367
Views
3
CrossRef citations to date
0
Altmetric
In vitro and animal studies

Epigallocatechin gallate (EGCG) alters body fat and lean mass through sex-dependent metabolic mechanisms in Drosophila melanogaster

, , , &
Pages 959-969 | Received 13 Dec 2018, Accepted 28 Mar 2019, Published online: 22 Apr 2019

References

  • Al-Anzi B, Zinn K. 2010. Colorimetric measurement of triglycerides cannot provide an accurate measure of stored fat content in Drosophila. PLoS One. 5(8):e12353.
  • Axling U, Olsson C, Xu J, Fernandez C, Larsson S, Strom K, Ahrne S, Holm C, Molin G, Berger K. 2012. Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J mice. Nutr Metab (Lond). 9(1):105.
  • Azuma M, Dat Le T, Yoshimoto Y, Hiraki N, Yamanaka M, Omura F, Inoue YH. 2019. RNA-seq analysis of diet-driven obesity and anti-obesity effects of quercetin glucoside or epigallocatechin gallate in Drosophila adults. Eur Rev Med Pharmacol Sci. 23(2):857–876.
  • Barbehenn RV, Peter Constabel C. 2011. Tannins in plant-herbivore interactions. Phytochemistry. 72(13):1551–1565.
  • Bartholomew NR, Burdett JM, VandenBrooks JM, Quinlan MC, Call GB. 2015. Impaired climbing and flight behaviour in Drosophila melanogaster following carbon dioxide anaesthesia. Sci Rep. 5:15298.
  • Becker A, Schloder P, Steele JE, Wegener G. 1996. The regulation of trehalose metabolism in insects. Experientia. 52(5):433–439.
  • Birse RT, Choi J, Reardon K, Rodriguez J, Graham S, Diop S, Ocorr K, Bodmer R, Oldham S. 2010. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Cell Metab. 12(5):533–544.
  • Chen N, Bezzina R, Hinch E, Lewandowski PA, Cameron-Smith D, Mathai ML, Jois M, Sinclair AJ, Begg DP, Wark JD, et al. 2009. Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. Nutr Res. 29(11):784–793.
  • Chiu JC, Low KH, Pike DH, Yildirim E, Edery I. 2010. Assaying locomotor activity to study circadian rhythms and sleep parameters in Drosophila. J Vis Exp. 43:2157.
  • Diepvens K, Kovacs EM, Nijs IM, Vogels N, Westerterp-Plantenga MS. 2005. Effect of green tea on resting energy expenditure and substrate oxidation during weight loss in overweight females. Br J Nutr. 94(6):1026–1034.
  • Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. 1999. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 70(6):1040–1045.
  • Eschbach J, Schwalenstocker B, Soyal SM, Bayer H, Wiesner D, Akimoto C, Nilsson AC, Birve A, Meyer T, Dupuis L, et al. 2013. PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis. Hum Mol Genet. 22(17):3477–3484.
  • Ferguson CT, O'Neill TL, Audsley N, Isaac RE. 2015. The sexually dimorphic behaviour of adult Drosophila suzukii: elevated female locomotor activity and loss of siesta is a post-mating response. J Exp Biol. 218(23):3855–3861.
  • Frazier MR, Harrison JF, Kirkton SD, Roberts SP. 2008. Cold rearing improves cold-flight performance in Drosophila via changes in wing morphology. J Exp Biol. 211(Pt 13):2116–2122.
  • Fu Z, Zhen W, Yuskavage J, Liu D. 2011. Epigallocatechin gallate delays the onset of type 1 diabetes in spontaneous non-obese diabetic mice. Br J Nutr. 105(8):1218–1225.
  • Heinrichsen ET, Zhang H, Robinson JE, Ngo J, Diop S, Bodmer R, Joiner WJ, Metallo CM, Haddad GG. 2014. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Mol Metab. 3(1):42–54.
  • Hursel R, Viechtbauer W, Westerterp-Plantenga MS. 2009. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes (Lond). 33(9):956–961.
  • Ja WW, Carvalho GB, Mak EM, de la Rosa NN, Fang AY, Liong JC, Brummel T, Benzer S. 2007. Prandiology of Drosophila and the CAFE assay. Proc Natl Acad Sci USA. 104(20):8253–8256.
