345
Views
8
CrossRef citations to date
0
Altmetric
In vitro and animal studies

Simultaneous determination of the pharmacokinetics of A-type EGCG and ECG dimers in mice plasma and its metabolites by UPLC-QTOF-MS

, , , &
Pages 211-220 | Received 29 Dec 2018, Accepted 19 Jun 2019, Published online: 03 Jul 2019

References

  • Baba S, Osakabe N, Natsume M, Terao J. 2002. Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats. Free Radic Biol Med. 33(1):142–148.
  • Bastos DH, Saldanha LA, Catharino RR, Sawaya AC, Cunha IB, Carvalho PO, Eberlin MN. 2007. Phenolic antioxidants identified by ESI-MS from Yerba maté (Ilex paraguariensis) and green tea (Camelia sinensis) extracts. Molecules. 12(3):423–432.
  • Buchner N, Krumbein A, Rohn S, Kroh LW. 2006. Effect of thermal processing on the flavonols rutin and quercetin. Rapid Commun Mass Spectrom. 20(21):3229–3235.
  • Chen J, Xu Z, Zhu W, Nie R, Li CM. 2016. Novel proanthocyanidin dimer analogues with the C-ring-opened diaryl-propan-2-gallate structural unit and enhanced antioxidant activities. J Funct Foods. 21:290–300.
  • Déprez S, Brezillon C, Rabot S, Philippe C, Mila I, Lapierre C, Scalbert A. 2000. Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids. J Nutr. 130(11):2733–2738.
  • Dong XQ, Zou B, Zhang Y, Ge ZZ, Du J, Li CM. 2013. Preparation of A-type proanthocyanidin dimers from peanut skins and persimmon pulp and comparison of the antioxidant activity of A-type and B-type dimers. Fitoterapia. 91:128–139.
  • Fröhlich B, Niemetz R, Gross GG. 2002. Gallotannin biosynthesis: two new galloyltransferases from Rhus typhina leaves preferentially acylating hexa- and heptagalloylglucoses. Planta. 216(1):168–172.
  • Fu T, Liang J, Han G, Lv L, Li N. 2008. Simultaneous determination of the major active components of tea polyphenols in rat plasma by a simple and specific HPLC assay. J Chromatogr B. 875(2):363–367.
  • Ge ZZ, Dong XQ, Zhu W, Zhang Y, Li CM. 2015. Metabolites and changes in antioxidant activity of A-type and B-type proanthocyanidin dimers after incubation with rat intestinal microbiota. J Agric Food Chem. 63(41):8991–8998.
  • Holt RR, Lazarus SA, M Cameron S, Qin Yan Z, Schramm DD, Hammerstone JF, Fraga CG, Schmitz HH, Keen CL. 2002. Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. Am J Clin Nutr. 76(4):798–804.
  • Li H-J, Deinzer ML. 2008. The mass spectral analysis of isolated hops A-type proanthocyanidins by electrospray ionization tandem mass spectrometry. J Mass Spectrom. 43(10):1353–1363.
  • Liu Y, Ge J, Wang MX, Cui L, Han BY. 2014. Research on the pharmacokinetics and elimination of epigallocatechin gallate (EGCG) in mice. Lect Notes Electr Eng. 269:1291–1298.
  • Ma F, Gong X, Xin Z, Yang Z, Li M. 2015. An UHPLC–MS/MS method for simultaneous quantification of gallic acid and protocatechuic acid in rat plasma after oral administration of Polygonum capitatum extract and its application to pharmacokinetics. J Ethnopharmacol. 162:377–383.
  • Mateos-Martín ML, Pérez-Jiménez J, Fuguet E, Torres JL. 2012. Non-extractable proanthocyanidins from grapes are a source of bioavailable (epi)catechin and derived metabolites in rats. Br J Nutr. 108(2):290–297.
  • Mena P, Bresciani L, Brindani N, Ludwig IA, Pereira-Caro G, Angelino D, Llorach R, Calani L, Brighenti F, Clifford MN, et al. 2019. Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity. Nat Prod Rep. 36:714–752.
  • Ou K, Gu L. 2014. Absorption and metabolism of proanthocyanidins. J Funct Foods. 7(1):43–53.
  • Pereira C, Barros L, Alves MJ, Pereira L, Santos-Buelga C, Ferreira I. 2015. Phenolic profile and antimicrobial activity of different dietary supplements based on Cochlospermum angolensis Welw. Ind Crop Prod. 74:412–416.
  • Rios LY, Gonthier MP, Rémésy C, Mila I, Lapierre C, Lazarus SA, Williamson G, Scalbert A. 2003. Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects. Am J Clin Nutr. 77(4):912–918.
  • Schroeter H, Heiss C, Spencer JP, Keen CL, Lupton JR, Schmitz HH. 2010. Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs. Mol Aspects Med. 31(6):546–557.
  • Spencer JP, Schroeter H, Rechner AR, Rice-Evans C. 2001. Bioavailability of flavan-3-ols and procyanidins: gastrointestinal tract influences and their relevance to bioactive forms in vivo. Antioxid Redox Signal. 3(6):1023–1039.
  • Stoupi S, Williamson G, Viton F, Barron D, King LJ, Brown JE, Clifford MN. 2010. In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats. Drug Metab Dispos. 38(2):287–291.
  • Su YL, Lai Kwok L, Huang Y, Chen ZY. 2003. Stability of tea theaflavins and catechins. Food Chem. 83:189–195.
  • Urpí-Sardà M, Jáuregui O, Lamuela-Raventós RM, Jaeger W, Miksits M, Covas MI, Andres-Lacueva C. 2005. Uptake of diet resveratrol into the human low-density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry. Anal Chem. 77(10):3149–3155.
  • Urpi-Sarda M, Monagas M, Khan N, Llorach R, Lamuelaraventós RM, Jáuregui O, Estruch R, Izquierdopulido M, Andréslacueva C, Cifuentes A. 2009. Targeted metabolic profiling of phenolics in urine and plasma after regular consumption of cocoa by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 1216(43):7258–7267.
  • Williamson G, Manach C. 2005. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr. 81(1 Suppl):243S–255S.
  • Zhang ZC, Xu M, Sun SF, Qiao X, Wang BR, Han J, Guo DA. 2008. Metabolic analysis of four phenolic acids in rat by liquid chromatography–tandem mass spectrometry. J Chromatogr B. 871(1):7–14.
  • Zhong S, Liu J, Ren X, Zhang J, Zhou S, Xu XP. 2008. Pharmacokinetics and excretion of chlorogenic acid in beagle dogs. Pharmazie. 63(7):520–524.
  • Zhu W, Zou B, Nie R, Zhang Y, Li CM. 2015. A-type ECG and EGCG dimers disturb the structure of 3T3-L1 cell membrane and strongly inhibit its differentiation by targeting peroxisome proliferator-activated receptor γ with miR-27 involved mechanism. J Nutr Biochem. 26(11):1124–1135.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.