The acute effects of the non-nutritive sweeteners aspartame and acesulfame-K in UK diet cola on glycaemic response

References

• Abdelaal M, Le Roux CW, Docherty NG. 2017. Morbidity and mortality associated with obesity. Ann Transl Med. 5(7):161.
   PubMed Web of Science ®Google Scholar
• Aldughpassi A, Wolever TMS. 2009. Effect of coffee and tea on the glycaemic index of foods: no effect on mean but reduced variability. Br J Nutr. 101(9):1282–1285.
   PubMed Web of Science ®Google Scholar
• Azad MB, Abou-Setta AM, Chauhan BF, Rabbani R, Lys J, Copstein L, Mann A, Jeyaraman MM, Reid AE, Fiander M, et al. 2017. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. CMAJ. 189(28):929–939.
   PubMed Web of Science ®Google Scholar
• Bhupathiraju SN, Pan A, Malik VS, Manson JE, Willett WC, van Dam RM, Hu FB. 2013. Caffeinated and caffeine-free beverages and risk of type 2 diabetes. Am J Clin Nutr. 97(1):155–166.
   PubMed Web of Science ®Google Scholar
• Brouns F, Bjorck I, Frayn KN, Gibbs AL, Lang V, Slama G, Wolever TM. 2005. Glycaemic index methodology. Nutr Res Rev. 18(1):145.
   PubMed Web of Science ®Google Scholar
• Bryant CE, Wasse LK, Astbury N, Nandra G, McLaughlin JT. 2014. Non-nutritive sweeteners: no class effect on the glycaemic or appetite responses to ingested glucose. Eur J Clin Nutr. 68(5):629–631.
   PubMed Web of Science ®Google Scholar
• Burke MV, Small DM. 2015. Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism. Physiol Behav. 152(Pt B):381–388.
   PubMedGoogle Scholar
• de Koning L, Malik VS, Rimm EB, Willett WC, Hu FB. 2011. Sugar-sweetened and artificially sweetened beverage consumption and risk of type 2 diabetes in men. Am J Clin Nutr. 93(6):1321–1327.
   PubMed Web of Science ®Google Scholar
• de la Hunty A, Gibson S, Ashwell M. 2006. A review of the effectiveness of aspartame in helping with weight control. Nutr Bull. 31(2):115–128.
   Google Scholar
• Fowler SP, Williams K, Resendez RG, Hunt KJ, Hazuda HP, Stern MP. 2008. Fueling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain. Obesity (Silver Spring). 16(8):1894–1900.
   PubMed Web of Science ®Google Scholar
• Greenwood DC, Threapleton DE, Evans CE, Cleghorn CL, Nykjaer C, Woodhead C, Burley VJ. 2014. Association between sugar-sweetened and artificially sweetened soft drinks and type 2 diabetes: systematic review and dose–response meta-analysis of prospective studies. Br J Nutr. 112(05):725–734.
   PubMedGoogle Scholar
• Hätönen KA, Virtamo J, Eriksson JG, Sinkko HK, Erlund I, Jousilahti P, Leiviskä JM, Valsta LM. 2012. Coffee does not modify postprandial glycaemic and insulinaemic responses induced by carbohydrates. Eur J Nutr. 51(7):801–806.
   PubMed Web of Science ®Google Scholar
• Henry CJK, Newens KJ, Lightowler HJ. 2009. Low-glycaemic index sweetener-based beverages reduce 24-h glucose profiles in healthy adults. J Hum Nutr Diet. 22(1):77–80.
   PubMed Web of Science ®Google Scholar
• [HMRC] Her Majesty's Revenue & Customs. 2018. Soft drinks industry levy; [accessed 2018 Aug]. https://www.gov.uk/topic/business-tax/soft-drinks-industry-levy
   Google Scholar
• Imamura F, O'Connor L, Ye Z, Mursu J, Hayashino Y, Bhupathiraju SN, Forouhi NG. 2015. Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction. BMJ. 351:h3576.
   PubMed Web of Science ®Google Scholar
• Ma J, Chang J, Checklin HL, Young RL, Jones KL, Horowitz M, Rayner CK. 2010. Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects. Br J Nutr. 104(6):803–806.
   PubMed Web of Science ®Google Scholar
• Malik VS, Popkin BM, Bray GA, Després JP, Hu FB. 2010. Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation. 121(11):1356–1364.
   PubMed Web of Science ®Google Scholar
• Malik VS, Popkin BM, Bray GA, Després JP, Willett WC, Hu FB. 2010. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care. 33(11):2477–2483.
   PubMed Web of Science ®Google Scholar
• Mattes RD, Popkin BM. 2009. Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Am J Clin Nutr. 89(1):1–14.
   PubMed Web of Science ®Google Scholar
• Miller PE, Perez V. 2014. Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies. Am J Clin Nutr. 100(3):765–777.
   PubMed Web of Science ®Google Scholar
• Moisey LL, Kacker S, Bickerton AC, Robinson LE, Graham TE. 2008. Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy men. Am J Clin Nutr. 87(5):1254–1261.
