Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway

References

• Angelino D, Jeffery E. 2014. Glucosinolate hydrolysis and bioavailability of resulting isothiocyanates: Focus on glucoraphanin. J Funct Foods. 7:67–76.
   Web of Science ®Google Scholar
• Brennan D, Chen X, Cheng L, Mahoney M, Riobo NA. 2012. Noncanonical hedgehog signaling. Vitam Horm. 88:55–72.
   PubMed Web of Science ®Google Scholar
• Chen M, Carkner R, Buttyan R. 2011. The hedgehog/Gli signaling paradigm in prostate cancer. Expert Rev Endocrinol Metab. 6:453–467.
   PubMedGoogle Scholar
• Chen Y, Wang XQ, Zhang Q, Zhu JY, Li Y, Xie CF, Li XT, Wu JS, Geng SS, Zhong CY, et al. 2017. (-)epigallocatechin-3-gallate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway. Nutrients 9. DOI:10.3390/nu9060572
   Web of Science ®Google Scholar
• Choy SW, Cheng SH. 2012. Hedgehog signaling. Vitam Horm. 88:1–23.
   PubMed Web of Science ®Google Scholar
• Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ, Wicha MS. 2003. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev. 17:1253–1270.
   PubMed Web of Science ®Google Scholar
• Duckworth CA, Burkitt MD, Williams JM, Parsons BN, Tang JM, Pritchard DM. 2015. Murine models of helicobacter (pylori or felis)-associated gastric cancer. Curr Protoc Pharmacol. 69:14.34.11–35.
   Google Scholar
• Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. 2015. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386.
   PubMed Web of Science ®Google Scholar
• Geybels MS, Neuhouser ML, Stanford JL. 2013. Associations of tea and coffee consumption with prostate cancer risk. Cancer Causes Control. 24:941–948.
   PubMed Web of Science ®Google Scholar
• Hashimoto K, Aoyagi K, Isobe T, Kouhuji K, Shirouzu K. 2014. Expression of CD133 in the cytoplasm is associated with cancer progression and poor prognosis in gastric cancer. Gastric Cancer. 17:97–106.
   PubMed Web of Science ®Google Scholar
• Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, et al. 2011. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell. 19:387–400.
   PubMed Web of Science ®Google Scholar
• Jia Y, Wang Y, Xie J. 2015. The Hedgehog pathway: role in cell differentiation, polarity and proliferation. Arch Toxicol. 89:179–191.
   PubMed Web of Science ®Google Scholar
• Jiang X, Huang J, Song D, Deng R, Wei J, Zhang Z. 2017. Increased consumption of fruit and vegetables is related to a reduced risk of cognitive impairment and dementia: meta-analysis. Front Aging Neurosci. 9:18.
   PubMed Web of Science ®Google Scholar
• Jordan CT, Guzman ML, Noble M. 2006. Cancer stem cells. N Engl J Med. 355:1253–1261.
   PubMed Web of Science ®Google Scholar
• Kallifatidis G, Labsch S, Rausch V, Mattern J, Gladkich J, Moldenhauer G, Buchler MW, Salnikov AV, Herr I. 2011. Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate. Mol Ther. 19:188–195.
   PubMed Web of Science ®Google Scholar
• Katsuno Y, Ehata S, Yashiro M, Yanagihara K, Hirakawa K, Miyazono K. 2012. Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-β. J Pathol. 228:391–404.
   PubMed Web of Science ®Google Scholar
• Kondo T, Setoguchi T, Taga T. 2004. Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci USA. 101:781–786.
   PubMed Web of Science ®Google Scholar
• Labsch S, Liu L, Bauer N, Zhang Y, Aleksandrowicz E, Gladkich J, Schonsiegel F, Herr I. 2014. Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells. Int J Oncol. 44:1470–1480.
   PubMed Web of Science ®Google Scholar
• Lau WM, Teng E, Chong HS, Lopez KA, Tay AY, Salto-Tellez M, Shabbir A, So JB, Chan SL. 2014. CD44v8-10 is a cancer-specific marker for gastric cancer stem cells. Cancer Res. 74:2630–2641.
   PubMed Web of Science ®Google Scholar
• Lee J, Kotliarova S, Kotliarov Y, Li A, Su Q, Donin NM, Pastorino S, Purow BW, Christopher N, Zhang W, et al. 2006. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell. 9:391–403.
   PubMed Web of Science ®Google Scholar
• Li SH, Fu J, Watkins DN, Srivastava RK, Shankar S. 2013. Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway. Mol Cell Biochem. 373:217–227.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhang T, Korkaya H, Liu S, Lee HF, Newman B, Yu Y, Clouthier SG, Schwartz SJ, Wicha MS, et al. 2010. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res. 16:2580–2590.
