Dietary fatty acids modulation of human colon cancer cells: mechanisms and future perspectives

References

• Abel S, Riedel S, Gelderblom WC. 2014. Dietary PUFA and cancer. Proc Nutr Soc. 73:361–367.
   PubMed Web of Science ®Google Scholar
• Allred CD, Talbert DR, Southard RC, Wang X, Kilgore MW. 2008. PPARgamma1 as a molecular target of eicosapentaenoic acid in human colon cancer (HT-29) cells. J Nutr. 138:250–256.
   PubMed Web of Science ®Google Scholar
• Beppu F, Hosokawa M, Tanaka L, Kohno H, Tanaka T, Miyashita K. 2006. Potent inhibitory effect of trans9, trans11 isomer of conjugated linoleic acid on the growth of human colon cancer cells. J Nutr Biochem. 17:830–836.
   PubMed Web of Science ®Google Scholar
• Berquin IM, Edwards IJ, Chen YQ. 2008. Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Lett. 269:363–377.
   PubMed Web of Science ®Google Scholar
• Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, et al. 2016. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 531:53–58.
   PubMed Web of Science ®Google Scholar
• Bocca C, Bozzo F, Gabriel L, Miglietta A. 2007. Conjugated linoleic acid inhibits Caco-2 cell growth via ERK-MAPK signaling pathway. J Nutr Biochem. 18:332–340.
   PubMed Web of Science ®Google Scholar
• Bozzo F, Bocca C, Colombatto S, Miglietta A. 2007. Antiproliferative effect of conjugated linoleic acid in caco-2 cells: involvement of PPARgamma and APC/beta-catenin pathways. Chem-Biol Interact. 169:110–121.
   PubMed Web of Science ®Google Scholar
• Calviello G, Di Nicuolo F, Gragnoli S, Piccioni E, Serini S, Maggiano N, Tringali G, Navarra P, Ranelletti FO, Palozza P. 2004. n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. Carcinogenesis. 25:2303–2310.
   PubMed Web of Science ®Google Scholar
• Calviello G, Di Nicuolo F, Serini S, Piccioni E, Boninsegna A, Maggiano N, Ranelletti FO, Palozza P. 2005. Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil. Cancer Chemother Pharmacol. 55:12–20.
   PubMed Web of Science ®Google Scholar
• Calviello G, Resci F, Serini S, Piccioni E, Toesca A, Boninsegna A, Monego G, Ranelletti FO, Palozza P. 2007. Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. Carcinogenesis. 28:1202–1209.
   PubMed Web of Science ®Google Scholar
• Carrillo C, Cavia Mdel M, Alonso-Torre SR. 2012. Antitumor effect of oleic acid; mechanisms of action: a review. Nutr Hospital. 27:1860–1865.
   PubMed Web of Science ®Google Scholar
• Center MM, Jemal A, Ward E. 2009. International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomark Prevent. 18:1688–1694.
   PubMed Web of Science ®Google Scholar
• Chamberland JP, Moon HS. 2015. Down-regulation of malignant potential by alpha linolenic acid in human and mouse colon cancer cells. Familial Cancer. 14:25–30.
   PubMed Web of Science ®Google Scholar
• Chen ZY, Istfan NW. 2000. Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. Prostagland Leuk Essent Fatty Acids. 63:301–308.
   PubMed Web of Science ®Google Scholar
• Cho HJ, Kim WK, Jung JI, Kim EJ, Lim SS, Kwon DY, Park JH. 2005. Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid decreases ErbB3 expression in HT-29 human colon cancer cells. World J Gastroenterol. 11:5142–5150.
   PubMed Web of Science ®Google Scholar
• Cho HJ, Kim WK, Kim EJ, Jung KC, Park S, Lee HS, Tyner AL, Park JH. 2003. Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line. Am J Physiol Gastrointest Liver Physiol. 284:G996–1005.
   PubMed Web of Science ®Google Scholar
• Cho HJ, Kwon GT, Park JH. 2009. trans-10,cis-12 Conjugated linoleic acid induces depolarization of mitochondrial membranes in HT-29 human colon cancer cells: a possible mechanism for induction of apoptosis. J Med Food. 12:952–958.
   PubMed Web of Science ®Google Scholar
• Colussi D, Brandi G, Bazzoli F, Ricciardiello L. 2013. Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention. Int J Mol Sci. 14:16365–16385.
