Diet-derived changes by sourdough-fermented rye bread in exhaled breath aspiration ion mobility spectrometry profiles in individuals with mild gastrointestinal symptoms

References

• Amal H, Leja M, Broza YY, Tisch U, Funka K, Liepniece-Karele I, Skapars R, Xu ZQ, Liu H, Haick H. 2013. Geographical variation in the exhaled volatile organic compounds. J Breath Res. 7:047102.
   PubMed Web of Science ®Google Scholar
• Amann A, Bde LC, Miekisch W, Schubert J, Buszewski B, Pleil J, Ratcliffe N, Risby T. 2014. The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva. J Breath Res. 8:034001.
   PubMed Web of Science ®Google Scholar
• Andersson AAM, Dimberg L, Åman P, Landberg R. 2014. Recent findings on certain bioactive components in whole grain wheat and rye. J Cereal Sci. 59:294–311.
   Web of Science ®Google Scholar
• Baranska A, Tigchelaar E, Smolinska A, Dallinga JW, Moonen EJ, Dekens JA, Wijmenga C, Zhernakova A, van Schooten FJ. 2013. Profile of volatile organic compounds in exhaled breath changes as a result of gluten-free diet. J Breath Res. 7:037104.
   PubMed Web of Science ®Google Scholar
• Belobrajdic DP, Bird AR. 2013. The potential role of phytochemicals in wholegrain cereals for the prevention of type-2 diabetes. Nutr J 12:62.
   PubMed Web of Science ®Google Scholar
• Bikov A, Lazar Z, Horvath I. 2015. Established methodological issues in electronic nose research: How far are we from using these instruments in clinical settings of breath analysis?. J Breath Res. 9:034001.
   PubMed Web of Science ®Google Scholar
• Bondia-Pons I, Nordlund E, Mattila I, Katina K, Aura AM, Kolehmainen M, Orešic M, Mykkänen H, Poutanen K. 2011. Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm rye bread versus white wheat bread. Nutr J. 10:116.
   PubMed Web of Science ®Google Scholar
• Bondia-Pons I, Aura AM, Vuorela S, Kolehmainen M, Mykkänen H, Poutanen K. 2009. Rye phenolics in nutrition and health. J Cereal Sci. 49:323–336.
   Web of Science ®Google Scholar
• Boots AW, van Berkel JJ, Dallinga JW, Smolinska A, Wouters EF, van Schooten FJ. 2012. The versatile use of exhaled volatile organic compounds in human health and disease. J Breath Res. 6:027108.
   PubMed Web of Science ®Google Scholar
• Brighenti F, Gullion F, Amado R, Amaral-Collaco MT, Andersson H, Asp NG, Bach Knudsen KE. 1998. Summary of the conclusion of the working group on profibre interlaboratory study on determination of short chain fatty acids in blood. In: Guillon F, Amadò R, Amaral-Collaco MT, Andersson H, Asp NG, Bach Knudsen KE, Champ M, Mathers J, Robertson JA, Rowland I, Van Loo J. editors. Profibre: functional properties of non-digestible carbohydrates. European Commission, Brussels, Belgium: DG XII, Science, Research and Development; p. 150–153.
   Google Scholar
• de Lacy Costello B, Amann A, Al-Kateb H, Flynn C, Filipiak W, Khalid T, Osborne D, Ratcliffe NM. 2014. A review of the volatiles from the healthy human body. J Breath Res. 8:014001.
   PubMed Web of Science ®Google Scholar
• Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, Pudlo NA, Kitamoto S, Terrapon N, Muller A, et al. 2016. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell Metab. 167:1339–1353.
   Web of Science ®Google Scholar
• de Vos WM, de Vos EA. 2012. Role of the intestinal microbiome in health and disease: from correlation to causation. Nutr Rev. 70:S45–S56.
   PubMed Web of Science ®Google Scholar
• Dundeman GH. 1989. Principal components analysis. Sage university paper series on quantitative applications in the social sciences, no 69. Newbury Park, California: Sage Publications, Inc.
   Google Scholar
• Galassetti PR, Novak B, Nemet D, Rose-Gottron C, Cooper DM, Meinardi S, Newcomb R, Zaldivar F, Blake DR. 2005. Breath ethanol and acetone as indicators of serum glucose levels: an initial report. Diabetes Technol Ther. 7:115–123.
   PubMedGoogle Scholar
• Gibson PR, Shepherd SJ. 2010. Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach. J Gastroenterol Hepatol 25:252–258.
