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Comprehensive reviews

Vitamin D, reproductive disorders and assisted reproduction: evidences and perspectives

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Pages 276-285 | Received 13 Jun 2019, Accepted 26 Aug 2019, Published online: 05 Sep 2019

References

  • Abdelraheem MS, Al-Hendy A. 2010. Serum vitamin D3 level inversely correlates with total fibroid tumor burden in women with symptomatic uterine fibroid. Fert Steril. 94(4):S74.
  • Almassinokiani F, Khodaverdi S, Solaymani-Dodaran M, Akbari P, Pazouki A. 2016. Effects of Vitamin D on endometriosis-related pain: a double-blind clinical trial. Med Sci Monit. 22:4960–4966.
  • Anastasi E, Fuggetta E, De Vito C, Migliar G, Viggiani V, Manganaro L, Granato T, Benedetti Panici P, Angeloni A, Porpora MG. 2017. Low levels of 25-OH vitamin D in women with endometriosis and associated pelvic pain. Clin Chem Lab Med. 55(12):e282–e284.
  • Artaza JN, Sirad F, Ferrini MG, Norris KC. 2010. 1,25(OH)2 vitamin D3 inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cells. J Steroid Biochem Mol Biol. 119(1–2):73–83.
  • Baird DD, Hill MC, Schectman JM, Hollis BW. 2013. Vitamin d and the risk of uterine fibroids. Epidemiology. 24(3):447–453.
  • Bandera Merchan B, Morcillo S, Martin-Nuñez G, Tinahones FJ, Macías-González M. 2017. The role of vitamin D and VDR in carcinogenesis: Through epidemiology and basic sciences. J Steroid Biochem Mol Biol. 167:203–218.
  • Barrera D, Díaz L, Noyola-Martínez N, Halhali A. 2015. Vitamin D and inflammatory cytokines in healthy and preeclamptic pregnancies. Nutrients. 7(8):6465–6490.
  • Bikle DD. 2014. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 21(3):319–329.
  • Borkowski J, Gmyrek GB, Madej JP, Nowacki W, Goluda M, Gabry M, Stefaniak T, Chełmońska-Soyta A. 2008. Serum and peritoneal evaluation of vitamin D-binding protein in women with endometriosis. Postepy Hig Med Dosw (Online). 62:103–109.
  • Chang EM, Kim YS, Won HJ, Yoon TK, Lee WS. 2014. Association between sex steroids, ovarian reserve, and vitamin D levels in healthy nonobese women. J Clin Endocrinol Metab. 99(7):2526–2532.
  • Chern CU, Tsui KH, Vitale SG, Chen SN, Wang PH, Cianci A, Tsai HW, Wen ZH, Lin LT. 2018. Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: a retrospective cohort study. Reprod Biol Endocrinol. 16(1):90.
  • Chiofalo B, Laganà AS, Vaiarelli A, La Rosa VL, Rossetti D, Palmara V, Valenti G, Rapisarda AMC, Granese R, Sapia F, et al. 2017. Do miRNAs play a role in fetal growth restriction? A fresh look to a busy corner. Biomed Res Int. 2017:6073167.
  • Chu J, Gallos I, Tobias A, Tan B, Eapen A, Coomarasamy A. 2018. Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-analysis. Hum Reprod. 33(1):65–80.
  • Ciavattini A, Delli Carpini G, Serri M, Vignini A, Sabbatinelli J, Tozzi A, Aggiusti A, Clemente N. 2016. Hypovitaminosis D and "small burden" uterine fibroids: Opportunity for a vitamin D supplementation. Medicine (Baltimore). 95(52):e5698
  • Ciavattini A, Serri M, Delli Carpini G, Morini S, Clemente N. 2017. Ovarian endometriosis and vitamin D serum levels. Gynecol Endocrinol. 33(2):164–167.
  • Ciebiera M, Włodarczyk M, Ciebiera M, Zaręba K, Łukaszuk K, Jakiel G. 2018. Vitamin D and uterine fibroids-review of the literature and novel concepts. Int J Mol Sci. 19(7):2051.
  • D’Aurizio F, Villalta D, Metus P, Doretto P, Tozzoli R. 2015. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmun Rev. 14(5):363–369.
  • Du H, Daftary GS, Lalwani SI, Taylor HS. 2005. Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Mol Endocrinol. 19(9):2222–2233.
