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International Journal of Food Sciences and Nutrition Volume 51, 2000 - Issue 2
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Research Article

Nutritional and hematological impact of dietary flaxseed and defatted flaxseed meal in rats

Uma S. Babu, Geraldine V. Mitchell, Paddy Wiesenfeld, Mamie Y. Jenkins, Hemavathi Gowda Division of Science and Applied Technology, Office of Special Nutritionals; Division of Science and Applied Technology, Office of Food Labeling Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301, Muirkirk Road, Laurel MD 20708, USA
Pages 109-117 | Published online: 06 Jul 2009

  • Allman MA, Pena MM & Pang D (1995) Supplementation with FS oil versus sunflower seed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur. J. Clin. Nutr. 49, 69-178.
  • Arjmandi BH, Juma S, Lucas EA, Wie LL, Venkatesh S & Khan DA (1998) Effcts of flaxseed supplementation on bone metabolism in postmenopausal women. Proceedings of the 57th Flax Institute, pp. 65-74.
  • Babu US, Bunning VK, Wiesenfeld P, Raybourne RB & O'Donnell M (1997) Effect of dietary flaxseed on fatty acid composition, superoxide, nitric oxide generation and antilisterial activity of peritoneal macrophages from female Sprague-Dawley rats. Life Sci. 60(8), 545-554.
  • Bierenbaum ML, Reichstein R & Watkins TR (1993) Reducing atherogenic risk in hyperlipemic humans with FS supplementation ‘a preliminary report'. J. Am. Coll. Nutr. 12(5), 501- 504.
  • Bieri JG, Tolliver TJ & Catignani GL (1979) Simultaneous determination of a-tocopherol and retinol in plasma and red blood cells by high pressure liquid chromatograph y. Am. J. Clin. Nutr. 32, 2143- 2149.
  • Borchgrevink F, Berg KJ, Skaga E, Skjeggestad O & Stormorken H (1965) Effect of linseed oil on platelet adhesiveness and bleeding-time in patients with coronary heart disease. Lancet 2, 980- 982.
  • Brunvand L, Henriksen C, Larsson M & Sandberg A-S (1995) Iron deficiency among pregnant Pakistanis in Norway and the content of phytic acid in their diet. Acta Obstet. Gynecol. Scand. 74, 520- 525.
  • Carter JF (1993) Potential of FS oil in baked goods and other products in human nutrition. Cereal Foods World 38(10), 753-759.
  • Choi YS, Cho SH, Kim HJ & Lee HJ (1998) Effects of soluble dietary fibers on lipid metabolism and activities of intestinal disaccharidases in rats. J. Nutr. Sci. Vitami-nol. 44(5), 591-600.
  • Chua B & Shrago E (1978) Effects of experimental diabetes and food intake on rat intestine and plasma alkaline phosphatase. J. Nutr. 108, 196- 202.
  • Claassen N, Coetzer H, Steinmann CM & Kruger MC (1995) The effect of differnt n-6/n-3 essential fatty acid ratiosoncalciumbalanceandboneinrats. Prostaglandins Leukot Essent. Fatty Acids53(1), 13-19.
  • Clark WF, Parbtani A, Huff MW, Spanner E, Salis HD, Chin-Yee I, Philbrick DJ & Holub BJ (1995) Flaxseed: a potential treatment for lupus nephritis. Kidney Int. 48, 475-480.
  • Clement M & Bourre JM (1997) Graded dietary levels of RRR-g-tocopherol induce a marked increase in the concentration of a- and g-tocopherol in nervous tissues,heart, liver and muscles of vitamin e deficient rats. Biochem. Biophys. Acta 1334, 173-181.
  • Cunnane SC, Ganguli S, Menard C, Liede AC, Hamadeh MJ, Chen ZY, Wolever TMS & Jenkins DJA (1993) High a-linolenic acid FS (Linum usitatissimum): some nutritio-nalproperties in humans. Br. J. Nutr. 69(2), 443-456.
  • Cunnane SC, Hamadeh MJ, Leide AC, Thompson LU, Wolever TMS & Jenkins DJA (1994) Nutritional attributes of traditional FS in healthy young adults. Am. J. Clin. Nutr. 61, 62- 68.
  • Ensinger HA & Pauly HE (1978) The role of Zn (II) in calf intestinal alkaline phosphatase studied by the influence of chelating agents and chemical modification of histidine residues. Biochem. Biophys. Acta. 527, 432- 441.
  • Evans WJ & Martin CJ (1988) Interactions of Mg(II), Co(II), Ni(II) and Zn(II) with phytic acid. VIII: a colorimetric study. J. Inorg. Chem. 32, 259- 267.
  • Ferrier LK, Caston LJ, Leeson S, Squires J, Weaver BJ & Holub BJ (1995) a-linolenic acid- and docosahexanoi c acid-enriched eggs from hens fed FS: influence on blood lipids and platelet phospholipid fatty acids in humans. Am. J. Clin. Nutr. 62, 81- 86.
  • Folch J, Lees M & Sloane-Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497- 509.
  • Garg ML, Wierzbicki AA, Thomson ABR & Clandinin MT (1989) Dietary saturated fat level alters the competition between a-linolenic and linoleic acids. Lipids 24, 334-339.
  • Hallberg L, Rossander L & Skanberg A-B (1987) Phytates and inhibitory effect of bran on iron absorption in man. Am. J. Clin. Nutr. 45, 988- 996.
  • Hallberg L, Brune M & Rossander L (1989) Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate. Am. J. Clin. Nutr. 49, 140-144.