   PubMed Web of Science ®Google Scholar
• Courtney ED, Matthews S, Finlayson C, Di Pierro D, Belluzzi A, Roda E, Kang JY, Leicester RJ. 2007. Eicosapentaenoic acid (EPA) reduces crypt cell proliferation and increases apoptosis in normal colonic mucosa in subjects with a history of colorectal adenomas. Int J Colorect Dis. 22:765–776.
   PubMed Web of Science ®Google Scholar
• De Carlo F, Witte TR, Hardman WE, Claudio PP. 2013. Omega-3 eicosapentaenoic acid decreases CD133 colon cancer stem-like cell marker expression while increasing sensitivity to chemotherapy. PLoS One. 8:e69760.
   PubMed Web of Science ®Google Scholar
• De la Torre A, Debiton E, Durand D, Chardigny JM, Berdeaux O, Loreau O, Barthomeuf C, Bauchart D, Gruffat D. 2005. Conjugated linoleic acid isomers and their conjugated derivatives inhibit growth of human cancer cell lines. Anticancer Res. 25:3943–3949.
   PubMed Web of Science ®Google Scholar
• Degen C, Ecker J, Piegholdt S, Liebisch G, Schmitz G, Jahreis G. 2011. Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA. Biochim Biophys Acta. 1811:1070–1080.
   PubMed Web of Science ®Google Scholar
• Elmore S. 2007. Apoptosis: a review of programmed cell death. Toxicol Pathol. 35:495–516.
   PubMed Web of Science ®Google Scholar
• Escrich E, Solanas M, Moral R, Costa I, Grau L. 2006. Are the olive oil and other dietary lipids related to cancer? Experimental evidence. Clin Transl Oncol. 8:868–883.
   PubMedGoogle Scholar
• Fasano E, Serini S, Piccioni E, Toesca A, Monego G, Cittadini AR, Ranelletti FO, Calviello G. 2012. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochim Biophys Acta. 1822:1762–1772.
   PubMed Web of Science ®Google Scholar
• Fazio C, Piazzi G, Vitaglione P, Fogliano V, Munarini A, Prossomariti A, Milazzo M, D'Angelo L, Napolitano M, Chieco P, et al. 2016. Inflammation increases NOTCH1 activity via MMP9 and is counteracted by eicosapentaenoic acid-free fatty acid in colon cancer cells. Sci Rep. 6:20670.
   PubMed Web of Science ®Google Scholar
• Fluckiger A, Dumont A, Derangere V, Rebe C, de Rosny C, Causse S, Thomas C, Apetoh L, Hichami A, Ghiringhelli F, Rialland M. 2016. Inhibition of colon cancer growth by docosahexaenoic acid involves autocrine production of TNFalpha. Oncogene. 35:4611–4622.
   PubMed Web of Science ®Google Scholar
• Fritz V, Fajas L. 2010. Metabolism and proliferation share common regulatory pathways in cancer cells. Oncogene. 29:4369–4377.
   PubMed Web of Science ®Google Scholar
• Gelsomino G, Corsetto PA, Campia I, Montorfano G, Kopecka J, Castella B, Gazzano E, Ghigo D, Rizzo AM, Riganti C. 2013. Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition. Mol Cancer. 12:137.
   PubMed Web of Science ®Google Scholar
• Granados S, Quiles JL, Gil A, Ramirez-Tortosa MC. 2006. Dietary lipids and cancer. Nutr Hosp. 21 Suppl.2:42–52, 44–54.
   PubMed Web of Science ®Google Scholar
• Grundmann E. 1985. What’s new in colon carcinogenesis? Pathol Res Pract. 179:429–432.
   PubMed Web of Science ®Google Scholar
• Habbel P, Weylandt KH, Lichopoj K, Nowak J, Purschke M, Wang JD, He CW, Baumgart DC, Kang JX. 2009. Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells. World J Gastroenterol. 15:1079–1084.
   PubMed Web of Science ®Google Scholar
• Habermann N, Christian B, Luckas B, Pool-Zobel BL, Lund EK, Glei M. 2009. Effects of fatty acids on metabolism and cell growth of human colon cell lines of different transformation state. BioFactors (Oxford, England). 35:460–467.
   PubMed Web of Science ®Google Scholar
• Habermann N, Lund EK, Pool-Zobel BL, Glei M. 2009. Modulation of gene expression in eicosapentaenoic acid and docosahexaenoic acid treated human colon adenoma cells. Genes Nutr. 4:73–76.