   PubMed Web of Science ®Google Scholar
• [NCD-RisC] NCD Risk Factor Collaboration. 2017. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 390(10113):2627–2642.
   PubMed Web of Science ®Google Scholar
• Nichol AD, Holle MJ, An R. 2018. Glycemic impact of non-nutritive sweeteners: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 72(6):796–804.
   PubMed Web of Science ®Google Scholar
• Nuttall FQ, Khan MA, Gannon MC. 2000. Peripheral glucose appearance rate following fructose ingestion in normal subjects. Metab Clin Exp. 49(12):1565–1571.
   PubMed Web of Science ®Google Scholar
• [ONS] Office for National Statistics 2017. Health Survey for England, 2016 – NHS Digital; [accessed 2018 Aug 8]. https://digital.nhs.uk/data-and-information/publications/statistical/health-survey-for-england/health-survey-for-england-2016
   Google Scholar
• Pepino MY, Tiemann CD, Patterson BW, Wice BM, Klein S. 2013. Sucralose affects glycemic and hormonal responses to an oral glucose load. Diabetes Care. 36(9):2530–2535.
   PubMed Web of Science ®Google Scholar
• Pereira MA. 2014. Sugar-sweetened and artificially-sweetened beverages in relation to obesity risk. Adv Nutr. 5(6):797–808.
   PubMed Web of Science ®Google Scholar
• Raben A, Richelsen B. 2012. Artificial sweeteners: a place in the field of functional foods? Focus on obesity and related metabolic disorders. Curr Opin Clin Nutr Metab Care. 15(6):597–604.
   PubMed Web of Science ®Google Scholar
• Robertson MD, Henderson RA, Vist GE, Rumsey RD. 2002. Extended effects of evening meal carbohydrate-to-fat ratio on fasting and postprandial substrate metabolism. Am J Clin Nutr. 75(3):505–510.
   PubMed Web of Science ®Google Scholar
• [SACN] Scientific Advisory Committee on Nutrition. 2015. Carbohydrates and health; [accessed 2018 Aug]. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/445503/SACN_Carbohydrates_and_Health.pdf
   Google Scholar
• Shi X, Xue W, Liang S, Zhao J, Zhang X. 2016. Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis. Nutr J. 15(1):103.
   PubMedGoogle Scholar
• Smeets PA, Erkner A, De Graaf C. 2010. Cephalic phase responses and appetite. Nutr Rev. 68(11):643–655.
   PubMed Web of Science ®Google Scholar
• Sørensen LB, Vasilaras TH, Astrup A, Raben A. 2014. Sucrose compared with artificial sweeteners: a clinical intervention study of effects on energy intake, appetite, and energy expenditure after 10 week of supplementation in overweight subjects. Am J Clin Nutr. 100(1):36–45.
   PubMed Web of Science ®Google Scholar
• Statista. 2018. Artificial sweetener usage frequency in the UK 2014–2017 | TGI survey; [accessed 2018 Aug 8]. https://www.statista.com/statistics/301975/artificial-sweetener-usage-frequency-in-the-uk/
   Google Scholar
• Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, et al. 2014. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 514(7521):181–186.
   PubMed Web of Science ®Google Scholar
• Swithers SE. 2013. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Trends Endocrinol Metab. 24(9):431–441.
   PubMed Web of Science ®Google Scholar
• Sylvetsky AC, Brown RJ, Blau JE, Walter M, Rother KI. 2016. Hormonal responses to non-nutritive sweeteners in water and diet soda. Nutr Metab (Lond). 13(1):71.
   PubMedGoogle Scholar
• Tey SL, Salleh NB, Henry J, Forde CG. 2017. Effects of aspartame-, monk fruit-, stevia- and sucrose-sweetened beverages on postprandial glucose, insulin and energy intake. Int J Obes. 41(3):450–457.
   Web of Science ®Google Scholar
• Wolever TM, Jenkins DJ, Ocana AM, Rao VA, Collier GR. 1988. Second-meal effect: low-glycemic-index foods eaten at dinner improve subsequent breakfast glycemic response. Am J Clin Nutr. 48(4):1041–1047.
   PubMed Web of Science ®Google Scholar
• [WHO] World Health Organisation. 2015. Sugars intake for adults and children; [accessed 2018 Aug]. http://www.who.int/nutrition/publications/guidelines/sugars_intake/en/
   Google Scholar
• Wu T, Bound MJ, Standfield SD, Bellon M, Young RL, Jones KL, Horowitz M, Rayner CK. 2013. Artificial sweeteners have no effect on gastric emptying, glucagon-like peptide-1, or glycemia after oral glucose in healthy humans. Diabetes Care. 36(12):202–203.
   PubMed Web of Science ®Google Scholar
• Yang Q. 2010. Gain weight by “going diet?” Artificial sweeteners and the neurobiology of sugar cravings: neuroscience 2010. Yale J Biol Med. 83(2):101–108.
   PubMedGoogle Scholar
• Yang Q, Zhang Z, Gregg E, Flanders WD, Merritt R, Hu FB. 2014. Added sugar intake and cardiovascular diseases mortality among US adults. JAMA Intern Med. 174(4):516.
   PubMed Web of Science ®Google Scholar