  • Kao YH, Hiipakka RA, Liao S. 2000. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology. 141(3):980–987.
  • Kaun KR, Chakaborty-Chatterjee M, Sokolowski MB. 2008. Natural variation in plasticity of glucose homeostasis and food intake. J Exp Biol. 211(Pt 19):3160–3166.
  • Kayashima Y, Murata S, Sato M, Matsuura K, Asanuma T, Chimoto J, Ishii T, Mochizuki K, Kumazawa S, Nakayama T, Yamakawa-Kobayashi K. 2015. Tea polyphenols ameliorate fat storage induced by high-fat diet in Drosophila melanogaster. Biochem Biophys Rep. 4:417–424.
  • Kim HJ, Jeon SM, Lee MK, Jung UJ, Shin SK, Choi MS. 2009. Antilipogenic effect of green tea extract in C57BL/6J-Lep ob/ob mice. Phytother Res. 23(4):467–471.
  • Lacaille F, Everaerts C, Ferveur JF. 2009. Feminization and alteration of Drosophila taste neurons induce reciprocal effects on male avoidance behavior. Behav Genet. 39(5):554–563.
  • Lee MS, Kim CT, Kim Y. 2009. Green tea (-)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice. Ann Nutr Metab. 54(2):151–157.
  • Lee G, Park JH. 2004. Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster. Genetics. 167(1):311–323.
  • Legeay S, Rodier M, Fillon L, Faure S, Clere N. 2015. Epigallocatechin gallate: a review of its beneficial properties to prevent metabolic syndrome. Nutrients. 7(7):5443–5468.
  • Li YM, Chan HY, Huang Y, Chen ZY. 2007. Green tea catechins upregulate superoxide dismutase and catalase in fruit flies. Mol Nutr Food Res. 51(5):546–554.
  • Li F, Gao C, Yan P, Zhang M, Wang Y, Hu Y, Wu X, Wang X, Sheng J. 2018. EGCG reduces obesity and white adipose tissue gain partly through AMPK activation in mice. Front Pharmacol. 9:1366.
  • Liu CY, Huang CJ, Huang LH, Chen IJ, Chiu JP, Hsu CH. 2014. Effects of green tea extract on insulin resistance and glucagon-like peptide 1 in patients with type 2 diabetes and lipid abnormalities: a randomized, double-blinded, and placebo-controlled trial. PLoS One. 9(3):e91163.
  • Lopez TE, Pham HM, Nguyen BV, Tahmasian Y, Ramsden S, Coskun V, Schriner SE, Jafari M. 2016. Green tea polyphenols require the mitochondrial iron transporter, mitoferrin, for lifespan extension in Drosophila melanogaster. Arch Insect Biochem Physiol. 93(4):210–221.
  • Manenti T, Pertoldi C, Moghadam NN, Nasiri N, Schou MF, Kjaersgaard A, Cavicchi S, Loeschcke V. 2015. Inbreeding affects locomotor activity in Drosophila melanogaster at different ages. Behav Genet. 45(1):127–134.
  • Martinez-Perez DA, Jimenez-Del-Rio M, Velez-Pardo C. 2018. Epigallocatechin-3-gallate protects and prevents paraquat-induced oxidative stress and neurodegeneration in knockdown dj-1-β Drosophila melanogaster. Neurotox Res. 34(3):401–416.
  • Mi Y, Qi G, Fan R, Qiao Q, Sun Y, Gao Y, Liu X. 2017. EGCG ameliorates high-fat- and high-fructose-induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS. Faseb J. 31(11):4998–5011.
  • Oliveira-Pinto AV, Santos RM, Coutinho RA, Oliveira LM, Santos GB, Alho AT, Leite RE, Farfel JM, Suemoto CK, Grinberg LT, et al. 2014. Sexual dimorphism in the human olfactory bulb: females have more neurons and glial cells than males. PLoS One. 9(11):e111733.
  • Ortsater H, Grankvist N, Wolfram S, Kuehn N, Sjoholm A. 2012. Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice. Nutr Metab (Lond). 9:11.