  • Fang F, Ni K, Cai Y, Shang J, Zhang X, Xiong C. 2017. Effect of vitamin D supplementation on polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Clin Pract. 26:53–60.
  • Faserl K, Golderer G, Kremser L, Lindner H, Sarg B, Wildt L, Seeber B. 2011. Polymorphism in vitamin D-binding protein as a genetic risk factor in the pathogenesis of endometriosis. J Clin Endocrinol Metab. 96(1):E233–E241.
  • Firouzabadi RD, Rahmani E, Rahsepar M, Firouzabadi MM. 2014. Value of follicular fluid vitamin D in predicting the pregnancy rate in an IVF program. Arch Gynecol Obstet. 289(1):201–206.
  • Giampaolino P, Della Corte L, Foreste V, Bifulco G. 2019. Is there a relationship between Vitamin D and endometriosis? An overview of literature. Curr Pharm Des. doi: 10.2174/1381612825666190722095401
  • Grundmann M, von Versen-Höynck F. 2011. Vitamin D - roles in women's reproductive health? Reprod Biol Endocrinol. 9:146.
  • Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S, Kimmig R, Mann K, Janssen OE. 2006. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes. 114(10):577–583.
  • Halder SK, Osteen KG, Al-Hend A. 2013. Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and -9 in human uterine fibroid cells. Hum Reprod. 28(9):2407–2416.
  • Harris HR, Chavarro JE, Malspeis S, Willett WC, Missmer SA. 2013. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol. 177(5):420–430.
  • He C, Lin Z, Robb SW, Ezeamama AE. 2015. Serum vitamin D levels and polycystic ovary syndrome: a systematic review and meta-analysis. Nutrients. 7(6):4555–4577.
  • Holick MF. 2004. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 80(6):1678S–1688S.
  • Holick MF. 2007. Vitamin D deficiency. N Engl J Med. 357(3):266–281.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine S. 2011. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 96(7):1911–1930.
  • Irani M, Merhi Z. 2014. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril. 102(2):460–468.e3.
  • Kassi E, Adamopoulos C, Basdra EK, Papavassiliou AG. 2013. Role of vitamin D in atherosclerosis. Circulation. 128(23):2517–2531.
  • Kelsey TW, Wright P, Nelson SM, Anderson RA, Wallace WH. 2011. A validated model of serum anti-müllerian hormone from conception to menopause. PLoS One. 6(7):e22024.
  • Laganà AS, Rossetti P, Sapia F, Chiofalo B, Buscema M, Valenti G, Rapisarda AMC, Vitale SG. 2017. Evidence-based and patient-oriented inositol treatment in polycystic ovary syndrome: changing the perspective of the disease. Int J Endocrinol Metab. 15(1):e43695.
  • Laganà AS, Vergara D, Favilli A, La Rosa VL, Tinelli A, Gerli S, Noventa M, Vitagliano A, Triolo O, Rapisarda AMC, Vitale SG. 2017. Epigenetic and genetic landscape of uterine leiomyomas: a current view over a common gynecological disease. Arch Gynecol Obstet. 296(5):855–867.
  • Laganà AS, Vitale SG, Ban Frangež H, Vrtačnik-Bokal E, D'Anna R. 2017. Vitamin D in human reproduction: the more, the better? An evidence-based critical appraisal. Eur Rev Med Pharmacol Sci. 21(18):4243–4251.
  • Lasco A, Catalano A, Benvenga S. 2012. Improvement of primary dysmenorrhea caused by a single oral dose of vitamin D: results of a randomized, double-blind, placebo-controlled study. Arch Intern Med. 172(4):366–367.
  • Lerchbaum E, Obermayer-Pietsch B. 2012. Vitamin D and fertility: a systematic review. Eur J Endocrinol. 166(5):765–778.
  • Li HW, Brereton RE, Anderson RA, Wallace AM, Ho CK. 2011. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metab Clin Exp. 60(10):1475–1481.
  • Lin LT, Vitale SG, Chen SN, Wen ZH, Tsai HW, Chern CU, Tsui KH. 2018. Luteal phase ovarian stimulation may improve oocyte retrieval and oocyte quality in poor ovarian responders undergoing in vitro fertilization: preliminary results from a single-center prospective pilot study. Adv Ther. 35(6):847–856.