   PubMed Web of Science ®Google Scholar
• Gruber B, Keller S, Groeger T, Matuschek G, Szymczak W, Zimmermann R. 2016. Breath gas monitoring during a glucose challenge by a combined PTR-QMS/GC × GC-TOFMS approach for the verification of potential volatile biomarkers. J Breath Res. 10:036003.
   PubMed Web of Science ®Google Scholar
• Gursoy O, Somervuo P, Alatossava T. 2009. Preliminary study of ion mobility based electronic nose MGD-1 for discrimination of hard cheeses. J Food Eng. 92:202–207.
   Web of Science ®Google Scholar
• Hackman RM, Aggarwal BB, Applebaum RS, deVere White RW, Dubick MA, Heber D, Ito T, Johnson GH, Keen CL, Winters BL, Stohs SJ. 2014. Forecasting nutrition research in 2020. J Am Coll Nutr. 33:340–346.
   PubMed Web of Science ®Google Scholar
• Hakalehto E, Pesola J, Heitto A, Deo BB, Rissanen K, Sankilampi U, Humppi T, Paakkanen H. 2009. Fast detection of bacterial growth by using portable microbe enrichment unit (PMEU) and ChemPro100i((R)) gas sensor. Pathophysiology. 16:57–62.
   PubMedGoogle Scholar
• Hallmans G, Zhang JX, Lundin E, Stattin P, Johansson A, Johansson I, Hultén K, Winkvist A, Aman P, Lenner P, Adlercreutz H. 2003. Rye, lignans and human health. Proc Nutr Soc. 62:193–199.
   PubMed Web of Science ®Google Scholar
• Juntunen KS, Laaksonen DE, Autio K, Niskanen LK, Holst JJ, Savolainen KE, Liukkonen KH, Poutanen KS, Mykkänen HM. 2003. Structural differences between rye and wheat breads but not total fiber content may explain the lower postprandial insulin response to rye bread. Am J Clin Nutr. 78:957–964.
   PubMed Web of Science ®Google Scholar
• Juntunen KS, Laaksonen DE, Poutanen KS, Niskanen LK, Mykkänen HM. 2003. High-fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women. Am J Clin Nutr. 77:385–391.
   PubMed Web of Science ®Google Scholar
• Kallio P, Kolehmainen M, Laaksonen DE, Pulkkinen L, Atalay M, Mykkänen H, Uusitupa M, Poutanen K, Niskanen L. 2008. Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome. Am J Clin Nutr. 87:1497–1503.
   PubMed Web of Science ®Google Scholar
• Kanu AB, Dwivedi P, Tam M, Matz L, Hill HH. 2008. Ion mobility-mass spectrometry. J Mass Spectrom. 43:1–22.
   PubMed Web of Science ®Google Scholar
• Kistler M, Szymczak W, Fedrigo M, Fiamoncini J, Hollriegl V, Hoeschen C, Klingenspor M, Hrabě de Angelis M, Rozman J. 2014. Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice. J Breath Res. 8:016004.
   PubMed Web of Science ®Google Scholar
• Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F. 2016. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell. 165:1332–1345.
   PubMed Web of Science ®Google Scholar
• Koistinen V, Hanhineva K. 2016. Microbial and endogenous metabolic conversions of rye phytochemicals. Mol Nutr Food Res. [Epub ahead of print]. doi:10.1002/mnfr.201600627.
   PubMed Web of Science ®Google Scholar
• Koistinen V, Nordlund E, Katina K, Mattila I, Poutanen K, Hanhineva K, Aura AM. 2017. Effect of bioprocessing on the in vitro colonic microbial metabolism of phenolic acids from rye bran fortified breads. J Agric Food Chem. 65:1854–1864.
   PubMed Web of Science ®Google Scholar
• Kolehmainen M, Rönkkö P, Raatikainen O. 2003. Monitoring of yeast fermentation by ion mobility spectrometry measurement and data visualisation with self-organizing maps. Anal Chim Acta. 484:93–100.
   Web of Science ®Google Scholar
• Kovatcheva-Datchary P, Nilsson A, Akrani R, Lee YS, De Vadder F, Arora T. 2015. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella. Cell Metab. 22:971–982.
   PubMed Web of Science ®Google Scholar
• Kurada S, Alkhouri N, Fiocchi C, Dweik R, Rieder F. 2015. Review article: breath analysis in inflammatory bowel diseases. Aliment Pharmacol Ther. 41:329–341.
