014.15.10.4311.
   PubMedGoogle Scholar
• El Shafay S, EI-Sheekh MM, Bases E, El-Shenoudy R. 2021. Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts. Food Sci Technol. 42:e20521. doi:10.1590/fst.20521.
   Web of Science ®Google Scholar
• El-Sheekh MM, El Shafey S, El-Shenody R, Bases E. 2020. Comparative assessment of antioxidant activity and biochemical composition of four seaweeds, rocky bay of Abu Qir in Alexandria, Egypt. Food Sci Technol. 41(1):29–40. doi:10.1590/fst.06120.
   Google Scholar
• El-Shenody RA, Ashour M, Ghobara MME. 2019. Evaluating the chemical composition and antioxidant activity of three Egyptian seaweeds: dictyota dichotoma. Turbinaria decurrens, Laurencia obtusa, Braz J Food Technol. 22(7): doi:10.1590/1981-6723.20318.
   Google Scholar
• Farghl A, Al-Hasawi Z, El-Sheekh MM. 2021. Assessment of antioxidant capacity and phytochemical composition of brown and red seaweeds collected from Red Sea coast. Appl Sci. 11:11079. doi:10.3390/app112311079.
   Google Scholar
• Farooqi AA, Butt G, Razzaq Z. 2012. Algae extracts and methyl jasmonate anticancer activities in prostate cancer: choreographers of “the dance macabre. Cancer Cell Int. 12:50. doi:10.1186/1475-2867-12-50.
   PubMed Web of Science ®Google Scholar
• Gadhi AAA, El-Sherbiny MMO, Al-Sofyani AMA, Ba-Akdah MA, Satheesh S. 2018. Antibiofilm activities of extracts of the macroalga Halimeda sp. from the ed sea. J Mar Sci Technol. 26(6):838–846.
   Web of Science ®Google Scholar
• Gheda S, El-Sheekh MM, AbouZeid A. 2018. In vitro anticancer activity of polysaccharide extracted from the red alga Jania rubens against breast and colon cancer cell lines. Asian Pac J Trop Med. 11(10):583–589. doi:10.4103/1995-7645.244523.
   Web of Science ®Google Scholar
• Gomha SM, Riyadh SM, Mahmmoud EA, Elaasser MM. 2015. Synthesis and anticancer activities of thiazoles, 1,3-Thiazines, and Thiazolidine using chitosan-grafted-poly (vinylpyridine) as basic Catalyst. Heterocycles. 91(6):1227–1243. doi:10.3987/COM-15-13210.
   Web of Science ®Google Scholar
• Guiry MD, Guiry GM (2019) AlgaeBase. Galway: National University of Ireland. Retrieved from https://www.algaebase.org/
   Google Scholar
• Gupta S, Cox S, Rajauria G, Jaiswal AK, Abu-Ghannam N. 2012. Growth inhibition of common food spoilage and pathogenic microorganisms in the presence of brown seaweed extracts. Food Bioprocess Technol. 5:1907–1916. doi:10.1007/s11947-010-0502-6.
   Web of Science ®Google Scholar
• Hu Y, Chen J, Hu G, Yu J, Zhu X, Lin Y, Chen S, Yuan J. 2015. Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012. Mar Drugs. 13:202–221. doi:10.3390/md13010202.
   PubMed Web of Science ®Google Scholar
• Hu Y, Pan ZJ, Liao W, Li J, Gruget P, Kitts DD, Lu X. 2016. Determination of antioxidant capacity and phenolic content of chocolate by attenuated total reflectance-Fourier transformed - infrared spectroscopy. Food Chem. 202:254–261. doi:10.1016/j.foodchem.2016.01.130.
   PubMed Web of Science ®Google Scholar
• Ibrahim EA, Aly HF, Baker DHA, Mahmoud K, El-Baz FK. 2016. Marine algal sterol hydrocarbon with anti-inflammatory, anticancer and antioxidant properties. Int J Pharm Bio Sci. 7:392–398.