   PubMed Web of Science ®Google Scholar
• Habermann N, Schon A, Lund EK, Glei M. 2010. Fish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo. Apoptosis. 15:621–630.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: the next generation. Cell. 144:646–674.
   PubMed Web of Science ®Google Scholar
• Hodge AM, Williamson EJ, Bassett JK, MacInnis RJ, Giles GG, English DR. 2015. Dietary and biomarker estimates of fatty acids and risk of colorectal cancer. Int J Cancer. 137:1224–1234.
   PubMed Web of Science ®Google Scholar
• Hofmanova J, Slavik J, Ovesna P, Tylichova Z, Vondracek J, Strakova N, Vaculova AH, Ciganek M, Kozubik A, Knopfova L. 2016. Dietary fatty acids specifically modulate phospholipid pattern in colon cells with distinct differentiation capacities. Eur J Nutr. 56:1493–1508.
   PubMed Web of Science ®Google Scholar
• Huang G, Zhong X, Cao Y, Chen Y. 2007. Antiproliferative effects of conjugated linoleic acid on human colon adenocarcinoma cell line Caco-2. Asia Pac J Clin Nutr. 16 Suppl.1:432–436.
   PubMed Web of Science ®Google Scholar
• Hull MA. 2011. Omega-3 polyunsaturated fatty acids. Best Pract Res Clin Gastroenterol. 25:547–554.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Djuric Z, Sen A, Ren J, Kuklev D, Waters I, Zhao L, Uhlson CL, Hong YH, Murphy RC, et al. 2014. Biomarkers for personalizing omega-3 fatty acid dosing. Cancer Prevent Res (Philadelphia, PA). 7:1011–1022.
   PubMed Web of Science ®Google Scholar
• Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS. 2016. The colonic crypt protects stem cells from microbiota-derived metabolites. Cell. 165:1708–1720.
   PubMed Web of Science ®Google Scholar
• Kato T, Kolenic N, Pardini RS. 2007. Docosahexaenoic acid (DHA), a primary tumor suppressive omega-3 fatty acid, inhibits growth of colorectal cancer independent of p53 mutational status. Nutr Cancer. 58:178–187.
   PubMed Web of Science ®Google Scholar
• Kerr JF, Wyllie AH, Currie AR. 1972. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 26:239–257.
   PubMed Web of Science ®Google Scholar
• Kim KJ, Lee J, Park Y, Lee SH. 2015. ATF3 mediates anti-cancer activity of trans-10, cis-12-conjugated linoleic acid in human colon cancer cells. Biomol Ther. 23:134–140.
   PubMed Web of Science ®Google Scholar
• Kolligs FT. 2016. Diagnostics and epidemiology of colorectal cancer. Visceral Med. 32:158–164.
   PubMed Web of Science ®Google Scholar
• Kopke S, Buhrke T, Lampen A. 2015. miRNA expression in human intestinal Caco-2 cells is comparably regulated by cis- and trans-fatty acids. Lipids. 50:227–239.
   PubMed Web of Science ®Google Scholar
• Kritchevsky D. 2000. Antimutagenic and some other effects of conjugated linoleic acid. Br J Nutr. 83:459–465.
   PubMed Web of Science ®Google Scholar
• Kuniyasu H, Yoshida K, Sasaki T, Sasahira T, Fujii K, Ohmori H. 2006. Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells. Int J Cancer. 118:571–576.
   PubMed Web of Science ®Google Scholar
• Kuppusamy P, Yusoff MM, Maniam GP, Ichwan SJ, Soundharrajan I, Govindan N. 2014. Nutraceuticals as potential therapeutic agents for colon cancer: a review. Acta Pharm Sin B. 4:173–181.
   PubMedGoogle Scholar
• Lau DS, Archer MC. 2010. The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells. Nutr Cancer. 62:116–121.
   PubMed Web of Science ®Google Scholar
• Lee SH, Yamaguchi K, Kim JS, Eling TE, Safe S, Park Y, Baek SJ. 2006. Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis. 27:972–981.
   PubMed Web of Science ®Google Scholar
• Marventano S, Kolacz P, Castellano S, Galvano F, Buscemi S, Mistretta A, Grosso G. 2015. A review of recent evidence in human studies of n-3 and n-6 PUFA intake on cardiovascular disease, cancer, and depressive disorders: does the ratio really matter? Int J Food Sci Nutr. 66:611–622.