  • Javouhey-Donzel A, Guenot L, Maupoll V, Rochette L & Rocquelin G (1993) Rat vitamin E status and heart lipid peroxidation: effect of dietary a-linolenic acid and marine n-3 fatty acids. Lipids 28, 651- 655.
  • Jenab M & Thompson LU (1996) The influence of flaxseed and lignans on colon carcinogenesis and b-glucuronidase activity. Carcinogenesis 17(6), 1343-1348.
  • Kaup SM, Hight SC, Ahn SM & Rader JI (1994) FS and mineral metabolism in rats, Proceedings of the 55th Flax Institute, pp. 29-38.
  • Kelley DS, Nelson GJ, Love JE, Branch LB, Taylor PC, Schmidt PC, Mackey BE & Iacono JM (1993) Dietary a-linolenic acid alters tissue fatty acid composition, but not blood lipids, lipoproteins or coagulation status in humans. Lipids 28(6), 533-537.
  • Knight DC & Eden JA (1996) A review of the clinical effects of phytoestrogens. Obstet. Gynecol. 87, 897- 904.
  • L'Abbe MR, Trick KD & Beare-Rogers JL (1991) Dietary (n-3) fatty acids affect rat heart, liver and aorta protective enzyme activities and lipid peroxidation. J. Nutr. 121, 1331-1340.
  • Layne KS, Goh YK, Jumpsen JA, Ryan EA, Chow P & Clandinin MT (1996) Normal subjects consuming physiological levels of 18 : 3 (n-3) and 20 : 5 (n-3) from flaxseed or fish oils have characteristic differences in plasma lipid and lipoprotein fatty acid levels. J. Nutr. 126(9), 2130-2140.
  • Lyon DB (1984) Studies on the solubility of Ca, Mg, Zn and Cu in cereal products. Am. J. Clin. Nutr. 39, 190-195.
  • Mantzioris E, James MJ, Gibson RA & Cleland LG (1994) Dietary substitution with an a-linolenic acid rich vegetable oil increases eicosapentanoic acid concentrations in tissues. Am. J. Clin. Nutr. 59(6), 1304-1309.
  • Mitchell GV, Grundel E, Jenkins MY & Blakely SR (1990) Effects of graded dietary levels of Spirulina maxima on vitamins A and E in male rats. J. Nutr. 120, 1235-1240.
  • Mitchell GV, Grundel E & Jenkins MY (1996) Bioavailability for rats of vitamin E from fortified breakfast cereals. J. Food Sci. 61(6), 1257-1260.
  • Morrison WR & Smith LM (1964) Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J. Lipid Res. 5, 600- 608.
  • Nordstrom DCE, Honkanen VEA, Nasu Y, Antila E, Friman C & Konttinen YT (1995) Alpha-linolenic acid in the treatment of rheumatoid arthritis, a double-blind, placebo-controlled and randomized study: FS vs. Safflower seed. Rheumatol Int. 14, 231- 234.
  • Olson B & Schneeman BO (1998) Alimentary lipemia is enhanced in fiber fed rats. J. Nutr. 128, 1031-1036.
  • Pal S & Davis PJ (1990) N-3 polyunsaturated fatty acids enhance cholesterol efflux from human fibroblasts in culture. Biochem. Biophys. Res. Commun. 173(2), 566-570.
  • Perez-Granados AM, Vaquero MP & Navarro MP (1995) Iron metabolism in rats consuming oil from fresh or fried sardines. Analyst 120, 899- 903.
  • Prasad K, Mantha SV, Muir AD & Wescott ND (1998) Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low ALA. Atherosclerosis 136(2), 367-375.
  • Reddy MB & Cook JD (1991) Assessment of dietary determinants of nonheme-iron absorption in humans and rats. Am. J. Clin. Nutr. 54, 723-728.
  • Rosalki SB & Foo AY (1984) Two new methods for separating and quantifying bone and liver alkaline phosphatase isozymes in plasma. Clin. Chem. 30(7), 1182-1186.
  • Singer P, Jaeger W, Berger I, Barlaben H, Wirth M, Richter-Heinrich E, Voigt S & Godicke, W (1990) Effects of dietary oleic, linoleic and a-linolenic acids on blood pressure, plasma lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild hypertension. J. Hum. Hypertens. 4, 227- 233.
  • Thompson LU (1993) Potential health benefits and problems associated with antinutrients in foods. Food Res. Int. 26, 131-149.
  • Thompson LU, Rickard SE, Orcheson LJ & Seidl M (1996) Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. Carcinogenesis 17(6), 1373-1376.
  • Tobiume H, Kanzaki S, Hida S, Ono T, Moriwake T, Yamauchi S, Tanaka H & Seino Y (1997) Plasma bone alkaline phosphatase isozyme levels in normal children and children with growth hormone (GH) deficiency: a potential marker for bone formation and response to GH therapy. J. Clin. Endocrinol. Metab. 82(7), 2056-2061.
  • Turnlund JR, King JC, Keyes WR, Gong B & Michel MC (1984) A stable isotope study of zinc absorption in young men: effects of phytate and a-cellulose. Am. J. Clin. Nutr. 40, 1071-1077.
  • Walisundera MN, Ratnayake WA, Fischer PWF, L'Abbe MR, Mongeau R & Beare-Rogers JL (1992) Chemical and nutritional studies of FS (variety Linott) in rats. J. Nutr. Biochem. 3, 232- 240.
  • Wolever TMS, Hegele RA, Connelly PW, Ransom TP, Story
  • JA, Furumoto EJ & Jenkins DJ (1997) Long-term effect
  • of soluble-fiber foods on postprandial fat metabolism in
  • dyslipidemic subjects with apo E3 and apo E4 genotypes.
  • Am. J. Clin. Nutr. 66, 584- 590.

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