   Google Scholar
• Ismail GA, Gheda SF, Abo-Shady AM, Abdel-Karim OH. 2020. In vitro potential activity of some seaweeds as antioxidants and inhibitors of diabetic enzymes. Food Sci Technol. 40(3):681–691. doi:10.1590/fst.15619.
   Web of Science ®Google Scholar
• Jha B, Reddy CRK, Thakur MC, Rao MU. 2009. Seaweeds of India: the diversity and distribution of seaweeds of Gujarat coast. Dordrecht: Springer Sci Bus Media. 22(3):381–383. doi:10.1007/s10811-010-9524-8.
   Google Scholar
• Jóźwiak M, Filipowska A, Fiorino F, Struga M. 2020. Anticancer activities of fatty acids and their heterocyclic derivatives. Eur J Pharmacol. 871: 102-097. 10.1016/j.ejphar.2020.172937.
   PubMed Web of Science ®Google Scholar
• Kamenarskaa Z, Gasicb MJ, Zlatovicb M, Rasovicd A, Sladicb D, Kljajicd Z, Stefanova K, Seizovaa K, Najdenskic H, Kujumgievc A, et al. 2002. Chemical composition of the brown alga Padina pavonia (L.) Gaill. from the adriatic sea. Bot Mar. 45:339–345. doi:10.1515/BOT.2002.034.
   Web of Science ®Google Scholar
• Kanaan H, Belous O. 2016. Marine algae of the Lebanese coast. New York: Nova Science Publisher.
   Google Scholar
• Kenny JG, Ward D, Josefsson E, Jonsson IM, Hinds J, Rees HH, Lindsay JA, Tarkowski A, Horsburgh MJ. 2009. The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications. PLoS ONE. 4:4344. doi:10.1371/journal.pone.0004344.
   PubMed Web of Science ®Google Scholar
• Kim EJ, Park SY, Lee JY, Park JH. 2010. Fucoidan present in brown algae induces apoptosis of human colon cancer cells. BMC Gastroenterol. 22:10–96. doi:10.1186/1471-230X-10-96.
   Google Scholar
• Kiuru P, D’Auria MV, Muller CD, Tammela P, Vuorela H, Yli-Kauhaluoma J. 2014. Exploring marine resources for bioactive compounds. Planta Med. 80:1234–1246. doi:10.1055/s-0034-1383001.
   PubMed Web of Science ®Google Scholar
• Lee JT, Connor-Appleton S, Haq AU, Bailey CA, Cartwright AL. 2004. Quantitative measurement of negligible trypsin inhibitor activity and nutrient analysis of guar meal fractions. J Agric Food Chem. 52:6492–6495.
   PubMed Web of Science ®Google Scholar
• Lopez-Santamarina A, Mondragon ADC, Lamas A, Miranda JM, Franco CM, Cepeda A. 2020. Animal-origin prebiotics based on chitin: an alternative for the future? A critical review. Foods. 9(6):782. doi:10.3390/foods9060782.
   PubMed Web of Science ®Google Scholar
• Luis J, Lopez G, Mickael L, Jerome L, Maria-Cruz F, Barouh N, Barea B, Villeneuve P. 2007. Lipase-catalyzed synthesis of chlorogenate fatty esters in solvent-free medium. Enz and Microbial Technol. 41:721–726. doi:10.1016/j.enzmictec.2007.06.004.
   Web of Science ®Google Scholar
• Lu X, Rasco BA. 2012. Determination of antioxidant content and antioxidant activity in foods using infrared spectroscopy and chemometrics: a review. Crit Rev Food Sci Nutr. 52(10):853–875. doi:10.1080/10408398.2010.511322.
   PubMed Web of Science ®Google Scholar
• Madhavi DR, Umamaheswari A, Venkateswarlu K. 1995. Effective concentrations of nitrophenolics toward growth yield of selected microalgae and Cyanobacteria Isolated from Soil. Ecotoxicol Environ Saf. 32(3):205–208. doi:10.1006/eesa.1995.1104.
   PubMed Web of Science ®Google Scholar
• Madsen HL, Bertelsen G. 1995. Spices as antioxidants. Trends Food Sci Technol. 6:271–277. doi:10.1016/S0924-2244(00)89112-8.
