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Studies in Humans

Ratio of serum levels of AGEs to soluble RAGE is correlated with trimethylamine-N-oxide in non-diabetic subjects

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Pages 1013-1020 | Received 25 Feb 2017, Accepted 07 Apr 2017, Published online: 23 Apr 2017

References

  • Bierhaus A, Hofmann MA, Ziegler R, Nawroth PP. 1998. AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept. Cardiovasc Res. 37:586–600.
  • Brown JM, Hazen SL. 2015. The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annu Rev Med. 66:343–359.
  • Cerami C, Founds H, Nicholl I, Mitsuhashi T, Giordano D, Vanpatten S, Lee A, Al-Abed Y, Vlassara H, Bucala R, et al. 1997. Tobacco smoke is a source of toxic reactive glycation products. Proc Natl Acad Sci USA. 94:13915–13920.
  • Colhoun HM, Betteridge DJ, Durrington P, Hitman G, Neil A, Livingstone S, Charlton-Menys V, Demicco DA, Preston GM. 2011. Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 diabetes: an analysis from the CARDS trial. Diabetes. 60:2379–2385.
  • Fretts AM, Howard BV, McKnight B, Duncan GE, Beresford SA, Mete M, Eilat-Adar S, Zhang Y, Siscovick DS. 2012. Associations of processed meat and unprocessed red meat intake with incident diabetes: the Strong Heart Family Study. Am J Clin Nutr. 95:752–758.
  • Fujisawa K, Katakami N, Kaneto H, Naka T, Takahara M, Sakamoto F, Irie Y, Miyashita K, Kubo F, Yasuda T, et al. 2013. Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes. Atherosclerosis. 227:425–428.
  • Fukami K, Yamagishi S, Sakai K, Kaida Y, Yokoro M, Ueda S, Wada Y, Takeuchi M, Shimizu M, Yamazaki H, et al. 2015. Oral L-carnitine supplementation increases trimethylamine-N-oxide but reduces markers of vascular injury in hemodialysis patients. J Cardiovasc Pharmacol. 65:289–295.
  • Fukushima Y, Daida H, Morimoto T, Kasai T, Miyauchi K, Yamagishi S, Takeuchi M, Hiro T, Kimura T, Nakagawa Y, JAPAN-ACS, et al. 2013. Relationship between advanced glycation end products and plaque progression in patients with acute coronary syndrome: the JAPAN-ACS sub-study. Cardiovasc Diabetol. 12:5–12.
  • Gao X, Liu X, Xu J, Xue C, Xue Y, Wang Y. 2014. Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet. J Biosci Bioeng. 118:476–481.
  • Hoelzel W, Weykamp C, Jeppsson JO, Miedema K, Barr JR, Goodall I, Hoshino T, John G, Kobold U, Little R, IFCC Working Group on HbA1c Standardization, et al. 2004. IFCC reference system for measurement of hemoglobin A1c in human blood and the national standardization schemes in the United States, Japan, and Sweden: a method-comparison study. Clin Chem. 50:166–174.
  • Kajikawa M, Nakashima A, Fujimura N, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Oda N, Hidaka T, Kihara Y, et al. 2015. Ratio of serum levels of AGEs to soluble form of RAGE is a predictor of endothelial function. Diabetes Care. 38:119–125.
  • Kilhovd BK, Juutilainen A, Lehto S, Rönnemaa T, Torjesen PA, Hanssen KF, Laakso M. 2007. Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes: a population-based 18 year follow-up study. Diabetologia. 50:1409–1417.
  • Kim Y, Keogh J, Clifton P. 2015. A review of potential metabolic etiologies of the observed association between red meat consumption and development of type 2 diabetes mellitus. Metab Clin Exp. 64:768–779.
  • Kimura Y, Hyogo H, Yamagishi S, Takeuchi M, Ishitobi T, Nabeshima Y, Arihiro K, Chayama K. 2010. Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH. J Gastroenterol. 45:750–757.
  • Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, et al. 2013. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 19:576–585.
  • Lever M, George PM, Slow S, Bellamy D, Young JM, Ho M, McEntyre CJ, Elmslie JL, Atkinson W, Molyneux SL, et al. 2014. Betaine and trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: an observational study. PLoS One. 9:e114969.
  • Luevano-Contreras C, Chapman-Novakofski K. 2010. Dietary advanced glycation end products and aging. Nutrients. 2:1247–1265.
  • Lundh T, Akesson B, Skerfving S. 1995. Effect of dietary intake of trimethylamine on human metabolism of the industrial catalyst dimethylethylamine. Occup Environ Med. 52:478–483.
  • Malinowska AM, Szwengiel A, Chmurzynska A. 2017. Dietary, anthropometric, and biochemical factors influencing plasma choline, carnitine, trimethylamine, and trimethylamine-N-oxide concentrations. Int J Food Sci Nutr. 68:488–495.
  • Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A; Collaborators developing the Japanese equation for estimated GFR. 2009. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 53:982–992.
  • Miao J, Ling AV, Manthena PV, Gearing ME, Graham MJ, Crooke RM, Croce KJ, Esquejo RM, Clish CB, Torrecilla E, et al. 2015. Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis. Nat Commun. 6:6498.
  • Monnier VM, Sell DR, Genuth S. 2005. Glycation products as markers and predictors of the progression of diabetic complications. Ann N Y Acad Sci. 1043:567–581.
