Tomato extract inhibits human platelet aggregation in vitro without increasing basal cAMP levels

References

• Agarwal S & Rao AV (1998): Tomato lycopene and low density lipoprotein oxidation: a human dietary interven-tion study. Lipids 33, 981–984.
   Google Scholar
• Anfossi G, Russo I, Massucco P, Mattiello L, Balbo A, Cavalot F & Trovati M (2001): Studies on inhibition of human platelet function by sodium nitroprusside. Kinetic evaluation of the effect on aggregation and cyclic nucleo-tide content. Thromb. Res. 102, 319–330.
   Google Scholar
• Arts IC, Hollman PC, Feskens EJ, Bueno de Mesquita HB & Kromhout D (2001): Catechin intake might explain the inverse relation between tea consumption and ischemic heart disease: the Zutphen Elderly Study. Am. J. Clin. Nutr. 74, 227–232.
   Google Scholar
• Barua AB, Kostic D & Olson JA (1993): New simplified procedures for the extraction and simultaneous high-performance liquid chromatographic analysis of retinol, tocopherols and carotenoids in human serum. J. Chro-matogr. 617, 257–264.
   Google Scholar
• Bub A, Watzl B, Abrahamse L, Delincee H, Adam S, Wever J, Muller H & Rechkemmer G (2000): Moderate inter-vention with carotenoid-rich vegetable products reduces lipid peroxidation in men. J. Nutr. 130, 2200–2206.
   Google Scholar
• Calzada C, Bruckdorfer KR & Rice-Evans CA (1997): The influence of antioxidant nutrients on platelet function in healthy volunteers. Atherosclerosis 128, 97–105.
   Google Scholar
• Conquer JA, Maiani G, Azzini E, Raguzzini A & Holub BJ (1998): Supplementation with quercetin markedly in-creases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. J. Nutr. 128, 593–597.
   Google Scholar
• Daniel JL, Dangelmaier C, Jin J, Kim YB & Kunapuli SP (1999): Role of intracellular signaling events in ADP-induced platelet aggregation. Thromb. Haemost. 82, 1322–1326. Dugas TR, Morel DW & Harrison EH (1999): Dietary
   Google Scholar
• supplementation with beta-carotene, but not with lyco-pene, inhibits endothelial cell-mediated oxidation of low-density lipoprotein. Free Radic. Biol. Med. 26, 1238–1244.
   Google Scholar
• Dutta-Roy AK, Crosbie L & Gordon MJ (2001): Effects of tomato extract on human platelet aggregation in vitro . Platelets 12, 218–227.
   Google Scholar
• Geleijnse JM, Launer LJ, Van der Kuip DA, Hofman A & Witteman JC (2002): Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study. Am. J. Clin. Nutr. 75, 880–886.
   Google Scholar
• Gianetti J, Pedrinelli R, Petrucci R, Lazzerini G, De Caterina M, Bellomo G & De Caterina R (2002): Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis. Am. Heart J. 143, 467–474.
   Google Scholar
• Hertog MGL, Hollman PCH & Katan MB (1992): Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands. J. Agric. Food Chem. 40, 2379–2383.
   Google Scholar
• Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, Giampaoli S, Jansen A, Menotti A, Nedeljkovic S, Pekkarinen M, Simic BS, Toshima H, Feskens EJM, Hollman PCH & Katan MB (1995): Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Intern. Med. 155, 381–386.
   Google Scholar
• Iribarren C, Folsom AR, Jacobs DR Jr, Gross MD, Belcher JD & Eckfeldt JH (1997): Association of serum vitamin levels, LDL susceptibility to oxidation, and autoantibo-dies against MDA-LDL with carotid atherosclerosis. A case-control study. The ARIC Study Investigators. Atherosclerosis Risk in Communities. Arterioscler. Thromb. Vasc. Biol. 17, 1171–1177.
   Google Scholar
• Justesen U, Knuthsen P & Leth T (1998): Quantitative analysis of flavonols, flavones, and flavanones in fruits, vegetables and beverages by high-performance liquid chromatography with photo-diode array and mass spec-trometric detection. J. Chromatogr. A 799, 101–110.
   Google Scholar
• Keularts IMLW, van Gorp RMA, Feijge MAH, Vuist WMJ & Heemskerk JWM (2000): a2A-Adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels. J. Biol. Chem. 275, 1763–1772. Klipstein-Grobusch K, Launer LJ, Geleijnse JM, Boeing H, Hofman A & Witteman JC (2000): Serum carotenoids and atherosclerosis. The Rotterdam Study. Atherosclerosis148, 49-56
   Google Scholar
• Knekt P, Kumpulainen J, Jarvinen R, Rissanen H, Helio-vaara M, Reunanen A, Hakulinen T & Aromaa A (2002): Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr. 76, 560–568.