   PubMed Web of Science ®Google Scholar
• Liu J, Ma L, Xu J, Liu C, Zhang J, Liu J, Chen R, Zhou Y. 2013. Spheroid body-forming cells in the human gastric cancer cell line MKN-45 possess cancer stem cell properties. Int J Oncol. 42:453–459.
   PubMed Web of Science ®Google Scholar
• Liu S, Dontu G, Mantle ID, Patel S, Ahn NS, Jackson KW, Suri P, Wicha MS. 2006. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 66:6063–6071.
   PubMed Web of Science ®Google Scholar
• Nishikawa S, Konno M, Hamabe A, Hasegawa S, Kano Y, Ohta K, Fukusumi T, Sakai D, Kudo T, Haraguchi N, et al. 2013. Aldehyde dehydrogenase high gastric cancer stem cells are resistant to chemotherapy. Int J Oncol. 42:1437–1442.
   PubMed Web of Science ®Google Scholar
• Oh J, Hlatky L, Jeong YS, Kim D. 2016. Therapeutic effectiveness of anticancer phytochemicals on cancer stem cells. Toxins (Basel). 8:199.
   Web of Science ®Google Scholar
• Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, De Maria R. 2007. Identification and expansion of human colon-cancer-initiating cells. Nature. 445:111–115.
   PubMed Web of Science ®Google Scholar
• Rodova M, Fu J, Watkins DN, Srivastava RK, Shankar S. 2012. Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal. PLoS One. 7:e46083.
   PubMed Web of Science ®Google Scholar
• Singh AK, Sharma N, Ghosh M, Park YH, Jeong DK. 2017. Emerging importance of dietary phytochemicals in fight against cancer: role in targeting cancer stem cells. Crit Rev Food Sci Nutr. 57:3449–3463.
   PubMed Web of Science ®Google Scholar
• Song Z, Yue W, Wei B, Wang N, Li T, Guan L, Shi S, Zeng Q, Pei X, Chen L. 2011. Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. PLoS One. 6:e17687
   PubMed Web of Science ®Google Scholar
• Srivastava RK, Tang SN, Zhu W, Meeker D, Shankar S. 2011. Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells. Front Biosci (Elite Ed). 3:515–528.
   PubMedGoogle Scholar
• Takaishi S, Okumura T, Tu S, Wang SS, Shibata W, Vigneshwaran R, Gordon SA, Shimada Y, Wang TC. 2009. Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells 27:1006–1020.
   PubMed Web of Science ®Google Scholar
• Takebe N, Miele L, Harris PJ, Jeong W, Bando H, Kahn M, Yang SX, Ivy SP. 2015. Targeting notch, hedgehog, and Wnt pathways in cancer stem cells: clinical update. Nat Rev Clin Oncol. 12:445–464.
   PubMed Web of Science ®Google Scholar
• Varjosalo M, Taipale J. 2008. Hedgehog: functions and mechanisms. Genes Dev. 22:2454–2472.
   PubMed Web of Science ®Google Scholar
• Wang F, Wang W, Li J, Zhang J, Wang X, Wang M. 2018. Sulforaphane reverses gefitinib tolerance in human lung cancer cells via modulation of sonic hedgehog signaling. Oncol Lett. 15:109–114.
   PubMed Web of Science ®Google Scholar
• Wen L, XZ, Chen K, Yang ZX, Chen B, Zhang JP, Chen ZG, Zhou XM, Mo JK, Hu 2013. Prognostic value of cancer stem cell marker CD133 expression in gastric cancer: a systematic review. PLoS One. 8:e59154.
   PubMedGoogle Scholar
• Yu D, Shin HS, Lee YS, Lee D, Kim S, Lee YC. 2014. Genistein attenuates cancer stem cell characteristics in gastric cancer through the downregulation of Gli1. Oncol Rep. 31:673–678.
   PubMed Web of Science ®Google Scholar
• Zhao P, Li Y, Lu Y. 2010. Aberrant expression of CD133 protein correlates with Ki-67 expression and is a prognostic marker in gastric adenocarcinoma. BMC Cancer. 10:218.
   PubMed Web of Science ®Google Scholar
• Zhi QM, Chen XH, Ji J, Zhang JN, Li JF, Cai Q, Liu BY, Gu QL, Zhu ZG, Yu YY. 2011. Salinomycin can effectively kill ALDH(high) stem-like cells on gastric cancer. Biomed Pharmacother. 65:509–515.
   PubMed Web of Science ®Google Scholar
• Zhu JY, Yang X, Chen Y, Jiang Y, Wang SJ, Li Y, Wang XQ, Meng Y, Zhu MM, Ma X, et al. 2017. Curcumin suppresses lung cancer stem cells via inhibiting Wnt/β-catenin and sonic hedgehog pathways. Phytother Res. 31:680–688.
   PubMed Web of Science ®Google Scholar