   Web of Science ®Google Scholar
• Maisuthisakul P, Suttajit M, Pongsawatmanit R. 2007. Assessment of phenolic content and free radical-scavenging capacity of some Thai indigenous plants. Food Chem. 100:1409–1418. doi:10.1016/j.foodchem.2005.11.032.
   Web of Science ®Google Scholar
• Makhlof MEM, Albalwe FM, Al‑shaikh TM, El‑Sheekh MM. 2022. Suppression effect of ulva lactuca Selenium nanoparticles (USeNps) on HepG2 carcinoma cells resulting from degradation of epidermal growth factor receptor (EGFR) with an evaluation of its antiviral and antioxidant activities. Appl Sci. 12:11645. doi:10.3390/app122211546.
   Google Scholar
• Mellier G, Huang S, Shenoy K, Pervaiz S. 2010. Trailing death in cancer. Mol Asp of Med. 31:93–112. doi:10.1016/j.mam.2009.12.002.
   PubMed Web of Science ®Google Scholar
• Middleton E, Kandaswami C, Theoharides T. 2000. Middleton Jr E, Kandaswami C & Theoharides TC: the effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev. 52(4):673–751.
   PubMed Web of Science ®Google Scholar
• Mofeed J, Deyab M, Sabry A, Ward F. 2021. In vitro anticancer activity of five marine seaweeds extract from Egypt against human breast and colon cancer cell lines. doi:10.21203/rs.3.rs-462221/v1.
   Google Scholar
• Moghadamtousi SZ, Kadir HA, Hassandarvish P, Tajik H, Abubakar S, Zandi K. 2014. A review on antibacterial, antiviral, and antifungal activity of curcumin. Biomed Res Int. 2014:186864. Epub 2014 Apr 29. PMID: 24877064; PMCID: PMC4022204. doi:10.1155/2014/186864.
   PubMed Web of Science ®Google Scholar
• Mohy El-Din SM, El-Ahwany AMD. 2016. Bioactivity and phytochemical constituents of marine red seaweeds (Jania rubens, Corallina mediterranea and Pterocladia capillacea). J Taibah Univ Sci. 10(4):471–484. doi:10.1016/j.jtusci.2015.06.004.
   Web of Science ®Google Scholar
• Mordechai S, Mordechai J, Ramesh J, Levi C, Huleihel M, Erukhimovitch V, Moser A, Kapelushnik J. 2001. Application of FTIR microspectroscopy for the follow-up of childhood leukaemia chemotherapy. Proc SPIE Subsurface Surf Sens Technol Appl III. 4491:243–250.
   Google Scholar
• Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 65:55–63. doi:10.1016/0022-1759(83)90303-4.
   PubMed Web of Science ®Google Scholar
• Nabti E, Jha B, Hartmann A. 2017. Impact of seaweeds on agricultural crop production as biofertilizer. Int J Environ Sci Technol. 14:1119–1134. doi:10.1007/s13762-016-1202-1.
   Web of Science ®Google Scholar
• Nakatani N. 1992. Natural antioxidants from spices. In: Huang MT, Ho CT, and Lee CY, editors. Phenolic compounds in food and their effects on health II: antioxidants and cancer prevention (72–86). Washington, DC: ACS Symposium Series 507. American Chemical Society. pp 8–34.
   Google Scholar
• National Center for Biotechnology Information (2022). PubChem Compound Summary for CID 637566, Geraniol.
   Google Scholar
• Ozdemir G, Horzum Z, Sukatar A, Yavasoglu NUK. 2006. Antimicrobial activities of volatile components and various extracts of dictyopteris membranaceae and cystoseira barbata from the coat of Izmir, Turkey. Pharm Biol. 44:183–188. doi:10.1080/13880200600685949.
   Web of Science ®Google Scholar
• Park AH, Sugiyama M, Harashima S, Kim YH. 2012. Creation of an ethanol-tolerant yeast strain by genome reconstruction based on chromosome splitting technology. J Microbiol Biotechnol. 22(2):184–189. doi:10.4014/jmb.1109.09046.