   PubMed Web of Science ®Google Scholar
• Lankinen M, Schwab U, Gopalacharyulu PV, Seppänen-Laakso T, Yetukuri L, Sysi-Aho M, Kallio P, Suortti T, Laaksonen DE, Gylling H, et al. 2010. Dietary carbohydrate modification alters serum metabolic profiles in individuals with the metabolic syndrome. Nutr Metab Cardiovasc Dis. 20:249–257.
   PubMed Web of Science ®Google Scholar
• Lappi J, Mykkänen H, Bach Knudsen KE, Kirjavainen P, Katina K, Pihlajamäki J, Poutanen K, Kolehmainen M. 2014. Postprandial glucose metabolism and SCFA after consuming wholegrain rye bread and wheat bread enriched with bioprocessed rye bran in individuals with mild gastrointestinal symptoms. Nutr J. 13:104.
   PubMed Web of Science ®Google Scholar
• Lappi J, Salojärvi J, Kolehmainen M, Mykkänen H, Poutanen K, de Vos WM, Salonen A. 2013. Intake of wholegrain and fiber-rich rye bread versus refined wheat bread does not differentiate intestinal microbiota composition in Finnish adults with metabolic syndrome. J Nutr. 143:648–655.
   PubMed Web of Science ®Google Scholar
• Lee J, Ngo J, Blake D, Meinardi S, Pontello AM, Newcomb R, Galassetti PR. 2009. Improved predictive models for plasma glucose estimation from multi-linear regression analysis of exhaled volatile organic compounds. J Appl Phys. 107:155–160.
   PubMed Web of Science ®Google Scholar
• Liukkonen KH, Katina K, Wilhelmsson A, Myllymäki O, Lampi AM, Kariluoto S, Piironen V, Heinonen SM, Nurmi T, Adlercreutz H, et al. 2003. Process-induced changes on bioactive compounds in whole grain rye. Proc Nutr Soc. 62:117–122.
   PubMed Web of Science ®Google Scholar
• Lourenço C, Turner C. 2014. Breath analysis in disease diagnosis: methodological considerations and applications. Metabolites. 4:465–498.
   PubMedGoogle Scholar
• Mathew TL, Pownraj P, Abdulla S, Pullithadathil B. 2015. Technologies for clinical diagnosis using expired human breath analysis. Diagnostics (Basel). 5:27–60.
   PubMedGoogle Scholar
• Minh TDC, Oliver SR, Flores RL, Ngo J, Meinardi S, Carlson MK, Midyett J, Rowland FS, Blake DR, Galassetti PR. 2012. Noninvasive measurement of plasma triglycerides and free fatty acids from exhaled breath. J Diabetes Sci Technol. 6:86–101.
   PubMedGoogle Scholar
• Minh TDC, Oliver SR, Flores RL, Ngo J, Meinardi S, Carlson MK, Midyett J, Rowland FS, Blake DR, Galassetti PR. 2011. Noninvasive measurement of plasma glucose from exhaled breath in healthy and type 1 diabetic subjects. Am J Physiol Endocrinol Metab. 300:E1166–E1175.
   PubMed Web of Science ®Google Scholar
• Pereira J, Porto-Figueira P, Cavaco C, Taunk K, Rapole S, Dhakne R, Nagarajaram H, Camara JS. 2015. Breath analysis as a potential and non-invasive frontier in disease diagnosis: an overview. Metabolites. 5:3–55.
   PubMed Web of Science ®Google Scholar
• Phillips M, Herrera J, Krishnan S, Zain M, Greenberg J, Cataneo RN. 1999. Variation in volatile organic compounds in the breath of normal humans. J Chromatogr B Biomed Sci Appl. 729:75–88.
   PubMed Web of Science ®Google Scholar
• Phillips M, Greenberg J, Awad J. 1994. Metabolic and environmental origins of volatile organic compounds in breath. J Clin Pathol. 47:1052–1053.
   PubMed Web of Science ®Google Scholar
• Raatikainen O, Reinikainen V, Minkkinen P, Ritvanen T, Muje P, Pursiainen J, Hiltunen T, Hyvönen P, von Wright A, Reinikainen S-P, et al. 2005. Multivariate modelling of fish freshness index based on ion mobility spectrometry measurements. Anal Chim Acta. 544:128–134.
   Web of Science ®Google Scholar
• Rajilic-Stojanovic M, Heilig HG, Tims S, Zoetendal EG, de Vos WM. 2013. Long-term monitoring of the human intestinal microbiota composition. Environ Microbiol. 15:1146–1159.