   PubMed Web of Science ®Google Scholar
• Mikirova N, Riordan HD, Jackson JA, Wong K, Miranda-Massari JR, Gonzalez MJ. 2004. Erythrocyte membrane fatty acid composition in cancer patients. Puerto Rico Health Sci J. 23:107–113.
   PubMedGoogle Scholar
• Moro K, Nagahashi M, Ramanathan R, Takabe K, Wakai T. 2016. Resolvins and omega three polyunsaturated fatty acids: clinical implications in inflammatory diseases and cancer. World J Clin Cases. 4:155–164.
   PubMed Web of Science ®Google Scholar
• Muller MF, Ibrahim AE, Arends MJ. 2016. Molecular pathological classification of colorectal cancer. Virchows Archiv: Int J Pathol. 469:125–134.
   PubMed Web of Science ®Google Scholar
• Murff HJ, Shu XO, Li H, Dai Q, Kallianpur A, Yang G, Cai H, Wen W, Gao Y-T, Zheng W. 2009. A prospective study of dietary polyunsaturated fatty acids and colorectal cancer risk in Chinese women. Cancer Epidemiol Biomark Prevent. 18:2283–2291.
   PubMed Web of Science ®Google Scholar
• Murphy EF, Hooiveld GJ, Muller M, Calogero RA, Cashman KD. 2007. Conjugated linoleic acid alters global gene expression in human intestinal-like Caco-2 cells in an isomer-specific manner. J Nutr. 137:2359–2365.
   PubMed Web of Science ®Google Scholar
• Nadolski MJ, Linder ME. 2007. Protein lipidation. FEBS J. 274:5202–5210.
   PubMed Web of Science ®Google Scholar
• Narayanan BA, Narayanan NK, Reddy BS. 2001. Docosahexaenoic acid regulated genes and transcription factors inducing apoptosis in human colon cancer cells. Int J Oncol. 19:1255–1262.
   PubMed Web of Science ®Google Scholar
• Okuno M, Hamazaki K, Ogura T, Kitade H, Matsuura T, Yoshida R, Hijikawa T, Kwon M, Arita S, Itomura M, et al. 2013. Abnormalities in fatty acids in plasma, erythrocytes and adipose tissue in Japanese patients with colorectal cancer. In Vivo (Athens, Greece). 27:203–210.
   PubMed Web of Science ®Google Scholar
• Oraldi M, Trombetta A, Biasi F, Canuto RA, Maggiora M, Muzio G. 2009. Decreased polyunsaturated fatty acid content contributes to increased survival in human colon cancer. J Oncol. 2009:867915.
   PubMedGoogle Scholar
• Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B, Bao JK. 2012. Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Proliferat. 45:487–498.
   PubMed Web of Science ®Google Scholar
• Pan J, Keffer J, Emami A, Ma X, Lan R, Goldman R, Chung FL. 2009. Acrolein-derived DNA adduct formation in human colon cancer cells: its role in apoptosis induction by docosahexaenoic acid. Chem Res Toxicol. 22:798–806.
   PubMed Web of Science ®Google Scholar
• Pauwels EK. 2011. The protective effect of the Mediterranean diet: focus on cancer and cardiovascular risk. Med Princ Pract. 20:103–111.
   PubMed Web of Science ®Google Scholar
• Pellatt AJ, Slattery ML, Mullany LE, Wolff RK, Pellatt DF. 2016. Dietary intake alters gene expression in colon tissue: possible underlying mechanism for the influence of diet on disease. Pharmacogenet Genomics. 26:294–306.
   PubMed Web of Science ®Google Scholar
• Persengiev SP, Green MR. 2003. The role of ATF/CREB family members in cell growth, survival and apoptosis. Apoptosis. 8:225–228.
   PubMed Web of Science ®Google Scholar
• Pettersen K, Monsen VT, Hakvag Pettersen CH, Overland HB, Pettersen G, Samdal H, Tesfahun AN, Lundemo AG, Bjørkøy G, Schønberg SMA. 2016. DHA-induced stress response in human colon cancer cells – focus on oxidative stress and autophagy. Free Radic Biol Med. 90:158–172.
   PubMed Web of Science ®Google Scholar
• Schonberg SA, Lundemo AG, Fladvad T, Holmgren K, Bremseth H, Nilsen A, Gederaas O, Tvedt KE, Egeberg KW, Krokan HE. 2006. Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1. FEBS J. 273:2749–2765.