   PubMed Web of Science ®Google Scholar
• Pereira L, Gheda SF, Ribeiro-Claro PJA. 2013. Analysis by vibrational spectroscopy of seaweed polysaccharides with potential use in food, pharmaceutical, and cosmetic industries. Int J Carbohyd Chem. 537202. doi:10.1155/2013/537202.
   Google Scholar
• Rajasulochana, Dhamotharan R, Krishnamoorthy P, Murugesan S. 2009. Antibacterial activity of the extracts of marine red and brown algae. J Am Sci. 5(3):20–25.
   Google Scholar
• Rebecca L, Siegel MPH, Kimberly D, Miller MPH, Ahmedin Jemal DVM. 2016. Ph.D., Cancer statistics. 66(1):7–30. 10.3322/caac.21332.
   Google Scholar
• Robledo D, Freile-Pelegrin Y. 1997. Chemical and mineral composition of six potentially edible seaweed species of yucatán. Bot Mar - BOT MAR. 40:301–306. doi:10.1515/botm.1997.40.1-6.301.
   Web of Science ®Google Scholar
• Saadaoui I, Rasheed R, Abdulrahman N, Bounnit T, Cherif M, Al Jabri H, Mraiche F. 2020. Algae-derived bioactive compounds with anti-lung cancer potential. Mar Drugs. 18(4):197. doi:10.3390/md18040197.
   PubMed Web of Science ®Google Scholar
• Sameeh MY, Mohamed AA, Elazzazy AM. 2016. Polyphenolic contents and antimicrobial activity of different extracts of padina boryana thivy and enteromorpha sp marine algae. J Appl Pharm Sci. 6(09):087–092. doi:10.7324/JAPS.2016.60913.
   Google Scholar
• Seema FMS, Vijaya PP, Vimal M. 2013. Antioxidant activity of geraniol, geranial acetate, gingerol and eugenol. Res in Pharm. 3(1):01–06.
   Google Scholar
• Shimizu Y. 1996. Microalgal metabolites: a new perspective. Annu Rev Microbiol. 50:431–465. doi:10.1146/annurev.micro.50.1.431.
   PubMed Web of Science ®Google Scholar
• Shinde S, Lee LH, Chu T. 2021. Inhibition of biofilm formation by the synergistic action of EGCG-S and antibiotics. Antibiotics. 10(2):102. doi:10.3390/antibiotics10020102.
   Google Scholar
• Silva SD, Feliciano RP, Boas LV, Bronze MR. 2014. Application of FTIR-ATR to Moscatel dessert wines for prediction of total phenolic and flavonoid contents and antioxidant capacity. Food Chem. 150:489–493. doi:10.1016/j.foodchem.2013.11.028.
   PubMed Web of Science ®Google Scholar
• Singh RK, Kukrety A, Sharma OP, Baranwal S, Atray N, Ray SS. 2016. Study of a novel phenolic-ester as antioxidant additive in lube, biodiesel and blended diesel. J Ind Eng Chem. 37:27–31. doi:10.1016/j.jiec.2016.03.029.
   Web of Science ®Google Scholar
• Sonbol H, Ameen F, AlYahya S, Almansob A, Alwakeel S. 2021. Padina boryana mediated green synthesis of crystalline palladium nanoparticles as potential nanodrug against multidrug resistant bacteria and cancer cells. Sci Rep. 11(2021):5444. doi:10.1038/s41598-021-84794-6.
   PubMedGoogle Scholar
• Souza BWS, Cerqueira MA, Bourbon AI, Pinheiro ACM, J. T, José A, Teixeiraa MAV, A CA. 2012. Chemical characterization and antioxidant activity of sulfated polysaccharide from the red seaweed Gracilaria birdiae. Food Hydrocoll. 27(2):287–292.
   Web of Science ®Google Scholar
• Stepanovic´ S, Vukovic´ D, Hola V, Bonaventura GD, Djukic´ S, C´ Irkovic´ I, Ruzicka F. 2007. Quantification of biofilm in microtiter plates: overview of testing conditions and practical recommendations for assessment of biofilm production by staphylococci. APMIS. 115:891–899. doi:10.1111/j.1600-0463.2007.apm_630.x.