  • Pallauf K, Duckstein N, Rimbach G. 2017. A literature review of flavonoids and lifespan in model organisms. Proc Nutr Soc. 76(2):145–162.
  • Pandey UB, Nichols CD. 2011. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev. 63(2):411–436.
  • Park JH, Bae JH, Im SS, Song DK. 2014. Green tea and type 2 diabetes. Integr Med Res. 3(1):4–10.
  • Park JH, Jin JY, Baek WK, Park SH, Sung HY, Kim YK, Lee J, Song DK. 2009. Ambivalent role of gallated catechins in glucose tolerance in humans: a novel insight into non-absorbable gallated catechin-derived inhibitors of glucose absorption. J Physiol Pharmacol. 60(4):101–109.
  • Ramirez-Sanchez I, Nogueira L, Moreno A, Murphy A, Taub P, Perkins G, Ceballos GM, Hogan M, Malek M, Villarreal F. 2012. Stimulatory effects of the flavanol (-)-epicatechin on cardiac angiogenesis: additive effects with exercise. J Cardiovasc Pharmacol. 60(5):429–438.
  • Reiter LT, Potocki L, Chien S, Gribskov M, Bier E. 2001. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res. 11(6):1114–1125.
  • Rumpler W, Seale J, Clevidence B, Judd J, Wiley E, Yamamoto S, Komatsu T, Sawaki T, Ishikura Y, Hosoda K. 2001. Oolong tea increases metabolic rate and fat oxidation in men. J Nutr. 131(11):2848–2852.
  • Samavat H, Newman AR, Wang R, Yuan JM, Wu AH, Kurzer MS. 2016. Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial. Am J Clin Nutr. 104(6):1671–1682.
  • Song X, Du J, Zhao W, Guo Z. 2017. Epigallocatechin-3-gallate(EGCG): mechanisms and the combined applications. CCHTS. 20(10):872–885.
  • Stillwell RC, Blanckenhorn WU, Teder T, Davidowitz G, Fox CW. 2010. Sex differences in phenotypic plasticity affect variation in sexual size dimorphism in insects: from physiology to evolution. Annu Rev Entomol. 55:227–245.
  • Strobel P, Allard C, Perez-Acle T, Calderon R, Aldunate R, Leighton F. 2005. Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. Biochem J. 386(Pt 3):471–478.
  • Sun Q, Yue Y, Shen P, Yang JJ, Park Y. 2016. Cranberry product decreases fat accumulation in Caenorhabditis elegans. J Med Food. 19(4):427–433.
  • Swarup S, Morozova TV, Sridhar S, Nokes M, Anholt RR. 2014. Modulation of feeding behavior by odorant-binding proteins in Drosophila melanogaster. Chem Senses. 39(2):125–132.
  • Tcherepanova I, Puigserver P, Norris JD, Spiegelman BM, McDonnell DP. 2000. Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. J Biol Chem. 275(21):16302–16308.
  • Tennessen JM, Barry WE, Cox J, Thummel CS. 2014. Methods for studying metabolism in Drosophila. Methods. 68(1):105–115.
  • Tinkerhess MJ, Healy L, Morgan M, Sujkowski A, Matthys E, Zheng L, Wessells RJ. 2012. The Drosophila PGC-1α homolog spargel modulates the physiological effects of endurance exercise. PLoS One. 7(2):e31633.
  • Trinh I, Boulianne GL. 2013. Modeling obesity and its associated disorders in Drosophila. Physiology (Bethesda). 28(2):117–124.
  • Wagner AE, Piegholdt S, Rabe D, Baenas N, Schloesser A, Eggersdorfer M, Stocker A, Rimbach G. 2015. Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster. Oncotarget. 6(31):30568–30578.
  • Wolfram S, Raederstorff D, Wang Y, Teixeira SR, Elste V, Weber P. 2005. TEAVIGO (epigallocatechin gallate) supplementation prevents obesity in rodents by reducing adipose tissue mass. Ann Nutr Metab. 49(1):54–63.
  • Yang CS, Zhang J, Zhang L, Huang J, Wang Y. 2016. Mechanisms of body weight reduction and metabolic syndrome alleviation by tea. Mol Nutr Food Res. 60(1):160–174.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.