A randomised, double-blind, placebo-controlled clinical study: the effects of a synbiotic, Lepicol, in adults with chronic, functional constipation

References

• Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Talley NJ. 2007. Cumulative incidence of chronic constipation: a population-based study 1988–2003. Aliment Pharmacol Ther. 26:1521–1528.
   PubMed Web of Science ®Google Scholar
• Crowell M, Harries LA, Lunsford TN, Dibiase JK. 2009. Emerging drugs for chronic constipation. Expert Opin Emerg Drugs. 14:493–504.
   PubMed Web of Science ®Google Scholar
• Dik VK, Siersema PD, Joseph A, Hodgkins P, Smeets HM, van Oijen MG. 2014. Constipation-related direct medical costs in 16887 patients newly diagnosed with chronic constipation. Eur J Gastroenterol Hepatol. 26:1260–1266.
   PubMed Web of Science ®Google Scholar
• Fateh R, Iravani S, Frootan M, Rasouli MR, Saadat S. 2011. Synbiotic preparation in men suffering from functional constipation: a randomised controlled trial. Swiss Med Wkly. 141:w13239.
   PubMed Web of Science ®Google Scholar
• Ford AC, Moayyedi P, Lacy BE, Lembo AJ, Saito YA, Schiller LR, Soffer EE, et al. 2014. American college of gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. Am J Gastroenterol. 109(Suppl 1):S2–S26.
   Google Scholar
• Frank L, Kleinman L, Farup C, Taylor L, Miner P, Jr. 1999. Psychometric validation of a constipation symptom assessment questionnaire. Scand J Gastroenterol. 34:870–877.
   PubMed Web of Science ®Google Scholar
• Gibson GR, Roberfroid MB. 1995. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 125:1401–1412.
   PubMed Web of Science ®Google Scholar
• Gudsoorkar VS1, Quigley EM. 2013. Emerging treatments for chronic constipation. Expert Opin Emerg Drugs. 18:365–373.
   PubMed Web of Science ®Google Scholar
• Heaton KW, Radvan J, Cripps H, Mountford RA, Braddon FE, Hughes AO. 1992. Defecation frequency and timing, and stool form in the general population: a prospective study. Gut. 33:818–824.
   PubMed Web of Science ®Google Scholar
• Hunt R, Dhaliwal S, Tougas G, Pedro C, Labbé JF, Paul H, Ennamorato M. 2007. Prevalence, impact and attitudes toward lower gastrointestinal dysmotility and sensory symptoms, and their treatment in Canada: a descriptive study. Can J Gastroenterol. 21:31–37.
   PubMed Web of Science ®Google Scholar
• Irvine EJ, Ferrazzi S, Pare P, Thompson WG, Rance L. 2002. Health-related quality of life in functional GI disorders: Focus on constipation and resource utilization. Am J Gastroenterol. 97:1986–1993.
   PubMed Web of Science ®Google Scholar
• Marquis P, De La Loge C, Dubois D, McDermott A, Chassany O. 2005. Development and validation of the Patient Assessment of Constipation Quality of Life questionnaire. Scand J Gastroenterol. 40:540–551.
   PubMed Web of Science ®Google Scholar
• Marteau P, Jacobs H, Cazaubiel M, Signoret C, Prevel JM, Housez B. 2011. Effects of chicory inulin in constipated elderly people: a double-blind controlled trial. Int J Food Sci Nutr. 62:164–170.
   PubMed Web of Science ®Google Scholar
• McRorie J, Daggy B, Morel J, Diersing P, Miner P, Robinson M. 1998. Psyllium is superior to docusate sodium for treatment of chronic constipation. Aliment Pharmacol Ther. 12:491–497.
   PubMed Web of Science ®Google Scholar
• Musial F, Klosterhalfen S, Enck P. 2007. Placebo responses in patients with gastrointestinal disorders. World J Gastroenterol. 13:3425–3429.
   PubMed Web of Science ®Google Scholar
• Pare P, Ferrazzi S, Thompson WG, Irvine EJ, Rance L. 2001. An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking. Am J Gastroenterol. 96:3130–3137.
   PubMed Web of Science ®Google Scholar
• Petschow B, Doré J, Hibberd P, Dinan T, Reid G, Blaser M, Cani PD, Degnan FH, et al. 2013. Probiotics, prebiotics, and the host microbiome: the science of translation. Ann NY Acad Sci. 1306:1–17.
   PubMed Web of Science ®Google Scholar
• Phatak UP, Pashankar DS. 2014. Prevalence of functional gastrointestinal disorders in obese and overweight children. Int J Obes (Lond). 38:1324–1327.
   PubMed Web of Science ®Google Scholar
• Pinto Sanchez MI, Bercik P. 2011. Epidemiology and burden of chronic constipation. Can J Gastroenterol. 25(Suppl B):11B–15B.
   PubMedGoogle Scholar
• Quigley EM. 2012. Probiotics in the management of functional bowel disorders: promise fulfilled? Gastroenterol Clin North Am. 41:805–819.
   PubMed Web of Science ®Google Scholar
• Quigley EM. 2011. The enteric microbiota in the pathogenesis and management of constipation. Best Pract Res Clin Gastroenterol. 25:119–126.
   PubMed Web of Science ®Google Scholar
• Roerig JL, Steffen KJ, Mitchell JE, Zunker C. 2010. Laxative abuse: epidemiology, diagnosis and management. Drugs. 70:1487–1503.
   PubMed Web of Science ®Google Scholar
• Suares NC, Ford AC. 2011. Systematic review: the effects of fibre in the management of chronic idiopathic constipation. Aliment Pharmacol Ther. 33:895–901.
   PubMed Web of Science ®Google Scholar
• Talley NJ, Fleming KC, Evans JM, O'keefe EA, Weaver AL, Zinsmeister AR, Melton LJ, 3rd. 1996. Constipation in an elderly community: a study of prevalence and potential risk factors. Am J Gastroenterol. 91:19–25.
   PubMed Web of Science ®Google Scholar
• Talley NJ, Weaver AL, Zinsmeister AR, Melton LJ. 3rd. 1993. Functional constipation and outlet delay: a population-based study. Gastroenterology. 105:781–790.
   PubMed Web of Science ®Google Scholar
• Tejero-Sarinena S, Barlow J, Costabile A, Gibson GR, Rowland I. 2012. In vitro evaluation of the antimicrobial activity of a range of probiotics against pathogens: evidence for the effects of organic acids. Anaerobe. 18:530–538.
   PubMed Web of Science ®Google Scholar