   PubMed Web of Science ®Google Scholar
• Suganya S, Ishwarya R, Jayakumar R, Govindarajan M, Alharbi NS, Kadaikunnan S, Khaled JM, Al-Anbr MN, Vaseeharan B. 2019. New insecticides and antimicrobials derived from Sargassum wightii and Halimeda gracillis seaweeds: toxicity against mosquito vectors and antibiofilm activity against microbial pathogens. S Afr J Bot. 125:466–480. doi:10.1016/j.sajb.2019.08.006.
   Web of Science ®Google Scholar
• Truong H, Nguyen D, Ta N, Bui Anh V, Nguyen HC. 2019. Evaluation of the use of different solvents for phytochemical constituents, antioxidants, and in vitro anti-inflammatory activities of severinia buxifolia. J Food Qual. 1:1–9. doi:10.1155/2019/8178294.
   Google Scholar
• Tüney I, Çadircl BH, Ünal D, Sukatar A. 2006. Antimicrobial activity of the extracts of marine algae from coast of urla (Izmir, Turkey). Turk J Biol. 30:171–175.
   Google Scholar
• Waterman PG, Mole S. 1994. Method in ecology: analysis of phenolic plant metabolites. London: blackwell. Sci Pub. 38(4):1064. doi:10.1016/0031-9422(95)90191-4.
   Google Scholar
• Wijesekara G, Gupta A, Valeo C, Hasbani J-G, Qiao Y, Delaney P, Marceau D. 2012. Assessing the impact of future land-use changes on hydrological processes in the elbow river watershed in Southern Alberta, Canada. J Hydrol. 412:220–232. doi:10.1016/j.jhydrol.2011.04.018.
   Web of Science ®Google Scholar
• World Health Organization (WHO) 2020. Assessing national capacity for the prevention and control of noncommunicable diseases: report of the 2019 global survey. Geneva: World Health Organization.
   Google Scholar
• Yang L, Wang P, Wang H, Li Q, Teng H, Liu Z, Yang W, Hou L, Zou X. 2013. Fucoidan derived from undaria pinnatifada induces apoptosis in human hepatocellular carcinoma SMMC-7721 cells via the ROS mediated mitochondrial pathway. Mar Drugs. 11(6):1961–1976. doi:10.3390/md11061961.
   PubMed Web of Science ®Google Scholar
• Yen GC, Duh PD. 1994. Scavenging effect of methanolic extracts of peanut hulls on free radical and active oxygen species. J Agric Food Chem. 42:629–632. doi:10.1021/jf00039a005.
   Web of Science ®Google Scholar
• Younger P. 2014. The merck index (15th edition). Emerald Group Publ Limited, London. 28(8):38–39. doi:10.1108/RR-08-2014-0224.
   Google Scholar
• Zarovnaya I, Zlenko H, Palchykov V. 2014. Synthesis and neurotropic activity of novel sulfolane-containing cage sulfonamides. Eur Chem Bull. 3:543–547.
   Google Scholar
• Zbakh H, Chiheb H, Bouziane H, Sánchez VM, Riadi H. 2012. Antibacterial activity of benthic marine algae extracts from the Mediterranean coast of Morocco. J Microbiol, Biotechnol Food sci. 2(1):219–228.
   Google Scholar
• Zheng CJ, Yoo JS, Lee TG, Cho HY, Kim YH, Kim WG. 2005. Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids. FEBS Lett. 579:5157–5162. doi:10.1016/j.febslet.2005.08.028.
   PubMed Web of Science ®Google Scholar
• Zugazagoitia J, Biosca M, Oliveira J, Olmedo ME, Dómine M, Nadal E, Ruffinelli JC, Muñoz N, Luna AM, Hernández B, et al. 2018. Incidence, predictors and prognostic significance of thromboembolic disease in patients with advanced ALK-rearranged non-small cell lung cancer. Eur Respir J. 51(5):170. doi:10.1183/13993003.02431-2017.
   Web of Science ®Google Scholar