   Google Scholar
• Kohlmeier L, Kark JD, Gomez-Gracia E, Martin BC, Steck SE, Kardinaal AF, Ringstad J, Thamm M, Masaev V, Riemersma R, Martin-Moreno JM, Huttunen JK & Kok FJ (1997): Lycopene and myocardial infarction risk in the EURAMIC Study. Am. J. Epidemiol. 146, 618–626.
   Google Scholar
• Kristenson M, Zieden B, Kucinskiene Z, Elinder LS, Bergdahl B, Elwing B, Abaravicius A, Razinkoviene L, Calkauskas H & Olsson AG (1997): Antioxidant state and mortality from coronary heart disease in Lithuanian and Swedish men: concomitant cross sectional study of men aged 50. BMJ 314, 629–633.
   Google Scholar
• Kroll MH & Schafer AI (1989): Biochemical mechanism of platelet activation. Blood 74, 1181–1195.
   Google Scholar
• Lee A, Thurnham DI & Chopra M (2000): Consumption of tomato products with olive oil but not sunflower oil increases the antioxidant activity of plasma. Free Radic. Biol. Med. 29, 1051–1055.
   Google Scholar
• Maruyama C, Imamura K, Oshima S, Suzukawa M, Egami S, Tonomoto M, Baba N, Harada M, Ayaori M, Inakuma T & Ishikawa T (2001): Effects of tomato juice consump-tion on plasma and lipoprotein carotenoid concentrations and the susceptibility of low density lipoprotein to oxidative modification. J. Nutr. Sci. Vitaminol. (Tokyo) 47, 213–221.
   Google Scholar
• McQuillan BM, Hung J, Beilby JP, Nidorf M & Thompson PL (2001): Antioxidant vitamins and the risk of carotid atherosclerosis. The Perth Carotid Ultrasound Disease Assessment study (CUDAS). J. Am. Coll. Cardiol. 38, 1788–1794.
   Google Scholar
• Neiva TJ, Morais L, Polack M, Simoes CM & D’Amico EA (1999): Effects of catechins on human blood platelet aggregation and lipid peroxidation. Phytother. Res. 13, 597–600.
   Google Scholar
• Osman HE, Maalej N, Shanmuganayagam D & Folts JD (1998): Grape juice but not orange or grapefruit juice inhibits platelet activity in dogs and monkeys. J. Nutr. 128, 2307–2312.
   Google Scholar
• Parfitt VJ, Rubba P, Bolton C, Marotta G, Hartog M & Mancini M (1994): A comparison of antioxidant status and free radical peroxidation of plasma lipoproteins in healthy young persons from Naples and Bristol. Eur. Heart J. 15, 871–876.
   Google Scholar
• Pignatelli P, Pulcinelli FM, Lenti L, Gazzaniga PP & Violi F (1999): Vitamin E inhibits collagen-induced platelet activation by blunting hydrogen peroxide. Arterioscler.-Thromb. Vasc. Biol. 19, 2542–2547.
   Google Scholar
• Rein D, Paglieroni TG, Pearson DA, Wun T, Schmitz HH, Gosselin R & Keen CL (2000): Cocoa and wine poly-phenols modulate platelet activation and function. J. Nutr. 130, 2120S–2126S.
   Google Scholar
• Rissanen T, Voutilainen S, Nyyssonen K, Salonen R & Salonen JT (2000): Low plasma lycopene concentration is associated with increased intima-media thickness of the carotid artery wall. Arterioscler.Thromb. Vasc. Biol. 20, 2677–2681.
   Google Scholar
• Rissanen TH, Voutilainen S, Nyyssonen K, Lakka TA, Sivenius J, Salonen R, Kaplan GA & Salonen JT (2001): Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br. J. Nutr. 85, 749–754.
   Google Scholar
• Ross R (1999): Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340, 115–126.
   Google Scholar
• Ruggeri ZM (1997): Mechanisms initiating platelet throm-bus formation. Thromb. Haemost. 78, 611–616.
   Google Scholar
• Street DA, Comstock GW, Salkeld RM, Schuep W & Klag MJ (1994): Serum antioxidants and myocardial infarc-tion. Are low levels of carotenoids and alpha-tocopherol risk factors for myocardial infarction? Circulation 90, 1154–1161.
   Google Scholar
• Sutherland WH, Walker RJ, De Jong SA & Upritchard JE (1999): Supplementation with tomato juice increases plasma lycopene but does not alter susceptibility to oxidation of low-density lipoproteins from renal trans-plant recipients. Clin. Nephrol. 52, 30–36.
   Google Scholar
• Upritchard JE, Sutherland WH & Mann JI (2000): Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflamma-tory activity in type 2 diabetes. Diabetes Care 23, 733–738.
   Google Scholar
• Yochum L, Kushi LH, Meyer K & Folsom AR (1999): Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women. Am. J. Epidemiol. 149, 943–949.
   Google Scholar