  • Mueller DM, Allenspach M, Othman A, Saely CH, Muendlein A, Vonbank A, Drexel H, von Eckardstein A. 2015. Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control. Atherosclerosis. 243:638–644.
  • Nettleton JA, Polak JF, Tracy R, Burke GL, Jr., Jacobs DR. 2009. Dietary patterns and incident cardiovascular disease in the multi-ethnic study of atherosclerosis. Am J Clin Nutr. 9:647–654.
  • Nin JW, Jorsal A, Ferreira I, Schalkwijk CG, Prins MH, Parving HH. 2010. Higher plasma soluble receptor for advanced glycation end products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study. Diabetes. 59:2027–2032.
  • Nin JW, Jorsal A, Ferreira I, Schalkwijk CG, Prins MH, Parving HH, Tarnow L, Rossing P, Stehouwer CD. 2011. Higher plasma levels of advanced glycation end products are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study. Diabetes Care. 34:442–447.
  • Okamoto T, Yamagishi S, Inagaki Y, Amano S, Koga K, Abe R, Takeuchi M, Ohno S, Yoshimura A, Makita Z, et al. 2002. Angiogenesis induced by advanced glycation end products and its prevention by cerivastatin. Faseb J. 16:1928–1930.
  • Ozasa H, Shimizu M, Koizumi A, Wakabayashi A, Yamazaki H. 2014. Trimethylamine generation in patients receiving hemodialysis treated with l-carnitine. Clin Kidney J. 7:329.
  • Rahbar S. 2005. The discovery of glycated hemoglobin: a major event in the study of nonenzymatic chemistry in biological systems. Ann N Y Acad Sci. 1043:9–19.
  • Ramasamy R, Yan SF, Schmidt AM. 2012. The diverse ligand repertoire of the receptor for advanced glycation endproducts and pathways to the complications of diabetes. Vascul Pharmacol. 57:160–167.
  • Raucci A, Cugusi S, Antonelli A, Barabino SM, Monti L, Bierhaus A, Reiss K, Saftig P, Bianchi ME. 2008. A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10). Faseb J. 22:3716–3727.
  • Schmidt AM, Stern D. 2000. Atherosclerosis and diabetes: the RAGE connection. Curr Atheroscler Rep. 2:430–436.
  • Shimizu M, Kozono M, Murayama N, Yamazaki H. 2009. Bonitos with low content of malodorous trimethylamine as palliative care for self-reported Japanese trimethylaminuria subjects. Drug Metab Pharmacokinet. 24:549–552.
  • Stitt AW, Bucala R, Vlassara H. 1997. Atherogenesis and advanced glycation: promotion, progression, and prevention. Ann N Y Acad Sci. 811:115–127.
  • Stubbs JR, House JA, Ocque AJ, Zhang S, Johnson C, Kimber C, Schmidt K, Gupta A, Wetmore JB, Nolin TD. 2016. Serum trimethylamine-N-oxide is elevated in CKD and correlates with coronary atherosclerosis burden. J Am Soc Nephrol. 27:305–313.
  • Tahara N, Yamagishi S, Takeuchi M, Honda A, Tahara A, Nitta Y, Kodama N, Mizoguchi M, Kaida H, Ishibashi M. 2012. Positive association between serum level of glyceraldehyde-derived advanced glycation end products and vascular inflammation evaluated by [(18)F]fluorodeoxy-glucose positron emission tomography. Diabetes Care. 35:2618–2625.
  • Tan AL, Forbes JM, Cooper ME. 2007. AGE, RAGE, and ROS in diabetic nephropathy. Semin Nephrol. 27:130–143.
  • Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL. 2013. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 368:1575–1584.
  • Ufnal M, Zadlo A, Ostaszewski R. 2015. TMAO: a small molecule of great expectations. Nutrition. 31:1317–1323.
  • Uribarri J, Cai W, Sandu O, Peppa M, Goldberg T, Vlassara H. 2005. Diet-derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects. Ann N Y Acad Sci. 1043:461–466.
  • Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H. 2010. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 110:911–916.
  • Uribarri J, Cai W, Ramdas M, Goodman S, Pyzik R, Chen X, Zhu L, Striker GE, Vlassara H. 2011. Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1. Diabetes Care. 34:1610–1616.
  • Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung Y-M, et al. 2011. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 472:57–63.
  • Yamagishi S, Imaizumi T. 2005. Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy. Curr Pharm Des. 11:2279–2299.
  • Yamagishi S, Ueda S, Okuda S. 2007. Food-derived advanced glycation end products (AGEs): a novel therapeutic target for various disorders. Curr Pharm Des. 13:2832–2836.
  • Yamagishi S, Maeda S, Matsui T, Ueda S, Fukami K, Okuda S. 2012. Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes. Biochim Biophys Acta. 1820:663–671.
  • Yamagishi S, Matsui T. 2010. Soluble form of a receptor for advanced glycation end products (sRAGE) as a biomarker. Front Biosci (Elite Ed). 2:1184–1195.
  • Yamagishi S, Fukami K, Matsui T. 2015. Evaluation of tissue accumulation levels of advanced glycation end products by skin autofluorescence: a novel marker of vascular complications in high-risk patients for cardiovascular disease. Int J Cardiol. 185:263–268.
  • Yamagishi S, Matsui T. 2016. Pathologic role of dietary advanced glycation end products in cardiometabolic disorders, and therapeutic intervention. Nutrition. 32:157–165.
  • Yamazaki H, Fujieda M, Togashi M, Saito T, Preti G, Cashman JR, Kamataki T. 2004. Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients. Life Sci. 74:2739–2747.

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