  • Maestro B, Molero S, Bajo S, Dávila N, Calle C. 2002. Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D(3). Cell Biochem Funct. 20(3):227–232.
  • Merhi Z, Doswell A, Krebs K, Cipolla M. 2014. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab. 99(6):E1137–E1145.
  • Milner RD, Hales CN. 1967. The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro. Diabetologia. 3(1):47–49.
  • Miyashita M, Koga K, Izumi G, Sue F, Makabe T, Taguchi A, Nagai M, Urata Y, Takamura M, Harada M, et al. 2016. Effects of 1,25-dihydroxy vitamin D3 on endometriosis. J Clin Endocrinol Metab. 101(6):2371–2379.
  • Monastra G, De Grazia S, De Luca L, Vittorio S, Unfer V. 2018. Vitamin D: a steroid hormone with progesterone-like activity. Eur Rev Med Pharmacol Sci. 22(8):2502–2512.
  • Murthi P, Yong HE, Ngyuen TP, Ellery S, Singh H, Rahman R, Dickinson H, Walker DW, Davies-Tuck M, Wallace EM, Ebeling PR. 2016. Role of the placental vitamin D receptor in modulating feto-placental growth in fetal growth restriction and preeclampsia-affected pregnancies. Front Physiol. 7:43.
  • Ngo DTM, Chan WP, Rajendran S, Heresztyn T, Amarasekera A, Sverdlov AL, O’Loughlin PD, Morris HA, Chirkov YY, Norman RJ, Horowitz JD. 2011. Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D. Nitric Oxide. 25(3):326–330.
  • Norman AW. 2012. The history of the discovery of vitamin D and its daughter steroid hormone. Ann Nutr Metab. 61(3):199–206.
  • Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, Pal L. 2010. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 94(4):1314–1319.
  • Pawlowska E, Wysokinski D, Blasiak J. 2016. Nucleotide excision repair and vitamin D-relevance for skin cancer therapy. Int J Mol Sci. 17(4):372.
  • Pittas AG, Lau J, Hu FB, Dawson-Hughes B. 2007. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 92(6):2017–2029.
  • Polyzos NP, Anckaert E, Guzman L, Schiettecatte J, Van Landuyt L, Camus M, Smitz J, Tournaye H. 2014. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI. Hum Reprod. 29(9):2032–2040.
  • Rahimi-Ardabili H, Pourghassem Gargari B, Farzadi L. 2013. Effects of vitamin D on cardiovascular disease risk factors in polycystic ovary syndrome women with vitamin D deficiency. J Endocrinol Invest. 36(1):28–32.
  • Reyes-Muñoz E, Sathyapalan T, Rossetti P, Shah M, Long M, Buscema M, Valenti G, La Rosa VL, Cianci S, Vitale SG. 2018. Polycystic ovary syndrome: implication for drug metabolism on assisted reproductive techniques-a literature review. Adv Ther. 35(11):1805–1815.
  • Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. 2012. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 33(3):456–492.
  • Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, et al. 2011. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 96(1):53–58.
  • Rudick BJ, Ingles SA, Chung K, Stanczyk FZ, Paulson RJ, Bendikson KA. 2014. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril. 101(2):447–452.
  • Sabry M, Halder SK, Allah AS, Roshdy E, Rajaratnam V, Al-Hendy A. 2013. Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: a cross-sectional observational study. Int J Womens Health. 5:93–100.
  • Salman H, Shah M, Ali A, Aziz A, Vitale SG. 2018. Assessment of relationship of serum neurokinin-B level in the pathophysiology of pre-eclampsia: a case-control study. Adv Ther. 35(7):1114–1121.
  • Sayegh L, Fuleihan GE-H, Nassar AH. 2014. Vitamin D in endometriosis: a causative or confounding factor? Metabolism. 63(1):32–41.
  • Seifer DB, Maclaughlin DT. 2007. Mullerian inhibiting substance is an ovarian growth factor of emerging clinical significance. Fertil Steril. 88(3):539–546.
  • Sharan C, Halder SK, Thota C, Jaleel T, Nair S, Al-Hendy A. 2011. Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. Fertil Steril. 95(1):247–253.
  • Shoelson SE, Herrero L, Naaz A. 2007. Obesity, inflammation, and insulin resistance. Gastroenterology. 132(6):2169–2180.
