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Studies in Humans

Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults: a randomised cross-over study

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Pages 74-83 | Received 13 Apr 2017, Accepted 05 May 2017, Published online: 31 May 2017

References

  • Berry MJ, Justus NW, Hauser JI, Case AH, Helms CC, Basu S, Rogers Z, Lewis MT, Miller GD. 2015. Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients. Nitric Oxide. 48:22–30.
  • Bond V Jr, Curry BH, Adams RG, Millis RM, Haddad GE. 2014. Cardiorespiratory function associated with dietary nitrate supplementation. Appl Physiol Nutr Metab. 39:168–172.
  • Bondonno CP, Liu AH, Croft KD, Ward NC, Shinde S, Moodley Y, Lundberg JO, Puddey IB, Woodman RJ, Hodgson JM. 2015. Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trial. Am J Clin Nutr. 102:368–375.
  • Bondonno CP, Liu AH, Croft KD, Ward NC, Yang X, Considine MJ, Puddey IB, Woodman RJ, Hodgson JM. 2014. Short-term effects of nitrate-rich green leafy vegetables on blood pressure and arterial stiffness in individuals with high-normal blood pressure. Free Radic Biol Med. 77:353–362.
  • Cheitlin MD. 2003. Cardiovascular physiology – changes with aging. Am J Geriatr Cardiol. 12:9–13.
  • Coggan AR, Leibowitz JL, Spearie CA, Kadkhodayan A, Thomas DP, Ramamurthy S, Mahmood K, Park S, Waller S, Farmer M, Peterson LR. 2015. Acute dietary nitrate intake improves muscle contractile function in patients with heart failure: a double-blind, placebo-controlled, randomized trial. Circ Heart Fail. 8:914–920.
  • Coggan AR, Peterson LR. 2016. Dietary nitrate and skeletal muscle contractile function in heart failure. Curr Heart Fail Rep. 13:158–165.
  • Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. 2003. International Physical Activity Questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 35:1381–1395.
  • DeVan AE, Johnson LC, Brooks FA, Evans TD, Justice JN, Cruickshank-Quinn C, Reisdorph N, Bryan NS, McQueen MB, Santos-Parker JR, et al. 2015. Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults. J Appl Physiol. 120:416–425.
  • Di Lisa F, Menabò R, Canton M, Barile M, Bernardi P. 2001. Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD + and is a causative event in the death of myocytes in postischemic reperfusion of the heart. J Biol Chem. 276:2571–2575.
  • Eggebeen J, Kim-Shapiro DB, Haykowsky M, Morgan TM, Basu S, Brubaker P, Rejeski J, Kitzman DW. 2016. One week of daily dosing with beetroot juice improves submaximal endurance and blood pressure in older patients with heart failure and preserved ejection fraction. JACC Heart Fail. 4:428–437.
  • Gee LC, Ahluwalia A. 2016. Dietary nitrate lowers blood pressure: epidemiological, pre-clinical experimental and clinical trial evidence. Curr Hypertens Rep. 18:17.
  • Gilchrist M, Winyard PG, Aizawa K, Anning C, Shore A, Benjamin N. 2013. Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes. Free Radic Biol Med. 60:89–97.
  • Gosse P. 2005. Left ventricular hypertrophy as a predictor of cardiovascular risk. J Hypertens Suppl. 23:S27–S33.
  • Houghton D, Jones TW, Cassidy S, Siervo M, MacGowan GA, Trenell MI, Jakovljevic DG. 2016. The effect of age on the relationship between cardiac and vascular function. Mech Ageing Dev. 153:1–6.
  • Jajja A, Sutyarjoko A, Lara J, Rennie K, Brandt K, Qadir O, Siervo M. 2014. Beetroot supplementation lowers daily systolic blood pressure in older, overweight subjects. Nutr Res. 34:868–875.
  • Jakovljevic DG, Trenell MI, MacGowan GA. 2014. Bioimpedance and bioreactance methods for monitoring cardiac output. Best Pract Res Clin Anaesthesiol. 28:381–394.
  • Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A. 2015. Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension. 65:320–327.