   Web of Science ®Google Scholar
• Raninen K, Kolehmainen M, Tuomainen T, Mykkänen H, Poutanen K, Raatikainen O. 2015. Exhaled breath aspiration ion mobility spectrometry profiles reflect metabolic changes induced by diet. J Physiobiochem Metab 3:1000116.
   Google Scholar
• Raninen KJ, Lappi JE, Mukkala ML, Tuomainen TP, Mykkänen HM, Poutanen KS, Raatikainen OJ. 2016. Fiber content of diet affects exhaled breath volatiles in fasting and postprandial state in a pilot crossover study. Nutr Res. 36:612–619.
   PubMed Web of Science ®Google Scholar
• Räsänen R, Håkansson M, Viljanen M. 2010. Differentiation of air samples with and without microbial volatile organic compounds by aspiration ion mobility spectrometry and semiconductor sensors. Build Environ. 45:2184–2191.
   Web of Science ®Google Scholar
• Rattray NJW, Hamrang Z, Trivedi DK, Goodacre R, Fowler SJ. 2014. Taking your breath away: metabolomics breathes life in to personalized medicine. Trends Biotechnol. 32:538–548.
   PubMed Web of Science ®Google Scholar
• Roine A, Tolvanen M, Sipiläinen M, Kumpulainen P, Helenius MA, Lehtimäki T, Vepsäläinen J, Keinänen TA, Häkkinen MR, Koskimäki J, et al. 2012. Detection of smell print differences between nonmalignant and malignant prostate cells with an electronic nose. Future Oncol. 8:1157–1165.
   PubMed Web of Science ®Google Scholar
• Roine A, Veskimae E, Tuokko A, Kumpulainen P, Koskimäki J, Keinänen TA, Häkkinen MR, Vepsäläinen J, Paavonen T, Lekkala J, et al. 2014. Detection of prostate cancer by an electronic nose: a proof of principle study. J Urol. 192:230–235.
   PubMed Web of Science ®Google Scholar
• Rosen LA, Silva LO, Andersson UK, Holm C, Östman EM, Björck IM. 2009. Endosperm and whole grain rye breads are characterized by low post-prandial insulin response and a beneficial blood glucose profile. Nutr J. 8:42.
   PubMed Web of Science ®Google Scholar
• Schmidt K, Podmore I. 2015. Current challenges in volatile organic compounds analysis as potential biomarkers of cancer. J Biomark. 2015:981458.
   PubMedGoogle Scholar
• Smith D, Španěl P, Davies S. 1999. Trace gases in breath of healthy volunteers when fasting and after a protein-calorie meal: a preliminary study. J Appl Physiol. 87:1584–1588.
   PubMed Web of Science ®Google Scholar
• Smith D, Španěl P, Fryer AA, Hanna F, Ferns GA. 2011. Can volatile compounds in exhaled breath be used to monitor control in diabetes mellitus? J Breath Res. 5:022001.
   PubMed Web of Science ®Google Scholar
• Smolinska A, Hauschild AC, Fijten RR, Dallinga JW, Baumbach J, van Schooten FJ. 2014. Current breathomics-a review on data pre-processing techniques and machine learning in metabolomics breath analysis. J Breath Res. 8:027105.
   PubMed Web of Science ®Google Scholar
• Španěl P, Dryahina K, Rejskova A, Chippendale TW, Smith D. 2011. Breath acetone concentration; biological variability and the influence of diet. Physiol Meas. 32:N23–31.
   PubMed Web of Science ®Google Scholar
• Španěl P, Smith D. 2011. Volatile compounds in health and disease. Curr Opin Clin Nutr Metab Care. 14:455–460.
   PubMed Web of Science ®Google Scholar
• Sun X, Shao K, Wang T. 2016. Detection of volatile organic compounds (VOCs) from exhaled breath as noninvasive methods for cancer diagnosis. Anal Bioanal Chem. 408:2759–2780.
   PubMed Web of Science ®Google Scholar
• Utriainen M, Kärpänoja E, Paakkanen H. 2003. Combining miniaturized ion mobility spectrometer and metal oxide gas sensor for the fast detection of toxic chemical vapors. Sens Actuators B Chem. 93:17–24.
   Web of Science ®Google Scholar
• van der Schee MP, Paff T, Brinkman P, van Aalderen WM, Haarman EG, Sterk PJ. 2015. Breathomics in lung disease. Chest. 147:224–231.
   PubMed Web of Science ®Google Scholar
• Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R, et al. 2011. Linking long-term dietary patterns with gut microbial enterotypes. Science. 334:105–108.
   PubMed Web of Science ®Google Scholar