Carnosic acid protects starvation-induced SH-SY5Y cell death through Erk1/2 and Akt pathways, autophagy, and FoxO3a

References

• Biggs WH 3rd, Meisenhelder J, Hunter T, Cavenee WK, Arden KC. 1999. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA. 96:7421–7426.
   PubMed Web of Science ®Google Scholar
• Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96:857–868.
   PubMed Web of Science ®Google Scholar
• Cheng HC, Kim SR, Oo TF, Kareva T, Yarygina O, Rzhetskaya M, Wang C, During M, Talloczy Z, Tanaka K, et al. 2011. Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy. J Neurosci. 31:2125–2135.
   PubMed Web of Science ®Google Scholar
• Desai Bradaric B, Patel A, Schneider JA, Carvey PM, Hendey B. 2012. Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsy. J Neural Transm (Vienna). 119:59–71.
   PubMed Web of Science ®Google Scholar
• Gao Q, Liu H, Yao Y, Geng L, Zhang X, Jiang L, Shi B, Yang F. 2015. Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells. J Appl Toxicol. 35:485–492.
   PubMed Web of Science ®Google Scholar
• Kayashima T, Matsubara K. 2012. Antiangiogenic effect of carnosic acid and carnosol, neuroprotective compounds in rosemary leaves. Biosci Biotechnol Biochem. 76:115–119.
   PubMed Web of Science ®Google Scholar
• Kobayashi A, Ohta T, Yamamoto M. 2004. Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes. Meth Enzymol. 378:273–286.
   PubMed Web of Science ®Google Scholar
• Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM. 1999. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature. 398:630–634.
   PubMed Web of Science ®Google Scholar
• Kosaka K, Mimura J, Itoh K, Satoh T, Shimojo Y, Kitajima C, Maruyama A, Yamamoto M, Shirasawa T, et al. 2010. Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells. J Biochem. 147:73–81.
   PubMed Web of Science ®Google Scholar
• Levine B, Klionsky DJ. 2004. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 6:463–477.
   PubMed Web of Science ®Google Scholar
• Lin CY, Tsai CW. 2016. Carnosic acid attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells by inducing autophagy through an enhanced interaction of parkin and beclin1. Mol Neurobiol. [Epub ahead of print]. doi: 10.1007/s12035-016-9873-7.
   Google Scholar
• Liu JW, Chandra D, Rudd MD, Butler AP, Pallotta V, Brown D, Coffer PJ, Tang DG. 2005. Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS. Oncogene. 24:2020–2031.
   PubMed Web of Science ®Google Scholar
• Meijer AJ, Codogno P. 2006. Signalling and autophagy regulation in health, aging and disease. Mol Aspects Med. 27:411–425.
   PubMedGoogle Scholar
• Mizushima N. 2007. Autophagy: process and function. Genes Dev. 21:2861–2873.
   PubMed Web of Science ®Google Scholar
• Park JA, Kim S, Lee SY, Kim CS, Kim DK, Kim SJ, Chun HS. 2008. Beneficial effects of carnosic acid on dieldrin-induced dopaminergic neuronal cell death. Neuroreport. 19:1301–1304.
   PubMed Web of Science ®Google Scholar
• Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y, Kitajima C, Cui J, Kamins J, Okamoto S, et al. 2008. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem. 104:1116–1131.
   PubMed Web of Science ®Google Scholar
• Schwarz K, Ternes W. 1992. Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes. Z Lebensm Unters Forsch. 195:99–103.
   PubMedGoogle Scholar
• Tzeng YW, Lee LY, Chao PL, Lee HC, Wu RT, Lin AM. 2010. Role of autophagy in protection afforded by hypoxic preconditioning against MPP+-induced neurotoxicity in SH-SY5Y cells. Free Radic Biol Med. 49:839–846.
   PubMed Web of Science ®Google Scholar
• Vagnucci AHJ, Li WW. 2003. Alzheimer's disease and angiogenesis. Lancet. 361:605–608.
   PubMed Web of Science ®Google Scholar
• Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL. 2007. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab. 6:472–483.
   PubMed Web of Science ®Google Scholar
• Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y, Chu CT. 2007. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol. 170:75–86.
   PubMed Web of Science ®Google Scholar