   PubMed Web of Science ®Google Scholar
• Schwartz B, Birk Y, Raz A, Madar Z. 2004. Nutritional-pharmacological combinations – a novel approach to reducing colon cancer incidence. Eur J Nutr. 43:221–229.
   PubMed Web of Science ®Google Scholar
• Skender B, Hofmanova J, Slavik J, Jelinkova I, Machala M, Moyer MP, Kozubik A, Hyrslova Vaculova A. 2014. DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism. Biochim Biophys Acta. 1841:1308–1317.
   PubMed Web of Science ®Google Scholar
• Skender B, Vaculova AH, Hofmanova J. 2012. Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: a review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 156:186–199.
   PubMed Web of Science ®Google Scholar
• Slagsvold JE, Pettersen CH, Storvold GL, Follestad T, Krokan HE, Schonberg SA. 2010. DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells. Nutr Cancer. 62:611–621.
   PubMed Web of Science ®Google Scholar
• Stocks P. 1957. Cancer in North Wales and Liverpool region. British Empire Cancer Campaign, Thirty-fifth Annual Report. Supplement II:51–113.
   Google Scholar
• Stoneham M, Goldacre M, Seagroatt V, Gill L. 2000. Olive oil, diet and colorectal cancer: an ecological study and a hypothesis. J Epidemiol Commun Health. 54:756–760.
   PubMed Web of Science ®Google Scholar
• Theodoratou E, McNeill G, Cetnarskyj R, Farrington SM, Tenesa A, Barnetson R, Porteous M, Dunlop M, Campbell H. 2007. Dietary fatty acids and colorectal cancer: a case-control study. Am J Epidemiol. 166:181–195.
   PubMed Web of Science ®Google Scholar
• Toit-Kohn JL, Louw L, Engelbrecht AM. 2009. Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways. J Nutr Biochem. 20:106–114.
   PubMed Web of Science ®Google Scholar
• Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. 1999. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA. 96:8681–8686.
   PubMed Web of Science ®Google Scholar
• Vasudevan A, Yu Y, Banerjee S, Woods J, Farhana L, Rajendra SG, Patel A, Dyson G, Levi E, Maddipati KR, et al. 2014. Omega-3 fatty acid is a potential preventive agent for recurrent colon cancer. Cancer Prevent Res (Philadelphia, PA). 7:1138–1148.
   PubMed Web of Science ®Google Scholar
• Vinikoor LC, Millikan RC, Satia JA, Schroeder JC, Martin CF, Ibrahim JG, Sandler RS. 2010. trans-Fatty acid consumption and its association with distal colorectal cancer in the North Carolina Colon Cancer Study II. Cancer Causes Control: CCC. 21:171–180.
   PubMed Web of Science ®Google Scholar
• Wang Q, Hao J, Guan Q, Yuan W. 2014. The Mediterranean diet and gastrointestinal cancers risk. Recent Patents Food Nutr Agric. 6:23–26.
   PubMedGoogle Scholar
• Wendel M, Heller AR. 2009. Anticancer actions of omega-3 fatty acids – current state and future perspectives. Anti-Cancer Agents Med Chem. 9:457–470.
   PubMed Web of Science ®Google Scholar
• Xia LJ, Li MG. 2012. Effect of n-3 polyunsaturated fatty acids on proliferation and apoptosis of human colon cancer cell. Zhonghua Wei Chang Wai Ke Za Zhi = Chin J Gastrointest Surg. 15:490–494.
   PubMedGoogle Scholar
• Xing X, Lai M, Wang Y, Xu E, Huang Q. 2006. Overexpression of glucose-regulated protein 78 in colon cancer. Clin Chim Acta; Int J Clin Chem. 364:308–315.
   PubMed Web of Science ®Google Scholar
• Yamanashi Y, Tezuka T, Yokoyama K. 2012. Activation of receptor protein-tyrosine kinases from the cytoplasmic compartment. J Biochem. 151:353–359.
   PubMed Web of Science ®Google Scholar
• Yang L, Pei Z. 2006. Bacteria, inflammation, and colon cancer. World J Gastroenterol. 12:6741–6746.
   PubMed Web of Science ®Google Scholar
• Zhang C, Yu H, Shen Y, Ni X, Shen S, Das UN. 2015. Polyunsaturated fatty acids trigger apoptosis of colon cancer cells through a mitochondrial pathway. Arch Med Sci: AMS. 10:1081–1094.
   Google Scholar