  • Kelm M. 1999. Nitric oxide metabolism and breakdown. Biochim Biophys Acta Bioenerg. 1411:273–289.
  • Kenjale AA, Ham KL, Stabler T, Robbins JL, Johnson JL, Vanbruggen M, Privette G, Yim E, Kraus WE, Allen JD. 2011. Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. J Appl Physiol (1985). 110:1582–1591.
  • Khatri J, Mills CE, Maskell P, Odongerel C, Webb AJ. 2016. It is rocket science – why dietary nitrate is hard to beet! Part I: twists and turns in the realisation of the nitrate-nitrite-NO pathway. Br J Clin Pharmacol. 83:129–139.
  • Lara J, Ashor AW, Oggioni C, Ahluwalia A, Mathers JC, Siervo M. 2015a. Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis. Eur J Nutr. 55:451–459.
  • Lara J, Ogbonmwan I, Oggioni C, Zheng D, Qadir O, Ashor A, Brandt K, Mathers JC, Siervo M. 2015b. Effects of handgrip exercise or inorganic nitrate supplementation on 24-h ambulatory blood pressure and peripheral arterial function in overweight and obese middle age and older adults: a pilot RCT. Maturitas. 82:228–235.
  • Lee JS, Stebbins CL, Jung E, Nho H, Kim JK, Chang MJ, Choi HM. 2015. Effects of chronic dietary nitrate supplementation on the hemodynamic response to dynamic exercise. Am J Physiol Regul Integr Comp Physiol. 309:R459–R466.
  • Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, et al. 2009. Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol. 5:865–869.
  • Massion PB, Feron O, Dessy C, Balligand JL. 2003. Nitric oxide and cardiac function: ten years after, and continuing. Circ Res. 93:388–398.
  • Mills CE, Khatri J, Maskell P, Odongerel C, Webb AJ. 2017. It is rocket science – why dietary nitrate is hard to beet! Part II: further mechanisms and therapeutic potential of the nitrate-nitrite-NO pathway. Br J Clin Pharmacol. 83:140–151.
  • Mulligan AA, Luben RN, Bhaniani A, Parry-Smith DJ, O'connor L, Khawaja AP, Forouhi NG, Khaw KT. 2014. A new tool for converting food frequency questionnaire data into nutrient and food group values: FETA research methods and availability. BMJ Open. 4:e004503.
  • North BJ, Sinclair DA. 2012. The intersection between aging and cardiovascular disease. Circ Res. 110:1097–1108.
  • Omar SA, Webb AJ, Lundberg JO, Weitzberg E. 2016. Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases. J Intern Med. 279:315–336.
  • Pironti G, Ivarsson N, Yang J, Farinotti AB, Jonsson W, Zhang SJ, Bas D, Svensson CI, Westerblad H, Weitzberg E, et al. 2016. Dietary nitrate improves cardiac contractility via enhanced cellular Ca2+ signaling. Basic Res Cardiol. 111:34.
  • Qadir OK, Teh J, Siervo M, Seal CJ, Brandt K. 2013. Method using gas chromatography mass spectrometry (GC–MS) for analysis of nitrate and nitrite in vegetables. Ghent, Belgium: NUTRIHORT: Nutrient management, innovative techniques and nutrient legislation in intensive horticulture for an improved water quality.
  • Rastaldo R, Pagliaro P, Cappello S, Penna C, Mancardi D, Westerhof N, Losano G. 2007. Nitric oxide and cardiac function. Life Sci. 81:779–793.
  • Siervo M, Lara J, Jajja A, Sutyarjoko A, Ashor AW, Brandt K, Qadir O, Mathers JC, Benjamin N, Winyard PG, et al. 2015. Ageing modifies the effects of beetroot juice supplementation on 24-hour blood pressure variability: an individual participant meta-analysis. Nitric Oxide. 47:97–105.
  • Siervo M, Lara J, Ogbonmwan I, Mathers JC. 2013. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr. 143:818–826.
  • Tsikas D. 2000. Simultaneous derivatization and quantification of the nitric oxide metabolites nitrite and nitrate in biological fluids by gas chromatography/mass spectrometry. Anal Chem. 72:4064–4072.
  • Zamani P, Rawat D, Shiva-Kumar P, Geraci S, Bhuva R, Konda P, Doulias PT, Ischiropoulos H, Townsend RR, Margulies KB, et al. 2015. Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction. Circulation. 131:371–380; discussion 380.

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