  • Skowrońska P, Pastuszek E, Kuczyński W, Jaszczoł M, Kuć P, Jakiel G, Wocławek-Potocka I, Łukaszuk K. 2016. The role of vitamin D in reproductive dysfunction in women - a systematic review. Ann Agric Environ Med. 23(4):671–676.
  • Somigliana E, Panina-Bordignon P, Murone S, Di Lucia P, Vercellini P, Vigano P. 2007. Vitamin D reserve is higher in women with endometriosis. Hum Reprod. 22(8):2273–2278.
  • Spiro A, Buttriss JL. 2014. Vitamin D: an overview of vitamin D status and intake in Europe. Nutr Bull. 39(4):322–350.
  • Viganò P, Lattuada D, Mangioni S, Ermellino L, Vignali M, Caporizzo E, Panina-Bordignon P, Besozzi M, Di Blasio AM. 2006. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J Mol Endocrinol. 36(3):415–424.
  • Vilarino FL, Bianco B, Lerner TG, Teles JS, Mafra FA, Christofolini DM, Barbosa CP. 2011. Analysis of vitamin D receptor gene polymorphisms in women with and without endometriosis. Hum Immunol. 72(4):359–363.
  • Visser JA, de Jong FH, Laven JS, Themmen AP. 2006. Anti-Müllerian hormone: a new marker for ovarian function. Reproduction. 131(1):1–9.
  • Vitale SG, Capriglione S, Peterlunger I, La Rosa VL, Vitagliano A, Noventa M, Valenti G, Sapia F, Angioli R, Lopez S, et al. 2018. The role of oxidative stress and membrane transport systems during endometriosis: a fresh look at a busy corner. Oxid Med Cell Longev. 2018:7924021.
  • Vitale SG, Capriglione S, Zito G, Lopez S, Gulino FA, Di Guardo F, Vitagliano A, Noventa M, La Rosa VL, Sapia F, et al. 2019. Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition. Arch Gynecol Obstet. 299(2):299–315.
  • Vitale SG, La Rosa VL, Rapisarda AMC, Laganà AS. 2017. Endometriosis and infertility: the impact on quality of life and mental health. J Endometr Pelvic Pain Disord. 9(2):112–115.
  • Vitale SG, Padula F, Gulino FA. 2015. Management of uterine fibroids in pregnancy: recent trends. Curr Opin Obstet Gynecol. 27(6):432–437.
  • Vitale SG, Rossetti P, Corrado F, Rapisarda AM, La Vignera S, Condorelli RA, Valenti G, Sapia F, Laganà AS, Buscema M. 2016. How to achieve high-quality oocytes? The key role of myo-inositol and melatonin. Int J Endocrinol. 2016:4987436.
  • Voulgaris N, Papanastasiou L, Piaditis G, Angelousi A, Kaltsas G, Mastorakos G, Kassi E. 2017. Vitamin D and aspects of female fertility. Hormones (Athens). 16(1):5–21.
  • Walker CL, Stewart EA. 2005. Uterine fibroids: the elephant in the room. Science. 308(5728):1589–1592.
  • Wehr E, Pilz S, Schweighofer N, Giuliani A, Kopera D, Pieber TR, Obermayer-Pietsch B. 2009. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol. 161(4):575–582.
  • Wei SQ. 2014. Vitamin D and pregnancy outcomes. Curr Opin Obstet Gynecol. 26(6):438–447.
  • Yamamoto N, Naraparaju VR, Moore M, Brent LH. 1997. Deglycosylation of serum vitamin D3-binding protein by alpha-N-acetylgalactosaminidase detected in the plasma of patients with systemic lupus erythematosus. Clin Immunol Immunopathol. 82(3):290–298.
  • Yildizhan R, Kurdoglu M, Adali E, Kolusari A, Yildizhan B, Sahin HG, Kamaci M. 2009. Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome. Arch Gynecol Obstet. 280(4):559–563.
  • Zhu L, Chen H, Liu M, Yuan Y, Wang Z, Chen Y, Wei J, Su F, Zhang J. 2017. Treg/Th17 cell imbalance and IL-6 profile in patients with unexplained recurrent spontaneous abortion. Reprod Sci. 24(6):882–890.

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